{"id":52881,"date":"2023-09-20T09:39:36","date_gmt":"2023-09-20T09:39:36","guid":{"rendered":"https:\/\/medsname.com\/danogen\/"},"modified":"2026-04-30T10:18:07","modified_gmt":"2026-04-30T10:18:07","slug":"danogen","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/danogen\/","title":{"rendered":"Danogen"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 8px 0;\"><strong>\ud83d\udca1 R\u0103spuns rapid<\/strong><\/p>\n<p style=\"margin:0;\"><strong>Danogen<\/strong> este <strong>danazol 50 mg<\/strong>, un derivat androgen care suprim\u0103 gonadotropinele hipofizare (FSH, LH) \u0219i are activitate androgen\u0103 slab\u0103 + anti-estrogenic\u0103. <strong>Utiliz\u0103ri principale:<\/strong> endometrioza (istoric; acum folosit mai rar din cauza efectelor secundare), boala fibrochistic\u0103 a s\u00e2nului (sever\u0103) \u0219i profilaxia angioedemului ereditar (HAE). Nu este utilizat pentru terapia hormonal\u0103 de \u00eenlocuire la menopauz\u0103. Efectele secundare androgenice caracteristice (\u00eengro\u0219area vocii \u2014 uneori permanent\u0103, acnee, cre\u0219tere \u00een greutate, hirsutism) necesit\u0103 o discu\u021bie riguroas\u0103 risc-beneficiu.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.95em;\">\n<strong>\ud83d\udd12 De ce s\u0103 comanzi de la MedsBase:<\/strong> Aprovizionare verificat\u0103 direct de la produc\u0103tor \u00b7 Livrare discret\u0103 \u00een \u00eentreaga lume \u00b7 Plat\u0103 securizat\u0103 (card de credit, crypto) \u00b7 Evaluat 4,9\u2605 de peste 1.400 de clien\u021bi\n<\/div>\n<h2><strong>Ce este Danogen?<\/strong><\/h2>\n<p>Danogen este un medicament generic marca al <strong>danazol 50 mg<\/strong>, danazolului, un steroid sintetic derivat din 17-alfa-etinil testosteron. Este un <strong>androgen slab<\/strong> cu activitate anti-gonadotropin\u0103, anti-progestin\u0103 \u0219i anti-estrogenic\u0103. Prin suprimarea produc\u021biei hipotalamo-hipofizo-ovariene, induce o stare de estrogen sc\u0103zut care reduce implanturile endometriotice, amelior\u00e2nd simptomele fibrochistice ale s\u00e2nului \u0219i reduc\u00e2nd atacurile de HAE. Fabricat de German Remedies.<\/p>\n<p><strong>Not\u0103 de categorie:<\/strong> de\u0219i acest produs apare \u00een categoria THS, danazolul nu este un \u00eenlocuitor hormonal pentru menopauz\u0103. Utilizarea sa este limitat\u0103 la afec\u021biuni ginecologice \u0219i alergice specifice. Practica modern\u0103 prefer\u0103 adesea agonistii GnRH (leuprolida), contraceptivele combinate sau DIU-urile cu levonorgestrel \u00een locul danazolului pentru endometioz\u0103 din cauza efectelor secundare.<\/p>\n<h2><strong>Utiliz\u0103ri clinice<\/strong><\/h2>\n<ul>\n<li><strong>Endometrioza:<\/strong> 200\u2013800 mg\/zi, administrate frac\u021bionat (istoric, linie primar\u0103; acum utilizat mai rar din cauza efectelor adverse).<\/li>\n<li><strong>Boal\u0103 fibrochistic\u0103 a s\u00e2nului<\/strong> \u2014 durere moderat\u0103 p\u00e2n\u0103 la sever\u0103: 100\u2013400 mg\/zi.<\/li>\n<li><strong>Profilaxie pentru angioedem ereditar (HAE)<\/strong>: 200 mg de 2\u20133 ori pe zi, cu titrare descresc\u0103toare p\u00e2n\u0103 la cea mai mic\u0103 doz\u0103 eficient\u0103.<\/li>\n<li><strong>Purpur\u0103 trombocitopenic\u0103 idiopatic\u0103 (ITP)<\/strong> adjunct (off-label, utilizare de ni\u0219\u0103).