{"id":51176,"date":"2023-09-20T09:18:19","date_gmt":"2023-09-20T09:18:19","guid":{"rendered":"https:\/\/medsname.com\/tenvir-em\/"},"modified":"2026-05-21T05:27:39","modified_gmt":"2026-05-21T05:27:39","slug":"tenvir-em","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/tenvir-em\/","title":{"rendered":"Tenvir Em"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Tenvir-EM?<\/h3>\n<p style=\"margin:0;\"><strong>Tenvir-EM<\/strong> este un comprimat cu doz\u0103 fix\u0103 care combin\u0103 <strong>tenofovir disoproxil fumarat (TDF) 300 mg<\/strong> \u0219i <strong>emtricitabin\u0103 (FTC) 200 mg<\/strong>. Este utilizat pentru <strong>Profilaxia pre-expunere la HIV (PrEP)<\/strong> prevenirea transmiterii HIV prin contact sexual, ca parte a <strong>tratamentului combinat \u00eempotriva HIV<\/strong>, precum \u0219i \u00een <strong>Profilaxia post-expunere la HIV (PEP)<\/strong>. Fabricat de <strong>Cipla<\/strong> ca echivalent generic al produsului Gilead <strong>Truvada<sup>\u00ae<\/sup><\/strong>. O tablet\u0103 o dat\u0103 pe zi; statutul HIV-negativ \u0219i func\u021bia renal\u0103 trebuie confirmate \u00eenainte de a \u00eencepe PrEP.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f6f7fb;border:1px solid #e3e5ee;border-radius:8px;padding:14px 18px;margin:18px 0;font-size:14px;line-height:1.55;\"><strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Provenit de la un produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare worldwide \u00b7 <a href=\"\/ro\/reviews\/\" rel=\"noopener\">Peste 1.400 de recenzii verificate ale clien\u021bilor<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Comand\u00e2nd de la MedsBase beneficia\u021bi de surs\u0103 de la un produc\u0103tor certificat WHO-GMP, ambalaj discret \u00een plic simplu, livrare worldwide \u0219i evalu\u0103ri de 4.9\u2605 de la peste 1.400 de clien\u021bi verifica\u021bi. Pl\u0103\u021bile cu cardul sunt procesate printr-un on-ramp crypto reglementat \u2014 descriptorul de pe extrasul de cont va afi\u0219a numele procesatorului (un procesator de pl\u0103\u021bi cu card reglementat), niciodat\u0103 \u201cMedsBase\u201d sau nume de medicamente. Fiecare colet este acoperit de <a href=\"\/ro\/medsbase-re-shipment-assurance-policy\/\" rel=\"noopener\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a>.<\/p>\n<p><strong>Tenvir-EM<\/strong> este un <strong>comprimat antiretroviral cu doz\u0103 fix\u0103 de dou\u0103 medicamente<\/strong> combin\u00e2nd <strong>tenofovir disoproxil fumarat (TDF) 300 mg<\/strong> \u0219i <strong>emtricitabin\u0103 (FTC) 200 mg<\/strong>. Este fabricat de <strong>Cipla<\/strong> conform standardelor farmaceutice \u0219i con\u021bine acelea\u0219i ingrediente active ca produsul original Gilead Sciences <strong>Truvada<sup>\u00ae<\/sup><\/strong> \u2014 la o frac\u021biune din pre\u021b. Fiecare comprimat se ia o dat\u0103 pe zi, cu sau f\u0103r\u0103 m\u00e2ncare.<\/p>\n<p>Tenvir-EM are trei utiliz\u0103ri clinice majore: <strong>Profilaxia pre-expunere la HIV (PrEP)<\/strong>, <strong>tratament combinat pentru HIV<\/strong>, \u0219i <strong>Profilaxia post-expunere la HIV (PEP)<\/strong>. Este inclus \u00een <strong>Lista Model OMS a Medicamentelor Esen\u021biale<\/strong> \u0219i reprezint\u0103 baza majorit\u0103\u021bii programelor globale de PrEP, inclusiv cele ale CDC din Statele Unite.<\/p>\n<h2 class=\"wp-block-heading\">Ce este Tenvir-EM?