{"id":54846,"date":"2023-09-20T10:05:42","date_gmt":"2023-09-20T10:05:42","guid":{"rendered":"https:\/\/medsname.com\/roko\/"},"modified":"2026-04-30T10:24:53","modified_gmt":"2026-04-30T10:24:53","slug":"roko","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/roko\/","title":{"rendered":"Roko"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"margin:0 0 22px;padding:16px 20px;background:#fff8e1;border-left:4px solid #f5a623;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px;font-size:18px;color:#2c3e50;\">R\u0103spuns Rapid \u2014 Ce este Roko?<\/h3>\n<p style=\"margin:0;font-size:15px;line-height:1.55;color:#333;\">Comprimatul Roko con\u021bine loperamid\u0103 hidroclorur\u0103 2 mg \u2014 un agonist al receptorilor opioizi restric\u021bionat la peretele intestinal care \u00eencetine\u0219te motilitatea intestinal\u0103 \u0219i amelioraz\u0103 diareea acut\u0103 \u0219i cronic\u0103. Fabricat de Cipla, doza standard este de 4 mg ini\u021bial, urmat\u0103 de 2 mg dup\u0103 fiecare scaun lichid, p\u00e2n\u0103 la maximum 16 mg \u00een 24 de ore. Reduce frecven\u021ba \u0219i urgen\u021ba scaunelor f\u0103r\u0103 efectele asupra sistemului nervos central ale altor opioide.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<h2 class=\"wp-block-heading\">Ce este Roko?<\/h2>\n<p>Roko este un comprimat antidiareic care con\u021bine <strong>loperamid\u0103 hidroclorur\u0103 2 mg<\/strong>, fabricat\u0103 de <strong>Cipla Ltd<\/strong> \u00een India. Loperamida este un agonist sintetic al receptorilor opioizi care ac\u021bioneaz\u0103 specific \u00een peretele intestinal pentru a \u00eencetini motilitatea intestinal\u0103 \u0219i a reduce frecven\u021ba scaunelor. Spre deosebire de opioizii mai vechi (codein\u0103, difenoxilat), loperamida nu are practic nicio activitate asupra sistemului nervos central la dozele terapeutice, deoarece este exclus\u0103 activ din creier de c\u0103tre transportorul P-glicoprotein al barierei hemato-encefalice.<\/p>\n<p>Aceast\u0103 direc\u021bionare farmacologic\u0103 face ca Roko s\u0103 fie deosebit de potrivit pentru controlul diareei, f\u0103r\u0103 sedarea, euforia, depresia respiratorie sau poten\u021bialul de abuz asociat cu alte opioide. A fost un pilon al tratamentului antidiareic la nivel mondial de la introducerea sa \u00een anii 1970 \u0219i este inclus \u00een Lista Model OMS de Medicamente Esen\u021biale.<\/p>\n<h2 class=\"wp-block-heading\">Utiliz\u0103ri ale Roko<\/h2>\n<ul>\n<li><strong>Diaree acut\u0103 neinfec\u021bioas\u0103<\/strong> \u2014 debut brusc, de obicei autolimitativ\u0103, cauzat\u0103 de indisciplin\u0103 alimentar\u0103, gastroenterit\u0103 viral\u0103 (dup\u0103 dispari\u021bia simptomelor infec\u021bioase) sau efecte secundare ale medicamentelor.<\/li>\n<li><strong>Diaree cronic\u0103<\/strong> \u2014 \u00een sindromul intestinului iritabil cu diaree (IBS-D), boala inflamatorie intestinal\u0103 \u00een remisie, post-vagotomie sau sindromul intestinului scurt.<\/li>\n<li><strong>Diareea c\u0103l\u0103torului<\/strong> \u2014 ameliorare simptomatic\u0103 \u00een plus fa\u021b\u0103 de rehidratarea adecvat\u0103.<\/li>\n<li><strong>Reducerea debitului ileostomiei<\/strong> \u2014 la pacien\u021bii cu stomii cu debit ridicat unde pierderea de lichide este problematic\u0103.<\/li>\n<li><strong>Diaree indus\u0103 de radioterapie<\/strong> \u2014 la pacien\u021bii care urmeaz\u0103 radioterapie pelvin\u0103.<\/li>\n<li><strong>Diaree indus\u0103 de chimioterapie<\/strong> \u2014 \u00een special la regimurile bazate pe irinotecan.