<\/li>\n<li><strong>Contrac\u021bii ventriculare premature<\/strong> \u0219i alte indica\u021bii limitate.<\/li>\n<\/ul>\n<h2><strong>Cum se administreaz\u0103<\/strong><\/h2>\n<ol>\n<li>\u00cenghi\u021bi\u021bi capsulele \u00eentregi cu ap\u0103, \u00een acela\u0219i moment al zilei, cu m\u00e2ncare pentru a reduce disconfortul gastrointestinal.<\/li>\n<li><strong>Endometrioza:<\/strong> \u00eencepe\u021bi cu 400 mg\/zi, divizat, de obicei \u00een prima zi a ciclului. Durat\u0103 tipic\u0103: 3\u20136 luni (nu se recomand\u0103 dep\u0103\u0219irea a 9 luni).<\/li>\n<li><strong>S\u00e2n fibrocistic:<\/strong> 100\u2013400 mg\/zi; continua\u021bi timp de 4\u20136 luni, cu reducerea treptat\u0103 la dispari\u021bia simptomelor.<\/li>\n<li><strong>Profilaxie HAE:<\/strong> 200 mg de 2\u20133 ori pe zi, cu reducerea treptat\u0103 pe parcursul lunilor p\u00e2n\u0103 la doza minim\u0103 eficient\u0103.<\/li>\n<li>Utiliza\u021bi contracep\u021bie non-hormonal\u0103 \u00een timpul tratamentului \u2014 danazolul poate provoca masculinizarea fetusului feminin.<\/li>\n<\/ol>\n<h2><strong>Efecte Secundare (Semnificative)<\/strong><\/h2>\n<p><strong>Androgene (frecvente):<\/strong> acnee, piele gras\u0103, hirsutism (p\u0103r facial\/corporal), \u00een\u0103sprirea vocii (<strong>poate fi permanent\u0103<\/strong>), clitoromegalie, cre\u0219tere \u00een greutate, modific\u0103ri u\u0219oare ale siluetei.<\/p>\n<p><strong>Anti-estrogene (frecvente):<\/strong> amenoree, valuri de c\u0103ldur\u0103, uscare vaginal\u0103, reducerea dimensiunii s\u00e2nilor.<\/p>\n<p><strong>Mai pu\u021bin frecvente:<\/strong> schimb\u0103ri de dispozi\u021bie, reten\u021bie de lichide, crampe musculare, insomnie, cefalee.<\/p>\n<p><strong>Grave (rare):<\/strong> icter colestatic, adenom hepatic, carcinom hepatocelular (la utilizarea pe termen lung la doze mari), TEV, hipertensiune intracranian\u0103 benign\u0103, masculinizarea fetusului feminin (teratogen).<\/p>\n<h2><strong>Cine nu ar trebui s\u0103 ia Danogen<\/strong><\/h2>\n<ul>\n<li><strong>Sarcin\u0103<\/strong> \u2014 strict contraindicated (teratogen, masculinizeaz\u0103 f\u0103tul feminin)<\/li>\n<li>Boli active ale ficatului, rinichilor sau cardiace<\/li>\n<li>S\u00e2ngerare vaginal\u0103 nediagnosticat\u0103<\/li>\n<li>Porfire<\/li>\n<li>Istoric de tumori androgen-dependente<\/li>\n<li>Hipersensibilitate cunoscut\u0103<\/li>\n<li>Virilizare existent\u0103 sau modific\u0103ri ale vocii \u2014 se pot agrava permanent<\/li>\n<\/ul>\n<h2><strong>Interac\u021biuni medicamentoase<\/strong><\/h2>\n<ul>\n<li><strong>Warfarin:<\/strong> danazolul cre\u0219te efectul warfarinului \u2014 monitoriza\u021bi str\u00e2ns INR.<\/li>\n<li><strong>Carbamazepin\u0103, ciclosporin\u0103, tacrolimus, sirolimus:<\/strong> danazolul cre\u0219te nivelurile lor plasmatice.<\/li>\n<li><strong>Statine<\/strong> (simvastatin\u0103, atorvastatin\u0103): niveluri crescute de statine, risc crescut de rabdomioliz\u0103.<\/li>\n<li><strong>Insulin\u0103 \u0219i hipoglicemiante orale:<\/strong> danazolul poate afecta controlul glicemic.<\/li>\n<\/ul>\n<h2><strong>Depozitare<\/strong><\/h2>\n<p>P\u0103stra\u021bi la temperatura camerei (15\u201330 \u00b0C \/ 59\u201386 \u00b0F). P\u0103stra\u021bi \u00een blisterul original, departe de umiditate \u0219i lumin\u0103. P\u0103stra\u021bi departe de reach-ul copiilor.