<\/h2>\n<p>Tenvir-EM este o combina\u021bie de doi <strong>inhibitori nucleozidici\/nucleotidici de transcriptaz\u0103 invers\u0103 (NRTI)<\/strong>:<\/p>\n<ul>\n<li><strong>Tenofovir disoproxil fumarat (TDF)<\/strong> \u2014 un analog de nucleotid\u0103 care blocheaz\u0103 transcriptaza invers\u0103 a HIV<\/li>\n<li><strong>Emtricitabina (FTC)<\/strong> \u2014 un analog de citidin\u0103 care blocheaz\u0103, de asemenea, transcriptaza invers\u0103 \u0219i ac\u021bioneaz\u0103 sinergic cu TDF<\/li>\n<\/ul>\n<p>Atunci c\u00e2nd este luat \u00een mod constant, Tenvir-EM produce niveluri intracelulare ale medicamentului \u00een \u021besuturile genitale, rectale \u0219i sangvine suficient de ridicate pentru a preveni infectarea cu HIV dup\u0103 expunere \u2014 sau pentru a suprima replicarea HIV la o persoan\u0103 deja infectat\u0103 (c\u00e2nd este utilizat ca parte a unui regim cu trei medicamente).<\/p>\n<p>Tenvir-EM este indicat pentru:<\/p>\n<ul>\n<li><strong>Profilaxia pre-expunere la HIV-1 (PrEP)<\/strong> \u2014 la adul\u021bi HIV-negativi cu risc substan\u021bial de achizi\u021bie a HIV<\/li>\n<li><strong>Profilaxia post-expunere la HIV-1 (PEP)<\/strong> \u2014 ca parte a unui regim triplu de 28 de zile dup\u0103 expunerea suspect\u0103 la HIV<\/li>\n<li><strong>Tratamentul combinat al HIV-1<\/strong> \u2014 ca baz\u0103 de NRTI al\u0103turi de un al treilea agent (inhibitor de integraz\u0103, NNRTI sau inhibitor de proteaz\u0103 poten\u021biat)<\/li>\n<li><strong>Hepatita B cronic\u0103<\/strong> \u2014 \u00een afara indica\u021biilor, dar frecvent \u00een practica clinic\u0103, deoarece TDF este autorizat pentru monoterapia HBV \u00een alte produse<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Cum func\u021bioneaz\u0103 Tenvir-EM?<\/h2>\n<p>At\u00e2t TDF, c\u00e2t \u0219i FTC sunt <strong>pro-droguri<\/strong> care sunt fosforilate \u00een interiorul celulelor \u00een formele lor active trifosfat:<\/p>\n<ul>\n<li>Tenofovir difosfat intracelular \u0219i emtricitabin trifosfat concureaz\u0103 cu nucleotidele naturale pentru a fi \u00eencorporate \u00een lan\u021bul de ADN HIV \u00een cre\u0219tere<\/li>\n<li>Odat\u0103 \u00eencorporate, acestea ac\u021bioneaz\u0103 ca <strong>terminatori de lan\u021b<\/strong> \u2014 transcriptaza invers\u0103 HIV nu poate prelungi lan\u021bul de ADN, astfel \u00eenc\u00e2t genomul viral nu se poate replica<\/li>\n<li>Cu dozarea zilnic\u0103 constant\u0103, nivelurile medicamentului \u00een \u021besutul rectal ating concentra\u021bii protectoare \u00een aproximativ <strong>7 zile<\/strong> \u0219i \u00een \u021besutul vaginal \u00een aproximativ <strong>20 de zile<\/strong><\/li>\n<li>Studiile clinice (iPrEx, Partners PrEP, PROUD) arat\u0103 c\u0103 atunci c\u00e2nd Tenvir-EM este luat conform prescrip\u021biei, reduce achizi\u021bia sexual\u0103 a HIV cu mai mult de <strong>99%<\/strong><\/li>\n<\/ul>\n<p>PrEP este cel mai eficient atunci c\u00e2nd este luat zilnic. Dozele ratate reduc protec\u021bia, \u00een special pentru expunerea vaginal\u0103 receptiv\u0103, unde absorb\u021bia medicamentului \u00een \u021besut este mai lent\u0103 dec\u00e2t \u00een \u021besutul rectal.<\/p>\n<h2 class=\"wp-block-heading\">Utiliz\u0103ri \u0219i indica\u021bii<\/h2>\n<ul>\n<li><strong>Profilaxia pre-expunere la HIV-1 (PrEP)<\/strong> \u2014 b\u0103rba\u021bii care au rela\u021bii sexuale cu b\u0103rba\u021bi, cupluri serodiscordante, persoane transgender, persoane care injecteaz\u0103 droguri \u0219i orice adult HIV-negativ cu risc sexual continuu<\/li>\n<li><strong>Profilaxia post-expunere la HIV-1 (PEP)<\/strong> \u2014 combinat cu un al treilea agent (de obicei un inhibitor de integraz\u0103 precum dolutegravir sau raltegravir) timp de 28 de zile dup\u0103 expunerea suspectat\u0103 la HIV. Trebuie \u00eenceput\u0103 \u00een termen de <strong>72 de