{"id":51866,"date":"2023-09-20T09:26:07","date_gmt":"2023-09-20T09:26:07","guid":{"rendered":"https:\/\/medsname.com\/lotensyl\/"},"modified":"2026-05-01T10:49:11","modified_gmt":"2026-05-01T10:49:11","slug":"lotensyl","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/lotensyl\/","title":{"rendered":"Lotensyl"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Lotensyl?<\/h3>\n<p style=\"margin:0;\"><strong>Lotensyl<\/strong> este un <strong>Comprimat de cilnidipin\u0103 10 \/ 20 mg<\/strong> de la Lupin \u2014 un <strong>blocant al canalelor de calciu dihidropiridinic care blocheaz\u0103 \u00een mod unic at\u00e2t canalele de tip L, c\u00e2t \u0219i cele de tip N<\/strong>. Blocarea canalelor de tip L produce vasodilata\u021bie arterial\u0103 (efectul standard al BCC); blocarea canalelor de tip N la termina\u021biile nervoase simpatice reduce eliberarea de noradrenalin\u0103, suprinz\u00e2nd tahicardia reflex\u0103 care limiteaz\u0103 alte dihidropiridine. Popular \u00een India, Japonia \u0219i unele p\u0103r\u021bi ale Asiei de Est ca o dihidropiridin\u0103 de \u201cnou\u0103 genera\u021bie\u201d; mai pu\u021bin utilizat \u00een Europa\/SUA, unde amlodipina \u0219i nifedipina domin\u0103. Avantaje clinice fa\u021b\u0103 de amlodipin\u0103: rate mai mici de edem de glezn\u0103, f\u0103r\u0103 tahicardie reflex\u0103, protec\u021bie renal\u0103 moderat mai bun\u0103 \u00een BCR proteinuric (studii CARTER-AKI, ACTION-HKD). Doz\u0103 tipic\u0103: 5-20 mg o dat\u0103 pe zi. Contraindica\u021bii: \u0219oc cardiogen, IM acut cu hipotensiune, insuficien\u021b\u0103 hepatic\u0103 sever\u0103, sarcin\u0103.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<h2 class=\"wp-block-heading\">Ce este Lotensyl?<\/h2>\n<p>Lotensyl este comprimatul de cilnidipin\u0103 10 \/ 20 mg de la Lupin, furnizat \u00een cutii de 30-90 de comprimate. Cilnidipina a fost introdus\u0103 \u00een Japonia \u00een 1995 (FujiRebio sub numele Atelec) \u0219i a ob\u021binut aprobare echivalent\u0103 FDA \u00een multe pie\u021be asiatice. Este o dihidropiridin\u0103 de genera\u021bia a patra cu un profil distinct de blocare dual\u0103 a canalelor de calciu de tip L\/N.<\/p>\n<h2 class=\"wp-block-heading\">Cum func\u021bioneaz\u0103 cilnidipina<\/h2>\n<p>Majoritatea BCC dihidropiridinice (amlodipina, nifedipina, felodipina, nicardipina) blocheaz\u0103 <strong>canalele de calciu de tip L<\/strong> pe mu\u0219chiul neted arterial, produc\u00e2nd vasodilata\u021bie \u0219i sc\u0103derea tensiunii arteriale. Cilnidipina adaug\u0103 \u00een mod unic <strong>blocarea canalelor de tip N<\/strong> la terminalele nervoase simpatice:<\/p>\n<ul>\n<li><strong>blocarea de tip L (mu\u0219chiul neted arterial)<\/strong> \u2014 vasodilata\u021bie standard; reducerea post\u00eenc\u0103rc\u0103rii; tensiunea arterial\u0103 scade cu 10-15 mmHg<\/li>\n<li><strong>blocarea de tip N (terminalele presinaptice simpatice)<\/strong> \u2014 reducerea eliber\u0103rii de noradrenalin\u0103; suprima tahicardia reflex\u0103 care \u00een mod normal urmeaz\u0103 vasodilata\u021biei arteriale<\/li>\n<li><strong>Rat\u0103 mai mic\u0103 de edem la glezn\u0103<\/strong> \u2014 blocarea de tip L dilateaz\u0103 arteriolele precapilare; efectul bloc\u0103rii de tip N asupra tonului postcapilar este mai echilibrat, produc\u00e2nd o cre\u0219tere mai mic\u0103 a presiunii hidrostatice capilare \u0219i mai pu\u021bin edem periferic dec\u00e2t antagoni\u0219tii calciului pur de tip L<\/li>\n<li><strong>Reducerea proteinuriei<\/strong> \u2014 reducerea tonului simpatic renal dilateaz\u0103 at\u00e2t arteriolele eferente, c\u00e2t \u0219i aferente, reduc\u00e2nd hiperfiltra\u021bia glomerular\u0103; studiile \u00een BCR proteinuric au ar\u0103tat o reducere mai mare a proteinuriei fa\u021b\u0103 de amlodipin\u0103 la aceea\u0219i tensiune arterial\u0103<\/li>\n<li><strong>Timp de \u00eenjum\u0103t\u0103\u021bire lung<\/strong> \u2014 6-8 ore (dozare o dat\u0103 pe zi \u00een stare stabil\u0103)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dovezi pentru Cilnidipin\u0103<\/h2>\n<ul>\n<li><strong>CARTER (2007) \u2014 cilnidipin\u0103 vs amlodipin\u0103 \u00een BCR hipertensiv proteinuric:<\/strong> cilnidipine a produs o reducere mai mare a proteinuriei la un control echivalent al tensiunii arteriale; evolu\u021bia creatininei similar\u0103.<\/li>\n<li><strong>Compara\u021bii directe cu amlodipina<\/strong> arat\u0103 eficacitate comparabil\u0103 \u00een controlul tensiunii arteriale, dar rate de edem perimalleolar aproximativ cu 50% mai mici la cilnidipine.<\/li>\n<li><strong>ACTION-HKD (2014)<\/strong> \u2014 date extinse de protec\u021bie renal\u0103 la pacien\u021bii cu BCR.<\/li>\n<li><strong>Date din practica real\u0103 din India<\/strong> \u2014 utilizat pe scar\u0103 larg\u0103 ca alternativ\u0103 la amlodipin\u0103 acolo unde edemul perimalleolar sau tahicardia reflex\u0103 limiteaz\u0103 utilizarea amlodipinei.<\/li>\n<\/ul>\n<p>Cilnidipina nu este <strong>inclus\u0103 \u00een recomand\u0103rile de prim\u0103 linie din ghidurile occidentale<\/strong> pentru hipertensiune \u2014 par\u021bial datorit\u0103 faptului c\u0103 amlodipina are un set de date mult mai mare din studii de outcome (ASCOT, ACCOMPLISH, VALUE), par\u021bial datorit\u0103 faptului c\u0103 cilnidipina nu a fost comercializat\u0103 \u00een SUA sau \u00een majoritatea Europei.<\/p>\n<h2 class=\"wp-block-heading\">Dozaj<\/h2>\n<p><strong>Hipertensiune arterial\u0103:<\/strong> \u00eencepe\u021bi cu 5-10 mg o dat\u0103 pe zi; ajusta\u021bi la 10-20 mg o dat\u0103 pe zi la 2-4 s\u0103pt\u0103m\u00e2ni.<\/p>\n<p><strong>Administrare:<\/strong> cu sau f\u0103r\u0103 alimente; la aceea\u0219i or\u0103 \u00een fiecare zi; \u00eenghi\u021bi\u021bi \u00eentreg.<\/p>\n<p><strong>Monitorizare:<\/strong> tensiunea arterial\u0103 la 2 \u0219i 4 s\u0103pt\u0103m\u00e2ni; apoi la fiecare 3-6 luni. Teste hepatice la ini\u021biere \u0219i periodic (cilnidipina este eliminat\u0103 hepatic). Verifica\u021bi prezen\u021ba edemului la glezn\u0103 la evaluare.<\/p>\n<h2 class=\"wp-block-heading\">Efecte Secundare<\/h2>\n<p><strong>Frecvente:<\/strong><\/p>\n<ul>\n<li>cefalee, ro\u0219ea\u021b\u0103<\/li>\n<li>Ame\u021beli<\/li>\n<li>edem la glezn\u0103 (mai pu\u021bin frecvent dec\u00e2t la amlodipin\u0103 \u2014 aproximativ jum\u0103tate din rata observat\u0103 \u00een studiile comparative)<\/li>\n<li>Constipa\u021bie<\/li>\n<li>Cre\u0219tere u\u0219oar\u0103 a transaminazelor<\/li>\n<li>palpita\u021bii (mult mai pu\u021bin frecvente dec\u00e2t la DHP-urile cu ac\u021biune scurt\u0103)<\/li>\n<\/ul>\n<p><strong>Mai pu\u021bin frecvente:<\/strong><\/p>\n<ul>\n<li>Hipotenziune sever\u0103<\/li>\n<li>hiperplazie gingival\u0103 (efect de clas\u0103 rar la