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">Este permanent\u0103 ad\u00e2ncirea vocii la administrarea de danazol?<\/h3>\n<p>Adesea da, \u00een special la doze mai mari sau pe o perioad\u0103 mai lung\u0103. Chiar \u0219i modific\u0103rile u\u0219oare ale vocii pot s\u0103 nu se inverseze complet dup\u0103 \u00eentrerupere. Acesta este cel mai preocupant efect secundar pentru multe femei. Monitoriza\u021bi frecvent vocea \u2014 dac\u0103 observa\u021bi modific\u0103ri, opri\u021bi \u0219i discuta\u021bi cu un medic.<\/p>\n<h3 class=\"wp-block-heading\">Este danazolul tratament de prim\u0103 linie pentru endometrioza?<\/h3>\n<p>Nu mai este. Op\u021biunile moderne de prim\u0103 linie sunt contraceptivele hormonale combinate, dispozitivul intrauterin cu levonorgestrel \u0219i agonistii GnRH (leuprolida). Danazolul este o op\u021biune istoric\u0103 rezervat\u0103 pentru cazurile \u00een care alte abord\u0103ri au e\u0219uat sau sunt contraindicate.<\/p>\n<h3 class=\"wp-block-heading\">C\u00e2t timp pot lua danazol?<\/h3>\n<p>Endometrioz\u0103: 3\u20136 luni (p\u00e2n\u0103 la 9). S\u00e2n fibrocistic: 4\u20136 luni. Profilaxia HAE: utilizare pe termen lung posibil\u0103 cu minimizarea dozei. Monitorizarea anual\u0103 a func\u021biei hepatice este recomandat\u0103 pentru utilizarea pe termen lung.<\/p>\n<h3 class=\"wp-block-heading\">Pot r\u0103m\u00e2ne \u00eens\u0103rcinat\u0103 \u00een timp ce iau danazol?<\/h3>\n<p>Nu \u2014 contracep\u021bia este obligatorie. Danazolul este teratogen. Folosi\u021bi metode contraceptive non-hormonale (barier\u0103) \u00een timpul tratamentului \u0219i pentru 1 ciclu dup\u0103 \u00eentrerupere.<\/p>\n<h3 class=\"wp-block-heading\">Ce este HAE \u0219i cum ajut\u0103 danazolul?<\/h3>\n<p>Angioedem ereditar \u2014 o afec\u021biune genetic\u0103 cu atacuri episodice de umfl\u0103turi severe (adesea ale fe\u021bei, c\u0103ilor respiratorii sau abdomenului). Danazolul cre\u0219te sinteza hepatic\u0103 a inhibitorului C1 esterazei, reduc\u00e2nd frecven\u021ba atacurilor. Este utilizat la pacien\u021bii selecta\u021bi cu HAE care au contraindica\u021bii sau r\u0103spuns inadecvat la terapiile moderne (ecallantid\u0103, lanadelumab).<\/p>\n<h3 class=\"wp-block-heading\">Pot lua danazol cu warfarin?<\/h3>\n<p>Doar cu monitorizare foarte atent\u0103 a INR-ului. Danazolul cre\u0219te semnificativ nivelurile de warfarin. Clinica dumneavoastr\u0103 de anticoagulare poate reduce substan\u021bial doza de warfarin.<\/p>\n<h3 class=\"wp-block-heading\">Danazolul poate provoca cre\u0219tere \u00een greutate?<\/h3>\n<p>~30\u201350% dintre utilizatori raporteaz\u0103 cre\u0219tere \u00een greutate (1\u20135 kg tipic). Exerci\u021biile fizice \u0219i m\u0103surile dietetice ajut\u0103; greutatea revine de obicei la nivelul ini\u021bial \u00een 3\u20136 luni dup\u0103 \u00eentrerupere.<\/p>\n<h3 class=\"wp-block-heading\">Ce se \u00eent\u00e2mpl\u0103 dac\u0103 \u00eentrerup brusc danazolul?<\/h3>\n<p>Nu exist\u0103 sindrom de sevraj, dar afec\u021biunea subiacent\u0103 (endometrioza, boala fibrochistic\u0103, HAE) va reap\u0103rea. Lua\u021bi \u00een considerare o reducere progresiv\u0103 a dozei la \u00eentreruperea profilaxiei HAE pentru a men\u021bine controlul.