{"id":54618,"date":"2023-09-20T10:00:58","date_gmt":"2023-09-20T10:00:58","guid":{"rendered":"https:\/\/medsname.com\/pirfenex\/"},"modified":"2026-04-30T10:24:55","modified_gmt":"2026-04-30T10:24:55","slug":"pirfenex","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/pirfenex\/","title":{"rendered":"Pirfenex"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 10px 0;font-size:18px;color:#1a1a1a;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Pirfenex?<\/h3>\n<p><strong>Pirfenex<\/strong> con\u021bine <strong>pirfenidone<\/strong>, un antifibrotic oral utilizat pentru <strong>fibroz\u0103 pulmonar\u0103 idiopatic\u0103 (IPF)<\/strong> \u2014 o boal\u0103 pulmonar\u0103 progresiv\u0103 cu cicatrizare. Pirfenidone reduce rata de declin a func\u021biei pulmonare (FVC) \u0219i poate \u00eembun\u0103t\u0103\u021bi supravie\u021buirea \u00een IPF, \u00eencetinind progresia bolii. Se administreaz\u0103 de trei ori pe zi \u00een timpul meselor pentru a minimiza efectele secundare gastrointestinale, cu o escaladare planificat\u0103 a dozei pe parcursul a 14 zile. Fabricat de <strong>Cipla<\/strong> \u00een unit\u0103\u021bi certificate WHO-GMP. Acela\u0219i principiu activ ca \u0219i marca interna\u021bional\u0103 <strong>Esbriet<\/strong> (Roche).<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #e0e0e0;padding:12px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;text-align:center;\">\n<strong>\ud83d\udd12 Checkout criptat<\/strong> \u00b7 <strong>\ud83d\udcb3 Procesator Verificat<\/strong> \u00b7 <strong>\ud83d\ude9a Livrare Worldwide<\/strong> \u00b7 <strong>\u2b50 4,9\/5 de la peste 1.400 de clien\u021bi<\/strong>\n<\/div>\n<h2>Ce este Pirfenex?<\/h2>\n<p>Pirfenex este un derivat de piridon antifibrotic\/antiinflamator oral. Pirfenidone este unul dintre cele dou\u0103 medicamente autorizate pentru IPF (cel\u0103lalt este nintedanib\/Ofev). Ambele \u00eencetinesc progresia bolii, dar nu vindec\u0103 sau inverseaz\u0103 fibroza. Pirfenidone este utilizat off-label \u0219i pentru alte boli pulmonare intersti\u021biale cu fenotipuri fibrotice.<\/p>\n<h2>Cum func\u021bioneaz\u0103 Pirfenex?<\/h2>\n<p>Pirfenidone are multiple mecanisme relevante pentru fibroza pulmonar\u0103:<\/p>\n<ul>\n<li><strong>Reduce proliferarea fibroblastelor indus\u0103 de TGF-\u03b2<\/strong> \u0219i sinteza de colagen<\/li>\n<li><strong>Suprim\u0103 TNF-\u03b1 \u0219i IL-1\u03b2<\/strong> semnalizare inflamatorie<\/li>\n<li><strong>Inhib\u0103 tranzi\u021bia epitelial-mezenchimatic\u0103<\/strong> (EMT) \u2014 un factor cheie \u00een fibroz\u0103<\/li>\n<li><strong>Reduce stresul oxidativ<\/strong> prin captarea radicalilor liberi<\/li>\n<\/ul>\n<p>Beneficiul clinic (studiiile CAPACITY, ASCEND) este o reducere cu 50% a ratei de declin a func\u021biei pulmonare pe parcursul a 12 luni. Unele meta-analize arat\u0103 beneficii de supravie\u021buire.<\/p>\n<h2>Utiliz\u0103ri \u0219i indica\u021bii<\/h2>\n<ul>\n<li><strong>Fibroz\u0103 pulmonar\u0103 idiopatic\u0103 (IPF)<\/strong> \u2014 terapie de prim\u0103 linie pentru \u00eencetinirea progresiei, al\u0103turi de nintedanib<\/li>\n<li><strong>Alte fibroze pulmonare progresive<\/strong> (boal\u0103 pulmonar\u0103 intersti\u021bial\u0103 cu fenotip fibrotic) \u2014 utilizare off-label<\/li>\n<li><strong>Fibroz\u0103 pulmonar\u0103 post-COVID-19<\/strong> \u2014 cercet\u0103ri \u00een curs de dezvoltare<\/li>\n<\/ul>\n<h2>Doza Pirfenex<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Faz\u0103<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Doza<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Frecven\u021b\u0103<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Zilele 