{"id":51132,"date":"2023-09-20T09:17:48","date_gmt":"2023-09-20T09:17:48","guid":{"rendered":"https:\/\/medsname.com\/zimivir\/"},"modified":"2026-04-30T16:19:01","modified_gmt":"2026-04-30T16:19:01","slug":"zimivir","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/zimivir\/","title":{"rendered":"Zimivir"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">R\u0103spuns rapid<\/h3>\n<p style=\"margin-bottom:0;\"><strong>Zimivir<\/strong> \u2014 valacyclovir 500\/1000 mg (GlaxoSmithKline). Prodrug al aciclovirului \u2014 pentru herpes genital (tratament ini\u021bial + supresie), herpes labial, herpes zoster (zona zoster) \u0219i profilaxia CMV la pacien\u021bii transplanta\u021bi. Preferat \u00een locul aciclovirului datorit\u0103 biodisponibilit\u0103\u021bii orale superioare, permi\u021b\u00e2nd administrarea de 2-3 ori pe zi.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>Ce beneficii ofer\u0103 MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>produc\u0103tor certificat WHO-GMP<\/li>\n<li>Ambalaj discret \u00een plic simplu<\/li>\n<li>Livrare \u00een toat\u0103 lumea<\/li>\n<li>Evaluat de peste 1.400 de clien\u021bi (<a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">cite\u0219te recenziile<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>Garan\u021bia de retransmitere:<\/strong> dac\u0103 comanda dvs. nu a ajuns \u00een 20 de zile lucr\u0103toare de la expediere, o retransmitem f\u0103r\u0103 costuri suplimentare. <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Cite\u0219te politica<\/a>.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Zimivir este expediat de la un produc\u0103tor certificat WHO-GMP \u00een ambalaj neutru, facturat prin procesator de plat\u0103 reglementat (descrierea extrasului de cont men\u021bioneaz\u0103 un procesator de pl\u0103\u021bi cu cardul reglementat \u2014 niciodat\u0103 MedsBase sau nume de medicamente). Fiecare comand\u0103 beneficiaz\u0103 de Asigurarea de Reexpediere pe 20 de zile lucr\u0103toare.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Ajustare doz\u0103 renal\u0103 + hidratare<\/strong><br \/>Valaciclovirul este eliminat renal; deshidratarea poate provoca cristalizare \u0219i leziune renal\u0103 acut\u0103. Men\u021bine\u021bi o hidratare adecvat\u0103. Ajusta\u021bi doza pentru CrCl &lt;50 mL\/min. Precau\u021bie la v\u00e2rstnici.<\/div>\n<h2>Doze \u00een func\u021bie de indica\u021bie<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:12px 0;\">\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;border:1px solid #ddd;\">Indica\u021bie<\/th>\n<th style=\"padding:8px;border:1px solid #ddd;\">Doza<\/th>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Herpes genital primar (imunocompetent)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">1 g de 2 ori\/zi \u00d7 7-10 zile<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Herpes genital recurent (\u00eencepe\u021bi \u00een primele 24 de ore)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">500 mg de 2 ori\/zi \u00d7 3 zile SAU 1 g o dat\u0103\/zi \u00d7 5 zile<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Terapie supresiv\u0103 (\u22656 episoade\/an)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">500 mg sau 1 g o dat\u0103\/zi pe termen lung<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Herpes labial (\u00eencepe\u021bi la primele simptome prodromice)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">2 g de 2 ori pe zi \u00d7 1 zi (regim de o singur\u0103 zi)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Herpes zoster (zona, &lt;72 de ore de la apari\u021bia erup\u021biei)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">1 g de 3 ori pe zi \u00d7 7 zile<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Prevenirea transmiterii HSV c\u0103tre partener (cu practici sexuale sigure)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">500 mg o dat\u0103 pe zi pe termen lung<\/td>\n<\/tr>\n<\/table>\n<p>Este necesar\u0103 ajustarea dozei la pacien\u021bii cu clearance renal (CrCl) &lt;50 mL\/min. Hidratarea adecvat\u0103 \u00een timpul terapiei reduce riscul de cristalizare.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>Valacyclovir vs acyclovir \u2014 care este mai bun?<\/h3>\n<p>Acela\u0219i principiu activ (acyclovir). Valacyclovir are o biodisponibilitate oral\u0103 de 3-5 ori mai mare \u0219i permite administrarea de 2-3 ori pe zi \u00een loc de 5 ori, \u00eembun\u0103t\u0103\u021bind dramatic adheren\u021ba. Rezervat pentru afec\u021biuni severe (encefalita HSV, HSV neonatal), acyclovirul IV r\u0103m\u00e2ne preferat.<\/p>\n<h3>C\u00e2nd s\u0103 \u00eencepe\u021bi tratamentul?<\/h3>\n<p>\u00cen primele 24 de ore de la debutul simptomelor pentru herpes genital episodic. \u00cen primele 72 de ore de la erup\u021bie pentru zona. La primul prodrom pentru herpesul labial. Cu c\u00e2t mai devreme = puseu mai scurt.