{"id":52828,"date":"2023-09-20T09:38:33","date_gmt":"2023-09-20T09:38:33","guid":{"rendered":"https:\/\/medsname.com\/proluton-depot\/"},"modified":"2026-05-16T05:24:27","modified_gmt":"2026-05-16T05:24:27","slug":"proluton-depot","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/proluton-depot\/","title":{"rendered":"Proluton Depot"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 8px 0;\"><strong>\ud83d\udca1 R\u0103spuns rapid<\/strong><\/p>\n<p style=\"margin:0;\"><strong>Proluton Depot<\/strong> este <strong>17-alfa hidroxiprogesteron\u0103 caproat\u0103 (17-OHPC) 250 mg<\/strong> \u00een ulei pentru injec\u021bie intramuscular\u0103. Utilizat\u0103 istoric pentru prevenirea na\u0219terii premature la sarcini unice cu antecedente de na\u0219tere prematur\u0103, amenin\u021bare de avort \u0219i suport luteal. <strong>Not\u0103 regulatorie important\u0103<\/strong>: FDA <strong>a retras aprobarea pentru Makena (17-OHPC) \u00een 2023<\/strong> dup\u0103 ce studiul confirmator PROLONG nu a reu\u0219it s\u0103 demonstreze beneficii \u00een prevenirea na\u0219terii premature. Utilizarea clinic\u0103 a sc\u0103zut \u00een consecin\u021b\u0103 \u00een practica din SUA. Acest produs nu este destinat terapiei hormonale de substitu\u021bie la menopauz\u0103.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.95em;\">\n<strong>\ud83d\udd12 De ce s\u0103 comanzi de la MedsBase:<\/strong> Aprovizionare verificat\u0103 direct de la produc\u0103tor \u00b7 Livrare discret\u0103 \u00een \u00eentreaga lume \u00b7 Plat\u0103 securizat\u0103 (card de credit, crypto) \u00b7 Evaluat 4,9\u2605 de peste 1.400 de clien\u021bi\n<\/div>\n<h2><strong>Ce este Proluton Depot?<\/strong><\/h2>\n<p>Proluton Depot este un medicament generic marca a <strong>17-alfa hidroxiprogesteron\u0103 caproat\u0103 (17-OHPC) 250 mg<\/strong>, un progestin sintetic cu ac\u021biune prelungit\u0103, administrat prin injec\u021bie intramuscular\u0103 \u00een ulei. Se deosebe\u0219te de progesteronul natural \u2014 17-OHPC este un progestogen mai lipofil cu o durat\u0103 de ac\u021biune mult mai lung\u0103. Fabricat de Bayer.<\/p>\n<h2><strong>Context regulator important (Retragerea FDA din 2023)<\/strong><\/h2>\n<p>Aprobarea ini\u021bial\u0103 FDA a 17-OHPC (Makena) pentru prevenirea na\u0219terii premature s-a bazat pe studiul Meis din 2003, care a ar\u0103tat o reducere a na\u0219terilor premature la femeile cu antecedente de na\u0219tere prematur\u0103. <strong>Studiul de confirmare PROLONG (2019)<\/strong> nu a replicat beneficiul. \u00cen <strong>martie 2023, FDA a retras oficial aprobarea pentru Makena<\/strong> (17-OHPC) \u00een prevenirea na\u0219terii premature.<\/p>\n<p>Practica clinic\u0103 a sc\u0103zut \u00een consecin\u021b\u0103. Unele centre \u00eenc\u0103 folosesc 17-OHPC off-label sau \u00een subgrupuri specifice de risc ridicat; altele au renun\u021bat complet. <strong>Orice decizie de a utiliza 17-OHPC ar trebui s\u0103 implice un obstetrician specialist care s\u0103 evalueze dovezile actuale pentru cazul t\u0103u individual.<\/strong><\/p>\n<h2><strong>Utiliz\u0103ri istorice \u0219i actuale<\/strong><\/h2>\n<ul>\n<li><strong>Prevenirea na\u0219terii premature (retras de FDA \u00een 2023):<\/strong> 250 mg IM s\u0103pt\u0103m\u00e2nal de la s\u0103pt\u0103m\u00e2na 16\u201320 p\u00e2n\u0103 la s\u0103pt\u0103m\u00e2na 37 la femeile cu sarcin\u0103 unic\u0103 \u0219i na\u0219tere spontan\u0103 prematur\u0103 anterioar\u0103. Eficacitatea neconfirmat\u0103 de studiul PROLONG.