{"id":52859,"date":"2023-09-20T09:39:09","date_gmt":"2023-09-20T09:39:09","guid":{"rendered":"https:\/\/medsname.com\/meprate\/"},"modified":"2026-04-30T10:25:14","modified_gmt":"2026-04-30T10:25:14","slug":"meprate","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/meprate\/","title":{"rendered":"Meprate"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 8px 0;\"><strong>\ud83d\udca1 R\u0103spuns rapid<\/strong><\/p>\n<p style=\"margin:0;\"><strong>Meprate<\/strong> este <strong>acetat de medroxiprogesteron\u0103 (MPA) 10 mg<\/strong>, un progestin sintetic oral utilizat pentru <strong>amenoreea secundar\u0103, s\u00e2nger\u0103ri uterine anormale, endometrioz\u0103 \u0219i protec\u021bie endometrial\u0103<\/strong> la femeile care urmeaz\u0103 terapie cu estrogen \u0219i care \u00eenc\u0103 au uter. Not\u0103: \u00een terapia hormonal\u0103 substitutiv\u0103 postmenopauz\u0103, progesterona micronizat\u0103 (Susten\/Endogest\/Naturogest) este de obicei preferat\u0103 \u00een locul MPA sintetic datorit\u0103 datelor de siguran\u021b\u0103 mai clare din era WHI privind cancerul de s\u00e2n \u0219i rezultatele cardiovasculare.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.95em;\">\n<strong>\ud83d\udd12 Ce beneficia\u021bi cu MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret simplu (f\u0103r\u0103 denumirea medicamentului pe exterior) \u00b7 Livrare worldwide \u00b7 Citeste-ne <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">Peste 1.400 de recenzii ale clien\u021bilor<\/a>\n<\/div>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Fiecare comand\u0103 MedsBase este expediat\u0103 de la un produc\u0103tor certificat WHO-GMP \u00een ambalaj simplu, complet discret \u2014 nimic pe exterior nu identific\u0103 con\u021binutul sau farmacia. Pl\u0103\u021bile cu cardul sunt procesate printr-un on-ramp crypto reglementat; descriptorul din extrasul de cont este numele procesatorului (un procesator de pl\u0103\u021bi cu card reglementat) \u2014 niciodat\u0103 \u201cMedsBase\u201d sau orice legat de farmacie. Pl\u0103\u021bile crypto prin Plisio r\u0103m\u00e2n complet anonime. Fiecare colet este acoperit de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a>.<\/p>\n<h2>Ce este Meprate?<\/h2>\n<p>Meprate este un medicament generic de marc\u0103 a <strong>acetat de medroxiprogesteron\u0103 (MPA) 10 mg<\/strong>, un derivat sintetic de 17-hidroxiprogesteron\u0103 cu activitate progesta\u021bional\u0103 puternic\u0103. Se leag\u0103 de receptorul de progesteron \u0219i induce transformarea secretorie a endometrului preg\u0103tit cu estrogen \u2014 baza pentru reglarea ciclului, inducerea s\u00e2nger\u0103rii de retragere \u0219i protec\u021bia endometrial\u0103 \u00een timpul terapiei cu estrogen. MPA are \u0219i activitate androgen\u0103 \u0219i glucocorticoid\u0103 slab\u0103, ceea ce o diferen\u021biaz\u0103 de progesteronul micronizat bioidentic (care este metabolic mai inert).<\/p>\n<h2>Indica\u021bii<\/h2>\n<ul>\n<li><strong>Amenoree secundar\u0103<\/strong> \u2014 5\u201310 mg\/zi timp de 5\u201310 zile; s\u00e2ngerarea de retragere apare dup\u0103 \u00eentrerupere.<\/li>\n<li><strong>S\u00e2ngerare uterin\u0103 disfunc\u021bional\u0103\/anormal\u0103<\/strong> \u2014 5\u201310 mg\/zi timp de 5\u201310 zile, \u00eencep\u00e2nd cu ziua 16\u201321 a ciclului.<\/li>\n<li><strong>Endometrioza<\/strong> \u2014 10 mg de trei ori pe zi timp de 90 de zile, \u00eencep\u00e2nd cu ziua 1 a ciclului.<\/li>\n<li><strong>Op\u021biune de progestin \u00een terapia hormonal\u0103 substitutiv\u0103<\/strong> \u2014 5\u201310 mg\/zi timp de 12\u201314 zile \u00een fiecare lun\u0103 (ciclic) sau 2,5\u20135 mg\/zi continuu, al\u0103turi de estrogen sistemic, pentru a preveni hiperplazia endometrial\u0103.