ore<\/strong> de la expunere; cu c\u00e2t mai devreme, cu at\u00e2t mai bine<\/li>\n<li><strong>Tratamentul combinat al HIV-1<\/strong> \u2014 schelet NRTI cu un al treilea agent partener<\/li>\n<li><strong>Hepatita B cronic\u0103<\/strong> \u2014 componenta TDF este activ\u0103 \u00eempotriva HBV<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dozarea \u0219i administrarea Tenvir-EM<\/h2>\n<table>\n<thead>\n<tr>\n<th>Scenariu<\/th>\n<th>Doza recomandat\u0103<\/th>\n<th>Durat\u0103 \/ Observa\u021bii<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>PrEP zilnic (standard)<\/strong><\/td>\n<td>1 tablet\u0103 o dat\u0103 pe zi<\/td>\n<td>Pe perioada nedeterminat\u0103 c\u00e2t persist\u0103 riscul de expunere; este recomandat s\u0103 fie luat\u0103 \u00een acela\u0219i moment al zilei<\/td>\n<\/tr>\n<tr>\n<td><strong>PrEP la cerere \u201c2-1-1\u201d (doar pentru MSM)<\/strong><\/td>\n<td>2 tablete cu 2\u201324 h \u00eenainte de sex; 1 tablet\u0103 la 24 h dup\u0103; 1 tablet\u0103 la 48 h dup\u0103<\/td>\n<td>Conform protocolului studiu IPERGAY; doar pentru popula\u021bia MSM, nevalidat pentru rela\u021bii vaginale<\/td>\n<\/tr>\n<tr>\n<td><strong>PEP (terapie tripl\u0103)<\/strong><\/td>\n<td>1 tablet\u0103 o dat\u0103 pe zi + un al treilea agent<\/td>\n<td>\u00cencepe\u021bi \u00een termen de 72 de ore de la expunere; curs de 28 de zile<\/td>\n<\/tr>\n<tr>\n<td><strong>Tratament HIV<\/strong><\/td>\n<td>1 tablet\u0103 o dat\u0103 pe zi + un al treilea agent<\/td>\n<td>Pe via\u021b\u0103; este necesar\u0103 o conformitate &gt;95% pentru suprimare viral\u0103 durabil\u0103<\/td>\n<\/tr>\n<tr>\n<td><strong>CrCl 30\u201349 mL\/min<\/strong><\/td>\n<td>1 tablet\u0103 la fiecare 48 de ore<\/td>\n<td>Interval de dozaj redus<\/td>\n<\/tr>\n<tr>\n<td><strong>CrCl &lt;30 mL\/min sau dializ\u0103<\/strong><\/td>\n<td>Nu este recomandat<\/td>\n<td>Comuta\u021bi la o op\u021biune bazat\u0103 pe tenofovir alafenamid\u0103 (TAF), cum ar fi <a href=\"https:\/\/medsbase.com\/ro\/tenvir-af\/\" rel=\"noopener\">Tenvir-AF<\/a><\/td>\n<\/tr>\n<tr>\n<td><strong>Insuficien\u021b\u0103 hepatic\u0103<\/strong><\/td>\n<td>Doza standard<\/td>\n<td>Nu este necesar\u0103 ajustare<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 class=\"wp-block-heading\">Cum s\u0103 lua\u021bi corect Tenvir-EM<\/h3>\n<ul>\n<li>\u00cenghi\u021bi\u021bi comprimatul \u00eentreg cu ap\u0103; poate fi luat cu sau f\u0103r\u0103 m\u00e2ncare<\/li>\n<li>Lua\u021bi la aproximativ acela\u0219i <strong>moment \u00een fiecare zi<\/strong> \u2014 dozele ratate reduc protec\u021bia<\/li>\n<li>\u00cenainte de a \u00eencepe PrEP, confirma\u021bi <strong>statu HIV-negativ<\/strong> cu un test antigen\/anticorp de genera\u021bia a 4-a \u0219i un screening pentru <strong>hepatita B<\/strong> \u0219i <strong>creatinin\u0103 \/ eGFR<\/strong><\/li>\n<li>\u00cen timp ce sunte\u021bi pe PrEP, testa\u021bi-v\u0103 pentru HIV la fiecare 3 luni, func\u021bia renal\u0103 la fiecare 6 luni \u0219i IST-uri cel pu\u021bin la fiecare 6 luni<\/li>\n<li>Nu <strong>nu lua\u021bi Tenvir-EM singur ca tratament pentru HIV<\/strong> dac\u0103 sunte\u021bi HIV-pozitiv \u2014 acest lucru poate selecta virusuri rezistente la medicamente. Este necesar un al treilea agent<\/li>\n<li>Dac\u0103 o doz\u0103 de PrEP este ratat\u0103 cu mai pu\u021bin de 24 de ore, lua\u021bi-o c\u00e2t mai cur\u00e2nd posibil. Dac\u0103 este ratat\u0103 cu mai mult de 24 de ore, lua\u021bi urm\u0103toarea doz\u0103 programat\u0103 \u0219i continua\u021bi<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Efecte secundare ale Tenvir-EM<\/h2>\n<p>Majoritatea pacien\u021bilor tolereaz\u0103 bine Tenvir-EM. Efectele secundare sunt de obicei u\u0219oare \u0219i se amelioraz\u0103 \u00een 2\u20134 s\u0103pt\u0103m\u00e2ni de la \u00eenceperea tratamentului.