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Cum func\u021bioneaz\u0103 Roko<\/h2>\n<p>Loperamida se leag\u0103 de <strong>receptorii \u03bc-opioizi<\/strong> din plexul mienteric al intestinului gros \u2014 re\u021beaua de celule nervoase care regleaz\u0103 peristaltismul. Legarea inhib\u0103 eliberarea de acetilcolin\u0103 \u0219i prostaglandine, ceea ce reduce for\u021ba \u0219i frecven\u021ba contrac\u021biilor intestinale. Rezultatul este <strong>timp de tranzit mai lent<\/strong>, oferind colonului mai mult\u0103 oportunitate de a reabsorbi ap\u0103 \u0219i electroli\u021bi din scaun. Volumul net al scaunului scade \u0219i scaunul devine mai ferm.<\/p>\n<p>Loperamida reduce, de asemenea, anomalile tonusului sfincterului anal observate \u00een diaree, \u00eembun\u0103t\u0103\u021bind continen\u021ba. La doze terapeutice, nu exist\u0103 efect analgezic sau opioid central datorit\u0103 barierei de eflux P-glicoproteic\u0103 la nivelul barierei hemato-encefalice. Acesta este motivul pentru care loperamida nu este clasificat\u0103 ca substan\u021b\u0103 controlat\u0103 \u00een majoritatea \u021b\u0103rilor.<\/p>\n<h2 class=\"wp-block-heading\">Doza \u0219i administrare<\/h2>\n<p>Doza pentru adul\u021bi pentru <strong>diaree acut\u0103<\/strong>: 4 mg (dou\u0103 comprimate) ini\u021bial, urmat de 2 mg (un comprimat) dup\u0103 fiecare scaun lichid ulterior. Maxim 16 mg (8 comprimate) \u00een 24 de ore. \u00centrerupe\u021bi c\u00e2nd scaunul devine format.<\/p>\n<p>Doza pentru adul\u021bi pentru <strong>diaree cronic\u0103<\/strong>: 4 mg ini\u021bial, apoi 2 mg dup\u0103 fiecare scaun lichid sau dup\u0103 necesitate. Doza de \u00eentre\u021binere 2\u201312 mg zilnic, ajustat\u0103 \u00een func\u021bie de r\u0103spunsul clinic. Maxim 16 mg zilnic.<\/p>\n<p><strong>Copii cu v\u00e2rsta \u00eentre 4\u20138 ani<\/strong>: 1 mg de p\u00e2n\u0103 la 3 ori pe zi, maxim 2 zile. <strong>Copii 9\u201312 ani<\/strong>: 2 mg de dou\u0103 ori pe zi, maxim 5 zile. Nu utiliza\u021bi la copiii sub 4 ani f\u0103r\u0103 sfat medical.<\/p>\n<h2 class=\"wp-block-heading\">Cum se utilizeaz\u0103 Roko<\/h2>\n<ol>\n<li>Lua\u021bi comprimatele \u00eentregi cu ap\u0103. Roko nu trebuie luat \u00een combina\u021bie cu alimente.<\/li>\n<li>\u00cen paralel cu Roko, men\u021bine\u021bi o hidratare corespunz\u0103toare \u2014 sunt recomandate s\u0103ruri de rehidratare oral\u0103 (SRO) pentru a \u00eenlocui fluidele \u0219i electroli\u021bii pierdu\u021bi.<\/li>\n<li>\u00centrerupe\u021bi administrarea Roko imediat ce diareea se rezolv\u0103 sau scaunul devine format. Nu continua\u021bi profilactic.<\/li>\n<li>Solicita\u021bi sfat medical dac\u0103 diareea nu se \u00eembun\u0103t\u0103\u021be\u0219te \u00een 48 de ore sau dac\u0103 apar febr\u0103, scaun s\u00e2ngeros sau dureri abdominale severe.<\/li>\n<li>Nu dep\u0103\u0219i\u021bi 16 mg (8 comprimate) \u00eentr-o perioad\u0103 de 24 de ore.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Efecte secundare ale Roko<\/h2>\n<ul>\n<li><strong>Frecvente:<\/strong> constipa\u021bie (\u00een special la utilizarea prelungit\u0103); dureri abdominale sau crampe; balonare; grea\u021b\u0103; gur\u0103 uscat\u0103; ame\u021beli.<\/li>\n<li><strong>Mai pu\u021bin frecvente:<\/strong> erup\u021bii cutanate; flatulen\u021b\u0103; v\u0103rs\u0103turi; oboseal\u0103.<\/li>\n<li><strong>Rare dar grave:<\/strong> ileus paralitic (\u00een special la doze mari sau la copii mici); megacolon toxic \u00een puseul de colit\u0103 ulceroas\u0103; reac\u021bii alergice, inclusiv angioedem; constipa\u021bie sever\u0103 care duce la obstruc\u021bie intestinal\u0103.<\/li>\n<li><strong>La supradoz\u0103 extrem\u0103 (&gt;60 mg):<\/strong> aritmie cardiac\u0103 \u2014 prelungirea intervalului QT, torsade de pointes \u2014 datorit\u0103 bloc\u0103rii canalelor de sodiu periferice. Acest risc a dus la limit\u0103ri privind dimensiunile ambalajelor \u00een mai multe \u021b\u0103ri.