<\/li>\n<li><strong>Hiperplazie endometrial\u0103 f\u0103r\u0103 atipie<\/strong> \u2014 10\u201320 mg\/zi, cu monitorizare histologic\u0103 la 3\u20136 luni.<\/li>\n<li><strong>Adjuvant \u00een carcinomul endometrial avansat sau cel renal<\/strong> \u2014 doze mai mari sub supraveghere specializat\u0103.<\/li>\n<\/ul>\n<h2>Cum se ia Meprate<\/h2>\n<ol>\n<li>Se administreaz\u0103 pe cale oral\u0103, cu sau f\u0103r\u0103 m\u00e2ncare, aproximativ la aceea\u0219i or\u0103 \u00een fiecare zi.<\/li>\n<li>S\u00e2ngerarea de retragere \u00eencepe de obicei la 3\u20137 zile dup\u0103 ultima tablet\u0103 dintr-un tratament de 5\u201310 zile.<\/li>\n<li>Pentru terapia hormonal\u0103 substitutiv\u0103 (THS), lua\u021bi acest produs \u00eempreun\u0103 cu (nu \u00een loc de) componenta de estrogen (oral\u0103, gel sau plasture).<\/li>\n<li>Sarcina trebuie exclus\u0103 \u00eenainte de a \u00eencepe orice tratament.<\/li>\n<\/ol>\n<h2>MPA vs Progesteron Micronizat \u2014 De Ce Conteaz\u0103<\/h2>\n<p>Numele <strong>Ini\u021biativa pentru S\u0103n\u0103tatea Femeilor (WHI) 2002<\/strong> studiu care a ridicat \u00eengrijor\u0103ri cu privire la terapia hormonal\u0103 substitutiv\u0103 combinat\u0103 utiliz\u00e2nd <strong>estrogeni conjuga\u021bi de origine equin\u0103 + MPA<\/strong> \u2014 nu progesteron bioidentic. Datele observa\u021bionale ulterioare (E3N, KEEPS) sugereaz\u0103 c\u0103 <strong>progesteronului micronizat<\/strong> are un profil mai sigur \u00een ceea ce prive\u0219te riscul de cancer de s\u00e2n \u0219i cardiovascular. \u00cen practica actual\u0103 a THS postmenopauzal\u0103 din 2024, progesteronul micronizat (Susten \/ Endogest \/ Naturogest) este \u00een general preferat. MPA r\u0103m\u00e2ne util \u0219i ieftin pentru tratamente scurte (reglarea ciclului, s\u00e2nger\u0103ri de retragere, hiperplazie endometrial\u0103) unde transformarea endometrial\u0103 puternic\u0103 este scopul.<\/p>\n<h2>Efecte Secundare<\/h2>\n<p><strong>Frecvente:<\/strong> tendin\u021b\u0103 mamar\u0103, cefalee, modific\u0103ri ale st\u0103rii de spirit, s\u00e2nger\u0103ri break-through, modific\u0103ri ale greut\u0103\u021bii, reten\u021bie de lichide, acnee, balonare abdominal\u0103.<\/p>\n<p><strong>Mai pu\u021bin frecvente:<\/strong> hirsutism (activitate androgen\u0103), toleran\u021b\u0103 la glucoz\u0103 redus\u0103, u\u0219oar\u0103 cre\u0219tere a tensiunii arteriale, simptome depresive.<\/p>\n<p><strong>Grave (c\u0103uta\u021bi \u00eengrijire urgent\u0103):<\/strong> cefalee sever\u0103 brusc\u0103, modific\u0103ri ale vederii, durere sau umflare \u00een gamb\u0103 (TVP), durere toracic\u0103, icter, nodul mamar.<\/p>\n<h2>Contraindica\u021bii<\/h2>\n<ul>\n<li>Sarcin\u0103 sau sarcin\u0103 suspectat\u0103<\/li>\n<li>S\u00e2ngerare vaginal\u0103 nediagnosticat\u0103<\/li>\n<li>Cancer mamar activ sau trecut (rud\u0103; consult specializat)<\/li>\n<li>TVP activ sau accident vascular cerebral; infarct miocardic recent<\/li>\n<li>Boal\u0103 hepatic\u0103 sever\u0103<\/li>\n<li>Hipersensibilitate cunoscut\u0103 la MPA<\/li>\n<\/ul>\n<h2>Interac\u021biuni medicamentoase<\/h2>\n<p>Inductorii CYP3A4 (rifampicin\u0103, carbamazepin\u0103, fenitoin\u0103, fenobarbital, iarba Sf\u00e2ntului Ioan) reduc nivelurile de MPA \u0219i pot provoca s\u00e2nger\u0103ri nea\u0219teptate sau pierdere a efectului. Inhibitorii CYP3A4 (azole, macrolide, ritonavir, grapefruit) cresc expunerea. MPA poate reduce, de asemenea, eficacitatea unor medicamente pentru diabet \u0219i poate cre\u0219te u\u0219or TA \u2014 monitoriza\u021bi pacien\u021bii diabetici \u0219i hipertensivi.