{"id":53241,"date":"2023-09-20T09:44:01","date_gmt":"2023-09-20T09:44:01","guid":{"rendered":"https:\/\/medsname.com\/celkeran\/"},"modified":"2026-04-30T10:25:12","modified_gmt":"2026-04-30T10:25:12","slug":"celkeran","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/celkeran\/","title":{"rendered":"Celkeran"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Celkeran?<\/h3>\n<p style=\"margin:0;\"><strong>Celkeran<\/strong> este o tablet\u0103 oral\u0103 de la Celon Laboratories care con\u021bine <strong>clorambucil<\/strong> la <strong>2 mg sau 5 mg<\/strong> doze \u2014 un agent citotoxic alchilant cu ac\u021biune lent\u0103 din familia mu\u0219tarului de azot. Utilizat pentru <strong>leucemie limfocitic\u0103 cronic\u0103 (LLC)<\/strong>, <strong>limfom non-Hodgkin de grad sc\u0103zut<\/strong>, <strong>macroglobulinemie Waldenstr\u00f6m<\/strong> \u0219i <strong>limfom Hodgkin avansat<\/strong> (regimuri vechi). Doz\u0103 standard pentru adul\u021bi: <strong>0,1\u20130,2 mg\/kg\/zi continuu<\/strong> sau 0,4\u20130,8 mg\/kg la fiecare 2 s\u0103pt\u0103m\u00e2ni (intermitent). Se administreaz\u0103 pe stomac gol (1 or\u0103 \u00eenainte de mese) pentru absorb\u021bie constant\u0103. Monitorizare obligatorie: hemogram\u0103 complet\u0103 la fiecare 1\u20132 s\u0103pt\u0103m\u00e2ni \u2014 clorambucil produce mielosupresie cu debut lent \u0219i prelungit, cu nadir \u00eent\u00e2rziat. Contraindica\u021bie \u00een sarcin\u0103; gonadotoxicitate (se recomand\u0103 preservarea fertilit\u0103\u021bii la pacien\u021bii \u00een v\u00e2rst\u0103 reproductiv\u0103).<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Supraveghere specializat\u0103 necesar\u0103.<\/strong> Medicamentele pentru cancer trebuie prescrise de un oncolog tratant, cu un diagnostic confirmat, stadializare ini\u021bial\u0103 \u0219i un plan de tratament definit. Nu \u00eencepe\u021bi, nu opri\u021bi, nu modifica\u021bi doza \u0219i nu utiliza\u021bi medicamente pentru cancer \u00een afara unui plan de \u00eengrijire condus de oncologie. Majoritatea medicamentelor pentru cancer necesit\u0103 monitorizare regulat\u0103 prin analize de s\u00e2nge (hemoleucogram\u0103, teste hepatice, func\u021bie renal\u0103), sunt absolut contraindicate \u00een sarcin\u0103 \u0219i au interac\u021biuni medicamentoase semnificative.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 Checkout criptat<\/strong> \u00b7 <strong>\ud83d\udcb3 Procesor verificat<\/strong> \u00b7 <strong>\ud83d\ude9a Livrare worldwide<\/strong> \u00b7 <strong>\u2b50 4,9\/5 de la peste 1.400 de clien\u021bi<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">Ce este Celkeran?<\/h2>\n<p>Celkeran este un comprimat oral de la Celon Laboratories care con\u021bine <strong>clorambucil<\/strong>. Clorambucilul este unul dintre cele mai vechi agen\u021bi citotoxici alchilan\u021bi orali (derivat din mu\u0219tarul de azot, utilizat clinic din anii 1950). Este bl\u00e2nd, bine tolerat \u0219i r\u0103m\u00e2ne relevant pentru pacien\u021bii \u00een v\u00e2rst\u0103 sau fragili cu leucemie limfocitic\u0103 cronic\u0103 sau limfom de grad sc\u0103zut care nu pot tolera chimio-imunoterapii mai intensive.