{"id":54331,"date":"2023-09-20T09:57:38","date_gmt":"2023-09-20T09:57:38","guid":{"rendered":"https:\/\/medsname.com\/doxolin\/"},"modified":"2026-04-30T10:24:59","modified_gmt":"2026-04-30T10:24:59","slug":"doxolin","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/doxolin\/","title":{"rendered":"Doxolin"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 10px 0;font-size:18px;color:#1a1a1a;\">\u26a1 R\u0103spuns Rapid \u2014 Ce este Doxolin?<\/h3>\n<p><strong>Doxolin<\/strong> con\u021bine <strong>doxofilin\u0103<\/strong>, un <strong>bronhodilatator metilxantinic<\/strong> cu efecte antiinflamatoare, utilizat ca terapie adjunct\u0103 \u00een astmul cronic \u0219i BPOC. Doxofilina este o metilxantin\u0103 mai nou\u0103, cu eficacitate similar\u0103 teofilinei, dar cu un profil de siguran\u021b\u0103 mai bun \u2014 mai pu\u021bine efecte adverse cardiace, gastrointestinale \u0219i ale SNC. Nu este necesar\u0103 monitorizarea regulat\u0103 a nivelului medicamentului. Doza este de 400 mg o dat\u0103 sau de dou\u0103 ori pe zi. Fiecare tablet\u0103 con\u021bine <strong>400 mg<\/strong>, fabricat\u0103 de <strong>Zydus Cadila<\/strong> \u00een fabrici certificate WHO-GMP.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #e0e0e0;padding:12px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;text-align:center;\">\n<strong>\ud83d\udd12 Checkout criptat<\/strong> \u00b7 <strong>\ud83d\udcb3 Procesator Verificat<\/strong> \u00b7 <strong>\ud83d\ude9a Livrare Worldwide<\/strong> \u00b7 <strong>\u2b50 4,9\/5 de la peste 1.400 de clien\u021bi<\/strong>\n<\/div>\n<h2>Ce este Doxolin?<\/h2>\n<p>Doxolin este un bronhodilatator metilxantinic oral. Metilxantinele sunt derivate din alcaloizi naturali (teofilina este dimetilxantina prezent\u0103 \u00een ceai). Utilizarea lor a sc\u0103zut \u00eencep\u00e2nd din anii 1990, odat\u0103 cu apari\u021bia agonilor \u03b22 inhala\u021bi \u0219i a corticosteroidelor ca tratamente de prim\u0103 linie \u2014 dar ele \u00ee\u0219i p\u0103streaz\u0103 rolul ca terapie adi\u021bional\u0103 de a treia linie \u00een astmul sever \u0219i BPOC.<\/p>\n<h2>Cum func\u021bioneaz\u0103 Doxolin?<\/h2>\n<ul>\n<li><strong>Inhibarea fosfodiesterazei (PDE3, PDE4)<\/strong> \u2014 cre\u0219te nivelul de AMP ciclic \u00een mu\u0219chii netezi ai c\u0103ilor respiratorii \u0219i \u00een celulele inflamatorii; rezultatul net este bronhodilata\u021bia \u0219i reducerea eliber\u0103rii de mediatorii.<\/li>\n<li><strong>Antagonismul receptorilor de adenozin\u0103<\/strong> \u2014 blocheaz\u0103 bronhoconstric\u021bia mediat\u0103 de adenozin\u0103 \u0219i eliberarea de mediatorii din celulele mast.<\/li>\n<li><strong>Activarea HDAC2<\/strong> (teofilina la niveluri serice sc\u0103zute 5\u201310 mg\/L) \u2014 restabile\u0219te r\u0103spunsul la corticosteroizi \u00een BPOC \u0219i astmul sever, unde rezisten\u021ba la steroizi este par\u021bial mediat\u0103 de sc\u0103derea HDAC2.<\/li>\n<li><strong>Contractilitatea diafragmatic\u0103<\/strong> \u2014 metilxantinele reduc oboseala diafragmatic\u0103, utile \u00een BPOC cu limitare sever\u0103 a fluxului de aer.