<\/p>\n<h2>Sarcin\u0103 &amp; Al\u0103ptare<\/h2>\n<p>Contraindicate \u00een sarcin\u0103. \u00centrerupe\u021bi dac\u0103 sarcina este confirmat\u0103. Cantit\u0103\u021bi mici trec \u00een laptele matern; pentru cursuri scurte postpartum (de ex., \u00een contextul suprim\u0103rii lacta\u021biei) discuta\u021bi cu un clinician. Progesteronul bioidentic este preferat \u00een suportul luteal \u0219i \u00een set\u0103rile de FIV.<\/p>\n<h2>Depozitare<\/h2>\n<p>Depozita\u021bi sub 25 \u00b0C \u00een blisterul original. P\u0103stra\u021bi departe de reach-ul copiilor.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>Meprate este acela\u0219i lucru cu progesteronul natural?<\/h3>\n<p>Nu. Meprate este un <strong>progestin sintetic<\/strong> (acetat de medroxiprogesteron\u0103) cu activitate endometrial\u0103 puternic\u0103, dar \u0219i efecte androgenice \u0219i glucocorticoide slabe. Progesteronul natural micronizat (Susten \/ Endogest \/ Naturogest) este bioidentic, are un profil de efecte adverse mai curat \u0219i este \u00een general preferat pentru THS postmenopauz\u0103.<\/p>\n<h3>C\u00e2t dureaz\u0103 p\u00e2n\u0103 \u00eencepe s\u00e2ngerarea de retragere dup\u0103 un tratament de 5\u201310 zile?<\/h3>\n<p>S\u00e2ngerarea \u00eencepe de obicei la 3\u20137 zile dup\u0103 ultima tablet\u0103, dur\u00e2nd 3\u20135 zile. Dac\u0103 nu s\u00e2ngera\u021bi \u00een dou\u0103 s\u0103pt\u0103m\u00e2ni de la oprire, exclude\u021bi sarcina \u0219i consulta\u021bi-v\u0103 cu clinicianul.<\/p>\n<h3>Poate fi folosit Meprate ca contraceptiv?<\/h3>\n<p>MPA oral la aceast\u0103 doz\u0103 este <strong>prime\u0219te,<\/strong> o metod\u0103 contraceptiv\u0103 fiabil\u0103. MPA depot (medroxyprogesteron acetat 150 mg IM la fiecare 12 s\u0103pt\u0103m\u00e2ni \u2014 Depo-Provera) este contraceptiv, dar este un produs diferit. Utiliza\u021bi o metod\u0103 contraceptiv\u0103 non-hormonal\u0103 \u00een timp ce lua\u021bi MPA oral dac\u0103 trebuie evitat\u0103 sarcina.<\/p>\n<h3>Pot lua Meprate cu plasturele\/gelul meu de estrogen pentru THS?<\/h3>\n<p>Da \u2014 acesta este regimul standard combinat de THS pentru femeile cu uter. Meprate asigur\u0103 opozi\u021bia progestinic\u0103 pentru a preveni hiperplazia endometrial\u0103 indus\u0103 de estrogen. Administrarea ciclic\u0103 (12\u201314 zile\/lun\u0103) provoac\u0103 s\u00e2ngerare de retragere; doza continu\u0103 mic\u0103 nu provoac\u0103 s\u00e2ngerare programat\u0103 odat\u0103 ce endometrul devine atrofic.<\/p>\n<h3>Meprate poate cauza cre\u0219tere \u00een greutate?<\/h3>\n<p>Sunt raportate modific\u0103ri modeste \u00een greutate (1\u20132 kg), adesea legate de reten\u021bia de ap\u0103. Activitatea androgen\u0103 a MPA este mai probabil s\u0103 determine efecte secundare metabolice dec\u00e2t progesteronul micronizat.<\/p>\n<h3>Ce fac dac\u0103 uit o doz\u0103?<\/h3>\n<p>Lua\u021bi-l c\u00e2nd v\u0103 aminti\u021bi, cu excep\u021bia cazului \u00een care este aproape de urm\u0103toarea doz\u0103 programat\u0103 \u2014 nu dubla\u021bi doza. Dozele ratate pot declan\u0219a s\u00e2nger\u0103ri neprogramate.<\/p>\n<h3>Meprate poate cauza depresie?<\/h3>\n<p>Progestinele sintetice, inclusiv MPA, pot agrava starea de disforie la femeile susceptibile. Dac\u0103 observa\u021bi modific\u0103ri de stare, trece\u021bi la progesteron bioidentic sau discuta\u021bi alternative cu medicul dumneavoastr\u0103.<\/p>\n<h3>Meprate este sigur \u00een antecedente de cancer de s\u00e2n?