{"id":54156,"date":"2023-09-20T09:55:36","date_gmt":"2023-09-20T09:55:36","guid":{"rendered":"https:\/\/medsname.com\/topgraf-ointment\/"},"modified":"2026-04-30T10:25:02","modified_gmt":"2026-04-30T10:25:02","slug":"topgraf-ointment","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/topgraf-ointment\/","title":{"rendered":"Unguentul Topgraf"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:20px 0;border-radius:6px;\">\n<h3 style=\"margin:0 0 10px 0;font-size:1.15em;\">\ud83d\udca1 R\u0103spuns rapid \u2014 Ce este unguentul Topgraf?<\/h3>\n<p style=\"margin:0;\"><strong>Unguentul Topgraf<\/strong> con\u021bine tacrolimus 0.03% sau 0.1% \u2014 un inhibitor al calcineurinei topic (imunomodulator care \u00eenlocuie\u0219te steroizii) pentru dermatita atopic\u0103 moderat\u0103 p\u00e2n\u0103 la sever\u0103 (eczem\u0103), \u00een special pe fa\u021b\u0103, pleoape \u0219i zonele de flexiune. Aplica\u021bi un strat sub\u021bire de dou\u0103 ori pe zi pe pielea afectat\u0103 p\u00e2n\u0103 la vindecare, apoi de dou\u0103 ori pe s\u0103pt\u0103m\u00e2n\u0103 ca \u00eentre\u021binere. Concentra\u021bia standard pentru adul\u021bi este 0.1%; pentru copii este 0.03%. Arsur\u0103\/\u00een\u021bep\u0103tur\u0103 ini\u021bial\u0103 este frecvent\u0103 \u00een prima s\u0103pt\u0103m\u00e2n\u0103 \u0219i de obicei dispare cu utilizarea continu\u0103. SPF 30+ zilnic \u00een timpul terapiei.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:6px;font-size:0.95em;\">\n<strong>\ud83c\udfed Produc\u0103tor certificat WHO-GMP<\/strong> \u00b7 <strong>\ud83d\udce6 Ambalaj discret<\/strong> (plic simplu) \u00b7 <strong>\ud83c\udf0d Livrare \u00een toat\u0103 lumea<\/strong> cu <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance<\/strong><\/a> \u00b7 <strong>\u2b50 Peste 1.400 de clien\u021bi<\/strong> \u2014 <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">cite\u0219te recenziile<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<h3 class=\"wp-block-heading\">De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Alegerea unguentului Topgraf de la MedsBase:<\/p>\n<ul>\n<li><strong>produc\u0103tor certificat WHO-GMP<\/strong> \u2014 provenit de la o unitate reglementat\u0103, ambalaj final cu num\u0103r de lot \u0219i dat\u0103 de expirare.<\/li>\n<li><strong>Ambalaj discret<\/strong> \u2014 plic simplu, f\u0103r\u0103 denumirea medicamentului pe exterior.<\/li>\n<li><strong>Livrare \u00een toat\u0103 lumea<\/strong> cu <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu ajunge \u00een 20 de zile lucr\u0103toare, v\u0103 retrimitem gratuit (conform termenilor politicii).<\/li>\n<li><strong>Puncte de loialitate<\/strong> \u2014 1 punct pentru fiecare 1$ cheltuit (excluz\u00e2nd peptidele); 100 de puncte = reducere de 5$.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Ce este unguentul Topgraf \u0219i cum func\u021bioneaz\u0103<\/h2>\n<p>Unguentul Topgraf con\u021bine <strong>tacrolimus 0.03% sau 0.1%<\/strong>. Tacrolimusul este un inhibitor macrolid al calcineurinei \u2014 se leag\u0103 de proteina FK-binding protein-12 (FKBP-12); complexul rezultat inhib\u0103 fosfataza calcineurinei, bloc\u00e2nd defosforilarea NFAT \u0219i prevenind transcrip\u021bia citokinelor de activare a celulelor T (IL-2, IL-4, IFN-\u03b3). Efectul net este suprima\u021bia \u021bintit\u0103 a inflama\u021biei pielii f\u0103r\u0103 efectele de sub\u021biere a pielii, atrofie sau asupra axei HPA ale corticosteroidelor topice. Produc\u0103tor: Glenmark \/ generice (certificat WHO-GMP).<\/p>\n<h2 class=\"wp-block-heading\">Indica\u021bii<\/h2>\n<ul>\n<li><strong>Dermatit\u0103 atopic\u0103 moderat\u0103 p\u00e2n\u0103 la sever\u0103 (eczem\u0103)<\/strong> \u2014 linia a doua acolo unde steroizii topici sunt nesiguri sau inadecva\u021bi.