{"id":51193,"date":"2023-09-20T09:18:21","date_gmt":"2023-09-20T09:18:21","guid":{"rendered":"https:\/\/medsname.com\/valgan\/"},"modified":"2026-04-30T16:19:01","modified_gmt":"2026-04-30T16:19:01","slug":"valgan","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/valgan\/","title":{"rendered":"Valgan"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">R\u0103spuns rapid<\/h3>\n<p style=\"margin-bottom:0;\"><strong>Valgan<\/strong> \u2014 valganciclovir 450 mg (Cipla). Prodrug de ganciclovir \u2014 utilizat pentru retinit\u0103 cu citomegalovirus (CMV) la pacien\u021bii cu HIV\/SIDA, profilaxia \u0219i tratamentul CMV la recipien\u021bii de transplant de organe solide \u0219i de m\u0103duv\u0103 osoas\u0103, precum \u0219i pentru CMV congenital. Biodisponibilitate oral\u0103 superioar\u0103 fa\u021b\u0103 de ganciclovir.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>Ce beneficii ofer\u0103 MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>produc\u0103tor certificat WHO-GMP<\/li>\n<li>Ambalaj discret \u00een plic simplu<\/li>\n<li>Livrare \u00een toat\u0103 lumea<\/li>\n<li>Evaluat de peste 1.400 de clien\u021bi (<a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">cite\u0219te recenziile<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>Garan\u021bia de retransmitere:<\/strong> dac\u0103 comanda dvs. nu a ajuns \u00een 20 de zile lucr\u0103toare de la expediere, o retransmitem f\u0103r\u0103 costuri suplimentare. <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Cite\u0219te politica<\/a>.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Valgan este expediat de la un produc\u0103tor certificat WHO-GMP \u00een ambalaje neutre, facturat prin intermediul unui procesor de pl\u0103\u021bi reglementat (descrierea extrasului de cont indic\u0103 un procesor de pl\u0103\u021bi cu carduri reglementat \u2014 niciodat\u0103 MedsBase sau numele vreunui medicament). Fiecare comand\u0103 beneficiaz\u0103 de Garan\u021bia noastr\u0103 de Retrimitere pe o perioad\u0103 de 20 de zile lucr\u0103toare.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Avertismente FDA \u00een caset\u0103 neagr\u0103<\/strong><br \/>Valganciclovirul are mai multe avertismente \u00een caset\u0103 neagr\u0103: suprimare a m\u0103duvei osoase (granulocitopenie, anemie, trombocitopenie), carcinogenitate \u0219i teratogenitate \u00een animale \u0219i afectarea fertilit\u0103\u021bii masculine\/feminine. Utiliza\u021bi doar atunci c\u00e2nd este clar indicat. Femeile gravide sau care ar putea deveni gravide trebuie s\u0103 foloseasc\u0103 metode contraceptive eficiente \u00een timpul tratamentului \u0218I cel pu\u021bin o lun\u0103 dup\u0103.<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Monitorizare obligatorie<\/strong><br \/>Hemogram\u0103 complet\u0103 s\u0103pt\u0103m\u00e2nal\u0103 \u00een timpul terapiei de induc\u021bie \u0219i \u00een prima lun\u0103 de \u00eentre\u021binere, apoi la fiecare 2-4 s\u0103pt\u0103m\u00e2ni. \u00centrerupe\u021bi dac\u0103 neutrofilele &lt;500\/\u03bcL, trombocitele &lt;25.000\/\u03bcL sau hemoglobina scade brusc. Monitoriza\u021bi func\u021bia renal\u0103 (ajustarea dozei \u00een func\u021bie de CrCl). Monitoriza\u021bi func\u021bia vizual\u0103 \u00een timpul tratamentului pentru retinit\u0103 cu CMV.<\/div>\n<h2>Doza<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:12px 0;\">\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;border:1px solid #ddd;\">Indica\u021bie<\/th>\n<th style=\"padding:8px;border:1px solid #ddd;\">Doza<\/th>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Induc\u021bie retinit\u0103 CMV (HIV)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">900 mg de 2 ori pe zi timp de 21 de zile cu m\u00e2ncare<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">\u00centre\u021binere retinit\u0103 CMV<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">900 mg o dat\u0103 pe zi cu m\u00e2ncare<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Prevenire CMV (transplant)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">900 mg o dat\u0103 pe zi \u00d7 100-200 de zile post-transplant<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">CMV congenital (pediatric)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">16 mg\/kg de dou\u0103 ori pe zi \u00d7 6 luni \u2014 supraveghere specializat\u0103<\/td>\n<\/tr>\n<\/table>\n<p>Lua\u021bi cu alimente. Ajustarea dozei pentru func\u021bia renal\u0103 la CrCl &lt;60 mL\/min. Comprimatele trebuie \u00eenghi\u021bite \u00eentregi \u2014 manipularea comprimatelor sparte reprezint\u0103 un risc de expunere teratogen\u0103.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>C\u00e2nd este indicat valganciclovirul?<\/h3>\n<p>Retinit\u0103 cu CMV \u00een HIV\/SIDA (\u00een mare parte istoric\u0103 cu terapia ART modern\u0103), prevenirea \u0219i tratamentul CMV \u00een transplantul de organe solide \u0219i de m\u0103duv\u0103 osoas\u0103, CMV congenital la nou-n\u0103scu\u021bii simptomatici. Discuta\u021bi cu un specialist \u00een boli infec\u021bioase sau transplant.