<\/p>\n<h2 class=\"wp-block-heading\">Utiliz\u0103ri \u0219i indica\u021bii<\/h2>\n<ul>\n<li><strong>Leucemie limfocitic\u0103 cronic\u0103 (LLC)<\/strong> \u2014 pacien\u021bi \u00een v\u00e2rst\u0103 sau fragili, adesea combinat cu rituximab sau obinutuzumab<\/li>\n<li><strong>Limfom non-Hodgkin de grad sc\u0103zut<\/strong> (folicular, zon\u0103 marginal\u0103)<\/li>\n<li><strong>macroglobulinemie Waldenstr\u00f6m<\/strong><\/li>\n<li><strong>Limfom Hodgkin avansat<\/strong> (regimuri vechi MOPP\/ChlVPP)<\/li>\n<li><strong>Off-label:<\/strong> sindrom nefrotic (modificare minim\u0103 rezistent\u0103 la steroizi), boala Beh\u00e7et<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Doza \u0219i mod de administrare<\/h2>\n<ul>\n<li><strong>Doza continu\u0103 mic\u0103:<\/strong> 0,1\u20130,2 mg\/kg\/zi<\/li>\n<li><strong>Doza intermitent\u0103 \u00een pulsuri:<\/strong> 0,4\u20130,8 mg\/kg la fiecare 2\u20134 s\u0103pt\u0103m\u00e2ni<\/li>\n<li><strong>Combinat cu anticorp anti-CD20:<\/strong> regim standard de induc\u021bie pentru LLA<\/li>\n<\/ul>\n<ol>\n<li>Lua\u021bi pe stomacul gol \u2014 cu 1 or\u0103 \u00eenainte de mese \u2014 pentru absorb\u021bie constant\u0103.<\/li>\n<li>Aceea\u0219i or\u0103 \u00een fiecare zi. \u00cenghi\u021bi\u021bi comprimatul \u00eentreg.<\/li>\n<li><strong>Monitorizare obligatorie:<\/strong> Analiz\u0103 sanguin\u0103 complet\u0103 la fiecare 1\u20132 s\u0103pt\u0103m\u00e2ni \u00een timpul tratamentului activ. Aten\u021bie: nadirul este \u00eent\u00e2rziat (3\u20134 s\u0103pt\u0103m\u00e2ni dup\u0103 doz\u0103), recuperarea lent\u0103 (4\u20136 s\u0103pt\u0103m\u00e2ni). Teste hepatice lunare.<\/li>\n<li>Suspendare sau reducere de doz\u0103 pentru ANC &lt; 1.500\/\u00b5L sau trombocite &lt; 100.000\/\u00b5L.<\/li>\n<li>\u00cengrijitorii care manipuleaz\u0103 comprimatele ar trebui s\u0103 poarte m\u0103nu\u0219i.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Efecte Secundare<\/h2>\n<p><strong>Frecvente:<\/strong> mielosupresie (cu debut \u00eent\u00e2rziat, prelungit), grea\u021b\u0103, anorexie u\u0219oar\u0103.<\/p>\n<p><strong>Important:<\/strong><\/p>\n<ul>\n<li>Pancitopenie sever\u0103 la doze cumulative mai mari<\/li>\n<li>Infertilitate permanent\u0103 (gonadotoxic\u0103)<\/li>\n<li>Leucemie secundar\u0103 \/ sindrom mielodisplazic (risc pe termen lung la doze cumulative)<\/li>\n<li>Hepatotoxicitate (rar\u0103)<\/li>\n<li>Reac\u021bii cutanate severe (rare)<\/li>\n<li>Crize epileptice (foarte rare, de obicei la doze mari)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Avertismente<\/h2>\n<ul>\n<li><strong>Sarcina:<\/strong> teratogen; contracep\u021bie strict\u0103 pe tot parcursul tratamentului + 6 luni dup\u0103.<\/li>\n<li><strong>Al\u0103ptarea:<\/strong> evita\u021bi.<\/li>\n<li><strong>Vaccinuri cu virus viu:<\/strong> contraindicated.<\/li>\n<li><strong>Infec\u021bie recent\u0103\/activ\u0103:<\/strong> trata\u021bi \u00eenainte de \u00eencepere; suspenda\u021bi \u00een caz de infec\u021bie grav\u0103.<\/li>\n<li><strong>Afectare renal\u0103\/hepatic\u0103:<\/strong> reducere de doz\u0103.<\/li>\n<li>M\u0103nu\u0219i pentru \u00eengrijitor la manipularea tabletelor.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Combina\u021bi cu<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Efect<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Ce s\u0103 face\u021bi<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Alte medicamente mielosupresoare<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Toxicitate medular\u0103 aditiv\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Supraveghere specializat\u0103.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vaccinuri cu virus viu<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Infec\u021bie diseminat\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Contraindicated.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Alopurinol (pentru hiperuricemia din cauza turnover-ului celular)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Compatibil - \u00eengrijire de suport standard<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Adesea coprescris.