{"id":53704,"date":"2023-09-20T09:49:35","date_gmt":"2023-09-20T09:49:35","guid":{"rendered":"https:\/\/medsname.com\/nizral\/"},"modified":"2026-04-30T10:25:10","modified_gmt":"2026-04-30T10:25:10","slug":"nizral","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/nizral\/","title":{"rendered":"Nizral"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 20px;margin:18px 0;border-radius:6px;\">\n<h3 style=\"margin-top:0;\">\ud83d\udca1 R\u0103spuns rapid<\/h3>\n<p style=\"margin-bottom:0;\">Nizral este un comprimat oral de ketoconazol 200 mg \u2014 un antifungic imidazolic mai vechi. <strong>FDA, EMA, MHRA, Health Canada au restric\u021bionat toate administrarea oral\u0103 de ketoconazol din cauza hepatotoxicit\u0103\u021bii severe, insuficien\u021bei adrenale \u0219i riscului de interac\u021biuni medicamentoase.<\/strong> NU ar trebui utilizat ca tratament de prim\u0103 linie pentru infec\u021bii fungice ale pielii, vaginale sau ale unghiilor \u2014 fluconazolul \/ itraconazolul \/ terbinafina sunt mai sigure. Indica\u021biile r\u0103mase restr\u00e2nse: micoze endemice (blastomicoz\u0103, paracoccidioidomicoz\u0103) \u00een cazurile \u00een care alternativele au e\u0219uat \u0219i sindromul Cushing (suprimarea cortizolului off-label). Formele topice de ketoconazol (crem\u0103, lo\u021biune, \u0219ampon) nu sunt afectate de aceste avertismente.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f5f5;border:1px solid #e1e1e1;padding:18px 22px;margin:24px 0;border-radius:8px;display:flex;flex-wrap:wrap;justify-content:space-around;gap:16px;align-items:center;font-size:0.95em;\">\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83c\udfed<br \/><strong>WHO-GMP<\/strong><br \/>produc\u0103tor autorizat<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83d\udce6<br \/><strong>Ambalaj discret<\/strong><br \/>plic simplu<\/div>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83c\udf0d<br \/><strong>Livrare \u00een toat\u0103 lumea<\/strong><br \/>\u00een majoritatea \u021b\u0103rilor<\/div>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\u2b50<br \/><strong>peste 1.400 de clien\u021bi<\/strong><br \/><a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">cite\u0219te recenziile<\/a><\/div>\n<\/div>\n<h2>\ud83d\udd12 De ce s\u0103 comanzi Nizral de la MedsBase<\/h2>\n<ul>\n<li><strong>produc\u0103tor certificat WHO-GMP<\/strong> \u2014 provenit de la o unitate reglementat\u0103, ambalaj final cu num\u0103r de lot \u0219i dat\u0103 de expirare.<\/li>\n<li><strong>Ambalaj discret<\/strong> \u2014 plic simplu, f\u0103r\u0103 denumirea medicamentului pe exterior.<\/li>\n<li><strong>Livrare \u00een toat\u0103 lumea<\/strong> \u00een majoritatea \u021b\u0103rilor cu <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance<\/a>.<\/li>\n<li><strong>Puncte de loialitate<\/strong> \u2014 1 punct pentru fiecare 1$ cheltuit (excluz\u00e2nd peptidele\/transportul); 100 puncte = 5$ reducere la urm\u0103toarea comand\u0103.<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 20px;margin:20px 0;border-radius:6px;\"><strong>Avertisment FDA black-box \u2014 ketoconazol oral<\/strong><\/p>\n<div>\n<p>Dup\u0103 evalu\u0103rile din 2013, agen\u021biile de reglementare au retras aprobarea pentru ketoconazolul oral \u00een cazul infec\u021biilor fungice de rutin\u0103:<\/p>\n<ul>\n<li><strong>Hepatotoxicitate sever\u0103<\/strong> \u2014 insuficien\u021b\u0103 hepatic\u0103 fatal\u0103 a ap\u0103rut chiar \u0219i la tratamente scurte. Riscul este dependent de doz\u0103 \u0219i idiosincratic.<\/li>\n<li><strong>Insuficien\u021b\u0103 adrenal\u0103<\/strong> \u2014 ketoconazolul inhib\u0103 steroidogeneza adrenal\u0103 la doze terapeutice (acesta este motivul pentru care este utilizat off-label \u00een sindromul Cushing).<\/li>\n<li><strong>Prelungirea intervalului QT \u0219i torsade de pointes<\/strong> cu medicamente co-administrate metabolizate de CYP3A4.