{"id":53030,"date":"2023-09-20T09:41:37","date_gmt":"2023-09-20T09:41:37","guid":{"rendered":"https:\/\/medsname.com\/synclar\/"},"modified":"2026-04-30T10:25:13","modified_gmt":"2026-04-30T10:25:13","slug":"synclar","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/synclar\/","title":{"rendered":"Synclar"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Synclar?<\/h3>\n<p style=\"margin:0;\"><strong>Synclar<\/strong> este <strong>clarithromycin 250 mg sau 500 mg comprimat<\/strong> de la Cipla \u2014 un antibiotic macrolid 14-membran. \u00cen context gastro, este piatra de temelie a <strong>eradic\u0103rii primare a Helicobacter pylori<\/strong> ca parte a unui regim de tripl\u0103 terapie cu un PPI \u0219i fie amoxicilin\u0103, fie metronidazol timp de 14 zile. Alte indica\u021bii includ <strong>infec\u021bii respiratorii (pneumonie dob\u00e2ndit\u0103 \u00een comunitate, exacerbare de BPOC), pneumonie atipic\u0103 (Mycoplasma, Legionella, Chlamydophila), complexul Mycobacterium avium (MAC) \u0219i infec\u021bii ale pielii\/\u021besuturilor moi<\/strong>. Doz\u0103 standard pentru adul\u021bi: <strong>250\u2013500 mg de dou\u0103 ori pe zi timp de 7\u201314 zile<\/strong>. Produc\u0103tor certificat WHO-GMP.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>De ce s\u0103 comanzi de la MedsBase:<\/strong> \u2714 <strong>produc\u0103tor certificat WHO-GMP<\/strong> \u2714 Ambalaj discret \u2714 Livrare worldwide \u2714 <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">Recenzii verificate ale clien\u021bilor (peste 1.400 de clien\u021bi)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>\u26a0\ufe0f Avertismente privind prelungirea intervalului QT \u0219i interac\u021biunile cu CYP3A4.<\/strong> Clarithromycin este un puternic inhibitor al CYP3A4 \u0219i un medicament care prelunge\u0219te intervalul QT. Evita\u021bi administrarea concomitent\u0103 cu simvastatin\u0103\/lovastatin\u0103 (rabdomioliz\u0103), alcaloizi ai ergotului (vasospasm), pimozid\u0103 (torsade de pointes), colchicin\u0103 \u00een insuficien\u021b\u0103 renal\u0103 (toxicitate) \u0219i alte substan\u021be care prelunge\u0219te QT (azithromycin, fluoroquinolone, ondansetron, citalopram, metadon\u0103, hidroxiclorochin\u0103). Verifica\u021bi aceste aspecte \u00eenainte de \u00eenceperea tratamentului. Clarithromycin a fost asociat cu o u\u0219oar\u0103 cre\u0219tere a mortalit\u0103\u021bii cardiovasculare \u00een datele observa\u021bionale pe termen lung.<\/div>\n<h3 class=\"wp-block-heading\">De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Synclar este furnizat de la <strong>produc\u0103tor certificat WHO-GMP<\/strong>. Fiecare comand\u0103 este expediat\u0103 discret \u00een \u00eentreaga lume \u0219i este acoperit\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> \u2014 dac\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, retrimitem f\u0103r\u0103 costuri suplimentare. Clarithromycin este antibioticul standard \u00een eradicarea primar\u0103 a H. pylori \u0219i r\u0103m\u00e2ne un agent de prim\u0103 alegere pentru pneumoniile atipice \u2014 eficacitate bine stabilit\u0103 cu sprijin larg din ghiduri.