{"id":54779,"date":"2023-09-20T10:03:48","date_gmt":"2023-09-20T10:03:48","guid":{"rendered":"https:\/\/medsname.com\/granicip\/"},"modified":"2026-04-30T10:24:53","modified_gmt":"2026-04-30T10:24:53","slug":"granicip","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/granicip\/","title":{"rendered":"Granicip"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Granicip?<\/h3>\n<p style=\"margin:0;\"><strong>Granicip<\/strong> con\u021bine <strong>granisetron 1 mg \/ 2 mg<\/strong>, un <strong>antagonist al receptorului 5-HT3 de genera\u021bia a doua<\/strong> \u00een aceea\u0219i clas\u0103 cu ondansetronul, dar cu o semivie\u021b\u0103 mai lung\u0103 (~9 ore vs 4 ore). Este utilizat pentru a preveni <strong>indus\u0103 de chimioterapie<\/strong>, <strong>indus\u0103 de radioterapie<\/strong>, \u0219i <strong>greata \u0219i voma postoperatorie<\/strong>. Semivia\u021ba mai lung\u0103 \u00eenseamn\u0103 acoperire oral\u0103 o dat\u0103 pe zi sau doz\u0103 unic\u0103 IV pentru chimioterapia moderat emetogen\u0103. Fabricat de Cipla conform standardelor WHO-GMP.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>De ce s\u0103 comanzi de la MedsBase:<\/strong> \u2714 <strong>produc\u0103tor certificat WHO-GMP<\/strong> \u2714 Ambalaj discret \u2714 Livrare worldwide \u2714 <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">Recenzii verificate ale clien\u021bilor (peste 1.400 de clien\u021bi)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>\u26a0\ufe0f Efect de clas\u0103 de prelungire a intervalului QT.<\/strong> Granisetronul, la fel ca ondansetronul, provoac\u0103 o prelungire u\u0219oar\u0103 a intervalului QT dependent\u0103 de doz\u0103. Evita\u021bi \u00een cazul QT lung congenital, hipokaliemie, hipomagnezemie sau cu alte medicamente care prelungesc QT (azitromicin\u0103, citalopram, metadon\u0103, antipsihotice). Semnalul cardiac este mai mic dec\u00e2t la ondansetron, iar palonosetronul este \u0219i mai sigur, dar un ECG de baz\u0103 este rezonabil la pacien\u021bii cu risc mai mare.<\/div>\n<h2 class=\"wp-block-heading\">Granisetron vs ondansetron \u2014 c\u00e2nd s\u0103 alegi granisetron<\/h2>\n<p>Ambele molecule blocheaz\u0103 receptorul 5-HT3 \u0219i au o eficacitate maxim\u0103 similar\u0103. Diferen\u021bele semnificative din punct de vedere clinic:<\/p>\n<ul>\n<li><strong>Timp de \u00eenjum\u0103t\u0103\u021bire:<\/strong> granisetron ~9 h, ondansetron ~4 h. O singur\u0103 doz\u0103 de granisetron acoper\u0103 mai bine o zi de chimioterapie de 24 de ore.<\/li>\n<li><strong>Semnal QT:<\/strong> ondansetron are cel mai semnificativ semnal cardiac (limita FDA de doz\u0103 de 16 mg IV); granisetronul este intermediar; palonosetronul este cel mai sigur.<\/li>\n<li><strong>Frecven\u021ba de administrare:<\/strong> granisetronul se administreaz\u0103 de obicei o dat\u0103 pe zi pe cale oral\u0103 sau o singur\u0103 dat\u0103 IV; ondansetronul se administreaz\u0103 la fiecare 8 ore.<\/li>\n<li><strong>Constipa\u021bie:<\/strong> similar\u0103 \u00eentre cele dou\u0103, dar pu\u021bin mai rar\u0103 cu granisetron.<\/li>\n<li><strong>Cost:<\/strong> ondansetronul este mai ieftin \u0219i mai larg disponibil; granisetronul este preferat atunci c\u00e2nd administrarea o dat\u0103 pe zi simplific\u0103 conformitatea.<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\">De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Granicip este furnizat de la <strong>produc\u0103tor certificat WHO-GMP<\/strong>. Fiecare comand\u0103 este expediat\u0103 discret \u00een \u00eentreaga lume \u0219i este acoperit\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> \u2014 dac\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, retrimitem f\u0103r\u0103 costuri suplimentare. Granisetronul este antagonistul 5-HT3 de administrare o dat\u0103 pe zi de alegere atunci c\u00e2nd respectarea unui program cu multiple doze este o problem\u0103 \u0219i este o alternativ\u0103 util\u0103 pentru pacien\u021bii care tolereaz\u0103 ondansetronul slab.