<\/li>\n<li><strong>Eczem\u0103 palpebral\u0103 \u0219i facial\u0103<\/strong> \u2014 op\u021biunea de prim\u0103 linie care \u00eenlocuie\u0219te steroizii (steroizii pe pleoape cauzeaz\u0103 cataract\u0103 \u0219i glaucom).<\/li>\n<li><strong>Vitiligo<\/strong> \u2014 utilizare off-label, adesea combinat\u0103 cu fototerapie, pentru pete faciale \u0219i intertriginoase.<\/li>\n<li><strong>Rozacee induse de steroizi \/ dermatit\u0103 perioral\u0103<\/strong> \u2014 reducere progresiv\u0103 a dozei de steroizi.<\/li>\n<li><strong>Lichen planus<\/strong> \u2014 inclusiv forme orale \u0219i vulvovaginale.<\/li>\n<li><strong>Lichen sclerosus<\/strong> \u2014 linia a doua dup\u0103 induc\u021bie cu steroizi puternici.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Cum s\u0103 aplica\u021bi<\/h2>\n<ul>\n<li>Sp\u0103la\u021bi m\u00e2inile. Aplica\u021bi un strat sub\u021bire doar pe zona afectat\u0103, de dou\u0103 ori pe zi.<\/li>\n<li>Continua\u021bi p\u00e2n\u0103 la vindecare, apoi \u00eentre\u021binere: aplicare de dou\u0103 ori pe s\u0103pt\u0103m\u00e2n\u0103 pe zonele anterior afectate pentru prevenirea recidivelor.<\/li>\n<li>Adul\u021bi: 0,1%. Copii 2\u201315 ani: 0,03%.<\/li>\n<li>Evita\u021bi pansamentele oclusive, cu excep\u021bia cazurilor \u00een care sunt recomandate.<\/li>\n<li>Utiliza\u021bi zilnic protec\u021bie solar\u0103 cu SPF 30+ spectru larg \u00een timpul terapiei \u2014 tacrolimusul cre\u0219te sensibilitatea la UV.<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:22px 0;border-radius:6px;\">\n<p style=\"margin:0;\"><strong>\u26a0\ufe0f Avertizare FDA black-box<\/strong> \u2014 Tacrolimusul poart\u0103 o avertizare FDA black-box privind un risc teoretic de limfom \u0219i cancer de piele, bazat pe studii pe animale \u0219i rapoarte rare post-marketing. Studiile pe cohorte umane pe termen lung nu au confirmat un risc crescut. Utiliza\u021bi cea mai mic\u0103 frecven\u021b\u0103 eficient\u0103 pentru cea mai scurt\u0103 durat\u0103; evita\u021bi la pacien\u021bii imunocompromi\u0219i; asigura\u021bi protec\u021bie solar\u0103 zilnic\u0103; raporta\u021bi orice leziune cutanat\u0103 persistent\u0103 nou\u0103.<\/p>\n<\/div>\n<h2 class=\"wp-block-heading\">Efecte secundare<\/h2>\n<ul>\n<li><strong>Foarte frecvent (primele 1\u20132 s\u0103pt\u0103m\u00e2ni):<\/strong> senza\u021bie de arsur\u0103, \u00een\u021bep\u0103turi, c\u0103ldur\u0103 la locul de aplicare \u2014 de obicei se atenueaz\u0103 cu utilizarea continu\u0103.<\/li>\n<li><strong>Frecvente:<\/strong> m\u00e2nc\u0103rime u\u0219oar\u0103, eritem, cefalee, intoleran\u021b\u0103 la alcool (ro\u0219ea\u021b\u0103 facial\u0103 chiar \u0219i la cantit\u0103\u021bi mici de alcool).<\/li>\n<li><strong>Mai pu\u021bin frecvente:<\/strong> foliculit\u0103, reactivare herpes simplex.<\/li>\n<li><strong>Rare:<\/strong> fotosensibilitate, alergie de contact.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindica\u021bii<\/h2>\n<ul>\n<li>Copii sub 2 ani.<\/li>\n<li>Infec\u021bii cutanate bacteriene, virale sau fungice active f\u0103r\u0103 tratament concomitent.<\/li>\n<li>Sindromul Netherton \u0219i alte tulbur\u0103ri genetice ale barierii cutanate (absorb\u021bie sistemic\u0103 excesiv\u0103).<\/li>\n<li>Imunosupresie (HIV, transplant, chimioterapie).<\/li>\n<li>Hipersensibilitate cunoscut\u0103 la tacrolimus.