<\/p>\n<h2 class=\"wp-block-heading\">Mecanism de ac\u021biune<\/h2>\n<p>Clarithromycin se leag\u0103 reversibil de subunitatea ribozomal\u0103 bacterian\u0103 50S la nivelul ARNr 23S, bloc\u00e2nd prelungirea peptidic\u0103. Este bacteriostatic pentru majoritatea speciilor \u0219i bactericid la concentra\u021bii mari \u00eempotriva organismelor sensibile. Medicamentul p\u0103trunde bine \u00een \u021besutul respirator, mucoasa gastric\u0103, macrofage \u0219i os. Metabolitul primar (14-OH-clarithromycin) este de asemenea activ \u0219i contribuie la spectru. Rezisten\u021ba apare prin muta\u021bii \u0219i metilare a ARNr 23S; rezisten\u021ba H. pylori la clarithromycin dep\u0103\u0219e\u0219te acum 20\u201330% \u00een multe regiuni.<\/p>\n<h2 class=\"wp-block-heading\">Indica\u021bii<\/h2>\n<ul>\n<li><strong>Eradicarea H. pylori (primar\u0103):<\/strong> clarithromycin 500 mg BD + amoxicilin\u0103 1 g BD + PPI BD timp de 14 zile; \u00eenlocui\u021bi cu metronidazol dac\u0103 exist\u0103 alergie la penicilin\u0103; \u00eenlocui\u021bi cu terapie quadrupl\u0103 cu bismut acolo unde rezisten\u021ba local\u0103 la clarithromycin dep\u0103\u0219e\u0219te 15%<\/li>\n<li>Pneumonie dob\u00e2ndit\u0103 \u00een comunitate (atipic\u0103 sau ca parte a terapiei combinate)<\/li>\n<li>Exacerbare acut\u0103 a bron\u0219itei cronice<\/li>\n<li>Faringit\u0103 streptococic\u0103 \/ amigdalit\u0103 (alergic la penicilin\u0103)<\/li>\n<li>Profilaxia \u0219i tratamentul complexului Mycobacterium avium (MAC) \u00een HIV \/ transplant<\/li>\n<li>Infec\u021bie cutanat\u0103 \u0219i de \u021besuturi moi (Staphylococcus, Streptococcus \u2014 dac\u0103 sunt sensibile)<\/li>\n<li>Sinusita bacterian\u0103 acut\u0103<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Doza<\/h2>\n<p>Adul\u021bi: 250\u2013500 mg de dou\u0103 ori pe zi timp de 7\u201314 zile. H. pylori: 500 mg de dou\u0103 ori pe zi timp de 14 zile ca parte a terapiei triple\/quadruple. MAC: 500 mg de dou\u0103 ori pe zi pe termen lung. CrCl &lt; 30: \u00eenjum\u0103t\u0103\u021bi\u021bi doza sau prelungi\u021bi intervalul. Insuficien\u021b\u0103 hepatic\u0103 sever\u0103 \u00een contextul func\u021biei renale normale: f\u0103r\u0103 modific\u0103ri; \u00een cazul combina\u021biei hepatice-renale: evita\u021bi. Copii: doz\u0103 \u00een func\u021bie de greutate 7,5 mg\/kg de dou\u0103 ori pe zi (maxim 500 mg BD).<\/p>\n<h2 class=\"wp-block-heading\">Efecte secundare<\/h2>\n<ul>\n<li>GI: gust amar \/ metalic, grea\u021b\u0103, v\u0103rs\u0103turi, diaree, dureri abdominale<\/li>\n<li>Prelungire QT, torsade de pointes (rar; riscul cre\u0219te cu utilizarea concomitent\u0103 a medicamentelor care prelungesc QT)<\/li>\n<li>Hepatotoxicitate (rar\u0103; hepatit\u0103 colestatic\u0103)<\/li>\n<li>Diaree asociat\u0103 cu C. difficile<\/li>\n<li>Reac\u021bii alergice: erup\u021bii cutanate, urticarie; rare sindrom Stevens-Johnson \u0219i DRESS<\/li>\n<li>Dureri de cap, ame\u021beli, pierdere temporar\u0103 a auzului (rar\u0103)<\/li>\n<li>Evenimente cardiovasculare la utilizarea pe termen lung (semnal u\u0219or \u00een datele observa\u021bionale)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<p>Claritromicina inhib\u0103 puternic CYP3A4. Multe interac\u021biuni; cele mai importante:<\/p>\n<ul>\n<li><strong>Statine<\/strong> (simvastatin\u0103, lovastatin\u0103, atorvastatin\u0103): rabdomioliz\u0103 \u2014 suspenda\u021bi sau trece\u021bi la pravastatin\u0103 \/ rosuvastatin\u0103 \/ fluvastatin\u0103.