<\/p>\n<h2 class=\"wp-block-heading\">Mecanism de ac\u021biune<\/h2>\n<p>Granisetronul este un antagonist foarte selectiv al receptorului de serotonin\u0103 5-HT3 pe aferentele vagale (periferice) \u0219i pe zona de declan\u0219are a chemoreceptorilor din area postrema (central\u0103). Chimioterapia \u0219i radia\u021biile determin\u0103 celulele enterocromafine din intestin s\u0103 elibereze serotonin\u0103, care altfel ar provoca v\u0103rs\u0103turi prin centrul medular al v\u0103rs\u0103turilor. Prin blocarea receptorului 5-HT3, granisetronul \u00eentrerupe acest semnal at\u00e2t la nivel periferic, c\u00e2t \u0219i central. Nu se leag\u0103 de receptorii D2, H1, muscarinici sau adrenergici alfa \u2014 de unde lipsa sed\u0103rii, a reac\u021biilor extrapiramidale \u0219i a efectelor secundare anticolinergice.<\/p>\n<h2 class=\"wp-block-heading\">Indica\u021bii<\/h2>\n<ul>\n<li><strong>CINV (indus\u0103 de chimioterapie):<\/strong> chimioterapie moderat \u0219i puternic emetogen\u0103 \u2014 de obicei combinat\u0103 cu dexametazon\u0103 \u00b1 un antagonist NK1 (aprepitant) pentru regimuri puternic emetogene.<\/li>\n<li><strong>Grea\u021b\u0103 indus\u0103 de radioterapie:<\/strong> iradiere total\u0103 a corpului, radioterapie abdominal\u0103 la doze mari.<\/li>\n<li><strong>Grea\u021b\u0103 \u0219i v\u0103rs\u0103turi postoperatorii (PONV):<\/strong> doz\u0103 unic\u0103 IV la induc\u021bie sau la sf\u00e2r\u0219itul interven\u021biei chirurgicale.<\/li>\n<li><strong>Grea\u021b\u0103 refractar\u0103 la chimioterapie:<\/strong> dup\u0103 e\u0219ecul ondansetronului (toleran\u021ba \u00eencruci\u0219at\u0103 este incomplet\u0103 \u2014 schimbarea poate salva unii pacien\u021bi).<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Doza<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;\">Indica\u021bie<\/th>\n<th style=\"padding:8px;text-align:left;\">Doza<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">CINV (oral, adul\u021bi)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">2 mg PO cu 1 or\u0103 \u00eenainte de chimioterapie, apoi 2 mg zilnic timp de p\u00e2n\u0103 la 5 zile (sau 1 mg de dou\u0103 ori pe zi)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">CINV (IV)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">10 mcg\/kg (sau doz\u0103 fix\u0103 de 1 mg) IV cu 30 de minute \u00eenainte de chimioterapie<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">PONV<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">1 mg IV la induc\u021bie sau la sf\u00e2r\u0219itul interven\u021biei chirurgicale (doz\u0103 unic\u0103)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Pediatric (CINV)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">10\u201340 mcg\/kg IV (max 3 mg pe doz\u0103); sub supraveghere specializat\u0103<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Afectare renal\u0103\/hepatic\u0103<\/td>\n<td style=\"padding:8px;\">Nu este necesar\u0103 reducerea de rutin\u0103 a dozei; disfunc\u021bia hepatic\u0103 sever\u0103 poate prelungi eliminarea<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Efecte secundare<\/h2>\n<ul>\n<li><strong>Foarte frecvente:<\/strong> cefalee (~14\u201321%), constipa\u021bie (~3\u20139%)<\/li>\n<li><strong>Frecvente:<\/strong> ame\u021beal\u0103, oboseal\u0103, astenie, cre\u0219tere tranzitorie a AST\/ALT, insomnie, tulburare u\u0219oar\u0103 a gustului<\/li>\n<li><strong>Mai pu\u021bin frecvente:<\/strong> hipertensiune, hipotensiune, durere abdominal\u0103, erup\u021bie cutanat\u0103<\/li>\n<li><strong>Rare dar grave:<\/strong> prelungire QT\/torsade de pointes, sindrom serotoninergic (cu SSRIs\/triptane), hipersensibilitate sever\u0103<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>Medicamente care prelunge\u0219te intervalul QT:<\/strong> evita\u021bi utilizarea concomitent\u0103 cu azitromicin\u0103, fluoroquinolone, citalopram, metadon\u0103, antipsihotice (\u00een special la pacien\u021bii cu tulbur\u0103ri electrolitice).