{"id":53570,"date":"2023-09-20T09:48:04","date_gmt":"2023-09-20T09:48:04","guid":{"rendered":"https:\/\/medsname.com\/xeloda\/"},"modified":"2026-04-30T16:30:25","modified_gmt":"2026-04-30T16:30:25","slug":"xeloda","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/xeloda\/","title":{"rendered":"Xeloda"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">R\u0103spuns rapid<\/h3>\n<p style=\"margin-bottom:0;\"><strong>Xeloda<\/strong> \u2014 capecitabine 500 mg (Roche). Prodrug oral pentru 5-fluorouracil (5-FU) \u2014 pentru cancerul colorectal adjuvant \u0219i metastatic, cancerul de s\u00e2n, cancerul gastric \u0219i pancreatic. Elimin\u0103 necesitatea accesului intravenos. Administrare oral\u0103 de dou\u0103 ori pe zi.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>Ce beneficii ofer\u0103 MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>produc\u0103tor certificat WHO-GMP<\/li>\n<li>Ambalaj discret \u00een plic simplu<\/li>\n<li>Livrare \u00een toat\u0103 lumea<\/li>\n<li>Evaluat de peste 1.400 de clien\u021bi (<a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">cite\u0219te recenziile<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>Garan\u021bia de retransmitere:<\/strong> dac\u0103 comanda dvs. nu a ajuns \u00een 20 de zile lucr\u0103toare de la expediere, o retransmitem f\u0103r\u0103 costuri suplimentare. <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Cite\u0219te politica<\/a>.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Xeloda este expediat de la un produc\u0103tor certificat WHO-GMP \u00een ambalaj neutru, facturat prin intermediul unui procesor de pl\u0103\u021bi reglementat (descrierea extrasului de cont indic\u0103 un procesor de pl\u0103\u021bi cu carduri reglementat \u2014 niciodat\u0103 MedsBase sau numele medicamentului). Fiecare comand\u0103 beneficiaz\u0103 de Garan\u021bia noastr\u0103 de Retrimitere \u00een 20 de zile lucr\u0103toare.<\/p>\n<div class=\"medsbase-specialist-strip\" style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0;\"><strong>\u26a0\ufe0f Terapie oncologic\u0103 supravegheat\u0103 de specialist<\/strong> \u2014 acest medicament este ini\u021biat, monitorizat \u0219i \u00eentrerupt de un oncolog sau hematolog. Dozarea depinde de tipul tumorii, stadiul, suprafa\u021ba corporal\u0103, func\u021bia organelor \u0219i terapia concomitant\u0103. Autotratamentul nu este adecvat; informa\u021biile de mai jos au scop educa\u021bional \u0219i sus\u021bin conversa\u021biile informate cu specialistul dumneavoastr\u0103.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Sindromul m\u00e2n\u0103-picior (eritrodizestezie palmoplantar\u0103)<\/strong><br \/>Frecvent (30-60%) \u0219i limitant de doz\u0103. Simptome: furnic\u0103turi, ro\u0219ea\u021b\u0103, fisuri dureroase, descuamare pe palme\/t\u0103lpi. Gradul 2+ necesit\u0103 \u00eentrerupere doz\u0103 + reducere. Profilaxie: emolien\u021bi, m\u0103nu\u0219i pentru treburi casnice, evitarea expunerii la c\u0103ldur\u0103, creme pe baz\u0103 de uree, vitamina B6 cu beneficii nedovedite. Reevaluare la fiecare ciclu.<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Testarea genotipului DPYD recomandat\u0103<\/strong><br \/>Deficien\u021ba de dihidropirimidindehidrogenaz\u0103 (DPD) provoac\u0103 toxicitate sever\u0103, uneori fatal\u0103 \u2014 neutropenie, mucozit\u0103, diaree, neuropatie. Unele linii directoare recomand\u0103 acum testarea genotipului DPYD \u00eenainte de a \u00eencepe orice tratament cu 5-FU sau capecitabin\u0103 pentru a identifica deficien\u021ba par\u021bial\u0103\/complet\u0103. Dac\u0103 pacientul este DPD-deficitar, este necesar\u0103 reducerea dozei sau terapie alternativ\u0103.<\/div>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>Cum se administreaz\u0103?<\/h3>\n<p>1250 mg\/m\u00b2 de dou\u0103 ori pe zi timp de 14 zile, urmat de o pauz\u0103 de 7 zile (ciclu de 3 s\u0103pt\u0103m\u00e2ni). Unele scheme terapeutice utilizeaz\u0103 1000 mg\/m\u00b2 BID \u00d7 14 zile. \u00centotdeauna prescris de specialist \u00een func\u021bie de suprafa\u021ba corporal\u0103.<\/p>\n<h3>Cu sau f\u0103r\u0103 m\u00e2ncare?<\/h3>\n<p>\u00cen maxim 30 de minute dup\u0103 o mas\u0103 \u2014 \u00eembun\u0103t\u0103\u021be\u0219te tolerabilitatea \u0219i standardizeaz\u0103 absorb\u021bia.<\/p>\n<h3>Efecte secundare frecvente?