1\u20137 (titrare)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>200 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">De trei ori pe zi \u00een timpul mesei<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Zilele 8\u201314 (titrare)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>400 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">De trei ori pe zi \u00een timpul mesei<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Ziua 15+ (mentenan\u021b\u0103)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>600 mg (3 \u00d7 200 mg)<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">De trei ori pe zi \u00een timpul mesei<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Afectare hepatic\u0103\/renal\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce\u021bi doza cu 50%<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">De trei ori pe zi<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Efecte secundare ale Pirfenex<\/h2>\n<ul>\n<li>Grea\u021b\u0103, dispepsie, anorexie (cele mai frecvente \u2014 administrarea dup\u0103 o mas\u0103 complet\u0103 ajut\u0103)<\/li>\n<li>Eruptie fotosensibil\u0103 (evita\u021bi expunerea la soare; SPF 50+ zilnic)<\/li>\n<li>Oboseal\u0103<\/li>\n<li>Ame\u021beli, cefalee<\/li>\n<li>Diaree<\/li>\n<li>Cre\u0219tere u\u0219oar\u0103 a enzimelor hepatice<\/li>\n<\/ul>\n<p><strong>Severe \u2014 \u00eentrerupe\u021bi \u0219i c\u0103uta\u021bi ajutor medical:<\/strong><\/p>\n<ul>\n<li>Eruptie sever\u0103, \u00een special fotodistribuit\u0103<\/li>\n<li>Hepatit\u0103 (icter, urin\u0103 \u00eenchis\u0103 la culoare, scaune decolorate, durere \u00een cadranul superior drept)<\/li>\n<li>Pierdere semnificativ\u0103 \u00een greutate (&gt;5%)<\/li>\n<li>V\u0103rs\u0103turi severe persistente<\/li>\n<\/ul>\n<h2>Avertismente \u0219i precau\u021bii<\/h2>\n<ul>\n<li><strong>Fotosensibilitate:<\/strong> evita\u021bi expunerea prelungit\u0103 la soare; purta\u021bi zilnic protec\u021bie solar\u0103 cu SPF 50+ cu spectru larg.<\/li>\n<li><strong>Monitorizarea func\u021biei hepatice:<\/strong> teste hepatice ini\u021biale, apoi lunar timp de 6 luni, ulterior la fiecare 3 luni.<\/li>\n<li><strong>Administra\u021bi \u00een timpul meselor complete<\/strong> pentru a reduce efectele adverse gastrointestinale \u0219i pentru a \u00eencetini absorb\u021bia (ceea ce reduce greata).<\/li>\n<li><strong>Fumatul<\/strong> reduce expunerea la pirfenidon cu ~50% \u2014 se recomand\u0103 ferm \u00eencetarea fumatului.<\/li>\n<li><strong>Inhibitori CYP1A2<\/strong> (fluvoxamina, ciprofloxacin) cresc semnificativ nivelurile \u2014 evita\u021bi sau reduce\u021bi doza.<\/li>\n<li><strong>Sarcin\u0103 \u0219i al\u0103ptare:<\/strong> contraindicated.<\/li>\n<\/ul>\n<h2>Contraindica\u021bii<\/h2>\n<ul>\n<li>Hipersensibilitate la pirfenidon<\/li>\n<li>Afectare hepatic\u0103 sever\u0103 (Child-Pugh C)<\/li>\n<li>Boal\u0103 renal\u0103 \u00een stadiu terminal (CrCl &lt;30 ml\/min) la dializ\u0103<\/li>\n<li>Administrare concomitent\u0103 cu fluvoxamin\u0103<\/li>\n<li>Sarcin\u0103<\/li>\n<\/ul>\n<h2>Interac\u021biuni medicamentoase<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Medicament interactiv<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Efect<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Ce s\u0103 face\u021bi<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Fluvoxamina (inhibitor puternic CYP1A2)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">cre\u0219tere de 4\u00d7 a nivelurilor de