{"id":53660,"date":"2023-09-20T09:49:03","date_gmt":"2023-09-20T09:49:03","guid":{"rendered":"https:\/\/medsname.com\/floslo\/"},"modified":"2026-04-30T10:25:10","modified_gmt":"2026-04-30T10:25:10","slug":"floslo","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/floslo\/","title":{"rendered":"Floslo"},"content":{"rendered":"

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R\u0103spuns rapid<\/h3>\n

Floslo<\/strong> con\u021bine solifenacin succinat 5 mg \/ 10 mg<\/strong> fabricat de Intas Pharma. Este utilizat pentru simptomele vezicii urinare hiperactive (VUH) \u2014 urgen\u021b\u0103, frecven\u021b\u0103 \u0219i incontinen\u021b\u0103 de urgen\u021b\u0103. Lua\u021bi exact conform indica\u021biilor medicului dumneavoastr\u0103 \u2014 nu ajusta\u021bi singur doza.<\/p>\n<\/div>\n

\nCe beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate ale clien\u021bilor<\/a>\n<\/div>\n

\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n

\ud83d\udd12 Checkout criptat<\/strong> \u00b7 \ud83d\udcb3 Procesor verificat<\/strong> \u00b7 \ud83d\ude9a Livrare worldwide<\/strong> \u00b7 \u2b50 4,9\/5 de la peste 1.400 de clien\u021bi<\/strong><\/div>\n

De ce s\u0103 comanzi de la MedsBase<\/h3>\n

Fiecare lot este procurat de la un produc\u0103tor certificat WHO-GMP<\/strong>. Comenzile sunt expediate \u00een ambalaje simple, f\u0103r\u0103 marc\u0103, de la partenerii no\u0219tri de onorare \u0219i sunt acoperite de Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a>. Am servit 1.400+ clien\u021bi verifica\u021bi<\/strong> cu un rating mediu de 4,9\/5<\/strong> pe mai mult de 600 de medicamente.<\/p>\n

Ce este Floslo \u0219i cum func\u021bioneaz\u0103<\/h2>\n

Floslo con\u021bine solifenacin succinat<\/strong>, un antagonist selectiv competitiv al receptorilor M3 muscarinici<\/strong>. Prin blocarea receptorilor M3 pe detrusorul (mu\u0219chiul neted al vezicii urinare), solifenacinul reduce contrac\u021biile involuntare \u00een timpul fazei de stocare a umplerii vezicii \u0219i atenueaz\u0103 episoadele de urgen\u021b\u0103, frecven\u021b\u0103 \u0219i incontinen\u021b\u0103 de urgen\u021b\u0103.<\/p>\n

Solifenacinul este autorizat pentru tratamentul simptomatic al vezic\u0103 hiperactiv\u0103 (OAB)<\/strong> cu urgen\u021b\u0103 urinar\u0103, frecven\u021b\u0103 \u0219i incontinen\u021b\u0103 de urgen\u021b\u0103. Este unul dintre cele mai prescrise antimuscarinice pentru OAB la nivel mondial datorit\u0103 doz\u0103rii o dat\u0103 pe zi \u0219i unui profil de tolerabilitate relativ favorabil.<\/p>\n

Doza \u0219i modul de administrare<\/h2>\n\n\n\n\n\n\n\n\n\n\n
Grup de pacien\u021bi<\/th>\nDoza recomandat\u0103<\/th>\n<\/tr>\n<\/thead>\n
Adul\u021bi cu OAB \u2014 doz\u0103 ini\u021bial\u0103<\/td>\n5 mg o dat\u0103 pe zi<\/strong><\/td>\n<\/tr>\n
Cre\u0219tere dup\u0103 4 s\u0103pt\u0103m\u00e2ni dac\u0103 este necesar<\/td>\nCre\u0219te la 10 mg o dat\u0103 pe zi<\/strong><\/td>\n<\/tr>\n
Insuficien\u021b\u0103 renal\u0103 sever\u0103 (TFG <30)<\/td>\nLimit\u0103 la 5 mg\/zi<\/td>\n<\/tr>\n
Insuficien\u021b\u0103 hepatic\u0103 moderat\u0103 (Child-Pugh B)<\/td>\nLimit\u0103 la 5 mg\/zi<\/td>\n<\/tr>\n
Afectare hepatic\u0103 sever\u0103 (Child-Pugh C)<\/td>\nEvita\u021bi<\/td>\n<\/tr>\n
Inhibitor puternic CYP3A4 concomitent<\/td>\nLimit\u0103 la 5 mg\/zi<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00cenghi\u021bi\u021bi \u00eentreg, cu sau f\u0103r\u0103 m\u00e2ncare, \u00een acela\u0219i timp \u00een fiecare zi.<\/strong> O ameliorare par\u021bial\u0103 apare \u00een 1\u20132 s\u0103pt\u0103m\u00e2ni; efectul complet \u00een 4\u20136 s\u0103pt\u0103m\u00e2ni. Trece\u021bi la 10 mg doar dac\u0103 r\u0103spunsul la 5 mg este insuficient dup\u0103 4 s\u0103pt\u0103m\u00e2ni \u2014 efectele secundare (\u00een special gura uscat\u0103 \u0219i constipa\u021bia) cresc semnificativ la doza mai mare.<\/p>\n