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Precau\u021bii \u0219i avertismente<\/h2>\n<ul>\n<li><strong>Diar\u0103 cu s\u00e2nge sau febr\u0103 ridicat\u0103:<\/strong> NU utiliza\u021bi Roko \u2014 acestea pot sugera o infec\u021bie bacterian\u0103 invaziv\u0103 (Salmonella, Shigella, C. difficile) sau colit\u0103, unde \u00eencetinirea motilit\u0103\u021bii poate \u00eenr\u0103ut\u0103\u021bi evolu\u021bia.<\/li>\n<li><strong>Puseu acut de colit\u0103 ulceroas\u0103:<\/strong> contraindicated \u2014 risc de megacolon toxic.<\/li>\n<li><strong>Colit\u0103 asociat\u0103 antibioticelor (C. difficile):<\/strong> evita\u021bi \u2014 \u00eencetinirea motilit\u0103\u021bii poate \u00eencremeni toxinele \u00een colon.<\/li>\n<li><strong>Copii sub 2 ani:<\/strong> contraindicate \u2014 risc de ileus paralitic.<\/li>\n<li><strong>Insuficien\u021b\u0103 hepatic\u0103 sever\u0103:<\/strong> metabolism redus \u2014 utiliza\u021bi cu precau\u021bie, doze mai mici.<\/li>\n<li><strong>Sarcina:<\/strong> date limitate; utiliza\u021bi doar dac\u0103 beneficiile dep\u0103\u0219esc clar riscurile.<\/li>\n<li><strong>Al\u0103ptarea:<\/strong> cantit\u0103\u021bi mici eliminate \u00een laptele matern \u2014 tratamentele scurte sunt \u00een general considerate sigure.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<p>Interac\u021biuni importante: <strong>ritonavir, quinidin\u0103, itraconazol, ketoconazol<\/strong> \u2014 inhib\u0103 metabolismul loperamidei \u0219i efluxul P-glicoproteic, cresc\u00e2nd nivelurile plasmatice \u0219i riscul de efecte opioid centrale \u0219i toxicitate cardiac\u0103; <strong>colestiramin\u0103<\/strong> \u2014 se leag\u0103 de loperamid\u0103 \u00een intestin, reduc\u00e2nd absorb\u021bia; <strong>Medicamente care prelungesc intervalul QT<\/strong> (amiodaron\u0103, sotalol, antibiotice macrolide, unele antipsihotice) \u2014 risc aditiv de aritmie la doze mari de loperamid\u0103; <strong>alte opioide<\/strong> \u2014 efecte centrale teoretice aditive la doze foarte mari.<\/p>\n<h2 class=\"wp-block-heading\">Depozitare<\/h2>\n<p>Depozita\u021bi sub 25 \u00b0C \u00een blisterul original, protejat de umiditate. P\u0103stra\u021bi \u00een afara accesului copiilor. Nu utiliza\u021bi dup\u0103 data de expirare.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">C\u00e2t de repede ac\u021bioneaz\u0103 Roko?<\/h3>\n<p>Alinarea simptomelor \u00eencepe de obicei \u00een 30 de minute - 1 or\u0103 de la prima doz\u0103 de 4 mg. Efectul maxim este la 4-5 ore. Majoritatea episoadelor de diaree acut\u0103 se rezolv\u0103 \u00een 24 de ore de la \u00eenceperea tratamentului cu Roko, de\u0219i diareea cronic\u0103 necesit\u0103 dozaj continuu pe termen mai lung, adaptat la r\u0103spunsul individual.<\/p>\n<h3 class=\"wp-block-heading\">Pot lua Roko pentru diareea c\u0103l\u0103torului?<\/h3>\n<p>Da \u2014 Roko este eficient pentru ameliorarea simptomatic\u0103 a diareei c\u0103l\u0103torului \u0219i poate fi combinat cu terapia antibiotic\u0103 adecvat\u0103 \u00een cazurile moderate-grav\u0103. Dac\u0103 apar scaun cu s\u00e2nge, febr\u0103 ridicat\u0103 sau dureri abdominale severe, c\u0103uta\u021bi ajutor medical \u00een loc s\u0103 v\u0103 trata\u021bi singur doar cu loperamid\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Este Roko sigur pentru utilizare pe termen lung?<\/h3>\n<p>Pentru afec\u021biuni cronice precum SII-D sau managementul ileostomiei, loperamida poate fi utilizat\u0103 pe termen lung sub supraveghere medical\u0103 la cea mai mic\u0103 doz\u0103 eficient\u0103. Monitoriza\u021bi apari\u021bia constipa\u021biei \u0219i ajusta\u021bi doza dup\u0103 necesit\u0103\u021bi. Utilizarea pe termen lung la doze standard nu este asociat\u0103 cu dependen\u021b\u0103 sau toleran\u021b\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Pot s\u0103-i administrez Roko copilului meu?