<\/p>\n<table>\n<thead>\n<tr>\n<th>Severitate<\/th>\n<th>Efect Secundar<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Frecvente (\u22651 din 10)<\/strong><\/td>\n<td>Dureri de cap, grea\u021b\u0103, diaree, oboseal\u0103 \u2014 \u00een special \u00een primele 2\u20134 s\u0103pt\u0103m\u00e2ni (\u201csindromul de \u00eenceput\u201d)<\/td>\n<\/tr>\n<tr>\n<td><strong>Frecvente (\u22651 din 100)<\/strong><\/td>\n<td>Ame\u021beli, dureri abdominale, flatulen\u021b\u0103, erup\u021bii cutanate u\u0219oare, tulbur\u0103ri de somn, cre\u0219terea enzimelor hepatice<\/td>\n<\/tr>\n<tr>\n<td><strong>Pu\u021bin frecvente<\/strong><\/td>\n<td>Sc\u0103derea func\u021biei renale (cre\u0219terea creatininiei, disfunc\u021bie tubular\u0103 proximal\u0103, rareori sindromul Fanconi), reducere u\u0219oar\u0103 a densit\u0103\u021bii minerale osoase<\/td>\n<\/tr>\n<tr>\n<td><strong>Rare, dar grave<\/strong><\/td>\n<td>Acidoz\u0103 lactic\u0103 cu stetoz\u0103 hepatic\u0103 (efect de clas\u0103 NRTI), insuficien\u021b\u0103 renal\u0103 sever\u0103, reactivarea hepatitei B la \u00eentreruperea tratamentului la pacien\u021bii cu HBV pozitiv<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Cere\u021bi imediat aten\u021bie medical\u0103<\/strong> pentru dureri abdominale severe cu v\u0103rs\u0103turi, icter, sc\u0103dere brusc\u0103 a debitului urinar, confuzie sau respira\u021bie rapid\u0103 \u2014 acestea pot fi semne de acidoz\u0103 lactic\u0103, o complica\u021bie rar\u0103 dar grav\u0103 specific\u0103 clasei NRTI.<\/p>\n<h2 class=\"wp-block-heading\">Avertismente \u0219i precau\u021bii<\/h2>\n<ul>\n<li><strong>Test HIV \u00eenainte \u0219i \u00een timpul PrEP.<\/strong> Ini\u021bierea Tenvir-EM (doar dou\u0103 medicamente) la cineva cu HIV nediagnosticat poate selecta rezisten\u021be \u0219i poate compromite tratamentul viitor. Un test HIV de genera\u021bia a 4-a la baz\u0103 \u0219i la fiecare 3 luni este esen\u021bial<\/li>\n<li><strong>Func\u021bia renal\u0103.<\/strong> TDF poate provoca leziuni renale dependente de doz\u0103. Verifica\u021bi eGFR la baz\u0103, la 3 luni, apoi la fiecare 6\u201312 luni. Evita\u021bi dac\u0103 eGFR &lt;30 mL\/min<\/li>\n<li><strong>S\u0103n\u0103tatea osoas\u0103.<\/strong> Reduceri modeste ale densit\u0103\u021bii minerale osoase sunt observate la utilizarea pe termen lung a TDF. Lua\u021bi \u00een considerare suplimente de calciu \u0219i vitamina D<\/li>\n<li><strong>Coinfec\u021bia cu hepatita B.<\/strong> \u00centreruperea Tenvir-EM la cineva cu HBV cronic poate declan\u0219a o reactivare sever\u0103 a hepatitei. Dac\u0103 \u00eentreruperea este necesar\u0103, func\u021bia hepatic\u0103 trebuie monitorizat\u0103 \u00eendeaproape<\/li>\n<li><strong>Testare pentru IST.<\/strong> PrEP previne HIV dar nu \u0219i alte IST \u2014 testarea rutin\u0103 pentru sifilis, gonoree \u0219i clamidie r\u0103m\u00e2ne important\u0103<\/li>\n<li><strong>Sarcin\u0103 \u0219i al\u0103ptare.