<\/li>\n<li><strong>Medicamente serotoninergice<\/strong> (SSRI, SNRI, IMAO, triptane, tramadol, fentanil, linezolid): sindrom serotoninergic raportat rar.<\/li>\n<li><strong>Inductori puternici ai CYP3A4<\/strong> (rifampicin\u0103, fenitoin\u0103, carbamazepin\u0103, iarba Sf\u00e2ntului Ioan): pot reduce nivelurile de granisetron.<\/li>\n<li><strong>Inhibitori puternici ai CYP3A4<\/strong> (ketoconazol, ritonavir, claritromicin\u0103): pot cre\u0219te u\u0219or nivelurile \u2014 impactul clinic este mic.<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">Cum difer\u0103 Granicip de Ondem (ondansetron)?<\/h3>\n<p>Ambele sunt antagoni\u0219ti 5-HT3, dar granisetronul are o semivia\u021b\u0103 mai lung\u0103 (~9 h vs ~4 h), astfel \u00eenc\u00e2t o singur\u0103 doz\u0103 oral\u0103 acoper\u0103 o zi de chimioterapie. Ondansetronul necesit\u0103 administrare la fiecare 8 ore. Ondansetronul are un semnal QT u\u0219or mai ridicat \u0219i o limit\u0103 FDA de 16 mg IV pe doz\u0103. Pentru grea\u021b\u0103 necomplicat\u0103, ondansetronul este mai ieftin; pentru adheren\u021ba \u00een ziua chimioterapiei, granisetronul simplific\u0103 programul.<\/p>\n<h3 class=\"wp-block-heading\">C\u00e2nd \u00eencepe s\u0103 ac\u021bioneze Granicip?<\/h3>\n<p>Ac\u021biunea \u00eencepe \u00een 30\u201360 de minute dup\u0103 administrare oral\u0103 \u0219i \u00een 5\u201310 minute dup\u0103 administrare intravenoas\u0103. Lua\u021bi doza oral\u0103 <strong>cu 1 or\u0103 \u00eenainte de chimioterapie<\/strong> pentru cea mai bun\u0103 protec\u021bie.<\/p>\n<h3 class=\"wp-block-heading\">Este granisetronul sigur \u00een timpul sarcinii?<\/h3>\n<p>Granisetronul este clasificat de FDA \u00een categoria B (studiile pe animale nu arat\u0103 efecte nocive; datele umane controlate sunt limitate). Rezerva\u021bi-l pentru greata refractar\u0103 indus\u0103 de chimioterapie sau hiperemez\u0103 c\u00e2nd agen\u021bii de prim\u0103 linie au e\u0219uat; se recomand\u0103 supraveghere specializat\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Pot lua Granicip pentru r\u0103u de mi\u0219care sau grea\u021b\u0103 \u00een sarcin\u0103?<\/h3>\n<p>Nu. Granisetronul este rezervat pentru grea\u021ba indus\u0103 de chimioterapie, radioterapie \u0219i postoperatorie. R\u0103ul de mi\u0219care este histaminergic\/colinergic \u2014 folosi\u021bi prometazin\u0103 (Avomine), cinarizin\u0103 sau meclozin\u0103. Primul tratament pentru grea\u021ba \u00een sarcin\u0103 este doxilamina + B6 (Doxinate, Pregnidoxin NU).<\/p>\n<h3 class=\"wp-block-heading\">Granicip provoac\u0103 sedare?<\/h3>\n<p>Nu. Ca \u0219i alte antagoniste 5-HT3, granisetronul nu provoac\u0103 sedare, reac\u021bii extrapiramidale sau efecte secundare anticolinergice. Durerile de cap \u0219i constipa\u021bia sunt principalele efecte secundare.<\/p>\n<h3 class=\"wp-block-heading\">Pot consuma alcool \u00een timp ce iau Granicip?<\/h3>\n<p>Cantit\u0103\u021bi mici ocazionale sunt pu\u021bin probabil s\u0103 interac\u021bioneze farmacologic, dar alcoolul poate agrava grea\u021ba \u0219i deshidratarea \u00een timpul chimioterapiei \u2014 evita\u021bi \u00een timpul ciclurilor active de tratament.<\/p>\n<h3 class=\"wp-block-heading\">Ce se \u00eent\u00e2mpl\u0103 dac\u0103 grea\u021ba mea nu este controlat\u0103?