<\/li>\n<li><strong>Interac\u021biuni medicamentoase majore<\/strong> prin inhibare puternic\u0103 a CYP3A4.<\/li>\n<\/ul>\n<p><strong>Pentru candidoz\u0103 vaginal\u0103, mugur\u0103 orofaringian\u0103, tinea dermatofit\u0103\/onicomicoz\u0103 sau pitiriazis versicolor \u2014 utiliza\u021bi fluconazol, itraconazol sau terbinafin\u0103 \u00een loc.<\/strong> Crema\/lotionul\/\u0219amponul cu ketoconazol topic nu este afectat \u2014 este slab absorbit \u0219i r\u0103m\u00e2ne o alegere bun\u0103 pentru piele \u0219i scalp.<\/p>\n<\/div>\n<\/div>\n<h2 id=\"uses\">Indica\u021bii restr\u00e2nse r\u0103mase<\/h2>\n<p>Nizral (ketoconazol 200 mg, Cipla) \u00een form\u0103 oral\u0103 este acum utilizat doar atunci c\u00e2nd alte agen\u021bi antifungici nu sunt tolera\u021bi sau sunt contraindica\u021bi, sau \u00een indica\u021bii specifice unde r\u0103m\u00e2ne bazat pe dovezi:<\/p>\n<ul>\n<li>Micoze endemice \u2014 blastomicoz\u0103, paracoccidioidomicoz\u0103, histoplasmoz\u0103, cromoblastomicoz\u0103 \u2014 unde amfotericina B sau itraconazolul au e\u0219uat sau nu sunt disponibile.<\/li>\n<li>Sindromul Cushing \u2014 agent de reducere a cortizolului de linia a doua (off-label, ini\u021biat \u00een spital, monitorizat).<\/li>\n<li>Pitiriazis versicolor recalcitrant care a e\u0219uat la tratamentul topic \u0219i oral cu fluconazol\/itraconazol.<\/li>\n<\/ul>\n<h2 id=\"dose\">Doza \u0219i monitorizarea<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Indica\u021bie<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Regim<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Micoze endemice<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">200\u2013400 mg zilnic cu m\u00e2ncare; durata conform indica\u021biilor specialistului \u00een boli infec\u021bioase (adesea 6\u201312 luni)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Sindromul Cushing (off-label)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">200 mg de dou\u0103 ori pe zi, ajustat la 400\u20131200 mg\/zi \u00een doze divizate<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Monitorizarea este obligatorie:<\/strong><\/p>\n<ul>\n<li>Teste hepatice ini\u021biale, apoi la fiecare 2 s\u0103pt\u0103m\u00e2ni pentru primele 2 luni, apoi lunar.<\/li>\n<li>\u00centrerupe\u021bi imediat dac\u0103 AST\/ALT &gt; 3\u00d7 ULN SAU icter, urin\u0103 \u00eenchis\u0103 la culoare sau grea\u021b\u0103 persistent\u0103.<\/li>\n<li>ECG ini\u021bial; repeta\u021bi dac\u0103 sunt prescrise concomitent medicamente care prelungesc intervalul QT.<\/li>\n<li>Pentru utilizarea \u00een sindromul Cushing: cortisol diminea\u021ba, cortisol liber urinar \u0219i test de stimulare cu ACTH dac\u0103 apar simptome sugestive pentru insuficien\u021b\u0103 adrenal\u0103.<\/li>\n<\/ul>\n<h2 id=\"how-to-take\">Cum se administreaz\u0103<\/h2>\n<p>Administra\u021bi \u00een timpul mesei \u2014 acidul gastric este necesar pentru dizolvarea capsulei \u0219i absorb\u021bie. Evita\u021bi utilizarea concomitent\u0103 cu IPP \/ antagoni\u0219ti H2 \/ antiacide, cu excep\u021bia cazului \u00een care sunt separate cu \u2265 2 ore.<\/p>\n<h2 id=\"mechanism\">Cum func\u021bioneaz\u0103<\/h2>\n<p>Ketoconazolul inhib\u0103 CYP51 fungic (lanosterol 14-\u03b1-demetilaza) \u2014 aceea\u0219i \u021bint\u0103 ca fluconazolul \u0219i itraconazolul. Este mai pu\u021bin selectiv dec\u00e2t triazolele noi, inhib\u00e2nd \u0219i enzimele umane de steroidogenez\u0103 (CYP17, CYP11B1, CYP11B2) \u2014 baza at\u00e2t pentru utilizarea \u00een sindromul Cushing, c\u00e2t \u0219i pentru insuficien\u021ba adrenal\u0103 ca efect advers.