<\/strong> Tenvir-EM este considerat sigur \u00een timpul sarcinii at\u00e2t pentru tratament c\u00e2t \u0219i pentru PrEP. Al\u0103ptarea nu este recomandat\u0103 pentru femeile HIV-pozitive (cu excep\u021bia zonelor cu resurse limitate conform recomand\u0103rilor OMS)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindica\u021bii \u2014 Cine NU ar trebui s\u0103 ia Tenvir-EM<\/h2>\n<ul>\n<li>Hipersensibilitate cunoscut\u0103 la tenofovir disoproxil fumarat, emtricitabin\u0103 sau orice excipient<\/li>\n<li>Utilizare \u00een <strong>PrEP<\/strong> persoane HIV-pozitive sau cu statut HIV necunoscut<\/li>\n<li>Insuficien\u021b\u0103 renal\u0103 sever\u0103 (CrCl &lt;30 mL\/min sau la dializ\u0103) \u2014 lua\u021bi \u00een considerare trecerea la o combina\u021bie pe baz\u0103 de tenofovir alafenamid\u0103 (TAF) precum <a href=\"https:\/\/medsbase.com\/ro\/tenvir-af\/\" rel=\"noopener\">Tenvir-AF<\/a><\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<table>\n<thead>\n<tr>\n<th>Medicament \/ Clas\u0103<\/th>\n<th>Interac\u021biune<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>AINS (ibuprofen, diclofenac, naproxen)<\/strong><\/td>\n<td>Nefrotoxicitate aditiv\u0103 \u2014 evita\u021bi doze mari cronice de AINS<\/td>\n<\/tr>\n<tr>\n<td><strong>Aminoglicozide, amfotericina B IV, vancomicin\u0103 IV<\/strong><\/td>\n<td>Nefrotoxicitate semnificativ\u0103 \u2014 evita\u021bi combina\u021bia acestora c\u00e2t posibil<\/td>\n<\/tr>\n<tr>\n<td><strong>Didanosine (ddI)<\/strong><\/td>\n<td>Nu combina\u021bi \u2014 cre\u0219te nivelul \u0219i toxicitatea ddI<\/td>\n<\/tr>\n<tr>\n<td><strong>Ledipasvir\/sofosbuvir (Harvoni) \u0219i alte antivirale directe pentru hepatita C<\/strong><\/td>\n<td>Poate cre\u0219te nivelul tenofovirului \u2014 monitoriza\u021bi func\u021bia renal\u0103<\/td>\n<\/tr>\n<tr>\n<td><strong>Alte NRTI-uri care con\u021bin emtricitabin\u0103 sau lamivudin\u0103<\/strong><\/td>\n<td>Redundant \u2014 nu combina\u021bi<\/td>\n<\/tr>\n<tr>\n<td><strong>Regimuri PI poten\u021bate cu ritonavir<\/strong><\/td>\n<td>Cre\u0219tere moderat\u0103 a nivelului tenofovirului \u2014 gestionabil clinic<\/td>\n<\/tr>\n<tr>\n<td><strong>Iarba Sf\u00e2ntului Ioan<\/strong><\/td>\n<td>Scade u\u0219or nivelul FTC \u0219i TDF; evita\u021bi \u00een tratamentul HIV<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00centotdeauna furniza\u021bi o list\u0103 complet\u0103 a medicamentelor prescrise \u0219i f\u0103r\u0103 prescrip\u021bie, inclusiv droguri recrea\u021bionale \u0219i suplimente herbale, medicului dumneavoastr\u0103 \u00eenainte de a \u00eencepe tratamentul cu Tenvir-EM.<\/p>\n<h2 class=\"wp-block-heading\">Ce s\u0103 Face\u021bi \u00een Caz de Supradozare<\/h2>\n<p>Supradozarea acut\u0103 cu TDF\/FTC este neobi\u0219nuit\u0103 \u0219i provoac\u0103 de obicei doar simptome gastrointestinale. Niciunul dintre medicamente nu este eliminat semnificativ prin dializ\u0103. Managementul este de sus\u021binere. Contacta\u021bi imediat centrul de toxicoze sau serviciul de urgen\u021b\u0103 local dac\u0103 se suspecteaz\u0103 o supradozare semnificativ\u0103.<\/p>\n<h2 class=\"wp-block-heading\">Instruc\u021biuni de Depozitare<\/h2>\n<ul>\n<li>P\u0103stra\u021bi la temperaturi sub 30 \u00b0C, \u00eentr-un loc uscat, departe de lumina direct\u0103 a soarelui<\/li>\n<li>P\u0103stra\u021bi \u00een ambalajul original sau \u00een blister.<\/li>\n<li>Se p\u0103streaz\u0103 \u00een afara accesului copiilor<\/li>\n<li>Nu utiliza\u021bi dup\u0103 data de expirare tip\u0103rit\u0103 pe ambalaj<\/li>\n<li>Elimina\u021bi comprimatele neutilizate prin programele de colectare disponibile \u00een farmacii<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Alternative conexe pe MedsBase<\/h2>\n<p>C\u0103uta\u021bi op\u021biuni de medicamente PrEP sau HIV?