{"id":53470,"date":"2023-09-20T09:46:41","date_gmt":"2023-09-20T09:46:41","guid":{"rendered":"https:\/\/medsname.com\/temonat\/"},"modified":"2026-04-30T16:30:25","modified_gmt":"2026-04-30T16:30:25","slug":"temonat","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/temonat\/","title":{"rendered":"Temonat"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">R\u0103spuns rapid<\/h3>\n<p style=\"margin-bottom:0;\"><strong>Temonat<\/strong> \u2014 temozolomide 20\/100\/250 mg (Natco Pharma). Agent alchilant ADN oral \u2014 chimioterapie de prim\u0103 linie pentru glioblastom multiform (cu radioterapie concomitent\u0103, apoi adjuvant\u0103), astrocitom anaplazic, melanom (off-label\/istoric). Trece bariera hemato-encefalic\u0103.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>Ce beneficii ofer\u0103 MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>produc\u0103tor certificat WHO-GMP<\/li>\n<li>Ambalaj discret \u00een plic simplu<\/li>\n<li>Livrare \u00een toat\u0103 lumea<\/li>\n<li>Evaluat de peste 1.400 de clien\u021bi (<a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">cite\u0219te recenziile<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>Garan\u021bia de retransmitere:<\/strong> dac\u0103 comanda dvs. nu a ajuns \u00een 20 de zile lucr\u0103toare de la expediere, o retransmitem f\u0103r\u0103 costuri suplimentare. <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Cite\u0219te politica<\/a>.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Temonat este expediat de la un produc\u0103tor certificat WHO-GMP \u00een ambalaj neutru, facturat prin procesator de plat\u0103 reglementat (descrierea extrasului de cont indic\u0103 un procesator de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 MedsBase sau nume de medicament). Fiecare comand\u0103 beneficiaz\u0103 de Garan\u021bia noastr\u0103 de Retrimitere \u00een 20 de zile lucr\u0103toare.<\/p>\n<div class=\"medsbase-specialist-strip\" style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0;\"><strong>\u26a0\ufe0f Terapie oncologic\u0103 supravegheat\u0103 de specialist<\/strong> \u2014 acest medicament este ini\u021biat, monitorizat \u0219i \u00eentrerupt de un oncolog sau hematolog. Dozarea depinde de tipul tumorii, stadiul, suprafa\u021ba corporal\u0103, func\u021bia organelor \u0219i terapia concomitant\u0103. Autotratamentul nu este adecvat; informa\u021biile de mai jos au scop educa\u021bional \u0219i sus\u021bin conversa\u021biile informate cu specialistul dumneavoastr\u0103.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Mielosupresie + profilaxie PCP<\/strong><br \/>Mielosupresie cumulativ\u0103 (\u00een special trombocitopenie \u0219i limfopenie). Hemogram\u0103 complet\u0103 s\u0103pt\u0103m\u00e2nal\u0103 obligatorie. Limfopenia + radioterapie concomitant\u0103 creeaz\u0103 risc de infec\u021bie \u2014 profilaxia pneumoniei Pneumocystis jirovecii (PCP) (cotrimoxazol sau atovaquon) este recomandat\u0103 \u00een faza de chimioradioterapie.<\/div>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>Regim standard?<\/h3>\n<p>Protocol Stupp: 75 mg\/m\u00b2\/zi \u00een timpul celor 6 s\u0103pt\u0103m\u00e2ni de radioterapie, apoi pauz\u0103 de 4 s\u0103pt\u0103m\u00e2ni, apoi adjuvant 150-200 mg\/m\u00b2 \u00d7 5 zile la fiecare 28 de zile pentru 6 cicluri. Regimuri noi (adjuvant extins, doz\u0103 dens\u0103) sunt utilizate \u00een cazuri selectate.<\/p>\n<h3>Se ia cu m\u00e2ncare?<\/h3>\n<p>Pe stomacul gol (1 or\u0103 \u00eenainte de m\u00e2ncare sau 2 ore dup\u0103) la aceea\u0219i or\u0103 \u00een fiecare zi. Profilaxia antiemetic\u0103 (antagonist 5-HT3) este standard.<\/p>\n<h3>Efecte secundare frecvente?<\/h3>\n<p>Grea\u021b\u0103\/v\u0103rs\u0103turi (controlate cu antiemetice), oboseal\u0103, limfopenie, trombocitopenie, cefalee, alopecie (cu radioterapie), constipa\u021bie.<\/p>\n<h3>Starea de metilare MGMT?