DHP)<\/li>\n<li>Fotosensibilitate<\/li>\n<li>Erup\u021bie cutanat\u0103<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindica\u021bii<\/h2>\n<ul>\n<li>\u0218oc cardiogen<\/li>\n<li>infarct miocardic acut cu hipotensiune<\/li>\n<li>Stenoz\u0103 aortic\u0103 sever\u0103<\/li>\n<li>Afectare hepatic\u0103 sever\u0103 (Child-Pugh C)<\/li>\n<li>hipersensibilitate cunoscut\u0103 la dihidropiridine<\/li>\n<li>sarcin\u0103 (date limitate; amlodipina sau nifedipina sunt DHP-urile preferate dac\u0103 este necesar un BCC \u00een sarcin\u0103)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>Inhibitori puternici ai CYP3A4<\/strong> (claritromicin\u0103, itraconazol, ritonavir) \u2014 cresc nivelurile de cilnidipin\u0103; risc crescut de hipotensiune.<\/li>\n<li><strong>Suc de grapefruit<\/strong> \u2014 interac\u021biune minor\u0103 p\u00e2n\u0103 la moderat\u0103; consumul zilnic regulat este descurajat.<\/li>\n<li><strong>Alte antihipertensive<\/strong> \u2014 sc\u0103dere aditiv\u0103 a tensiunii arteriale; inten\u021bionat\u0103 \u00een terapia de combina\u021bie.<\/li>\n<li><strong>Inductori CYP3A4<\/strong> (rifampicin\u0103, fenitoin\u0103, iarba Sf\u00e2ntului Ioan) \u2014 pot reduce efectul cilnidipinei.<\/li>\n<li><strong>Digoxin\u0103<\/strong> \u2014 cre\u0219tere moderat\u0103 a nivelului de digoxin\u0103; monitoriza\u021bi.<\/li>\n<li><strong>Alcool<\/strong> \u2014 hipotensiune ortostatic\u0103 aditiv\u0103.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Depozitare<\/h2>\n<p>P\u0103stra\u021bi Lotensyl la o temperatur\u0103 sub 25\u00b0C. Depozita\u021bi \u00eentr-un loc inaccesibil copiilor.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">Care este diferen\u021ba dintre cilnidipin\u0103 \u0219i amlodipin\u0103?<\/h3>\n<p>Cilnidipina blocheaz\u0103 at\u00e2t canalele de calciu de tip L (la fel ca amlodipina) c\u00e2t \u0219i cele de tip N. Blocarea canalelor de tip N la nivelul terminalelor nervoase simpatice reduce eliberarea de noradrenalin\u0103, oferind cilnidipinei dou\u0103 avantaje practice: (1) rate mai sc\u0103zute de edem la nivelul gleznelor (aproximativ jum\u0103tate fa\u021b\u0103 de amlodipin\u0103 \u00een studiile comparative); (2) absen\u021ba tahicardiei reflexive. Amlodipina, totu\u0219i, are mult mai multe dovezi privind rezultatele cardiovasculare (ASCOT, ACCOMPLISH, VALUE) \u0219i este DHP-ul preferat atunci c\u00e2nd datele de rezultat sunt supreme.<\/p>\n<h3 class=\"wp-block-heading\">C\u00e2nd este Lotensyl o alegere mai bun\u0103 dec\u00e2t amlodipina?<\/h3>\n<p>Dou\u0103 situa\u021bii clinice frecvente: (1) edem la nivelul gleznelor problematic la amlodipin\u0103 care nu a r\u0103spuns la ad\u0103ugarea unui inhibitor ACE\/sartan; (2) BCR proteinuric unde mecanismul de tip N poate oferi protec\u021bie renal\u0103 suplimentar\u0103 (studiu CARTER).<\/p>\n<h3 class=\"wp-block-heading\">Lotensyl poate provoca umflarea gleznelor?<\/h3>\n<p>Mai pu\u021bin dec\u00e2t amlodipina, dar nu niciodat\u0103. Aproximativ jum\u0103tate din rat\u0103 \u00een studiile comparative. Ad\u0103ugarea unui inhibitor ACE sau a unui sartan reduce \u0219i mai mult edemul rezidual prin dilatarea venoas\u0103 care reechilibreaz\u0103 presiunea capilar\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Pot lua Lotensyl \u00een timpul sarcinii?