{"id":53639,"date":"2023-09-20T09:49:00","date_gmt":"2023-09-20T09:49:00","guid":{"rendered":"https:\/\/medsname.com\/silofast\/"},"modified":"2026-04-30T10:25:11","modified_gmt":"2026-04-30T10:25:11","slug":"silofast","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/silofast\/","title":{"rendered":"Silofast"},"content":{"rendered":"

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R\u0103spuns rapid<\/h3>\n

Silofast<\/strong> con\u021bine silodosin 4 mg \/ 8 mg<\/strong> fabricat de Cipla Inc. Este utilizat pentru simptomele prostatei m\u0103rite (hiperplazie benign\u0103 de prostat\u0103, BPH) la b\u0103rba\u021bi. Lua\u021bi exact conform indica\u021biilor clinicianului \u2014 nu ajusta\u021bi singur doza.<\/p>\n<\/div>\n

\nCe beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate ale clien\u021bilor<\/a>\n<\/div>\n

\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n

\ud83d\udd12 Checkout criptat<\/strong> \u00b7 \ud83d\udcb3 Procesor verificat<\/strong> \u00b7 \ud83d\ude9a Livrare worldwide<\/strong> \u00b7 \u2b50 4,9\/5 de la peste 1.400 de clien\u021bi<\/strong><\/div>\n

De ce s\u0103 comanzi de la MedsBase<\/h3>\n

Fiecare lot este procurat de la un produc\u0103tor certificat WHO-GMP<\/strong>. Comenzile sunt expediate \u00een ambalaje simple, f\u0103r\u0103 marc\u0103, de la partenerii no\u0219tri de onorare \u0219i sunt acoperite de Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a>. Am servit 1.400+ clien\u021bi verifica\u021bi<\/strong> cu un rating mediu de 4,9\/5<\/strong> pe mai mult de 600 de medicamente.<\/p>\n

Ce este Silofast \u0219i cum func\u021bioneaz\u0103<\/h2>\n

Silofast con\u021bine silodosin<\/strong>, un antagonist uroselectiv al receptorilor adrenergici alfa-1A<\/strong>. Mu\u0219chiul neted al prostatei, uretrei prostatice \u0219i g\u00e2tului vezical este bogat \u00een receptori alfa-1A; blocarea acestora relaxeaz\u0103 acel mu\u0219chi \u0219i \u00eembun\u0103t\u0103\u021be\u0219te fluxul urinar. Deoarece silodosinul este de peste 100 de ori mai selectiv pentru receptorii alfa-1A dec\u00e2t pentru cei alfa-1B, efectele asupra tensiunii arteriale sunt mai mici dec\u00e2t \u00een cazul blocurilor alfa neselective, cum ar fi terazosinul sau doxazosinul.<\/p>\n

Silofast este autorizat pentru ameliorarea simptomelor tractului urinar inferior (STUI) ale hiperplaziei benigne a prostatei<\/strong> \u2014 jet slab, ezitare, intermiten\u021b\u0103, golire incomplet\u0103, frecven\u021b\u0103, urgen\u021b\u0103 \u0219i nicturie \u2014 la b\u0103rba\u021bii adul\u021bi. Nu prime\u0219te,<\/strong> mic\u0219oreaz\u0103 prostatei; dac\u0103 este necesar\u0103 mic\u0219orarea (gland\u0103 mare, PSA ridicat, reten\u021bie recurent\u0103), se adaug\u0103 un inhibitor al 5-alfa-reductazei, cum ar fi dutasterid sau finasterid.<\/p>\n

Doza \u0219i modul de administrare<\/h2>\n\n\n\n\n\n\n\n\n\n
Grup de pacien\u021bi<\/th>\nDoza recomandat\u0103<\/th>\n<\/tr>\n<\/thead>\n
B\u0103rba\u021bii adul\u021bi cu HBP (func\u021bie renal\u0103 normal\u0103)<\/td>\n8 mg o dat\u0103 pe zi<\/strong> cu alimente<\/td>\n<\/tr>\n
Insuficien\u021b\u0103 renal\u0103 u\u0219oar\u0103 (eGFR 50\u201380)<\/td>\n8 mg o dat\u0103 pe zi \u2014 de obicei tolerat<\/td>\n<\/tr>\n
Insuficien\u021b\u0103 renal\u0103 moderat\u0103 (eGFR 30\u201350)<\/td>\n\u00cencepe\u021bi cu 4 mg<\/strong> o dat\u0103 pe zi; titra\u021bi la 8 mg dac\u0103 este tolerat dup\u0103 1 s\u0103pt\u0103m\u00e2n\u0103<\/td>\n<\/tr>\n
Insuficien\u021b\u0103 renal\u0103 sever\u0103 (TFG <30)<\/td>\nEvita\u021bi<\/td>\n<\/tr>\n
Afectare hepatic\u0103 sever\u0103 (Child-Pugh C)<\/td>\nEvita\u021bi<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Lua\u021bi cu alimente la aceea\u0219i mas\u0103 \u00een fiecare zi<\/strong> \u2014 alimentele cresc tolerabilitatea \u0219i ofer\u0103 un nivel plasmatic mai previzibil. \u00cenghi\u021bi\u021bi \u00eentreg; nu zdrobi\u021bi. Apari\u021bia beneficiilor simptomatice este rapid\u0103 (\u00een c\u00e2teva zile pentru debitul urinar), dar efectul complet dureaz\u0103 2\u20134 s\u0103pt\u0103m\u00e2ni. Dac\u0103 omite\u021bi o doz\u0103, s\u0103ri\u021bi-o \u0219i lua\u021bi urm\u0103toarea conform programului \u2014 nu dubla\u021bi doza.<\/p>\n