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Depozitare<\/h2>\n<ul>\n<li>Se p\u0103streaz\u0103 la frigider <strong>2\u20138\u00b0C<\/strong> \u2014 comprimatele de chlorambucil sunt sensibile la temperatur\u0103.<\/li>\n<li>Depozita\u021bi \u00een afara zonei de acces a copiilor, femeilor \u00een v\u00e2rst\u0103 fertil\u0103 \u0219i animalelor de companie.<\/li>\n<li>\u00cengrijitorii trebuie s\u0103 poarte m\u0103nu\u0219i.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Alternative conexe pe MedsBase<\/h2>\n<p>Alte medicamente oncologice disponibile \u00eempreun\u0103 cu acest produs:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/endoxan\/\"><strong>Endoxan (ciclosfosfamid\u0103 50 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/temotero\/\"><strong>Temotero (temozolomid\u0103 20\/100 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/temozol-20\/\"><strong>Temozol (temozolomid\u0103 20 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/lomoother\/\"><strong>Lomoother (lomustin\u0103 40 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/endace\/\"><strong>Endace (megestrol 40\/160 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/ro\/anti-cancer-medication\/\">R\u0103sfoi\u021bi toate medicamentele anti-cancer \u2192<\/a><\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">De ce este \u00eenc\u0103 utilizat Celkeran \u00een 2026, c\u00e2nd exist\u0103 medicamente mai noi pentru LLC?<\/h3>\n<p>Terapia modern\u0103 a LLC-ului pune accent pe inhibitorii BTK (ibrutinib, acalabrutinib, zanubrutinib) \u0219i pe venetoclax + obinutuzumab pentru pacien\u021bii apti. Chlorambucilul \u00ee\u0219i p\u0103streaz\u0103 un rol pentru <strong>pacien\u021bi \u00een v\u00e2rst\u0103 sau fragili<\/strong> care nu pot tolera chimio-imunoterapia intensiv\u0103 sau terapia \u021bintit\u0103 \u2014 \u00een special \u00een combina\u021bie cu obinutuzumab (studiu CLL11). Cost-efectivitatea \u0219i tolerabilitatea sunt principalele motive pentru care persist\u0103.<\/p>\n<h3 class=\"wp-block-heading\">De ce trebuie s\u0103 p\u0103strez Celkeran la frigider?<\/h3>\n<p>Comprimatele de clorambucil sunt sensibile la c\u0103ldur\u0103 \u0219i se degradeaz\u0103 \u00een timp la temperatura camerei, mai ales \u00een clim\u0103 mai cald\u0103. Refrigerarea (2\u20138\u00b0C) p\u0103streaz\u0103 poten\u021ba. P\u0103stra\u021bi \u00een blisterul original, departe de alimente, din calea copiilor, femeilor \u00een v\u00e2rst\u0103 fertil\u0103 \u0219i a animalelor de companie.<\/p>\n<h3 class=\"wp-block-heading\">De ce este \u00eent\u00e2rziat\u0103 nadirul FBC?<\/h3>\n<p>Clorambucilul este unul dintre agen\u021bii alchilan\u021bi cu ac\u021biune cea mai lent\u0103. Nadirul m\u0103duvei osoase apare de obicei <strong>la 3\u20134 s\u0103pt\u0103m\u00e2ni dup\u0103 doz\u0103<\/strong> \u0219i recuperarea dureaz\u0103 \u00eenc\u0103 4\u20136 s\u0103pt\u0103m\u00e2ni. Aceasta \u00eenseamn\u0103 c\u0103 suprima\u021bia mieloic\u0103 cumulativ\u0103 poate ap\u0103rea pe nea\u0219teptate la pacien\u021bii sub tratament continuu \u2014 monitorizarea FBC la fiecare 1\u20132 s\u0103pt\u0103m\u00e2ni este esen\u021bial\u0103 \u00een timpul tratamentului activ.<\/p>\n<h3 class=\"wp-block-heading\">Celkeran \u00eemi va afecta fertilitatea?<\/h3>\n<p>Da \u2014 clorambucilul este gonadotoxic \u0219i poate provoca infertilitate permanent\u0103. Discuta\u021bi despre preservarea fertilit\u0103\u021bii (crioprezervarea spermei, ovocitelor) \u00eenainte de a \u00eencepe tratamentul la orice pacient \u00een v\u00e2rst\u0103 reproductiv\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Dar riscul de leucemie secundar\u0103?