<\/li>\n<\/ul>\n<h2>Utiliz\u0103ri \u0219i indica\u021bii<\/h2>\n<ul>\n<li><strong>Astm cronic sever<\/strong> \u2014 ad\u0103ugare la terapie cu doze mari de ICS-LABA acolo unde este necesar\u0103 bronhodilata\u021bie suplimentar\u0103<\/li>\n<li><strong>Men\u021binerea BPOC<\/strong> \u2014 ad\u0103ugare la terapie cu LAMA-LABA sau terapie tripl\u0103<\/li>\n<li><strong>Astm nocturn<\/strong> \u2014 forma de eliberare prelungit\u0103 asigur\u0103 bronhodilata\u021bie pe timpul nop\u021bii<\/li>\n<li><strong>Apnee la prematuri<\/strong> (teofilin\u0103) \u2014 utilizare neonatal\u0103<\/li>\n<li><strong>Pacien\u021bi intoleran\u021bi la teofilin\u0103<\/strong> \u2014 alternativ\u0103 mai bine tolerat\u0103<\/li>\n<\/ul>\n<h2>Doza Doxolin<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Pacient<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Doza<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Frecven\u021b\u0103<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Adul\u021bi \u2014 ini\u021bial<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>200 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">De trei ori pe zi \u2014 primele 7 zile<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Adul\u021bi \u2014 \u00eentre\u021binere<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>400 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">O dat\u0103 sau de dou\u0103 ori pe zi<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">V\u00e2rstnici \/ boli hepatice<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u00cenjum\u0103t\u0103\u021bi\u021bi doza<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">O dat\u0103 sau de dou\u0103 ori pe zi<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Efecte secundare Doxolin<\/h2>\n<ul>\n<li>Grea\u021b\u0103, v\u0103rs\u0103turi, dispepsie<\/li>\n<li>Dureri de cap<\/li>\n<li>Tremur<\/li>\n<li>Insomnie, agita\u021bie<\/li>\n<li>Palpita\u021bii u\u0219oare (mai pu\u021bin pronun\u021bate dec\u00e2t teofilina)<\/li>\n<li>Hipokaliemie u\u0219oar\u0103 la doze mari<\/li>\n<\/ul>\n<p><strong>Severe \u2014 \u00eentrerupe\u021bi \u0219i c\u0103uta\u021bi ajutor medical:<\/strong><\/p>\n<ul>\n<li>Palpita\u021bii severe sau aritmie<\/li>\n<li>V\u0103rs\u0103turi persistente<\/li>\n<li>Reac\u021bie alergic\u0103 sever\u0103<\/li>\n<\/ul>\n<h2>Avertismente \u0219i precau\u021bii<\/h2>\n<ul>\n<li><strong>Nu este necesar monitorizarea rutin\u0103 a nivelului sanguin<\/strong> \u2014 marj\u0103 de siguran\u021b\u0103 mai larg\u0103 dec\u00e2t teofilina.<\/li>\n<li><strong>Multe interac\u021biuni medicamentoase<\/strong> \u2014 consulta\u021bi tabelul de interac\u021biuni. Majoritatea sunt metabolizate de CYP1A2; numero\u0219i inhibitori \u0219i inductori modific\u0103 semnificativ nivelurile.<\/li>\n<li><strong>Fumatul<\/strong> induce CYP1A2 \u0219i reduce nivelurile de teofilin\u0103 cu ~50% \u2014 retitra\u021bi la \u00eencetarea fumatului.<\/li>\n<li><strong>Boal\u0103 cardiac\u0103:<\/strong> utiliza\u021bi cu precau\u021bie \u00een aritmii, insuficien\u021b\u0103 cardiac\u0103, hipertensiune sever\u0103.<\/li>\n<li><strong>Hipertiroidism:<\/strong> clearance crescut plus efecte adrenergice exagerate.<\/li>\n<li><strong>Sarcin\u0103 \u0219i al\u0103ptare:<\/strong> de obicei evitat; utiliza\u021bi doar dac\u0103 beneficiul este clar.<\/li>\n<li><strong>Boal\u0103 hepatic\u0103:<\/strong> reduce\u021bi doza \u2014 metilxantinele sunt metabolizate hepatic.<\/li>\n<\/ul>\n<h2>Contraindica\u021bii<\/h2>\n<ul>\n<li>Hipersensibilitate la doxofilin\u0103 sau alte xantine (cafein\u0103, teobromin\u0103)<\/li>\n<li>Boal\u0103 ulceroas\u0103 peptic\u0103 activ\u0103<\/li>\n<li>Tahiartmii necontrolate<\/li>\n<li>Insuficien\u021b\u0103 cardiac\u0103 sever\u0103 (NYHA IV)<\/li>\n<\/ul>\n<h2>Interac\u021biuni medicamentoase<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Medicament interactiv<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Efect<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Ce s\u0103 