pirfenidon\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Contraindica\u021bii<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Ciprofloxacin\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">cre\u0219tere de 60% a nivelurilor de pirfenidon\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Evita\u021bi sau \u00eenjum\u0103t\u0103\u021bi\u021bi doza de pirfenidon\u0103<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Fumatul (induce CYP1A2)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">reducere de ~50% a nivelurilor<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Se recomand\u0103 ferm renun\u021barea la fumat<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Inductori puternici ai CYP1A2 (rifampicin\u0103)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduc semnificativ nivelurile<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Evita\u021bi<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Depozitare<\/h2>\n<ul>\n<li>Depozita\u021bi la temperaturi sub <strong>25\u00b0C<\/strong> \u00eentr-un loc r\u0103coros \u0219i uscat, departe de lumina direct\u0103 a soarelui.<\/li>\n<li>P\u0103stra\u021bi \u00een ambalajul original p\u00e2n\u0103 la utilizare pentru a proteja de umiditate \u0219i lumin\u0103.<\/li>\n<li>Nu utiliza\u021bi dup\u0103 data de expirare tip\u0103rit\u0103 pe blister.<\/li>\n<li>P\u0103stra\u021bi la distan\u021b\u0103 de copii.<\/li>\n<\/ul>\n<h2>Alternative conexe pe MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/budecort-inhaler\/\"><strong>Budecort Inhalator \u2014 budesonid\u0103 ICS pentru boli pulmonare cronice<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tiova-inhaler\/\"><strong>Tiova Inhalator \u2014 tiotropiu pentru boli pulmonare cronice<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/unicontin-e\/\"><strong>Unicontin-E \u2014 teofilin\u0103 cu eliberare prelungit\u0103 pentru boli pulmonare severe<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/mucinac-effervescent\/\"><strong>Mucinac Effervescent \u2014 N-acetilcistein\u0103 cu efect antioxidant<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/rofaday\/\"><strong>Rofaday \u2014 roflumilast pentru BPOC sever\u0103<\/strong><\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>Pirfenidonul \u00eemi va vindeca fibroza pulmonar\u0103 idiopatic\u0103?<\/h3>\n<p>Nu \u2014 pirfenidonul \u00eencetine\u0219te progresia bolii, dar nu vindec\u0103 sau inverseaz\u0103 fibroza pulmonar\u0103. Majoritatea pacien\u021bilor \u00eenregistreaz\u0103 o sc\u0103dere lent\u0103 continu\u0103 a func\u021biei pulmonare; un grup mai mic prezint\u0103 boala stabil\u0103 timp de ani.<\/p>\n<h3>C\u00e2t de repede ac\u021bioneaz\u0103?<\/h3>\n<p>Reducerea ratei de declin a CVF este m\u0103surabil\u0103 la 6\u201312 luni \u00een studii. Beneficiul simptomatic este mai greu de perceput \u2014 scopul este prevenirea agrav\u0103rii.<\/p>\n<h3>De ce trebuie s\u0103 iau medicamentul de trei ori pe zi?<\/h3>\n<p>Pirfenidonul are o perioad\u0103 de \u00eenjum\u0103t\u0103\u021bire scurt\u0103 (~3 ore). Administrarea de trei ori pe zi men\u021bine niveluri constante \u00een \u021besut. Lua\u021bi \u00eentotdeauna cu m\u00e2ncare pentru a minimiza gre\u021burile.<\/p>\n<h3>De ce apare erup\u021bia cutanat\u0103?<\/h3>\n<p>Pirfenidonul are efect fotosensibilizant \u2014 expunerea la UV poate provoca reac\u021bii asem\u0103n\u0103toare arsurilor solare pe pielea expus\u0103. Utilizarea zilnic\u0103 a unui ecran solar cu SPF 50+ cu spectru larg, \u00eembr\u0103c\u0103minte protectoare \u0219i evitarea orelor de v\u00e2rf ale UV previne \u00een mare m\u0103sur\u0103 acest efect.