<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/ricovir-em\/\" rel=\"noopener\">Ricovir EM<\/a> \u2014 TDF\/FTC de la Mylan, echivalent clinic cu Tenvir-EM<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tavin-em\/\" rel=\"noopener\">Tavin EM<\/a> \u2014 Alternativ\u0103 TDF\/FTC de la Hetero Labs<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tenof-em\/\" rel=\"noopener\">Tenof-EM<\/a> \u2014 alt brand TDF\/FTC<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tenvir-af\/\" rel=\"noopener\">Tenvir-AF<\/a> \u2014 <strong>tenofovir alafenamid\u0103 (TAF) + FTC<\/strong>, alternativa de nou\u0103 genera\u021bie cu toxicitate renal\u0103 \u0219i osoas\u0103 redus\u0103<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tenvir\/\" rel=\"noopener\">Tenvir<\/a> \u2014 tenofovir 300 mg monoterapie pentru hepatita B<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tenvir-l\/\" rel=\"noopener\">Tenvir-L<\/a> \u2014 alternativ\u0103 tenofovir + lamivudin\u0103 (3TC) pentru scheletul NRTI<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/hiv-medication\/\" rel=\"noopener\">Vizualiza\u021bi toate medicamentele pentru HIV \u2192<\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">C\u00e2t de eficient este Tenvir-EM ca PrEP?<\/h3>\n<p>Atunci c\u00e2nd este luat zilnic conform prescrip\u021biei, TDF\/FTC PrEP reduce riscul de transmitere sexual\u0103 a HIV cu <strong>peste 99%<\/strong>. Eficacitatea scade la doze ratate \u2014 \u00een special la expunerile vaginale receptive, unde nivelurile de medicament \u00een \u021besut necesit\u0103 mai mult timp pentru a atinge concentra\u021biile protective.<\/p>\n<h3 class=\"wp-block-heading\">C\u00e2t dureaz\u0103 p\u00e2n\u0103 \u00eencepe s\u0103 ac\u021bioneze Tenvir-EM ca PrEP?<\/h3>\n<p>Nivelurile protectoare ale medicamentului \u00een <strong>\u021besutul rectal<\/strong> sunt atinse dup\u0103 aproximativ <strong>7 zile<\/strong> de administrare zilnic\u0103. Pentru <strong>\u021besutul vaginal<\/strong>, este necesar <strong>20 de zile<\/strong>. CDC recomand\u0103 7 zile de utilizare zilnic\u0103 \u00eenainte de a te baza pe el pentru sex anal receptiv \u0219i 20 de zile pentru expuneri vaginale sau alte tipuri.<\/p>\n<h3 class=\"wp-block-heading\">Pot folosi Tenvir-EM \u201cla cerere\u201d \u00een loc de zilnic?<\/h3>\n<p>Programul \u201c<strong>2-1-1<\/strong>\u201d la cerere (2 comprimate cu 2\u201324 h \u00eenainte de sex, 1 comprimat la 24 h dup\u0103, 1 comprimat la 48 h dup\u0103) este sus\u021binut de studiul IPERGAY \u0219i este o op\u021biune conform recomand\u0103rilor OMS \u0219i Fran\u021bei <strong>doar pentru b\u0103rba\u021bii care au rela\u021bii sexuale cu b\u0103rba\u021bi<\/strong>. Nu a fost <em>prime\u0219te,<\/em> validat pentru sex vaginal, femei trans sub hormonii feminizanti sau persoane care injecteaz\u0103 droguri \u2014 administrarea zilnic\u0103 r\u0103m\u00e2ne standardul \u00een afara acestei popula\u021bii specifice.<\/p>\n<h3 class=\"wp-block-heading\">Este Tenvir-EM acela\u0219i lucru cu Truvada?<\/h3>\n<p>Da, \u00een ceea ce prive\u0219te ingredientele active \u2014 ambele con\u021bin tenofovir disoproxil fumarat 300 mg \u0219i emtricitabin\u0103 200 mg. Tenvir-EM este fabricat de Cipla \u00een India \u0219i este echivalent clinic cu Truvada marca Gilead<sup>\u00ae<\/sup>, la un pre\u021b mult mai mic.<\/p>\n<h3 class=\"wp-block-heading\">Am nevoie de testare pentru IST \u00een timp ce sunt pe PrEP?<\/h3>\n<p>Da \u2014 Tenvir-EM previne HIV, dar nu sifilisul, gonoreea, clamidia, HSV sau alte ITS. Testarea periodic\u0103 la intervale de 3\u20136 luni este puternic recomandat\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Ce teste am nevoie \u00eenainte de a \u00eencepe PrEP?