face\u021bi<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Ciprofloxacin\u0103, eritromicin\u0103, claritromicin\u0103, fluvoxamin\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Inhib\u0103 CYP1A2 \u2192 cre\u0219te nivelul teofilinei \u2192 toxicitate (grea\u021b\u0103, aritmii, convulsii)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Evita\u021bi sau reduce\u021bi doza de teofilin\u0103 cu 50%; verifica\u021bi nivelul seric<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Cimetidin\u0103, alopurinol<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Cre\u0219te nivelul teofilinei<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce\u021bi doza; monitoriza\u021bi nivelurile<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Fenitoin\u0103, carbamazepin\u0103, rifampicin\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Induc CYP \u2014 niveluri mai sc\u0103zute<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Poate fi necesar\u0103 o doz\u0103 mai mare<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Fumatul<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Induce CYP1A2 \u2014 niveluri mai sc\u0103zute<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Re-titra\u021bi doza la renun\u021barea la fumat<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03b2-agoni\u0219ti, diuretice<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Hipokaliemie aditiv\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitorizare potasiu<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Depozitare<\/h2>\n<ul>\n<li>Depozita\u021bi la temperaturi sub <strong>25\u00b0C<\/strong> \u00eentr-un loc r\u0103coros \u0219i uscat, departe de lumina direct\u0103 a soarelui.<\/li>\n<li>P\u0103stra\u021bi \u00een ambalajul original p\u00e2n\u0103 la utilizare pentru a proteja de umiditate \u0219i lumin\u0103.<\/li>\n<li>Nu utiliza\u021bi dup\u0103 data de expirare tip\u0103rit\u0103 pe blister.<\/li>\n<li>P\u0103stra\u021bi la distan\u021b\u0103 de copii.<\/li>\n<\/ul>\n<h2>Alternative conexe pe MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/asthalin-inhaler\/\"><strong>Asthalin Inhaler \u2014 salbutamol pentru ameliorarea simptomelor<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/budecort-inhaler\/\"><strong>Budecort Inhaler \u2014 budesonide ICS pentru preven\u021bie<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/foracort-inhaler\/\"><strong>Foracort Inhaler \u2014 budesonide + formoterol ICS-LABA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tiova-inhaler\/\"><strong>Tiova Inhaler \u2014 tiotropium LAMA pentru BPOC<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/montair\/\"><strong>Montair \u2014 comprimat montelukast LTRA<\/strong><\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>Cum difer\u0103 doxofilina de teofilin\u0103?<\/h3>\n<p>Doxofilina este o metilxantin\u0103 mai nou\u0103 (introdus\u0103 \u00een anii 1990) cu eficacitate bronhodilatatoare similar\u0103 \u0219i un profil de siguran\u021b\u0103 mai larg. Efectele secundare cardiace, gastrointestinale \u0219i ale sistemului nervos central sunt mai pu\u021bin frecvente; nu este necesar\u0103 monitorizarea nivelurilor sanguine; \u0219i are mai pu\u021bine interac\u021biuni medicamentoase.<\/p>\n<h3>De ce s\u0103 prefera\u021bi doxofilina \u00een loc de teofilin\u0103?<\/h3>\n<p>Tolerabilitate mai bun\u0103, dozare mai simpl\u0103 (f\u0103r\u0103 monitorizare a nivelurilor), mai pu\u021bine interac\u021biuni. Deosebit de util\u0103 la pacien\u021bii \u00een v\u00e2rst\u0103 \u0219i la cei care nu au tolerat teofilina.<\/p>\n<h3>C\u00e2t de repede ac\u021bioneaz\u0103 Doxolin?