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<p>Absorb\u021bia topic\u0103 este sc\u0103zut\u0103, dar evita\u021bi utilizarea concomitent\u0103 a eritromicinei topice \u0219i a altor antibiotice macrolide pe aceea\u0219i zon\u0103 a pielii (efect aditiv). Precau\u021bie cu inhibitorii puternici ai CYP3A4 (claritromicin\u0103, itraconazol, ritonavir) \u2014 de\u0219i nivelurile sistematice sunt de obicei nesemnificative, aplicarea pe suprafe\u021be mari sau pe pielea cu barier\u0103 afectat\u0103 poate cre\u0219te nivelul sistemic de tacrolimus suficient pentru a conta.<\/p>\n<h2 class=\"wp-block-heading\">Depozitare<\/h2>\n<p>P\u0103stra\u021bi sub 25 \u00b0C \u00een tubul original. P\u0103stra\u021bi tubul bine \u00eenchis. Nu refrigera\u021bi.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">De ce arde unguentul Topgraf la prima aplicare?<\/h3>\n<p>Arsura\/\u00een\u021bep\u0103tura ini\u021bial\u0103 la locul de aplicare este cel mai frecvent efect secundar, care apare la ~50% dintre utilizatori \u00een prima s\u0103pt\u0103m\u00e2n\u0103. Se crede c\u0103 se datoreaz\u0103 eliber\u0103rii de substan\u021b\u0103-P \u00een fibrele nervoase cutanate. De obicei, dispare \u00een 7 zile de utilizare continu\u0103. R\u0103cirea cremei \u00een frigider \u00eenainte de aplicare poate ajuta.<\/p>\n<h3 class=\"wp-block-heading\">Este tacrolimusul mai sigur dec\u00e2t steroizii topici pentru utilizarea pe termen lung?<\/h3>\n<p>Da \u2014 tacrolimusul nu provoac\u0103 atrofie cutanat\u0103, telangectazii sau suprresie a axei HPA chiar \u0219i la utilizare prelungit\u0103, ceea ce \u00eel face preferabil pentru \u00eentre\u021binerea pe termen lung \u0219i pentru zonele cu piele sub\u021bire (fa\u021b\u0103, pleoape, pliuri). Compromisul este senza\u021bia ini\u021bial\u0103 de arsur\u0103 \u0219i avertizarea FDA privind riscul teoretic de malignitate.<\/p>\n<h3 class=\"wp-block-heading\">Pot folosi unguentul Topgraf pe fa\u021b\u0103?<\/h3>\n<p>Da \u2014 fa\u021ba, pleoapele \u0219i pliurile sunt exact zonele \u00een care tacrolimusul topic este cel mai util, deoarece steroizii puternici pe aceste zone provoac\u0103 atrofie, rozacee, dermatit\u0103 perioral\u0103, cataract\u0103 \u0219i glaucom. Tacrolimusul este preferat pentru eczemele faciale la adul\u021bi \u0219i copii.<\/p>\n<h3 class=\"wp-block-heading\">De ce trebuie s\u0103 folosesc protec\u021bie solar\u0103 cu tacrolimus?<\/h3>\n<p>Tacrolimusul cre\u0219te sensibilitatea la UV. FDA recomand\u0103 utilizarea zilnic\u0103 a unui produs de protec\u021bie solar\u0103 cu SPF 30+ cu spectru larg \u00een timpul terapiei \u0219i limitarea expunerii la paturile de bronzare \u0219i la soare prelungit.<\/p>\n<h3 class=\"wp-block-heading\">Este avertizarea privind limfomul real\u0103?<\/h3>\n<p>Studiile pe roz\u0103toare au ar\u0103tat limfom la doze sistematice foarte mari (~30\u201350\u00d7 expunerea topic\u0103 uman\u0103). Studiile de cohort\u0103 pe termen lung la oameni (&gt;20 de ani de la lansare) NU au confirmat o cre\u0219tere a ratei de limfom. Avertizarea este o clasificare precau\u021bional\u0103 a FDA \u0219i nu o dovad\u0103 a unui risc semnificativ \u00een utilizarea normal\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Pot consuma alcool \u00een timp ce folosesc unguentul Topgraf?<\/h3>\n<p>Unii utilizatori dezvolt\u0103 ro\u0219ea\u021b\u0103 facial\u0103 \u00een 5 minute dup\u0103 consumul de alcool \u2014 acesta este un efect secundar recunoscut \u0219i dispare la \u00eentreruperea medicamentului. Nu indic\u0103 toxicitate hepatic\u0103.<\/p>\n<h3 class=\"wp-block-heading\">C\u00e2t timp pot folosi unguentul Topgraf?<\/h3>\n<p>Indefinit, dac\u0103 este necesar. Utilizarea de \u00eentre\u021binere (de dou\u0103 ori pe s\u0103pt\u0103m\u00e2n\u0103) pentru dermatita atopic\u0103 este bine stabilit\u0103 pentru prevenirea rec\u0103derilor. Reevalua\u021bi la fiecare 6 luni \u0219i reduce\u021bi doza acolo unde este posibil.