{"id":52957,"date":"2023-09-20T09:40:36","date_gmt":"2023-09-20T09:40:36","guid":{"rendered":"https:\/\/medsname.com\/ciplox\/"},"modified":"2026-04-30T10:25:14","modified_gmt":"2026-04-30T10:25:14","slug":"ciplox","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/ciplox\/","title":{"rendered":"Ciplox"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Ciplox?<\/h3>\n<p style=\"margin:0;\"><strong>Ciplox<\/strong> este <strong>ciprofloxacin 250\/500\/750 mg comprimat<\/strong> de la Cipla \u2014 o fluoroquinolon\u0103 de genera\u021bia a doua cu activitate larg\u0103 \u00eempotriva aerobilor Gram-negativi, Pseudomonas aeruginosa, patogenilor respiratori atipici \u0219i multor organisme enterice. \u00cen context gastro, ciprofloxacina este utilizat\u0103 pentru <strong>diareea sever\u0103 invaziv\u0103 a c\u0103l\u0103torului, Salmonella complicat\u0103, Shigella, suspiciune de Campylobacter, infec\u021bie intra-abdominal\u0103 (cu metronidazol), profilaxia peritonitei bacteriene spontane \u00een ciroz\u0103 \u0219i boala perianal\u0103 a lui Crohn (cu metronidazol)<\/strong>. Doz\u0103 standard pentru adul\u021bi: <strong>500\u2013750 mg de dou\u0103 ori pe zi timp de 5\u201314 zile, \u00een func\u021bie de indica\u021bie<\/strong>. Produc\u0103tor certificat WHO-GMP.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>De ce s\u0103 comanzi de la MedsBase:<\/strong> \u2714 <strong>produc\u0103tor certificat WHO-GMP<\/strong> \u2714 Ambalaj discret \u2714 Livrare worldwide \u2714 <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">Recenzii verificate ale clien\u021bilor (peste 1.400 de clien\u021bi)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>\u26a0\ufe0f Avertismente FDA black-box \u2014 rezerva\u021bi pentru infec\u021bii grave.<\/strong> Fluoroquinolonele poart\u0103 avertismente FDA black-box pentru tendinopatie \u0219i ruptur\u0103 de tendon (\u00een special tendonul lui Ahile, la adul\u021bii \u00een v\u00e2rst\u0103, la cei care iau corticosteroizi, post-transplant), neuropatie periferic\u0103 (poten\u021bial permanent\u0103), efecte asupra SNC (anxietate, confuzie, halucina\u021bii, convulsii) \u0219i aneurism \u0219i disec\u021bie aortic\u0103 (~ risc dublu). De asemenea, afecteaz\u0103 func\u021bia mitocondrial\u0103 \u0219i au fost asociate cu hipoglicemie \u0219i prelungire a intervalului QT. Rezerva\u021bi-le pentru situa\u021bii \u00een care alternativele mai pu\u021bin toxice sunt nepotrivite. Nu utiliza\u021bi pentru UTI necomplicat, sinuzit\u0103 sau bron\u0219it\u0103 dac\u0103 exist\u0103 alternative.<\/div>\n<h3 class=\"wp-block-heading\">De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Ciplox este furnizat de la <strong>produc\u0103tor certificat WHO-GMP<\/strong>. Fiecare comand\u0103 este expediat\u0103 discret \u00een \u00eentreaga lume \u0219i este acoperit\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> \u2014 dac\u0103 nu ajunge \u00een 20 de zile lucr\u0103toare, retrimitem f\u0103r\u0103 costuri suplimentare. Ciprofloxacina r\u0103m\u00e2ne esen\u021bial\u0103 pentru mai multe indica\u021bii de ni\u0219\u0103, inclusiv infec\u021bia enteric\u0103 invaziv\u0103, febra neutropenic\u0103, UTI complicat\u0103 cu Pseudomonas \u0219i profilaxia SBP \u2014 avertismentele FDA black-box sunt un semnal de gestionare, nu de eliminare.