<\/h3>\n<p>Bronhodilatarea \u00eencepe \u00een decurs de 1 or\u0103; efectul complet se ob\u021bine \u00een c\u00e2teva zile.<\/p>\n<h3>Este Doxolin un medicament de salvare?<\/h3>\n<p>Nu \u2014 este un medicament de control. P\u0103stra\u021bi un SABA (Asthalin, Levolin) pentru crize acute.<\/p>\n<h3>Pot lua Doxolin \u00eempreun\u0103 cu ICS-ul meu?<\/h3>\n<p>Da \u2014 doxofilina este de obicei ad\u0103ugat\u0103 pe l\u00e2ng\u0103 ICS sau ICS-LABA atunci c\u00e2nd este necesar\u0103 bronhodilatare suplimentar\u0103.<\/p>\n<h3>Care sunt efectele secundare comune?<\/h3>\n<p>Grea\u021b\u0103, cefalee u\u0219oar\u0103, tremur, insomnie. \u00cen general, efectele sunt mai pu\u021bin intense dec\u00e2t \u00een cazul teofilinei la bronhodilata\u021bie echivalent\u0103.<\/p>\n<h3>Este Doxolin sigur \u00een timpul sarcinii?<\/h3>\n<p>Date limitate; terapia prin inhalare este preferat\u0103.<\/p>\n<h3>Copiii pot lua Doxolin?<\/h3>\n<p>Utiliza\u021bi cu precau\u021bie; se recomand\u0103 supraveghere specializat\u0103 \u00een cazul utiliz\u0103rii la copii.<\/p>\n<h3>Cum se compar\u0103 Doxolin cu roflumilast (Rofaday)?<\/h3>\n<p>Ambele sunt agen\u021bi orali din clasa non-bronhodilatatoare cu efecte antiinflamatorii. Roflumilast este specific pentru BPOC sever\u0103 cu bron\u0219it\u0103 cronic\u0103. Doxofilina are o utilizare mai larg\u0103 \u00een astm \u0219i BPOC ca bronhodilatator adjunct.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Avertizare medical\u0103:<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical profesionist. Consult\u0103 \u00eentotdeauna un profesionist calificat \u00een s\u0103n\u0103tate \u00eenainte de a \u00eencepe, \u00eentrerupe sau schimba orice inhalator sau medicament respirator, mai ales dac\u0103 ai alte afec\u021biuni medicale, iei alte re\u021bete, e\u0219ti gravid\u0103 sau al\u0103ptezi, sau ai peste 65 de ani.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alternative conexe<\/h3>\n<p>Alte produse din <strong>Afec\u021biuni cronice<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/asthalin-syrup\/\">Sirop Asthalin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/topme-xl\/\">Topme XL<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/bencid\/\">Bencid<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/dynapar\/\">Dynapar<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/decdan\/\">Decdan<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<h5>\u2705 Managementul simptomelor astmului<br \/>\n\u2705 Format convenabil de tablet\u0103<br \/>\n\u2705 Administrare u\u0219oar\u0103<br \/>\n\u2705 Confort respirator sporit<\/h5>\n<p><span style=\"color: #999999;\">Con\u021bine Doxofilin\u0103<\/span><\/p>","protected":false},"featured_media":54332,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3681,3141,3223],"product_tag":[3713],"class_list":{"0":"post-54331","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-asthma-copd-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-doxofylline","11":"first","12":"instock","13":"shipping-taxable","14":"purchasable","15":"product-type-variable","16":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/54331","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=54331"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/54332"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=54331"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=54331"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=54331"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=54331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}