<\/h3>\n<p>Sindromul m\u00e2n\u0103-picior (foarte frecvent), diaree, grea\u021b\u0103, oboseal\u0103, mucozit\u0103, hiperbilirubinemie, neutropenie u\u0219oar\u0103. Sever la pacien\u021bii cu deficien\u021b\u0103 de DPD.<\/p>\n<h3>Interac\u021biuni medicamentoase?<\/h3>\n<p>Warfarin: capecitabina cre\u0219te semnificativ INR \u2014 monitorizare frecvent\u0103 sau trecere la LMWH. Fenitoin\u0103: niveluri crescute. Acid folinic: poate amplifica toxicitatea \u00een unele scheme terapeutice. Substrate CYP2C9: interac\u021biuni variabile.<\/p>\n<h3>Contraindica\u021bii?<\/h3>\n<p>Insuficien\u021b\u0103 renal\u0103 sever\u0103 (CrCl &lt;30), deficien\u021b\u0103 sever\u0103 de DPD, sarcin\u0103, al\u0103ptare. Precau\u021bie \u00een insuficien\u021b\u0103 renal\u0103 moderat\u0103 (reducere doz\u0103 cu 25%).<\/p>\n<h3>Ce se \u00eent\u00e2mpl\u0103 dac\u0103 apare sindromul m\u00e2n\u0103-picior?<\/h3>\n<p>Gradul 1 (ro\u0219ea\u021b\u0103 u\u0219oar\u0103\/disestezie): continua\u021bi cu \u00eengrijiri topice. Gradul 2 (dureros, interfer\u00e2nd cu func\u021bia): \u00eentrerupe\u021bi p\u00e2n\u0103 la gradul 1, reduce\u021bi doza cu 25%. Gradul 3 (sever): \u00eentrerupe\u021bi, reduce\u021bi cu 50% la reluare.<\/p>\n<h3>Sarcin\u0103?<\/h3>\n<p>Puternic contraindicated \u2014 teratogen. Contraceptie eficient\u0103 \u00een timpul \u0219i pentru cel pu\u021bin 6 luni dup\u0103.<\/p>\n<h3>Monitorizare renal\u0103?<\/h3>\n<p>Func\u021bia renal\u0103 de baz\u0103 apoi \u00eenainte de fiecare ciclu. Ajusta\u021bi doza pentru CrCl 30-50 mL\/min. Evita\u021bi pentru CrCl &lt;30.<\/p>\n<h3>Fa\u021b\u0103 de 5-FU IV?<\/h3>\n<p>Eficacitate echivalent\u0103 sau superioar\u0103 \u00een majoritatea cazurilor (studiu X-ACT \u00een cancer colorectal). Administrarea oral\u0103 este mult mai convenabil\u0103 \u0219i evit\u0103 complica\u021biile legate de linia central\u0103.<\/p>\n<h3>Ce fac dac\u0103 uit o doz\u0103?<\/h3>\n<p>Omite\u021bi doza ratat\u0103 dac\u0103 a trecut mai mult de 6 ore. Nu dubla\u021bi doza. Discuta\u021bi cu echipa dvs. oncologic\u0103 dac\u0103 au fost ratate mai multe doze.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Alte Medicamente Anticanceroase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/xeloda\/\">Xeloda<\/a> \u2014 capecitabin\u0103 500 mg \u2014 prodrog oral de 5-FU pentru cancerul de s\u00e2n\/colorectal\/gastric<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/altraz\/\">Altraz<\/a> \u2014 anastrozol 1 mg \u2014 inhibitor de aromataz\u0103 pentru cancerul de s\u00e2n la femei postmenopauzale<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/xbira\/\">Xbira<\/a> \u2014 abirateron\u0103 250 mg \u2014 inhibitor CYP17 pentru cancerul metastatic de prostat\u0103<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/zoldria\/\">Zoldria<\/a> \u2014 acid zoledronic IV \u2014 pentru metastaze osoase \u0219i hipercalcemie<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/actorise\/\">Actorise<\/a> \u2014 darbepoetin alfa \u2014 pentru anemie indus\u0103 de chimioterapie<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>Disclaimer medical:<\/strong> Tratamentul cancerului este foarte individualizat. Medicamentul specific, doza, programul, monitorizarea \u0219i \u00eengrijirea de sus\u021binere trebuie stabilite de un oncolog sau hematolog calificat, pe baza biologiei tumorii, stadializ\u0103rii, comorbidit\u0103\u021bilor \u0219i obiectivelor terapiei. Aceast\u0103 informa\u021bie are caracter educa\u021bional; nu \u00eenlocuie\u0219te sfatul medical profesionist.<\/div>","protected":false},"excerpt":{"rendered":"<p>Xeloda (Capecitabine 500 mg) \u2014 prodrug oral Roche cu 5-FU pentru cancerul de s\u00e2n, colorectal, gastric \u0219i pancreatic. Cicluri de 14 zile de tratament\/7 zile pauz\u0103, cu managementul sindromului m\u00e2n\u0103-picior.<\/p>","protected":false},"featured_media":53571,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[],"class_list":{"0":"post-53570","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","10":"first","11":"outofstock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/53570","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=53570"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/53571"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=53570"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=53570"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=53570"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=53570"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}