<\/li>\n<li><strong>Avortament iminent<\/strong> (cazuri selecte de risc ridicat cu pierdere anterioar\u0103): indica\u021bie neaprobat\u0103 de FDA. Dovezile sunt limitate \u0219i mixte.<\/li>\n<li><strong>Suport pentru faza luteal\u0103<\/strong> \u00een tratamentul fertilit\u0103\u021bii (mai pu\u021bin frecvent dec\u00e2t progesteronul natural).<\/li>\n<li><strong>Amenoree secundar\u0103 \u0219i s\u00e2ngerare uterin\u0103 func\u021bional\u0103<\/strong> (utilizare istoric\u0103; progestinele orale sunt acum preferate).<\/li>\n<\/ul>\n<h2><strong>Cum se utilizeaz\u0103 Proluton Depot<\/strong><\/h2>\n<ol>\n<li>Administrat de un clinician sau pacient instruit ca o <strong>injec\u021bie intramuscular\u0103 profund\u0103<\/strong> \u00een cadranul superior extern al feselor (gluteus), folosind un ac de 21 gauge.<\/li>\n<li>Doza standard: <strong>250 mg (1 mL) s\u0103pt\u0103m\u00e2nal<\/strong> pentru protocolul istoric de prevenire a na\u0219terii premature.<\/li>\n<li>Rota\u021bi locurile de injec\u021bie pentru a reduce durerea \u0219i formarea de noduli.<\/li>\n<li>Momentul \u0219i durata trebuie stabilite de un obstetrician specialist, pe baza evalu\u0103rii individuale a raportului risc-beneficiu.<\/li>\n<\/ol>\n<h2><strong>Efecte Secundare<\/strong><\/h2>\n<p><strong>Locul inject\u0103rii:<\/strong> durere, umflare, m\u00e2nc\u0103rime, v\u00e2n\u0103t\u0103i, nodul.<\/p>\n<p><strong>Sistemic:<\/strong> urticarie, grea\u021b\u0103, diaree, modific\u0103ri ale st\u0103rii de spirit, reten\u021bie de lichide.<\/p>\n<p><strong>Grave:<\/strong> Tromboembolism venos (TVP, EP), reac\u021bii alergice, depresie, diabet gesta\u021bional (posibil).<\/p>\n<h2><strong>Cine nu ar trebui s\u0103 foloseasc\u0103 Proluton Depot<\/strong><\/h2>\n<ul>\n<li>Boal\u0103 tromboembolic\u0103 actual\u0103 sau \u00een antecedente<\/li>\n<li>Boal\u0103 hepatic\u0103 activ\u0103 sau tumori hepatice<\/li>\n<li>Neoplasm cunoscut sau suspectat la s\u00e2n sau organe genitale<\/li>\n<li>Hipertensiune arterial\u0103 necontrolat\u0103<\/li>\n<li>Alergie la uleiul de ricin sau deriva\u021bi ai acestuia<\/li>\n<li>Sarcin\u0103 multipl\u0103 (nu s-a demonstrat beneficiul; poten\u021bial d\u0103un\u0103toare)<\/li>\n<\/ul>\n<h2><strong>Depozitare<\/strong><\/h2>\n<p>P\u0103stra\u021bi la temperatura camerei (15\u201325 \u00b0C \/ 59\u201377 \u00b0F). Nu refrigera\u021bi. Proteja\u021bi de lumin\u0103. Depozita\u021bi \u00een loc inaccesibil copiilor.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">Este Proluton Depot \u00eenc\u0103 recomandat pentru prevenirea na\u0219terii premature?<\/h3>\n<p>\u00cen urma studiului PROLONG \u0219i retragerii FDA din 2023 a medicamentului Makena, utilizarea de rutin\u0103 a 17-OHPC pentru prevenirea na\u0219terii premature nu mai este standard \u00een SUA. Unii speciali\u0219ti pot \u00eenc\u0103 s\u0103-l foloseasc\u0103 \u00een subgrupuri specifice cu risc ridicat. Discuta\u021bi cu un specialist \u00een medicin\u0103 materno-fetal\u0103 cu experien\u021b\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Este Proluton Depot acela\u0219i lucru cu progesterona micronizat\u0103?