<\/p>\n<h2 id=\"side-effects\">Efecte secundare<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Frecven\u021b\u0103<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Efecte<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Frecvente<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Grea\u021b\u0103, dureri abdominale, cefalee, ame\u021beli, ginecomastie (la b\u0103rba\u021bi, dependent\u0103 de doz\u0103)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Pu\u021bin frecvente<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Sc\u0103derea libidoului, oligospermie, fotofobie<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Rare, dar grave<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\"><strong>Hepatotoxicitate fatal\u0103<\/strong> (1 la ~10 000 \u2014 idiosincratic\u0103, poate ap\u0103rea \u00een prima lun\u0103), insuficien\u021b\u0103 adrenal\u0103, prelungirea intervalului QT, anafilaxie, reac\u021bii cutanate severe<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"interactions\">Interac\u021biuni medicamentoase<\/h2>\n<p>Ketoconazolul este unul dintre cei mai puternici inhibitori de CYP3A4 cunoscu\u021bi \u2014 cre\u0219te nivelul oric\u0103rui medicament metabolizat de CYP3A4. Interac\u021biuni majore selectate:<\/p>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Medicament<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Efect<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Ac\u021biune<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Pimozid\u0103, terfenadin\u0103, astemizol, cisaprid\u0103, dofetilid\u0103, chinidin\u0103<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Prelungirea intervalului QT \u2192 torsade de pointes<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Contraindica\u021bii<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Triazolam, midazolam, alprazolam (oral)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Sedare profund\u0103<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Contraindica\u021bii<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Statine (simvastatin, atorvastatin, lovastatin)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Rabdomioliz\u0103<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Contraindicate; trece\u021bi la pravastatin \/ rosuvastatin<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Alcaloizi ergot<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Vasoconstric\u021bie, ergotism<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Contraindica\u021bii<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Tacrolimus, ciclosporin\u0103, sirolimus<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Toxicitate<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Reduce\u021bi substan\u021bial doza; monitorizare concentra\u021bie minim\u0103<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Warfarin<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Cre\u0219tere INR<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Monitoriza\u021bi \u00eendeaproape<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Apixaban, rivaroxaban<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">S\u00e2ngerare<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Evita\u021bi<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Metadon\u0103<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Prelungirea intervalului QT, sedare<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Evita\u021bi<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"contraindications\">Contraindica\u021bii<\/h2>\n<ul>\n<li>Boal\u0103 hepatic\u0103 acut\u0103 sau cronic\u0103.<\/li>\n<li>Medicamente concomitente care prelungesc intervalul QT enumerate mai sus.<\/li>\n<li>Administrare concomitent\u0103 cu simvastatin \/ atorvastatin \/ lovastatin \/ triazolam \/ midazolam (oral) \/ alcaloizi ai ergotului.<\/li>\n<li>Sarcin\u0103 \u0219i al\u0103ptare.<\/li>\n<li>Hipersensibilitate la azoli.<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>De ce este ketoconazolul oral \u2018restric\u021bionat\u2019?