<\/h3>\n<p>Loperamida nu este recomandat\u0103 pentru copiii sub 2 ani din cauza riscului crescut de ileus paralitic. Pentru copiii de 4-8 ani, pot fi administrate doze de 1 mg pentru perioade scurte. Consulta\u021bi \u00eentotdeauna un pediatru mai \u00eent\u00e2i \u0219i asigura\u021bi-v\u0103 c\u0103 copilul prime\u0219te suficiente fluide cu s\u0103ruri de rehidratare oral\u0103, indiferent dac\u0103 se folose\u0219te Roko sau nu.<\/p>\n<h3 class=\"wp-block-heading\">De ce loperamida nu creeaz\u0103 dependen\u021b\u0103?<\/h3>\n<p>Loperamida este eliminat\u0103 activ din creier de c\u0103tre P-glicoproteina de la bariera hemato-encefalic\u0103. La doze terapeutice, practic nici o cantitate nu ajunge la receptorii opioidii centrali responsabili de euforie sau dependen\u021b\u0103. La doze extrem de mari (&gt;60 mg), transportatorul se saturaz\u0103 \u0219i pot ap\u0103rea unele efecte centrale \u2014 motiv pentru care s-au introdus limite de ambalaj \u00een mai multe \u021b\u0103ri.<\/p>\n<h3 class=\"wp-block-heading\">C\u00e2nd NU ar trebui s\u0103 iau Roko?<\/h3>\n<p>Nu lua\u021bi Roko dac\u0103 ave\u021bi: scaun cu s\u00e2nge, febr\u0103 ridicat\u0103 (peste 38,5 \u00b0C), dureri abdominale severe sugestive pentru ileus sau peritonit\u0103, colit\u0103 asociat\u0103 antibioticelor sau o exacerbare activ\u0103 a colitei ulceroase sau a bolii Crohn. \u00cen aceste situa\u021bii, \u00eencetinirea motilit\u0103\u021bii poate agrava afec\u021biunea de baz\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Ce ar trebui s\u0103 fac dac\u0103 am luat accidental prea mult?<\/h3>\n<p>O supradoz\u0103 moderat\u0103 (p\u00e2n\u0103 la 16 mg peste limita zilnic\u0103) provoac\u0103 de obicei doar constipa\u021bie sever\u0103 sau crampe abdominale. Supradozele mari (peste 60 mg \u00eentr-o zi) pot provoca aritmii cardiace \u0219i necesit\u0103 aten\u021bie medical\u0103 urgent\u0103 \u2014 monitorizare ECG \u0219i \u00eengrijiri de sus\u021binere. Dac\u0103 ave\u021bi dubii, contacta\u021bi centrul de toxicoze sau c\u0103uta\u021bi \u00eengrijire de urgen\u021b\u0103.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alternative conexe<\/h3>\n<p>Alte produse din <strong>S\u0103n\u0103tate general\u0103<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/oflox-eye-drop\/\">Pic\u0103turi oculare Oflox<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/busiron\/\">Busiron<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/cenmox\/\">Cenmox<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/olopat-eye-drop\/\">Olopat Pic\u0103turi Oculare<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/xet-20\/\">Xet 20<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<h5>\u2705 U\u0219urare Simptome de Diaree<br \/>\n\u2705 Normalizeaz\u0103 Func\u021bia Intestinal\u0103<br \/>\n\u2705 Alin\u0103 Simptomele Asociate<br \/>\n\u2705 Rapid \u0219i Eficient<br \/>\n\u2705 \u00cembun\u0103t\u0103\u021bire a Calit\u0103\u021bii Vie\u021bii<\/h5>\n<p><span style=\"color: #999999;\">Roko con\u021bine Loperamid\u0103 hidroclorur\u0103<\/span><\/p>","protected":false},"featured_media":54847,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3812],"product_tag":[3813],"class_list":{"0":"post-54846","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-trapped-wind-relief","9":"product_tag-loperamide-hydrochloride","11":"first","12":"instock","13":"shipping-taxable","14":"purchasable","15":"product-type-variable","16":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/54846","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=54846"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/54847"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=54846"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=54846"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=54846"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=54846"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}