<\/h3>\n<p>Ad\u0103uga\u021bi dexametazon\u0103, un antagonist NK1 (aprepitant) sau olanzapin\u0103 pentru chimioterapie cu emetogenez\u0103 ridicat\u0103. Trecerea la un alt antagonist 5-HT3 (palonosetron) sau la o alt\u0103 clas\u0103 (antagonist D2) este rezonabil\u0103 atunci c\u00e2nd o molecul\u0103 a e\u0219uat.<\/p>\n<h3 class=\"wp-block-heading\">Constipa\u021bia este o problem\u0103?<\/h3>\n<p>Da \u2014 constipa\u021bia apare la p\u00e2n\u0103 la 1 din 11 utilizatori la tratamentele pe mai multe zile. Men\u021bine\u021bi hidratarea, fibrele \u0219i laxativele profilactice (senna\/bisacodil\/movicol) \u00een timpul ciclurilor de chimioterapie.<\/p>\n<h3 class=\"wp-block-heading\">Cum se p\u0103streaz\u0103 Granicip?<\/h3>\n<p>P\u0103stra\u021bi comprimatele la temperatura camerei (sub 30\u00b0C), protejate de lumin\u0103. Depozita\u021bi \u00een afara accesului copiilor. Nu utiliza\u021bi dup\u0103 data de expirare tip\u0103rit\u0103 pe cutie.<\/p>\n<h3 class=\"wp-block-heading\">Antagoni\u0219tii 5-HT3 sunt singura op\u021biune pentru grea\u021ba indus\u0103 de chimioterapie?<\/h3>\n<p>Nu. Regimurile moderne de prevenire a gre\u021bei \u0219i v\u0103rs\u0103turilor induse de chimioterapie (CINV) combin\u0103 un antagonist 5-HT3 + dexametazon\u0103 + (pentru chimioterapie cu emetogenez\u0103 ridicat\u0103) un antagonist NK1 precum aprepitant. Olanzapina este, de asemenea, util\u0103 \u00een cazurile refractare. Antagoni\u0219tii 5-HT3 ca monoterapie sunt recomanda\u021bi \u00een principal pentru regimuri cu emetogenez\u0103 moderat\u0103.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alte tratamente pentru grea\u021b\u0103<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/ondem\/\">Ondem (comprimat de ondansetron)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/emeset-4-odt\/\">Emeset 4 ODT (ondansetron orodispersibil)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/ondem-injection\/\">Ondem Injectabil (ondansetron IV\/IM)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/dompewal-tablet\/\">Dompewal (domperidon\u0103 \u2014 antagonist D2)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/stemetil-md\/\">Stemetil MD (proclorperazin\u0103 ODT)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/nausea-treatment\/\"><strong>Vizualiza\u021bi toate tratamentele pentru grea\u021b\u0103<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui profesionist calificat. V\u0103rs\u0103turi persistente, s\u00e2nge \u00een vom\u0103, dureri abdominale severe, semne de deshidratare, suspiciuni de complica\u021bii ale sarcinii sau simptome legate de chimioterapie necesit\u0103 evaluare medical\u0103.<\/div>","protected":false},"excerpt":{"rendered":"<p>Granicip (Granisetron 1 mg \/ 2 mg) \u2014 antagonist 5-HT3 de genera\u021bia a doua, o dat\u0103 pe zi, pentru chimioterapie, radioterapie \u0219i PONV. Timp de \u00eenjum\u0103t\u0103\u021bire mai lung (~9 ore) comparativ cu ondansetron.<\/p>","protected":false},"featured_media":54780,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3543],"product_tag":[3781,3782],"class_list":{"0":"post-54779","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-nausea-treatment","9":"product_tag-granicip","10":"product_tag-granisetron","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/54779","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=54779"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/54780"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=54779"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=54779"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=54779"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=54779"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}