<\/h3>\n<p>FDA, EMA, MHRA \u0219i Health Canada au concluzionat \u00eentre 2013 \u0219i 2014 c\u0103 hepatotoxicitatea fatal\u0103 face ca ketoconazolul oral s\u0103 fie nepotrivit pentru infec\u021bii fungice de rutin\u0103 atunci c\u00e2nd exist\u0103 alternative mai sigure (fluconazol, itraconazol, terbinafin\u0103). \u0218amponul \/ crema cu ketoconazol topic nu este afectat \u2014 este slab absorbit.<\/p>\n<h3>Ar trebui s\u0103 iau acest medicament pentru tinea pedis sau candidoz\u0103?<\/h3>\n<p>Aproape sigur c\u0103 nu. Tratamentul standard pentru candidoza vaginal\u0103 este fluconazol 150 mg \u00eentr-o singur\u0103 doz\u0103; pentru tinea pedis un antifungic topic de 4 s\u0103pt\u0103m\u00e2ni sau terbinafin\u0103 oral\u0103; pentru candidoza oral\u0103 fluconazol sau solu\u021bie oral\u0103 de itraconazol. Discuta\u021bi schimbarea tratamentului cu medicul dumneavoastr\u0103.<\/p>\n<h3>Este ketoconazolul topic \u00eenc\u0103 sigur?<\/h3>\n<p>Da \u2014 \u0219amponul cu ketoconazol (pentru dermatita seboreic\u0103, m\u0103trea\u021b\u0103) \u0219i crema \/ lo\u021biunea (pentru tinea, candidoz\u0103, pitiriazis versicolor) nu sunt afectate de aceste restric\u021bii reglementare. Absorb\u021bia topic\u0103 este minim\u0103.<\/p>\n<h3>Ce efect are ketoconazolul asupra hormonilor mei?<\/h3>\n<p>Inhib\u0103 sinteza de cortizol \u00een glandele suprarenale (de aceea este folosit off-label pentru sindromul Cushing) \u0219i sinteza de testosteron \u00een testicule. Terapia oral\u0103 cronic\u0103 cu doze mari poate provoca insuficien\u021b\u0103 suprarenal\u0103, ginecomastie la b\u0103rba\u021bi, oligospermie, pierdere a libidoului \u0219i menstrua\u021bii neregulate la femei.<\/p>\n<h3>Care sunt simptomele leziunilor hepatice?<\/h3>\n<p>G\u0103lbirea pielii sau a ochilor, urin\u0103 \u00eentunecat\u0103, scaune palide, grea\u021b\u0103 persistent\u0103, durere \u00een cadranul superior drept, oboseal\u0103 sever\u0103, confuzie. \u00centrerupe\u021bi imediat medicamentul \u0219i solicita\u021bi sfat medical. Hepatotoxicitatea poate ap\u0103rea brusc \u0219i poate fi fatal\u0103 \u2014 recunoa\u0219terea timpurie conteaz\u0103.<\/p>\n<h3>Ce se \u00eent\u00e2mpl\u0103 dac\u0103 am terminat deja un tratament scurt cu ketoconazol?<\/h3>\n<p>Dac\u0103 a\u021bi finalizat un tratament scurt (de ex. 1\u20132 s\u0103pt\u0103m\u00e2ni pentru blastomicoz\u0103 sau pitiriazis versicolor refractar) f\u0103r\u0103 simptome, este pu\u021bin probabil s\u0103 dezvolta\u021bi hepatotoxicitate \u00eent\u00e2rziat\u0103 acum. Dac\u0103 ave\u021bi orice simptome (icter, urin\u0103 \u00eentunecat\u0103), solicita\u021bi sfat medical. Pentru viitoare infec\u021bii fungice \u2014 discuta\u021bi alternative mai sigure.<\/p>\n<h3>De ce este ketoconazolul uneori \u00eenc\u0103 utilizat pentru sindromul Cushing?<\/h3>\n<p>Pentru c\u0103 inhib\u0103 sinteza de cortizol adrenal. \u00cen sindromul Cushing, acesta este efectul dorit \u2014 pentru a reduce excesul. Supraveghere endocrinologic\u0103 specializat\u0103; metirapona, mifepriston, osilodrostat sau adrenalectomie bilateral\u0103 sunt alternative.<\/p>\n<h3>Poate fi utilizat ketoconazolul \u00een cancer (prostat\u0103, etc.)?<\/h3>\n<p>Istoric, utilizat \u00een doze mari (1200 mg\/zi) pentru a suprima sinteza androgenilor testiculari \u0219i adrenali \u00een cancerul avansat de prostat\u0103. Acum \u00eenlocuit \u00een mare m\u0103sur\u0103 cu abirateron, enzalutamid, etc. Nu este terapia de prim\u0103 linie \u00een oncologie.<\/p>\n<h3>Nizral este acela\u0219i lucru cu Nizoral?<\/h3>\n<p>Da \u2014 Nizoral este marca original\u0103 Janssen a ketoconazolului. Nizral con\u021bine acela\u0219i principiu activ, fabricat de Cipla conform standardelor WHO-GMP. Restric\u021biile reglementare se aplic\u0103 \u00een mod egal tuturor m\u0103rcilor de ketoconazol oral.<\/p>\n<h3>Ce antifungic ar trebui s\u0103 iau \u00een schimb?