<\/h3>\n<p>Metilarea promotorului MGMT prezice un beneficiu mai mare de la temozolomid. Testa\u021bi toate glioboamele nou diagnosticate. Tumorile metilate au o supravie\u021buire median\u0103 de ~22 luni la regimul Stupp vs ~12 luni pentru cele nemetilate.<\/p>\n<h3>Profilaxie PCP \u2014 de ce?<\/h3>\n<p>Limfopenia prelungit\u0103 + radioterapie concomitant\u0103 creeaz\u0103 risc de infec\u021bie oportunist\u0103, \u00een special pneumonie Pneumocystis jirovecii. Cotrimoxazol 480 mg de trei ori pe s\u0103pt\u0103m\u00e2n\u0103 \u00een faza de chimioradioterapie este standard.<\/p>\n<h3>Sarcin\u0103?<\/h3>\n<p>Contraindica\u021bie categoric\u0103 \u2014 teratogen. Contraceptie eficient\u0103 \u00een timpul \u0219i cel pu\u021bin 6 luni dup\u0103 tratament pentru ambii parteneri.<\/p>\n<h3>Interac\u021biuni medicamentoase?<\/h3>\n<p>Efecte semnificative reduse. Valproatul poate afecta u\u0219or nivelurile. Antiemeticele (granisetron, ondansetron) sunt utilizate \u00een mod obi\u0219nuit.<\/p>\n<h3>Ce fac dac\u0103 uit o doz\u0103?<\/h3>\n<p>Omite\u021bi doza ratat\u0103; relua\u021bi programul normal a doua zi. Notifica\u021bi echipa de oncologie.<\/p>\n<h3>Complica\u021bii pe termen lung?<\/h3>\n<p>Mielosupresie cumulativ\u0103 \u0219i risc mic de malignitate secundar\u0103 (mielodisplazie, LMA) dup\u0103 ani de terapie cumulativ\u0103.<\/p>\n<h3>Ce op\u021biuni exist\u0103 pentru linia a doua?<\/h3>\n<p>\u00cen cazul progresiei glioblastomului, op\u021biunile includ bevacizumab, lomustin\u0103, re-irradiere sau studii clinice. Nu exist\u0103 un standard de \u00eengrijire pentru linia a doua \u2014 toate deciziile sunt conduse de specialist.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Alte Medicamente Anticanceroase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/xeloda\/\">Xeloda<\/a> \u2014 capecitabin\u0103 500 mg \u2014 prodrog oral de 5-FU pentru cancerul de s\u00e2n\/colorectal\/gastric<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/altraz\/\">Altraz<\/a> \u2014 anastrozol 1 mg \u2014 inhibitor de aromataz\u0103 pentru cancerul de s\u00e2n la femei postmenopauzale<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/xbira\/\">Xbira<\/a> \u2014 abirateron\u0103 250 mg \u2014 inhibitor CYP17 pentru cancerul metastatic de prostat\u0103<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/zoldria\/\">Zoldria<\/a> \u2014 acid zoledronic IV \u2014 pentru metastaze osoase \u0219i hipercalcemie<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/actorise\/\">Actorise<\/a> \u2014 darbepoetin alfa \u2014 pentru anemie indus\u0103 de chimioterapie<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>Disclaimer medical:<\/strong> Tratamentul cancerului este foarte individualizat. Medicamentul specific, doza, programul, monitorizarea \u0219i \u00eengrijirea de sus\u021binere trebuie stabilite de un oncolog sau hematolog calificat, pe baza biologiei tumorii, stadializ\u0103rii, comorbidit\u0103\u021bilor \u0219i obiectivelor terapiei. Aceast\u0103 informa\u021bie are caracter educa\u021bional; nu \u00eenlocuie\u0219te sfatul medical profesionist.<\/div>","protected":false},"excerpt":{"rendered":"<p>Temonat (Temozolomide 20\/100\/250 mg) \u2014 Natco agent alchilant oral pentru glioblastom multiform nou diagnosticat. Profilaxia PCP este recomandat\u0103 \u00een faza de chimioradioterapie.<\/p>","protected":false},"featured_media":53471,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[],"class_list":{"0":"post-53470","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","10":"first","11":"outofstock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/53470","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=53470"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/53471"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=53470"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=53470"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=53470"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=53470"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}