<\/h3>\n<p><strong>HIV<\/strong> (test de antigen\/anticorpi de genera\u021bia a 4-a), <strong>hepatita B<\/strong> (antigen de suprafa\u021b\u0103, anticorp de suprafa\u021b\u0103, anticorp de nucleu), <strong>creatinin\u0103 \/ eGFR<\/strong>, \u0219i ideal un screening de baz\u0103 pentru ITS. Dac\u0103 ave\u021bi hepatit\u0103 B cronic\u0103, Tenvir-EM este sigur \u0219i adesea benefic, dar \u00eentreruperea trebuie gestionat\u0103 cu aten\u021bie.<\/p>\n<h3 class=\"wp-block-heading\">Pot folosi Tenvir-EM pentru profilaxia post-expunere (PEP) la HIV?<\/h3>\n<p>Da \u2014 ca parte a unei <strong>regim PEP cu trei medicamente<\/strong>. Tenvir-EM furnizeaz\u0103 cei doi NRTI; se adaug\u0103 un al treilea medicament (de obicei dolutegravir sau raltegravir). PEP trebuie \u00eenceput \u00een termen de 72 de ore de la expunere, ideal \u00een primele 24 de ore, \u0219i continuat timp de 28 de zile.<\/p>\n<h3 class=\"wp-block-heading\">Ce se \u00eent\u00e2mpl\u0103 dac\u0103 uit o doz\u0103 de PrEP?<\/h3>\n<p>Dac\u0103 ai uitat o doz\u0103 cu mai pu\u021bin de 24 de ore, ia-o c\u00e2t mai cur\u00e2nd posibil. Dac\u0103 au trecut mai mult de 24 de ore, omite doza ratat\u0103 \u0219i ia urm\u0103toarea conform programului. Nu lua o doz\u0103 dubl\u0103. Dac\u0103 ui\u021bi mai multe doze, protec\u021bia este redus\u0103 \u2014 reia perioada de \u00eenc\u0103rcare tisular\u0103 de 7 sau 20 de zile.<\/p>\n<h3 class=\"wp-block-heading\">Este Tenvir-EM sigur pentru rinichii mei?<\/h3>\n<p>TDF poate provoca <strong>efecte renale dependente de doz\u0103<\/strong> la o minoritate de utilizatori. Este necesar\u0103 monitorizarea eGFR la baz\u0103 \u0219i periodic. Dac\u0103 func\u021bia renal\u0103 scade sau ai deja CrCl &lt;30 mL\/min, trecerea la noul <strong>tenofovir alafenamid (TAF)<\/strong> formulat (de ex. <a href=\"https:\/\/medsbase.com\/ro\/tenvir-af\/\" rel=\"noopener\">Tenvir-AF<\/a>) este preferat\u0103 \u2014 TAF are o toxicitate renal\u0103 \u0219i osoas\u0103 semnificativ mai mic\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Pot s\u0103 opresc Tenvir-EM dac\u0103 riscul meu de HIV se modific\u0103?<\/h3>\n<p>Da \u2014 PrEP poate fi oprit c\u00e2nd riscul scade. Recomand\u0103rile actuale sunt s\u0103 iei Tenvir-EM \u00eenc\u0103 <strong>7 zile dup\u0103 ultima expunere<\/strong> pentru a te asigura c\u0103 orice expunere recent\u0103 este acoperit\u0103 complet. Dac\u0103 ai hepatit\u0103 B cronic\u0103, NU opri f\u0103r\u0103 supraveghere medical\u0103 din cauza riscului de reactivare.<\/p>\n<h3 class=\"wp-block-heading\">Interac\u021bioneaz\u0103 Tenvir-EM cu contracep\u021bia hormonal\u0103 sau cu terapia hormonal\u0103 feminizant\u0103?<\/h3>\n<p>Nu exist\u0103 interac\u021biune clinic semnificativ\u0103 cu contraceptivele orale combinate sau cu cele doar progestative sau cu terapia hormonal\u0103 feminizant\u0103 (estradiol, ciproteron\u0103, spironolacton\u0103). Tenvir-EM nu reduce eficacitatea contraceptiv\u0103.<\/p>\n<p><!-- medsbase-faq-h3-converted --><\/p>\n<p class=\"medsbase-bundle-link-2026-05-01\" data-marker=\"mb-bundle-link-prep-starter-pack\">Tenvir-EM blocheaz\u0103 HIV dar nu previne infec\u021biile bacteriene cu transmitere sexual\u0103 (sifilis, clamidioz\u0103, gonoree); pentru protec\u021bie \u00een straturi, mul\u021bi utilizatori adaug\u0103 doxiciclin\u0103 100 mg ca doxy-PEP recomandat de CDC \u2014 oferim <a href='\/ro\/prep-starter-pack\/'>Pachetul de pornire PrEP (Tenvir-EM + doxiciclin\u0103 100 mg)<\/a> ambele \u00een pachete echilibrate pentru 1, 3 sau 6 luni, expediate \u00eentr-o singur\u0103 livrare.