<\/h3>\n<p>Depinde de infec\u021bie. Candidoz\u0103 vaginal\u0103 \u2192 fluconazol 150 mg doz\u0103 unic\u0103. Mugur\u0103 oral\u0103 \u2192 fluconazol 100 mg\/zi \u00d7 7 zile. Tinea pedis\/cruris \u2192 terbinafin\u0103 topic\u0103 sub form\u0103 de crem\u0103 \u00d7 1\u20134 s\u0103pt\u0103m\u00e2ni. Onihomicoz\u0103 \u2192 terbinafin\u0103 oral\u0103 250 mg\/zi \u00d7 6 s\u0103pt\u0103m\u00e2ni (unghii de la m\u00e2ini) sau 12 s\u0103pt\u0103m\u00e2ni (unghii de la picioare). Pitiriazis versicolor \u2192 \u0219ampon cu ketoconazol topic sau fluconazol oral.<\/p>\n<h2 id=\"storage\">Depozitare<\/h2>\n<p>P\u0103stra\u021bi comprimatele la 15\u201325 \u00b0C, departe de umiditate \u0219i lumin\u0103. Nu utiliza\u021bi dup\u0103 expirare. P\u0103stra\u021bi departe de copii.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Alte medicamente antifungice care te-ar putea interesa<\/h2>\n<p>Ketoconazolul oral nu mai este de prim\u0103 linie pentru infec\u021biile fungice obi\u0219nuite. Mai jos sunt enumerate alternative recomandate pentru indica\u021biile comune.<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/zocon\/\"><strong>Zocon (fluconazol 150 mg)<\/strong><\/a> \u2014 De prim\u0103 linie oral pentru Candida \u2014 mai sigur dec\u00e2t ketoconazolul oral.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/zimig\/\"><strong>Zimig (terbinafin\u0103 250 mg)<\/strong><\/a> \u2014 Tratament oral de prim\u0103 linie pentru dermatofitoze ale unghiilor\/scalpului\/pielii extinse.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/sporanox-capsule\/\"><strong>Sporanox (itraconazol 100 mg)<\/strong><\/a> \u2014 Pentru mucegaiuri nedermatofite, micoze dimorfice, infec\u021bii mixte cu Candida.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/keto-cream\/\"><strong>Keto Cream (ketoconazol 2%)<\/strong><\/a> \u2014 Ketoconazol topic \u2014 sigur chiar dac\u0103 forma oral\u0103 este restric\u021bionat\u0103.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/clocip\/\"><strong>Clocip (clotrimazol 1% crem\u0103)<\/strong><\/a> \u2014 Antifungic topic cu spectru larg.<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 18px;margin:24px 0;font-size:0.95em;\"><strong>Not\u0103 medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 con\u021bine informa\u021bii despre produse pentru adul\u021bi care comand\u0103 medicamente antifungice pentru uz personal. Nu \u00eenlocuie\u0219te sfatul medical individual. Discut\u0103 cu un clinician calificat despre antifungicul potrivit, doza \u0219i durata tratamentului \u2014 mai ales dac\u0103 ai probleme hepatice, e\u0219ti gravid\u0103 sau al\u0103ptezi, iei warfarin, iei un statin, iei imunosupresoare sau ai o infec\u021bie fungic\u0103 la unghii care ar putea fi o alt\u0103 afec\u021biune (psoriazis, lichen planus, traumatism).<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<h5>\u2705 Trateaz\u0103 infec\u021bii fungice largi<br \/>\n\u2705 \u021ainte\u0219te tulpini rezistente<br \/>\n\u2705 U\u0219or de utilizat<\/h5>\n<p><span style=\"color: #999999;\">Nizral con\u021bine Ketoconazol<\/span><\/p>","protected":false},"featured_media":53705,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3501,3141,3504,3342],"product_tag":[3623,3624],"class_list":{"0":"post-53704","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-fungal","7":"product_cat-category-overview","8":"product_cat-fungal-infection-treatment","9":"product_cat-general-health","10":"product_tag-ketoconazole","11":"product_tag-nizral","13":"first","14":"outofstock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/53704","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=53704"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/53705"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=53704"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=53704"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=53704"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=53704"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}