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\u26a0 Sarcina anticolinergic\u0103 \u2014 revizui\u021bi medicamentele concomitente<\/strong><\/p>\n

Solifenacinul contribuie la sarcina anticolinergic\u0103 total\u0103. La adul\u021bii \u00een v\u00e2rst\u0103, o sarcin\u0103 anticolinergic\u0103 ridicat\u0103 sus\u021binut\u0103 este asociat\u0103 cu declin cognitiv \u0219i risc crescut de demen\u021b\u0103<\/strong>. Verifica\u021bi alte medicamente anticolinergice (antidepresive triciclice, antihistaminice sedative, oxibutinin\u0103, hioscin\u0103, anumite medicamente pentru Parkinson). Mirabegronul (un agonist beta-3 f\u0103r\u0103 efect anticolinergic) este alternativa mai sigur\u0103 dac\u0103 sarcina este o problem\u0103.<\/p>\n<\/div>\n

Efecte secundare<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Efect secundar<\/th>\nFrecven\u021b\u0103 la 5 mg<\/th>\nFrecven\u021b\u0103 la 10 mg<\/th>\n<\/tr>\n<\/thead>\n
Gur\u0103 uscat\u0103<\/td>\n~11%<\/td>\n~28%<\/td>\n<\/tr>\n
Constipa\u021bie<\/td>\n~5%<\/td>\n~13%<\/td>\n<\/tr>\n
Vedere \u00eence\u021bo\u0219at\u0103<\/td>\n~4%<\/td>\n~5%<\/td>\n<\/tr>\n
Indigestie\/grea\u021b\u0103<\/td>\n~3%<\/td>\n~4%<\/td>\n<\/tr>\n
Ochi usca\u021bi<\/td>\nFrecvente<\/td>\nFrecvente<\/td>\n<\/tr>\n
Reten\u021bie urinar\u0103<\/td>\nPu\u021bin frecvente<\/td>\nPu\u021bin frecvente<\/td>\n<\/tr>\n
Prelungirea intervalului QT<\/td>\nRare<\/td>\nEvita\u021bi \u00een sindromul QT lung<\/td>\n<\/tr>\n
Efecte secundare cognitive<\/td>\nPu\u021bin frecvente<\/td>\nMai frecvent la adul\u021bii \u00een v\u00e2rst\u0103<\/td>\n<\/tr>\n
Glaucom cu unghi \u00eenchis acut<\/td>\nRare<\/td>\nOftalmologie \u00een aceea\u0219i zi<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Interac\u021biuni medicamentoase<\/h2>\n\n\n\n\n\n\n\n\n\n
Combina\u021bie<\/th>\nEfect<\/th>\nAc\u021biune<\/th>\n<\/tr>\n<\/thead>\n
Inhibitori puternici ai CYP3A4 (ketoconazol, itraconazol, claritromicin\u0103, ritonavir)<\/td>\nCre\u0219terea nivelurilor de solifenacin\u0103<\/td>\nLimit\u0103 la 5 mg\/zi<\/td>\n<\/tr>\n
Inductori puternici ai CYP3A4 (rifampicin\u0103, fenitoin\u0103, carbamazepin\u0103)<\/td>\nPierdere de efect<\/td>\nComutare la o alternativ\u0103 non-CYP3A4<\/td>\n<\/tr>\n
Alte anticolinergice<\/td>\nPovara aditiv\u0103<\/td>\nEvita\u021bi suprapunerea<\/td>\n<\/tr>\n
Medicamente care prelungesc intervalul QT (sotalol, amiodaron\u0103, citalopram > 20 mg, metadon\u0103)<\/td>\nEfect aditiv pe intervalul QT<\/td>\nEvita\u021bi combina\u021bia<\/td>\n<\/tr>\n
Bifosfona\u021bi<\/td>\nSolifenacina poate agrava irita\u021bia esofagian\u0103<\/td>\nLua\u021bi separat, sta\u021bi \u00een pozi\u021bie vertical\u0103 30 de minute dup\u0103 bifosfonat<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Cine nu ar trebui s\u0103 ia Floslo<\/h2>\n