<\/p>\n<h3>Pot lua pirfenidon cu nintedanib (Ofev)?<\/h3>\n<p>Terapia combinat\u0103 este \u00een studiu (pilotul INJOURNEY). Combinarea de rutin\u0103 nu este \u00eenc\u0103 standard \u00een afara studiilor clinice. Discuta\u021bi cu specialistul dumneavoastr\u0103.<\/p>\n<h3>De ce trebuie s\u0103 monitorizez testele hepatice?<\/h3>\n<p>Aproximativ 4% dintre pacien\u021bi au prezentat cre\u0219teri ale enzimelor hepatice \u00een studii. Testele hepatice lunare \u00een primele 6 luni identific\u0103 acest efect devreme \u2014 reducerea dozei sau \u00eentreruperea temporar\u0103 o rezolv\u0103 de obicei.<\/p>\n<h3>Pot consuma alcool \u00een timp ce iau pirfenidon?<\/h3>\n<p>Alcoolul poate amplifica greata \u0219i poate suprasolicita ficatul. Consumul moderat de alcool poate fi acceptabil; consumul excesiv nu este recomandat.<\/p>\n<h3>C\u00e2t timp trebuie s\u0103 iau pirfenidon?<\/h3>\n<p>Indefinit, at\u00e2ta timp c\u00e2t \u00eel tolera\u021bi \u0219i boala nu a progresat p\u00e2n\u0103 \u00een stadiul terminal. \u00centreruperea tratamentului duce la reluarea declinului accelerat al func\u021biei pulmonare.<\/p>\n<h3>Ce fac dac\u0103 uit o doz\u0103?<\/h3>\n<p>Lua\u021bi-l c\u00e2t mai cur\u00e2nd posibil dac\u0103 v\u0103 aminti\u021bi, cu excep\u021bia cazului \u00een care urmeaz\u0103 urm\u0103toarea doz\u0103. Nu lua\u021bi niciodat\u0103 o dobl\u0103 doz\u0103.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Avertizare medical\u0103:<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical profesionist. Consult\u0103 \u00eentotdeauna un profesionist calificat \u00een s\u0103n\u0103tate \u00eenainte de a \u00eencepe, \u00eentrerupe sau schimba orice inhalator sau medicament respirator, mai ales dac\u0103 ai alte afec\u021biuni medicale, iei alte re\u021bete, e\u0219ti gravid\u0103 sau al\u0103ptezi, sau ai peste 65 de ani.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alternative conexe<\/h3>\n<p>Alte produse din <strong>Afec\u021biuni cronice<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/angiotensin\/\">Angiotensin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/nebicard\/\">Nebicard<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/azoran\/\">Azoran<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/entavir\/\">Entavir<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/hydrocort-100-injection\/\">Injectie Hydrocort 100<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<h5>\u2705 Trateaz\u0103 fibroza pulmonar\u0103 idiopatic\u0103<br \/>\n\u2705 \u00cencetine\u0219te progresia bolii<br \/>\n\u2705 Sus\u021bine s\u0103n\u0103tatea pulmonar\u0103<br \/>\n\u2705 Format convenabil de tablet\u0103<\/h5>\n<p><span style=\"color: #999999;\">con\u021bine Pirfenidone<\/span><\/p>","protected":false},"featured_media":54619,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3681,3141,3223],"product_tag":[3761],"class_list":{"0":"post-54618","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-asthma-copd-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-pirfenidone","11":"first","12":"instock","13":"shipping-taxable","14":"purchasable","15":"product-type-variable","16":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/54618","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=54618"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/54619"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=54618"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=54618"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=54618"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=54618"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}