<\/h3>\n<p>Nu. 17-OHPC este un progestin sintetic cu ac\u021biune prelungit\u0103, cu o semivid\u0103 mai lung\u0103 \u0219i farmacologie diferit\u0103. Progesterona micronizat\u0103 vaginal\u0103 este acum adesea preferat\u0103 \u00een locul 17-OHPC pentru suportul luteal \u0219i prevenirea na\u0219terii premature la femeile cu col uterin scurt.<\/p>\n<h3 class=\"wp-block-heading\">Poate fi folosit Proluton Depot pentru terapia hormonal\u0103 de \u00eenlocuire (THI) la menopauz\u0103?<\/h3>\n<p>Nu este indicat pentru THI la menopauz\u0103. Progesterona micronizat\u0103 oral\u0103 (endogest, susten-capsule) sau dydrogesterona sunt standard pentru opozi\u021bia progestinic\u0103 \u00een THI.<\/p>\n<h3 class=\"wp-block-heading\">Care sunt alternativele actuale pentru prevenirea na\u0219terii premature?<\/h3>\n<p>Progesterona vaginal\u0103 (supozitor de 200 mg zilnic) este considerat\u0103 de prim\u0103 inten\u021bie la femeile cu col uterin scurt detectat la ecografia transvaginal\u0103. Cerclajul este o op\u021biune pentru femeile cu antecedente de na\u0219tere prematur\u0103 plus insuficien\u021b\u0103 cervical\u0103. Alegerea se face pe baza stratific\u0103rii individuale a riscului.<\/p>\n<h3 class=\"wp-block-heading\">Este Proluton Depot sigur dac\u0103 sunt alergic la ulei de susan sau ricin?<\/h3>\n<p>Verifica\u021bi vehiculul exact din formula dumneavoastr\u0103 \u2014 17-OHPC este de obicei \u00een ulei de ricin. Evita\u021bi dac\u0103 sunte\u021bi alergic la uleiul de ricin sau derivatele sale (unele \u0219ampoane, lubrifian\u021bi \u0219i medicamente).<\/p>\n<h3 class=\"wp-block-heading\">C\u00e2t timp trebuie s\u0103 continui Proluton Depot \u00een timpul sarcinii?<\/h3>\n<p>Protocolul istoric a fost s\u0103pt\u0103m\u00e2na 16\u201320 p\u00e2n\u0103 la s\u0103pt\u0103m\u00e2na 37 (prevenirea na\u0219terii premature). Pentru suportul luteal \u00een FIV, de obicei p\u00e2n\u0103 la preluarea placentar\u0103 timpurie (~s\u0103pt\u0103m\u00e2na 10\u201312). Urma\u021bi \u00eentotdeauna planul individualizat al specialistului dumneavoastr\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Proluton Depot poate provoca diabet gesta\u021bional?<\/h3>\n<p>Unele dovezi sugereaz\u0103 o cre\u0219tere moderat\u0103 a riscului de diabet gesta\u021bional cu utilizarea 17-OHPC, de\u0219i datele sunt mixte. Discuta\u021bi riscul cu obstetricianul dumneavoastr\u0103, mai ales dac\u0103 ave\u021bi al\u021bi factori de risc pentru diabet.<\/p>\n<h3 class=\"wp-block-heading\">De ce unor femeni li se recomand\u0103 s\u0103 foloseasc\u0103 progesteron vaginal \u00een loc?<\/h3>\n<p>Progesteronul vaginal are eficacitate comparabil\u0103 \u00een popula\u021biile relevante (col uterin scurt) cu mai pu\u021bine efecte secundare sistematice \u0219i f\u0103r\u0103 necesitatea injec\u021biilor intramusculare s\u0103pt\u0103m\u00e2nale. Ghidurile profesionale (SMFM, ACOG) au trecut spre progesteron vaginal pentru indica\u021bii selectate dup\u0103 studiul PROLONG.