<\/p>\n<h3>Cum func\u021bioneaz\u0103?<\/h3>\n<p>Prodrog al ganciclovirului, convertit \u00een forma activ\u0103 intracelular de c\u0103tre kinaze virale (preferen\u021bial \u00een celulele infectate cu CMV). Forma activ\u0103 este \u00eencorporat\u0103 \u00een ADN-ul viral ca terminator de lan\u021b.<\/p>\n<h3>De ce este necesar monitorizarea?<\/h3>\n<p>Supresia m\u0103duvei osoase este toxicitatea limitatoare de doz\u0103. P\u00e2n\u0103 la 25-40% dintre pacien\u021bi dezvolt\u0103 neutropenie sau anemie semnificativ\u0103. Analiza sanguin\u0103 s\u0103pt\u0103m\u00e2nal\u0103 \u00een timpul induc\u021biei este obligatorie. G-CSF (filgrastim) este uneori utilizat pentru a gestiona neutropenia f\u0103r\u0103 a opri terapia.<\/p>\n<h3>Sarcin\u0103?<\/h3>\n<p>Contraindicit puternic din cauza teratogenit\u0103\u021bii. Contraceptie eficient\u0103 \u00een timpul tratamentului \u0219i pentru cel pu\u021bin 1 lun\u0103 dup\u0103 pentru femei, 90 de zile dup\u0103 pentru b\u0103rba\u021bi. Test de sarcin\u0103 \u00eenainte de \u00eencepere dac\u0103 exist\u0103 poten\u021bial reproductiv.<\/p>\n<h3>Interac\u021biuni medicamentoase?<\/h3>\n<p>Interac\u021biuni majore: zidovudin\u0103 (supresie aditiv\u0103 a m\u0103duvei osoase), trimetoprim-sulfa, micofenolat (context de transplant), didanozin\u0103 (niveluri crescute). Probenecid reduce clearance-ul. Dezv\u0103lui\u021bi \u00eentotdeauna toate medicamentele, inclusiv imunosupresia de transplant.<\/p>\n<h3>Func\u021bia renal\u0103?<\/h3>\n<p>Eliminat renal \u2014 ajusta\u021bi doza \u00een func\u021bie de clearance-ul de creatinin\u0103. CrCl &lt;10 mL\/min: evita\u021bi; pacien\u021bii cu hemodializ\u0103 necesit\u0103 un program de dozare post-dializ\u0103.<\/p>\n<h3>Efecte secundare?<\/h3>\n<p>Supresie a m\u0103duvei osoase (cea mai frecvent\u0103), GI (gre\u021buri, v\u0103rs\u0103turi, diaree), cefalee, insomnie, febr\u0103, dezlipire de retin\u0103 \u00een retinit\u0103 cu CMV (legat\u0103 de boal\u0103, nu de medicament).<\/p>\n<h3>Depozitare?<\/h3>\n<p>P\u0103stra\u021bi sub 30\u00b0C \u00een ambalajul original. Comprimatele zdrobite\/sparte sunt teratogene \u2014 manipula\u021bi cu m\u0103nu\u0219i; membrii familiei gravide nu ar trebui s\u0103 le manipuleze.<\/p>\n<h3>Ce fac dac\u0103 uit o doz\u0103?<\/h3>\n<p>Lua\u021bi c\u00e2nd v\u0103 aminti\u021bi, cu excep\u021bia cazului \u00een care este aproape timpul pentru urm\u0103toarea doz\u0103. Nu dubla\u021bi doza. Discuta\u021bi provoc\u0103rile legate de conformitate cu echipa dumneavoastr\u0103 de transplant sau HIV \u2014 exist\u0103 agen\u021bi anti-CMV alternativi (foscarnet, cidofovir) dac\u0103 terapia oral\u0103 e\u0219ueaz\u0103.<\/p>\n<h3>Rezisten\u021b\u0103?<\/h3>\n<p>Rezisten\u021ba la CMV se poate dezvolta la expunere prelungit\u0103 \u2014 muta\u021biile UL97 \u0219i UL54 confer\u0103 rezisten\u021b\u0103 la ganciclovir. Maraviroc\/foscarnet\/cidofovir sunt op\u021biuni pentru boala rezistent\u0103, fiecare cu toxicit\u0103\u021bile sale specifice.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Alte medicamente antivirale<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/zimivir\/\">Zimivir<\/a> \u2014 valaciclovir pentru HSV<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/natclovir\/\">Natclovir<\/a> \u2014 valaciclovir \u2014 marc\u0103 Natco<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/centrex\/\">Centrex<\/a> \u2014 valaciclovir 500\/1000 mg<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/x-vir\/\">X-Vir<\/a> \u2014 entecavir pentru HBV<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/lamivir-hbv\/\">Lamivir HBV<\/a> \u2014 lamivudin\u0103 pentru HBV<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>Disclaimer medical:<\/strong> Aceast\u0103 pagin\u0103 este doar informativ\u0103 \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui clinician calificat. Discuta\u021bi orice medicament nou cu medicul sau farmacistul dumneavoastr\u0103.<\/div>","protected":false},"excerpt":{"rendered":"<p>Valgan (Valganciclovir 450 mg) \u2014 Cipla prodrug de ganciclovir pentru retinit\u0103 cu CMV la pacien\u021bii cu HIV\/SIDA \u0219i pentru prevenirea\/tratamentul CMV la recipien\u021bii de transplant de organe solide \u0219i de m\u0103duv\u0103 osoas\u0103.<\/p>","protected":false},"featured_media":51194,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3304],"product_tag":[],"class_list":{"0":"post-51193","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-hiv-medication","10":"first","11":"outofstock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/51193","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=51193"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/51194"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=51193"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=51193"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=51193"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=51193"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}