<\/p>\n<h2 class=\"wp-block-heading\">Mecanism de ac\u021biune<\/h2>\n<p>Ciprofloxacina inhib\u0103 giraza ADN-ului bacterian (topoizomeraza II) \u0219i topoizomeraza IV, prevenind replicarea \u0219i transcrierea ADN-ului. Este bactericid\u0103 la concentra\u021bii realizabile clinic. Rezisten\u021ba apare prin muta\u021bii punctuale \u00een gyrA\/parC \u0219i prin upregularea pompelor de efflux; rezisten\u021ba dep\u0103\u0219e\u0219te acum 30 la sut\u0103 \u00een unele popula\u021bii de Enterobacteriaceae \u0219i 50 la sut\u0103 \u00een Salmonella Typhi din Asia de Sud.<\/p>\n<h2 class=\"wp-block-heading\">Indica\u021bii gastrointestinale<\/h2>\n<ul>\n<li><strong>Diarhea sever\u0103 a c\u0103l\u0103torului<\/strong> (febr\u0103 &gt; 38,5\u00b0C, scaun s\u00e2ngeros, simptome septicemice): 500 mg de dou\u0103 ori pe zi timp de 1\u20133 zile<\/li>\n<li><strong>Bacteremie Salmonella \/ tifoid (tulpinile sensibile):<\/strong> 500 mg de dou\u0103 ori pe zi timp de 7\u201314 zile<\/li>\n<li><strong>Shigeloz\u0103 (sever\u0103):<\/strong> 500 mg de dou\u0103 ori pe zi timp de 3\u20135 zile<\/li>\n<li><strong>Infec\u021bie intra-abdominal\u0103 (cu metronidazol):<\/strong> 400 mg IV la fiecare 12 ore sau 500\u2013750 mg oral la fiecare 12 ore timp de 5\u201314 zile<\/li>\n<li><strong>Profilaxie pentru peritonita bacterian\u0103 spontan\u0103 \u00een ciroz\u0103:<\/strong> 500 mg o dat\u0103 pe zi pe termen lung<\/li>\n<li><strong>Boala perianal\u0103 Crohn (cu metronidazol):<\/strong> 500 mg de dou\u0103 ori pe zi timp de 4\u201312 s\u0103pt\u0103m\u00e2ni<\/li>\n<li><strong>Terapie de salvare pentru Helicobacter pylori:<\/strong> ciprofloxacin 500 mg BD + amoxicilin\u0103 + PPI + bismut (dup\u0103 e\u0219ecul terapiei standard)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Doza<\/h2>\n<p>Adul\u021bi: 250\u2013750 mg de dou\u0103 ori pe zi oral, \u00een func\u021bie de severitate. Infec\u021bie sever\u0103\/complicat\u0103: 500\u2013750 mg de dou\u0103 ori pe zi. Infec\u021bie osoas\u0103, articular\u0103, de \u021besut profund: 750 mg de dou\u0103 ori pe zi. CrCl 30\u201350: 250\u2013500 mg de dou\u0103 ori pe zi. CrCl &lt; 30: 250\u2013500 mg o dat\u0103 pe zi. Insuficien\u021b\u0103 hepatic\u0103: f\u0103r\u0103 ajustare de doz\u0103. Copii: indica\u021bii limitate (exacerbare pulmonar\u0103 la fibroz\u0103 chistic\u0103, antrax, infec\u021bie urinar\u0103 complicat\u0103) la 10\u201320 mg\/kg\/doz\u0103 BD.<\/p>\n<h2 class=\"wp-black-block-heading\">Efecte secundare<\/h2>\n<ul>\n<li>GI: grea\u021b\u0103, diaree, dureri abdominale, candidoz\u0103 oral\u0103<\/li>\n<li>SNC: cefalee, ame\u021beli, insomnie, anxietate, confuzie, halucina\u021bii, convulsii (rare)<\/li>\n<li>Tendinopatie\/ruptur\u0103 de tendon (avertisment FDA - cutie neagr\u0103): \u00een special tendonul Ahile, adesea \u00een c\u00e2teva zile; v\u00e2rsta \u00eenaintat\u0103, utilizarea de corticosteroizi, transplantul \u0219i boala renal\u0103 cronic\u0103 cresc riscul<\/li>\n<li>Neuropatie periferic\u0103 (avertisment FDA - cutie neagr\u0103): uneori permanent\u0103<\/li>\n<li>Anevrism\/disec\u021bie aortic\u0103 (avertisment FDA - cutie neagr\u0103, \u00een special la adul\u021bii \u00een v\u00e2rst\u0103 cu factori de risc)<\/li>\n<li>Prelungire QT, torsade de pointes (rar)<\/li>\n<li>Fotosensibilitate<\/li>\n<li>Hipoglicemie (\u00een special la diabeticii care iau sulfoniluree)<\/li>\n<li>Diaree asociat\u0103 cu C. difficile<\/li>\n<li>Sindromul Stevens-Johnson, necroliz\u0103 epidermic\u0103 toxic\u0103 (rar)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>Antiaci\u021bi, fier, zinc, calciu, lactate, sucralfat, multivitamine:<\/strong> chelarea ciprofloxacinei \u0219i reducerea absorb\u021biei cu 50\u201390% \u2014 administra\u021bi la interval de 2 ore \u00eenainte sau 6 ore dup\u0103.