<\/p>\n<h3 class=\"wp-block-heading\">Pot s\u0103-l folosesc \u00een timpul sarcinii?<\/h3>\n<p>Date limitate; tacrolimus trece prin placent\u0103. Absorb\u021bia topic\u0103 este minim\u0103, deci riscul este sc\u0103zut, dar utiliza\u021bi doar dac\u0103 beneficiul dep\u0103\u0219e\u0219te clar riscul \u0219i discuta\u021bi cu specialistul dumneavoastr\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Cu ce ar trebui s\u0103-l folosesc \u2014 crem\u0103 hidratant\u0103 \u00eenainte sau dup\u0103?<\/h3>\n<p>Hidrata\u021bi dup\u0103 a\u0219teptarea a 15\u201330 de minute de la aplicarea tacrolimusului. Cremele hidratante ocluzive grele imediat dup\u0103 aplicarea medicamentului pot amplifica absorb\u021bia.<\/p>\n<h3 class=\"wp-block-heading\">Unguentul Topgraf este acela\u0219i lucru cu Protopic?<\/h3>\n<p>Da \u2014 Protopic este marca original\u0103 de unguent cu tacrolimus de la Astellas. Topgraf Ointment este un echivalent generic care con\u021bine acela\u0219i principiu activ \u00een acelea\u0219i concentra\u021bii.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alte Medicamente de \u00cengrijire a Pielii \u0219i Frumuse\u021be<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/melalite-forte-cream\/\"><strong>Melalite Forte Cream \u2014 hidrochinon\u0103 4% pentru melasma<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/retino-a-cream\/\"><strong>Retino-A Cream \u2014 tretinoin\u0103 pentru acnee \u0219i \u00eemb\u0103tr\u00e2nire<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/melacare-cream\/\"><strong>Melacare Cream \u2014 formul\u0103 tripl\u0103 Kligman pentru melasm\u0103<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/permite-cream\/\"><strong>Permite Cream \u2014 permetrin\u0103 5% pentru scabie<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tenovate-cream\/\"><strong>Tenovate Cream \u2014 clobetasol 0,05% pentru inflama\u021bii severe<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:6px;font-size:0.95em;\">\n<p style=\"margin:0;\"><strong>Not\u0103 medical\u0103.<\/strong> Acest con\u021binut ofer\u0103 informa\u021bii generale despre produs \u0219i nu reprezint\u0103 sfat medical sau \u00eenlocuie\u0219te consultul unui medic calificat. Folosi\u021bi orice medicament topic sau oral doar sub supraveghere medical\u0103; utilizarea necorespunz\u0103toare poate provoca daune grave.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u2705 Reduce inflama\u021bia pielii<br \/>\n\u2705 Trateaz\u0103 simptomele eczemei<br \/>\n\u2705 Reduce disconfortul psoriazic<br \/>\n\u2705 Trateaz\u0103 afec\u021biunile de dermatit\u0103<br \/>\n\u2705 Promoveaz\u0103 vindecarea pielii<\/p>","protected":false},"featured_media":54157,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3642,3141,3342],"product_tag":[3677,3678,3679,3680],"class_list":{"0":"post-54156","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-beauty-skin-care","7":"product_cat-category-overview","8":"product_cat-general-health","9":"product_tag-tacrolimus","10":"product_tag-tacrolimus-ointment-0-03","11":"product_tag-topgraf","12":"product_tag-topgraf-ointment","14":"first","15":"outofstock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/54156","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=54156"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/54157"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=54156"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=54156"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=54156"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=54156"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}