<\/p>\n<h3>C\u00e2t timp pentru suprimare?<\/h3>\n<p>Cel pu\u021bin 6-12 luni pentru suprimarea herpesului genital la pacien\u021bii cu recuren\u021be frecvente. Reevalua\u021bi anual \u2014 evolu\u021bia natural\u0103 este adesea de \u00eembun\u0103t\u0103\u021bire pe parcursul anilor, a\u0219a c\u0103 o \u00eencercare f\u0103r\u0103 terapie este rezonabil\u0103.<\/p>\n<h3>Efecte secundare?<\/h3>\n<p>\u00cen general bine tolerat: cefalee, grea\u021b\u0103, oboseal\u0103, ame\u021beli. Rare: purpur\u0103 trombotic\u0103 trombocitopenic\u0103\/sindrom hemolitic uremic (TTP\/HUS) la pacien\u021bii imunocompromi\u0219i (avertizare FDA), leziune renal\u0103 acut\u0103 (mai ales dac\u0103 este deshidratat).<\/p>\n<h3>Sarcin\u0103?<\/h3>\n<p>Valacyclovir este utilizat pe scar\u0103 larg\u0103 \u00een sarcin\u0103 (Categoria B de sarcin\u0103), \u00een special terapia de suprimare de la 36 de s\u0103pt\u0103m\u00e2ni la femeile HSV-pozitive pentru a preveni HSV neonatal. Discuta\u021bi cu echipa obstetric\u0103.<\/p>\n<h3>Interac\u021biuni medicamentoase?<\/h3>\n<p>Interac\u021biuni majore rare. Evita\u021bi combina\u021bia cu alte medicamente nefrotoxice (AINS pe termen lung, aminoglicozide). Probenecid + cimetidin\u0103 cresc u\u0219or nivelurile \u2014 de obicei nesemnificativ clinic.<\/p>\n<h3>Ajustare de doz\u0103 la insuficien\u021b\u0103 renal\u0103?<\/h3>\n<p>Necesar\u0103 pentru CrCl &lt;50 mL\/min. Riscul de acumulare \u0219i simptome neuropsihiatrice (confuzie, halucina\u021bii) \u00een insuficien\u021b\u0103 renal\u0103, mai ales la v\u00e2rstnici.<\/p>\n<h3>Ce fac dac\u0103 uit o doz\u0103?<\/h3>\n<p>Lua\u021bi c\u00e2nd v\u0103 aminti\u021bi, cu excep\u021bia cazului c\u00e2nd este aproape timpul pentru urm\u0103toarea doz\u0103. Nu dubla\u021bi doza. Omiterile de doze \u00een terapia episodic\u0103 reduc efectul; \u00een terapia de suprimare, omiterile ocazionale sunt tolerabile, dar consecven\u021ba este important\u0103 pentru prevenirea transmiterii.<\/p>\n<h3>Vindec\u0103 herpesul?<\/h3>\n<p>Nu \u2014 infec\u021bia cu herpes este pe via\u021b\u0103. Antiviralele reduc replicarea viral\u0103 \u00een timpul erup\u021biilor \u0219i previne transmiterea, dar nu eradic\u0103 virusul latent. Cercet\u0103rile recente axate pe vindecare (CRISPR, editare genetic\u0103) sunt experimentale.<\/p>\n<h3>\u0218i riscul de transmitere?<\/h3>\n<p>Valaciclovirul de suprimare la partenerul HSV-pozitiv reduce transmiterea la partenerul negativ cu ~50% (Corey 2004). Combinat cu utilizarea consecvent\u0103 a prezervativului \u0219i evitarea rela\u021biilor sexuale \u00een timpul erup\u021biilor, riscul de transmitere scade \u0219i mai mult.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Alte medicamente antivirale<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/zimivir\/\">Zimivir<\/a> \u2014 valaciclovir 500\/1000 mg \u2014 marc\u0103 alternativ\u0103<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/natclovir\/\">Natclovir<\/a> \u2014 valaciclovir \u2014 marc\u0103 Natco<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/centrex\/\">Centrex<\/a> \u2014 valaciclovir 500\/1000 mg \u2014 marc\u0103 Centurion<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/valgan\/\">Valgan<\/a> \u2014 valganciclovir 450 mg \u2014 pentru CMV la pacien\u021bii transplanta\u021bi<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/zovirax\/\">Zovirax<\/a> \u2014 aciclovir \u2014 alternativ\u0103 mai veche<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>Disclaimer medical:<\/strong> Aceast\u0103 pagin\u0103 este doar informativ\u0103 \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui clinician calificat. Discuta\u021bi orice medicament nou cu medicul sau farmacistul dumneavoastr\u0103.<\/div>","protected":false},"excerpt":{"rendered":"<p>Zimivir (Valacyclovir 500\/1000 mg) \u2014 produs GSK derivat din aciclovir pentru herpes genital (tratament ini\u021bial + supresie), herpes labial \u0219i herpes zoster. Biodisponibilitate oral\u0103 \u00eembun\u0103t\u0103\u021bit\u0103 permite administrarea de 2-3 ori pe zi.<\/p>","protected":false},"featured_media":51133,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3304],"product_tag":[],"class_list":{"0":"post-51132","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-hiv-medication","10":"first","11":"outofstock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/51132","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=51132"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/51133"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=51132"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=51132"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=51132"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=51132"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}