<\/p>\n<p class=\"medsbase-link-boost-2026-05-21\" data-marker=\"mb-link-boost-tavin-em\">Dac\u0103 <a href=\"https:\/\/medsbase.com\/ro\/tenvir-em\/\">Tenvir EM<\/a> nu este disponibil sau prefera\u021bi un alt produc\u0103tor pentru regimul zilnic de PrEP, <a href=\"https:\/\/medsbase.com\/ro\/tavin-em\/\">Tavin EM (tenofovir disoproxil fumarat 300 mg + emtricitabin\u0103 200 mg)<\/a> de la Emcure Pharmaceuticals are aceea\u0219i compozi\u021bie TDF\/FTC men\u021bionat\u0103 \u00een studiile iPrEx, PROUD \u0219i Partners-PrEP.<\/p>\n<p data-marker=\"mb-link-boost-taficita\" class=\"medsbase-link-boost-2026-05-25\">B\u0103rba\u021bii care doresc o alternativ\u0103 cu impact renal redus fa\u021b\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/tenvir-em\/\">Tenvir-EM<\/a> (tenofovir disoproxil + emtricitabin\u0103) aleg adesea <a href=\"https:\/\/medsbase.com\/ro\/taficita\/\">Taficita (tenofovir alafenamid\u0103 25 mg + emtricitabin\u0103 200 mg)<\/a> \u2014 regimul de PrEP bazat pe TAF cu efecte reduse asupra rinichilor \u0219i densit\u0103\u021bii osoase.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2 id=\"related-alts\">Alte Medicamente pentru S\u0103n\u0103tate Sexual\u0103<\/h2>\n<ul>\n<li><a href=\"\/ro\/ricovir-em\/\">Ricovir EM (TDF\/FTC 300+200 mg)<\/a><\/li>\n<li><a href=\"\/ro\/tenof-em\/\">Tenof EM (TDF\/FTC 300+200 mg)<\/a><\/li>\n<li><a href=\"\/ro\/tavin-em\/\">Tavin EM (TDF\/FTC 300+200 mg)<\/a><\/li>\n<li><a href=\"\/ro\/taficita\/\">Taficita (TAF\/FTC 25+200 mg, generic Descovy)<\/a><\/li>\n<li><a href=\"\/ro\/std-protection-pack\/\">Pachet Protec\u021bie IST<\/a><\/li>\n<\/ul>\n<p style=\"font-size:13px;color:#555;margin:14px 0;font-style:italic;\"><strong>Disclaimer medical:<\/strong> Informa\u021biile de pe aceast\u0103 pagin\u0103 au doar scop educa\u021bional \u0219i nu \u00eenlocuiesc sfatul medical. Consulta\u021bi \u00eentotdeauna un medic calificat \u00eenainte de a \u00eencepe, \u00eentrerupe sau modifica orice tratament medicamentos.<\/p>","protected":false},"excerpt":{"rendered":"<h5>\u2705 Protejeaz\u0103 \u00eempotriva infec\u021biei cu HIV<br \/>\n\u2705 Previne multiplicarea virusului<br \/>\n\u2705 Poten\u021bial pentru tratamentul hepatitei B<br \/>\n\u2705 \u00cembun\u0103t\u0103\u021be\u0219te calitatea vie\u021bii<br \/>\n\u2705 Versiune generic\u0103 a Truvada \u00ae<\/h5>\n<p><span style=\"color: #999999;\"><strong>Tenvir Em<\/strong> con\u021bine <strong>Emtricitabine<\/strong> \u0219i <strong>Tenofovir.<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>","protected":false},"featured_media":51177,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3334,3304,3338,3337],"product_tag":[5675,3339,5674,5676,5672,5671,5673,3335,3340,5670],"class_list":{"0":"post-51176","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-hepatitis-medication","9":"product_cat-hiv-medication","10":"product_cat-prep-medication-pre-exposure-prophylaxis","11":"product_cat-sexual-health","12":"product_tag-antiretroviral","13":"product_tag-emtricitabine","14":"product_tag-ftc","15":"product_tag-hepatitis-b","16":"product_tag-hiv-pep","17":"product_tag-hiv-prep","18":"product_tag-tdf","19":"product_tag-tenofovir","20":"product_tag-tenvir-em","21":"product_tag-truvada-generic","23":"first","24":"instock","25":"featured","26":"shipping-taxable","27":"purchasable","28":"product-type-variable","29":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/51176","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=51176"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/51177"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=51176"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=51176"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=51176"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=51176"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}