<\/li>\n<li><strong>Alcaloizi ai ergotului:<\/strong> ergotism (vasospasm) \u2014 contraindica\u021bie absolut\u0103.<\/li>\n<li><strong>Pimozid\u0103:<\/strong> torsades \u2014 contraindica\u021bie absolut\u0103.<\/li>\n<li><strong>Colchicina \u00een insuficien\u021b\u0103 renal\u0103:<\/strong> toxicitate fatal\u0103 \u2014 contraindica\u021bie absolut\u0103.<\/li>\n<li><strong>Blocante ale canalelor de calciu:<\/strong> hipotensiune \u0219i insuficien\u021b\u0103 renal\u0103 acut\u0103 \u2014 reduce\u021bi doza, monitoriza\u021bi.<\/li>\n<li><strong>Warfarin:<\/strong> Cre\u0219tere INR \u2014 monitoriza\u021bi.<\/li>\n<li><strong>Medicamente care prelunge\u0219te intervalul QT:<\/strong> risc aditiv \u2014 evita\u021bi combina\u021bia.<\/li>\n<li><strong>Pilul\u0103 contraceptiv\u0103 combinat\u0103:<\/strong> eficacitate men\u021binut\u0103 pentru cursuri scurte.<\/li>\n<li><strong>Carbamazepin\u0103, fenitoin\u0103:<\/strong> niveluri crescute \u2014 monitoriza\u021bi.<\/li>\n<li><strong>Tacrolimus, ciclosporin\u0103:<\/strong> niveluri crescute \u2014 monitoriza\u021bi.<\/li>\n<li><strong>Theophylline:<\/strong> nivelurile cresc.<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">Cum se administreaz\u0103 terapia tripl\u0103 pentru H. pylori?<\/h3>\n<p>Regim standard: claritromicin\u0103 500 mg de dou\u0103 ori pe zi + amoxicilin\u0103 1 g de dou\u0103 ori pe zi + un IBP (omeprazol 20 mg, esomeprazol 40 mg sau echivalent) de dou\u0103 ori pe zi timp de 14 zile. Lua\u021bi toate cele trei \u00eempreun\u0103 pentru a maximiza eradicarea.<\/p>\n<h3 class=\"wp-block-heading\">Ce se \u00eent\u00e2mpl\u0103 dac\u0103 H. pylori revine?<\/h3>\n<p>Retestarea nu se face mai devreme de 4 s\u0103pt\u0103m\u00e2ni dup\u0103 terminarea terapiei \u0219i \u00eentreruperea IBP cu 2 s\u0103pt\u0103m\u00e2ni \u00eenainte de test (testul cu uree \u00een respira\u021bie sau antigen \u00een scaun). Dac\u0103 rezultatul este pozitiv, trece\u021bi la terapia cuaternar\u0103 cu bismut (IBP + bismut + tetraciclin\u0103 + metronidazol).<\/p>\n<h3 class=\"wp-block-heading\">Pot consuma alcool \u00een timpul tratamentului?<\/h3>\n<p>Consumul moderat de alcool este acceptabil. Consumul excesiv de alcool cre\u0219te riscul de hepatotoxicitate.<\/p>\n<h3 class=\"wp-block-heading\">De ce am gust metalic la toate?<\/h3>\n<p>Un efect secundar cunoscut al claritromicinei (~5% din pacien\u021bi). Dispare la c\u00e2teva zile dup\u0103 terminarea tratamentului.<\/p>\n<h3 class=\"wp-block-heading\">Este sigur \u00een sarcin\u0103?<\/h3>\n<p>Categoria C. Folosi\u021bi numai dac\u0103 beneficiul dep\u0103\u0219e\u0219te clar riscul; alternativele (amoxicilin\u0103 singur\u0103, azitromicin\u0103) sunt adesea disponibile.<\/p>\n<h3 class=\"wp-block-heading\">Va interac\u021biona cu statina mea?<\/h3>\n<p>Da \u2014 simvastatina \u0219i lovastatina trebuie \u00eentrerupte \u00een timpul administr\u0103rii claritromicinei (risc de rabdomioliz\u0103). Atorvastatina trebuie redus\u0103. Pravastatina, rosuvastatina \u0219i fluvastatina nu sunt afectate de inhibi\u021bia CYP3A4.<\/p>\n<h3 class=\"wp-block-heading\">Cum difer\u0103 de azitromicin\u0103?