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\u26a0 Opri\u021bi \u0219i spune\u021bi chirurgului oftalmolog c\u0103 lua\u021bi silodosin<\/strong><\/p>\n

Silodosinul (\u0219i al\u021bi alfa-blocan\u021bi) poate provoca Sindromul Iris Floppy Intraoperator (IFIS)<\/strong> \u00een timpul opera\u021biei de cataract\u0103 sau glaucom, complic\u00e2nd interven\u021bia. Dac\u0103 ave\u021bi planificat\u0103 o opera\u021bie, oftalmologul trebuie informat \u00een prealabil. Nu opri\u021bi medicamentul pe cont propriu; echipa chirurgical\u0103 va planifica \u00een consecin\u021b\u0103.<\/p>\n<\/div>\n

Efecte secundare<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n
Efect secundar<\/th>\nFrecven\u021b\u0103<\/th>\nAc\u021biune<\/th>\n<\/tr>\n<\/thead>\n
Ejaculare retrograd\u0103<\/strong> (ejaculare uscat\u0103)<\/td>\nFoarte frecvent (~28%)<\/td>\nReversibil la \u00eentrerupere; nu este d\u0103un\u0103tor, dar discuta\u021bi cu partenerul \/ planurile de fertilitate<\/td>\n<\/tr>\n
Ame\u021beli la sculare (hipotensiune ortostatic\u0103)<\/td>\nFrecvent (~3%)<\/td>\nRidica\u021bi-v\u0103 \u00eencet; mai ales la primele 1\u20132 doze<\/td>\n<\/tr>\n
Dureri de cap<\/td>\nFrecvente<\/td>\nDe obicei se amelior\u0103 \u00een decurs de o s\u0103pt\u0103m\u00e2n\u0103<\/td>\n<\/tr>\n
Congestie nazal\u0103 \/ rinoree<\/td>\nFrecvente<\/td>\nSimptomatic; antihistaminicele sunt acceptabile<\/td>\n<\/tr>\n
Diaree, grea\u021b\u0103<\/td>\nPu\u021bin frecvente<\/td>\nAdministra\u021bi \u00een timpul mesei; raporta\u021bi dac\u0103 persist\u0103<\/td>\n<\/tr>\n
Sc\u0103derea libidoului \/ disfunc\u021bie erectil\u0103<\/td>\nPu\u021bin frecvente<\/td>\nDiscuta\u021bi cu medicul prescriptor<\/td>\n<\/tr>\n
Le\u0219in (sincop\u0103)<\/td>\nRare<\/td>\n\u00centrerupe\u021bi \u0219i c\u0103uta\u021bi sfat medical<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Interac\u021biuni medicamentoase<\/h2>\n\n\n\n\n\n\n\n\n\n\n
Combina\u021bie<\/th>\nEfect<\/th>\nAc\u021biune<\/th>\n<\/tr>\n<\/thead>\n
Inhibitori puternici ai CYP3A4 (ketoconazol, itraconazol, ritonavir, claritromicin\u0103)<\/td>\nCre\u0219tere major\u0103 a nivelurilor de silodosin\u0103 \u2192 hipotensiune<\/td>\nEvita\u021bi combina\u021bia<\/strong><\/td>\n<\/tr>\n
Al\u021bi alfa-blocante (terazosin\u0103, doxazosin\u0103, tamsulosin\u0103, alfuzosin\u0103)<\/td>\nHipotenziune aditiv\u0103<\/td>\nNu combina\u021bi<\/td>\n<\/tr>\n
Inhibitori PDE-5 (sildenafil, tadalafil, vardenafil)<\/td>\nHipotensiune aditiv\u0103; tadalafil 5 mg zilnic pentru HBP\/DED este cea mai studiat\u0103 combina\u021bie<\/td>\nStabil pe silodosin mai \u00eent\u00e2i; introduce\u021bi PDE-5 cu precau\u021bie<\/td>\n<\/tr>\n
Antihipertensive<\/td>\nSc\u0103dere aditiv\u0103 a tensiunii arteriale<\/td>\nMonitoriza\u021bi; hipotensiune la prima doz\u0103 posibil\u0103<\/td>\n<\/tr>\n
Inhibitori P-gp (ciclosporin\u0103)<\/td>\nCre\u0219tere moderat\u0103 a nivelurilor de silodosin<\/td>\nMonitoriza\u021bi<\/td>\n<\/tr>\n
Diuretice, alcool<\/td>\nAgraveaz\u0103 simptomele ortostatice<\/td>\nPrecau\u021bie; mai ales la v\u00e2rstnici<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Cine nu ar trebui s\u0103 ia Silofast<\/h2>\n