<\/li>\n<li><strong>Tizanidin\u0103:<\/strong> COMBINA\u021aIA CIPROFLOXACIN\u0102-TIZANIDIN\u0102 ESTE ABSOLUT CONTRAINDICAT\u0102 \u2014 ciprofloxacina inhib\u0103 CYP1A2 \u0219i cre\u0219te nivelul tizanidinei de 10 ori, provoc\u00e2nd hipotensiune \u0219i sedare periculoase.<\/li>\n<li><strong>Teofilin\u0103, cafein\u0103:<\/strong> Inhibi\u021bia CYP1A2 cre\u0219te nivelurile \u2014 reduce\u021bi doza de teofilin\u0103 cu 30%.<\/li>\n<li><strong>Warfarin:<\/strong> Cre\u0219terea INR \u2014 monitoriza\u021bi \u00eendeaproape.<\/li>\n<li><strong>Sulfoniluree, insulin\u0103:<\/strong> risc de hipoglicemie.<\/li>\n<li><strong>Medicamente care prelunge\u0219te intervalul QT:<\/strong> risc aditiv de torsade.<\/li>\n<li><strong>Metotrexat, ciclosporin\u0103:<\/strong> nivelurile pot cre\u0219te.<\/li>\n<li><strong>AINS:<\/strong> poate cre\u0219te riscul de afectare SNC \/ convulsii.<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">C\u00e2nd ar trebui utilizat ciprofloxacinul pentru diaree?<\/h3>\n<p>Rezerva\u021bi pentru afec\u021biuni severe \u2014 febr\u0103 \u00eenalt\u0103 (&gt; 38,5\u00b0C), scaun s\u00e2ngeros, toxicitate sistemic\u0103, imunodepresie sau patogen suspectat specific (Shigella, Salmonella, diaree sever\u0103 a c\u0103l\u0103torului). Diareea u\u0219oar\u0103 a c\u0103l\u0103torului r\u0103spunde la rehidratare oral\u0103 singur\u0103 sau la rifaximin\u0103 (selectiv intestinal).<\/p>\n<h3 class=\"wp-block-heading\">Ce spune\u021bi despre rezisten\u021ba la Salmonella?<\/h3>\n<p>Rezisten\u021ba la fluoroquinolone \u00een S. Typhi din Asia de Sud dep\u0103\u0219e\u0219te 50 la sut\u0103. Tratamentul empiric la c\u0103l\u0103torii \u00eentor\u0219i din aceste regiuni ar trebui s\u0103 utilizeze azitromicin\u0103 sau o cefalosporin\u0103 de genera\u021bia a treia p\u00e2n\u0103 c\u00e2nd se cunosc sensibilit\u0103\u021bile.<\/p>\n<h3 class=\"wp-block-heading\">De ce este avertismentul despre ruptura tendonului at\u00e2t de prominent?<\/h3>\n<p>Ruptura tendonului lui Ahile a fost raportat\u0103 la c\u00e2teva zile dup\u0103 \u00eenceperea ciprofloxacinei, \u00een special la adul\u021bii \u00een v\u00e2rst\u0103, cei care iau corticosteroizi, pacien\u021bii post-transplant \u0219i cei cu boli renale. Opri\u021bi medicamentul la primul semn de durere sau umfl\u0103tur\u0103 a tendonului \u0219i evita\u021bi exerci\u021biile cu greutate.<\/p>\n<h3 class=\"wp-block-heading\">Iau antiacide pentru reflux. Pot lua totu\u0219i ciprofloxacin\u0103?<\/h3>\n<p>Da, dar separa\u021bi dozele. Lua\u021bi mai \u00eent\u00e2i ciprofloxacina; a\u0219tepta\u021bi 2 ore \u00eenainte de orice antiacid, calciu, fier sau produs lactate. Sau a\u0219tepta\u021bi 6 ore dup\u0103 antiacid pentru a lua ciprofloxacina.<\/p>\n<h3 class=\"wp-block-heading\">Pot bea cafea \u00een timp ce iau medicamentul?<\/h3>\n<p>Cafeina este metabolizat\u0103 de CYP1A2, pe care ciprofloxacina o inhib\u0103. Nivelurile de cafein\u0103 cresc; pute\u021bi observa agita\u021bie, palpita\u021bii \u0219i insomnie. Reduce\u021bi consumul de cafein\u0103 pe durata tratamentului.<\/p>\n<h3 class=\"wp-block-heading\">Este sigur \u00een sarcin\u0103?<\/h3>\n<p>Nu este recomandat \u00een general \u2014 datele animale arat\u0103 leziuni ale cartilajului; datele umane sunt limitate. Evita\u021bi, cu excep\u021bia cazurilor \u00een care indica\u021bia este sever\u0103 \u0219i alternativele sunt nepotrivite.