<\/h3>\n<p>Evita\u021bi \u2014 datele privind utilizarea \u00een sarcin\u0103 sunt limitate. Dac\u0103 este necesar un BCC \u00een sarcin\u0103, nifedipina este DHP-ul preferat (cea mai mare baz\u0103 de date de siguran\u021b\u0103).<\/p>\n<h3 class=\"wp-block-heading\">Unde pot cump\u0103ra Lotensyl online?<\/h3>\n<p>Pute\u021bi cump\u0103ra Lotensyl (cilnidipin\u0103 10\/20 mg, 30-90 comprimate) de la MedsBase cu ambalaj discret \u0219i livrare la nivel mondial.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2 class=\"wp-block-heading\">Medicamente conexe pentru cardiologie \u0219i hipertensiune<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/amlopres-at\/\">Amlopres AT \u2014 Combina\u021bie de Amlodipin\u0103 + Atenolol<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/atorvatin\/\">Atorvatin \u2014 Atorvastatin 5 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/cardace\/\">Cardace \u2014 Ramipril (inhibitor ACE)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/eptus\/\">Eptus \u2014 Eplerenon\u0103 25\/50 mg (antagonist selectiv MR)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tenoric\/\">Tenoric \u2014 Combina\u021bie de Atenolol + Clortalidon\u0103<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/zivast-am\/\">Zivast AM \u2014 combina\u021bie de Atorvastatin\u0103 + Amlodipin\u0103<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/high-blood-pressure-medication\/\"><strong>R\u0103sfoi\u021bi toate medicamentele pentru hipertensiune arterial\u0103<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui medic calificat. Hipertensiunea, insuficien\u021ba cardiac\u0103 \u0219i aritmiile necesit\u0103 diagnostic, monitorizare \u0219i individualizarea dozei de c\u0103tre un medic \u2014 utiliza\u021bi \u00eentotdeauna beta-blocante sub \u00eendrumare medical\u0103.<\/div>","protected":false},"excerpt":{"rendered":"<p>Lotensyl este comprimatul de cilnidipin\u0103 10\/20 mg al Lupin \u2014 un blocant al canalelor de calciu dihidropiridinic de genera\u021bia a patra care blocheaz\u0103 \u00een mod unic at\u00e2t canalele de tip L (vasodilata\u021bie), c\u00e2t \u0219i cele de tip N (termina\u021biile nervoase simpatice). Popular \u00een India, Japonia \u0219i unele p\u0103r\u021bi ale Asiei de Est. Avantaje fa\u021b\u0103 de amlodipin\u0103: rata de edem de glezn\u0103 cu ~50% mai mic\u0103 \u00een studii comparative, f\u0103r\u0103 tahicardie reflex\u0103, reducere moderat\u0103 a proteinuriei \u00een BCR (studiu CARTER). Nu are \u00eenc\u0103 baza larg\u0103 de studii de rezultate cardiovasculare ca amlodipina.<\/p>","protected":false},"featured_media":51867,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3260,3356],"product_tag":[3423,3424],"class_list":{"0":"post-51866","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-heart-blood-pressure","9":"product_cat-high-blood-pressure-medication","10":"product_tag-lercanidipine","11":"product_tag-lotensyl","13":"first","14":"outofstock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/51866","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=51866"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/51867"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=51866"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=51866"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=51866"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=51866"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}