<\/h3>\n<p>Expunerea pe termen lung la doze mari cumulative de clorambucil poart\u0103 un risc mic, dar real, de sindrom mielodisplazic secundar \u0219i leucemie acut\u0103 \u2014 \u00een principal la doze cumulative peste 1,3 g. Regimurile moderne limiteaz\u0103 expunerea total\u0103 pentru a atenua acest risc.<\/p>\n<h3 class=\"wp-block-heading\">Este Celkeran sigur \u00een sarcin\u0103?<\/h3>\n<p>Nu \u2014 teratogen. Contraceptie strict\u0103 pe tot parcursul tratamentului \u0219i pentru 6 luni dup\u0103 ultima doz\u0103, at\u00e2t la pacien\u021bii de sex masculin, c\u00e2t \u0219i feminin. Discuta\u021bi planificarea familiei \u00eenainte de a \u00eencepe tratamentul.<\/p>\n<h3 class=\"wp-block-heading\">Pot primi vaccinuri cu virus viu?<\/h3>\n<p>Nu \u2014 vaccinurile cu virus viu (MMR, febra galben\u0103, BCG, polio oral, varicel\u0103) sunt contraindicate \u00een timpul terapiei cu clorambucil \u0219i pentru c\u00e2teva luni dup\u0103. Vaccinurile inactivate sunt sigure \u0219i recomandate.<\/p>\n<h3 class=\"wp-block-heading\">Precau\u021bii pentru cei care administreaz\u0103 Celkeran?<\/h3>\n<p>Da \u2014 comprimatele sunt citotoxice. Persoanele care administreaz\u0103 medicamentul ar trebui s\u0103 poarte m\u0103nu\u0219i atunci c\u00e2nd le manipuleaz\u0103 \u0219i s\u0103 se spele pe m\u00e2ini dup\u0103 aceea. \u00cengrijitorii gravizi ar trebui s\u0103 evite complet manipularea clorambucilului.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Fiecare lot este procurat de la un <strong>produc\u0103tor certificat WHO-GMP<\/strong>. Comenzile sunt expediate \u00een ambalaje simple, f\u0103r\u0103 marc\u0103, de la partenerii no\u0219tri de onorare \u0219i acoperite de <a href=\"\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a>: dac\u0103 un colet nu ajunge \u00een 20 de zile lucr\u0103toare, trimitem gratuit o nou\u0103 comand\u0103, f\u0103r\u0103 \u00eentreb\u0103ri.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Medicamente Anticanceroase Asem\u0103n\u0103toare<\/h3>\n<p>Alte medicamente oncologice disponibile \u00eempreun\u0103 cu acest produs:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/endoxan\/\">Endoxan (ciclosfosfamid\u0103 50 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/lomoother\/\">Lomoother (lomustin\u0103 40 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/imatib\/\">Imatib (imatinib 100\/400 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/veenat\/\">Veenat (imatinib 100\/400 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/hydrosar\/\">Hydrosar (hidroxiuree 500 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Trateaz\u0103 leucemia<br \/>\n\u2705 Suprim\u0103 cre\u0219terea cancerului<br \/>\n\u2705 Controlleaz\u0103 simptomele limfomului<br \/>\n\u2705 \u00cembun\u0103t\u0103\u021be\u0219te ratele de supravie\u021buire<br \/>\n\u2705 Gestioneaz\u0103 boli autoimune<\/p>\n<p>Celkeran con\u021bine Clorambucil.<\/p>","protected":false},"featured_media":53242,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[3600,3601],"class_list":{"0":"post-53241","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-celkeran","10":"product_tag-chlorambucil","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/53241","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=53241"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/53242"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=53241"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=53241"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=53241"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=53241"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}