<\/p>\n<h3 class=\"wp-block-heading\">Pot copiii s\u0103 ia acest medicament?<\/h3>\n<p>Utilizare restric\u021bionat\u0103 la copii: exacerb\u0103ri ale fibrozei chistice, infec\u021bii urinare complicate, antrax \u0219i c\u00e2teva alte indica\u021bii definite. Semnal de afectare a cartilajului la animale la doze mari, dar dovezile umane au fost lini\u0219titoare la doze terapeutice.<\/p>\n<h3 class=\"wp-block-heading\">Va perturba flora intestinal\u0103?<\/h3>\n<p>Da, ca majoritatea antibioticelor cu spectru larg. Suplimentarea cu probiotice \u00een timpul \u0219i dup\u0103 tratament reduce riscul de diaree asociat\u0103 antibioticelor \u0219i de C. difficile.<\/p>\n<h3 class=\"wp-block-heading\">Ce fac dac\u0103 apar erup\u021bii cutanate?<\/h3>\n<p>\u00centrerupe\u021bi medicamentul \u0219i c\u0103uta\u021bi sfat medical. Erup\u021bia fotosensibil\u0103 este frecvent\u0103; reac\u021biile alergice sunt mai pu\u021bin frecvente, dar pot fi severe (SJS\/TEN).<\/p>\n<h3 class=\"wp-block-heading\">Depozitare<\/h3>\n<p>Sub 25\u00b0C \u00eentr-un loc uscat. Evita\u021bi \u00eenghe\u021barea. P\u0103stra\u021bi comprimatele \u00een blisterul original.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alte Medicamente pentru S\u0103n\u0103tatea Gastrointestinal\u0103<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/cendox\/\">Cendox \u2014 Doxycycline<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/synclar\/\">Synclar \u2014 Clarithromycin (H. pylori)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/rcifax\/\">Rcifax \u2014 Rifaximin (selectiv intestinal)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/rifagut\/\">Rifagut \u2014 Rifaximin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/flagyl-suspension\/\">Flagyl Suspensie \u2014 Metronidazol (anaerob \/ perianal \u00een Crohn)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/gastro-health\/\"><strong>Vede\u021bi toate Medicamentele pentru S\u0103n\u0103tatea Gastrointestinal\u0103<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui profesionist calificat din domeniul s\u0103n\u0103t\u0103\u021bii. Durere sau umfl\u0103turi \u00een tendoane, durere brusc\u0103 \u00een piept sau spate, dureri abdominale severe sau simptome neurologice noi la administrarea ciprofloxacinei necesit\u0103 evaluare URGENT\u0102 \u2014 \u00eentrerupe\u021bi medicamentul.<\/div>","protected":false},"excerpt":{"rendered":"<p>Ciplox (Ciprofloxacin 250\/500\/750 mg, Cipla) \u2014 fluorochinolon\u0103 pentru diareea sever\u0103 a c\u0103l\u0103torului, Salmonella, infec\u021bii intra-abdominale, profilaxie SBP \u0219i boala perianal\u0103 Crohn. Avertismentele FDA \u00een chenar negru se aplic\u0103. Livrare worldwide de la MedsBase.<\/p>","protected":false},"featured_media":52958,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[],"class_list":{"0":"post-52957","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","10":"first","11":"instock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/52957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=52957"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/52958"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=52957"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=52957"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=52957"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=52957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}