<\/p>\n<h3 class=\"wp-block-heading\">Produse conexe pentru s\u0103n\u0103tatea hormonal\u0103 \u0219i a femeii<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/premarin\/\">Premarin (Estrogeni conjuga\u021bi)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/premarin-cream\/\">Premarin Crem\u0103 (Estrogen vaginal)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/progynova\/\">Progynova (Valerat de estradiol)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/endogest\/\">Endogest (Progesteron\u0103 100 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/gestoford\/\">Gestoford (Progesteron\u0103 100 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/gestheal\/\">Gestheal (Progesteron\u0103 200 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/susten-capsule\/\">Capsule Susten (Progesteron\u0103)<\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.9em;\">\n<p style=\"margin:0;\"><strong>\u2695\ufe0f Disclaimer medical:<\/strong> Informa\u021biile au caracter educa\u021bional \u0219i nu \u00eenlocuiesc sfatul medical. Terapiile hormonale prezint\u0103 riscuri specifice (cancer de s\u00e2n, tromboz\u0103 venoas\u0103, accident vascular cerebral, cancer endometrial \u00een cazul estrogenului neopozat) \u2014 consulta\u021bi un medic \u00eenainte de a \u00eencepe, \u00eentrerupe sau modifica orice tratament hormonal. Raportul risc-beneficiu depinde de istoricul medical personal \u0219i familial.<\/p>\n<\/div>\n<p class=\"medsbase-link-boost-2026-05-16\" data-marker=\"mb-link-boost-eutrig-hp-5000iu-injection\">Proluton Depot furnizeaz\u0103 hidroxiprogesteron pentru suportul fazei luteale dup\u0103 transferul de embrion; etapa ini\u021bial\u0103 de declan\u0219are a ovula\u021biei \u00een acela\u0219i protocol de fertilitate este de obicei <a href=\"https:\/\/medsbase.com\/ro\/eutrig-hp-5000iu-injection\/\">Eutrig HP 5000IU (gonadotropin\u0103 corionic\u0103 uman\u0103 foarte purificat\u0103)<\/a> \u2014 \u00eempreun\u0103 acoper\u0103 ambele jum\u0103t\u0103\u021bi ale unui ciclu de FIV sau IUI.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alternative conexe<\/h3>\n<p>Alte produse din <strong>Women's Health<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/susten-vaginal-gel\/\">Susten Gel Vaginal<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/premarin\/\">Premarin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/cabgolin\/\">Cabgolin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/gestoford\/\">Gestoford<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/cystopen\/\">Cystopen<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<h5>\u2705 Sus\u021bine dezvoltarea sarcinii<br \/>\n\u2705 Reduce riscul de avort spontan<br \/>\n\u2705 Cre\u0219te nivelul de progesteron<br \/>\n\u2705 Cre\u0219te probabilitatea de sarcin\u0103<\/h5>\n<p><span style=\"color: #999999;\">Proluton Depot con\u021bine Hidroxiprogesteron\u0103<\/span><\/p>","protected":false},"featured_media":52829,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3521,3522,3502],"product_tag":[3525,3523,3526],"class_list":{"0":"post-52828","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-fertility","8":"product_cat-fertility-supplements-for-women","9":"product_cat-womens-health","10":"product_tag-hydroxyprogesterone","11":"product_tag-progesterone","12":"product_tag-proluton","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/52828","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=52828"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/52829"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=52828"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=52828"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=52828"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=52828"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}