<\/h3>\n<p>Azitromicina este un azalid cu 15 membri derivat din eritromicin\u0103. Are o inhibi\u021bie mai slab\u0103 a CYP3A4 (deci mai pu\u021bine interac\u021biuni medicamentoase), o semivid\u0103 mai lung\u0103 (tratamente de o zi sau 5 zile) \u0219i o activitate mai slab\u0103 \u00eempotriva H. pylori. Claritromicina r\u0103m\u00e2ne preferat\u0103 pentru H. pylori; azitromicina este preferat\u0103 c\u00e2nd interac\u021biunile CYP3A4 sau administrarea o dat\u0103 pe zi conteaz\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Pot copiii s\u0103 ia acest medicament?<\/h3>\n<p>Da, cu dozaj \u00een func\u021bie de greutate. Util pentru pneumoniile atipice pediatrice \u0219i tusea convulsiv\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Pot lua un probiotic \u00eempreun\u0103 cu el?<\/h3>\n<p>Da. Separa\u021bi probioticul de claritromicin\u0103 cu 2 ore. Probioteicele \u00een timpul \u0219i dup\u0103 tratament reduc riscul de diaree asociat\u0103 antibioticelor.<\/p>\n<h3 class=\"wp-block-heading\">Depozitare<\/h3>\n<p>Sub 25\u00b0C \u00eentr-un loc uscat. P\u0103stra\u021bi comprimatele \u00een blisterul original.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alte Medicamente pentru S\u0103n\u0103tatea Gastrointestinal\u0103<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/famocid\/\">Famocid \u2014 Famotidin\u0103 (partener pentru H. pylori: blocant H2)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/omez\/\">Omez \u2014 Omeprazol 20 mg (partener PPI)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/rcifax\/\">Rcifax \u2014 Rifaximin\u0103<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/cendox\/\">Cendox \u2014 Doxiciclin\u0103 (salvare pentru H. pylori)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/ciplox\/\">Ciplox \u2014 Ciprofloxacin\u0103 (salvare pentru H. pylori)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/gastro-health\/\"><strong>Vede\u021bi toate Medicamentele pentru S\u0103n\u0103tatea Gastrointestinal\u0103<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui profesionist calificat. Aritmie cardiac\u0103, interval QT prelungit la ECG, diaree sever\u0103 (mai ales cu febr\u0103), dureri abdominale severe sau dureri noi de tendon \u00een timpul terapiei cu macrolide necesit\u0103 evaluare urgent\u0103.<\/div>","protected":false},"excerpt":{"rendered":"<p>Synclar (Claritromicin\u0103 250\/500 mg, Cipla) \u2014 antibiotic macrolid pentru eradicarea de prim\u0103 inten\u021bie a H. pylori (cu PPI + amoxicilin\u0103), pneumonie atipic\u0103 \u0219i infec\u021bie MAC. Puternic inhibitor CYP3A4 \u2014 verifica\u021bi interac\u021biunile. Livrare worldwide de la MedsBase.<\/p>","protected":false},"featured_media":53031,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3215,3141,3223,3542,3342],"product_tag":[3498,3582],"class_list":{"0":"post-53030","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-acne-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_cat-gastro-health","10":"product_cat-general-health","11":"product_tag-clarithromycin","12":"product_tag-synclar","14":"first","15":"outofstock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/53030","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=53030"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/53031"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=53030"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=53030"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=53030"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=53030"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}