<\/h3>\n<p>Nu. O istoric personal de cancer de s\u00e2n sensibil la hormoni este o contraindica\u021bie. Este necesar\u0103 consultarea unui specialist pentru orice progestin \u00een acest context.<\/p>\n<h3>B\u0103rba\u021bii pot lua Meprate?<\/h3>\n<p>Exist\u0103 utiliz\u0103ri off-label pentru tulbur\u0103ri parafilice \u0219i terapia adjuvant\u0103 a cancerului de prostat\u0103 sub supraveghere specializat\u0103 \u2014 nu este potrivit pentru auto-administrare.<\/p>\n<h3>Care este diferen\u021ba dintre Meprate, Provera \u0219i Cycrin?<\/h3>\n<p>Toate trei sunt generice de MPA 10 mg cu brand diferit. Meprate este marca indian\u0103 (Mankind Pharma). Provera (Pfizer) este marca original\u0103 din SUA. Molecula \u0219i doza sunt identice.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Alte Medicamente Hormonale \u0219i pentru S\u0103n\u0103tatea Femeii<\/h2>\n<p>Alte produse din <strong>Terapia Hormonal\u0103 de \u00cenlocuire \u0219i S\u0103n\u0103tatea Femeii<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/susten-capsule\/\">Capsula Susten (Progesteron\u0103 Micronizat\u0103 100 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/endogest\/\">Endogest (Progesteron\u0103 Micronizat\u0103 100 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/naturogest\/\">Naturogest (Progesteron micronizat)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/progynova\/\">Progynova (Valerat de estradiol)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/oestrogel-gel\/\">Gel Oestrogel (Estradiol Transdermal)<\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>\u26a0\ufe0f Disclaimer medical<\/strong><\/p>\n<p style=\"margin:0;font-size:0.95em;\">Terapia hormonal\u0103 implic\u0103 beneficii \u0219i riscuri individuale care variaz\u0103 \u00een func\u021bie de v\u00e2rst\u0103, timpul de la menopauz\u0103, istoricul personal \u0219i familial, \u0219i afec\u021biuni concomitente. Discuta\u021bi \u00eentregul istoric medical cu un clinician \u00eenainte de a \u00eencepe, schimba sau \u00eentrerupe terapia hormonal\u0103 de \u00eenlocuire (HRT), terapia cu progestin sau estrogen vaginal. \u00centrerupe\u021bi \u0219i c\u0103uta\u021bi \u00eengrijire urgent\u0103 pentru s\u00e2nger\u0103ri vaginale neexplicate, dureri de cap severe \u0219i bru\u0219te, modific\u0103ri ale vederii, dureri sau umfl\u0103turi la nivelul gambei, dureri \u00een piept sau noduli mamari.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Meprate (acetat de medroxiprogesteron\u0103 10 mg) \u2014 progestin sintetic oral pentru amenoreea secundar\u0103, s\u00e2nger\u0103ri uterine anormale, endometrioz\u0103 \u0219i opozi\u021bie progestinic\u0103 \u00een terapia hormonal\u0103 substitutiv\u0103. Generic de marc\u0103 Mankind Pharma.<\/p>","protected":false},"featured_media":52860,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3519,3502],"product_tag":[3533,3534,3535],"class_list":{"0":"post-52859","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-hormone-replacement-therapy-hrt-medication-for-menopause","8":"product_cat-womens-health","9":"product_tag-medroxyprogesterone","10":"product_tag-meprate","11":"product_tag-progestrone","13":"first","14":"outofstock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/52859","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=52859"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/52860"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=52859"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=52859"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=52859"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=52859"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}