<\/p>\n<h3 class=\"wp-block-heading\">Produse conexe pentru s\u0103n\u0103tatea hormonal\u0103 \u0219i a femeii<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/premarin\/\">Premarin (Estrogeni conjuga\u021bi)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/premarin-cream\/\">Premarin Crem\u0103 (Estrogen vaginal)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/progynova\/\">Progynova (Valerat de estradiol)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/endogest\/\">Endogest (Progesteron\u0103 100 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/gestoford\/\">Gestoford (Progesteron\u0103 100 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/gestheal\/\">Gestheal (Progesteron\u0103 200 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/susten-capsule\/\">Capsule Susten (Progesteron\u0103)<\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.9em;\">\n<p style=\"margin:0;\"><strong>\u2695\ufe0f Disclaimer medical:<\/strong> Informa\u021biile au caracter educa\u021bional \u0219i nu \u00eenlocuiesc sfatul medical. Terapiile hormonale prezint\u0103 riscuri specifice (cancer de s\u00e2n, tromboz\u0103 venoas\u0103, accident vascular cerebral, cancer endometrial \u00een cazul estrogenului neopozat) \u2014 consulta\u021bi un medic \u00eenainte de a \u00eencepe, \u00eentrerupe sau modifica orice tratament hormonal. Raportul risc-beneficiu depinde de istoricul medical personal \u0219i familial.<\/p>\n<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alternative conexe<\/h3>\n<p>Alte produse din <strong>Women's Health<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/susten-injection\/\">Injectia Susten<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/cerazette\/\">Cerazette<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/cabgolin\/\">Cabgolin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/ovral-g\/\">Ovral G<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/evalon-cream\/\">Crem\u0103 Evalon<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<h5>\u2705 Reglarea nivelului hormonal<br \/>\n\u2705 Alinarea simptomelor endometriozei<br \/>\n\u2705 Managementul bolii fibrochistice a s\u00e2nului<br \/>\n\u2705 Alinarea simptomelor angioedemului ereditar<br \/>\n\u2705 \u00cembun\u0103t\u0103\u021birea calit\u0103\u021bii vie\u021bii<\/h5>\n<p><span style=\"color: #999999;\">Danogen con\u021bine Danazol<br \/>\n<\/span><\/p>","protected":false},"featured_media":52882,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3502],"product_tag":[3549,3550],"class_list":{"0":"post-52881","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-womens-health","8":"product_tag-danazol","9":"product_tag-danogen","11":"first","12":"instock","13":"shipping-taxable","14":"purchasable","15":"product-type-variable","16":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/52881","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=52881"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/52882"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=52881"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=52881"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=52881"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=52881"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}