{"id":54915,"date":"2023-09-20T10:06:40","date_gmt":"2023-09-20T10:06:40","guid":{"rendered":"https:\/\/medsname.com\/alzil\/"},"modified":"2026-04-30T16:30:23","modified_gmt":"2026-04-30T16:30:23","slug":"alzil","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/alzil\/","title":{"rendered":"Alzil"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">R\u0103spuns rapid<\/h3>\n<p style=\"margin-bottom:0;\"><strong>Alzil<\/strong> \u2014 donepezil 5\/10 mg (Intas Pharma). Inhibitor reversibil de acetilcolinesteraz\u0103 cu ac\u021biune central\u0103 pentru boala Alzheimer u\u0219oar\u0103, moderat\u0103 \u0219i sever\u0103 \u0219i demen\u021ba \u00een boala Parkinson. \u00cembun\u0103t\u0103\u021bire simptomatic\u0103 modest\u0103 a cogni\u021biei \u0219i activit\u0103\u021bilor de via\u021b\u0103 zilnic\u0103; nu \u00eencetine\u0219te progresia bolii.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>Ce beneficii ofer\u0103 MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>produc\u0103tor certificat WHO-GMP<\/li>\n<li>Ambalaj discret \u00een plic simplu<\/li>\n<li>Livrare \u00een toat\u0103 lumea<\/li>\n<li>Evaluat de peste 1.400 de clien\u021bi (<a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">cite\u0219te recenziile<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>Garan\u021bia de retransmitere:<\/strong> dac\u0103 comanda dvs. nu a ajuns \u00een 20 de zile lucr\u0103toare de la expediere, o retransmitem f\u0103r\u0103 costuri suplimentare. <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Cite\u0219te politica<\/a>.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Alzil este expediat de la un produc\u0103tor certificat WHO-GMP \u00een ambalaje discrete, facturat printr-un procesor de plat\u0103 reglementat (descrierea extrasului de cont men\u021bioneaz\u0103 un procesor de plat\u0103 cu card reglementat \u2014 niciodat\u0103 MedsBase sau nume de medicamente). Fiecare comand\u0103 beneficiaz\u0103 de Garan\u021bia noastr\u0103 de Reexpediere \u00een 20 de zile lucr\u0103toare.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Stabili\u021bi a\u0219tept\u0103ri realiste<\/strong><br \/>Donepezilul produce o \u00eembun\u0103t\u0103\u021bire modest\u0103 \u0219i de scurt\u0103 durat\u0103 a func\u021biilor cognitive (de obicei 2-4 puncte pe scala ADAS-cog) \u0219i poate am\u00e2na plasarea \u00een institu\u021bii specializate. NU \u00eencetine\u0219te neurodegenerarea subiacent\u0103. Efectul se stabilizeaz\u0103 \u0219i beneficiile pot disp\u0103rea \u00een 6-24 de luni. Discuta\u021bi obiective realiste cu familia \u00eenainte de \u00eenceperea tratamentului.<\/div>\n<h2>Doza<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:12px 0;\">\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;border:1px solid #ddd;\">Indica\u021bie<\/th>\n<th style=\"padding:8px;border:1px solid #ddd;\">Doza<\/th>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Alzheimer u\u0219or-moderat<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">5 mg la culcare \u00d7 4 s\u0103pt\u0103m\u00e2ni \u2192 10 mg la culcare<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Alzheimer sever<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">10 mg\/zi; unii clinicieni ajusteaz\u0103 p\u00e2n\u0103 la 23 mg\/zi (acolo unde este disponibil)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Demen\u021b\u0103 Parkinson \/ DLB<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">5-10 mg\/zi la culcare<\/td>\n<\/tr>\n<\/table>\n<p>Administra\u021bi seara, cu sau f\u0103r\u0103 m\u00e2ncare. Formularea de 23 mg trebuie \u00eenghi\u021bit\u0103 \u00eentreag\u0103; comprimatele de 5\/10 mg pot fi zdrobite dac\u0103 este necesar.<\/p>\n<h2>Efecte secundare<\/h2>\n<ul>\n<li><strong>Efecte gastrointestinale colinergice (cele mai frecvente, dependente de doz\u0103):<\/strong> gre\u021buri, v\u0103rs\u0103turi, diaree, anorexie, pierdere \u00een greutate<\/li>\n<li><strong>SNC:<\/strong> insomnie (\u00eencerca\u021bi administrarea diminea\u021ba dac\u0103 persist\u0103), vise vii, ame\u021beli, oboseal\u0103<\/li>\n<li><strong>Cardiovascular:<\/strong> bradicardie, sincop\u0103, bloc AV \u2014 precau\u021bie \u00een sindromul sinusului bolnav sau defecte de conducere preexistente; evita\u021bi combinarea cu CCB non-DHP sau beta-blocante f\u0103r\u0103 monitorizare<\/li>\n<li><strong>Altele:<\/strong> incontinen\u021b\u0103 urinar\u0103 (rar\u0103), sc\u0103derea pragului convulsiv, hemoragii gastrointestinale augmentate de AINS<\/li>\n<\/ul>\n<h2>Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>Anticolinergice puternice:<\/strong> oxybutinin\u0103, hioscin\u0103, TCA-uri, antihistaminice de prim\u0103 genera\u021bie \u2014 antagonizeaz\u0103 direct donepezilul; evita\u021bi combinarea dac\u0103 este posibil<\/li>\n<li><strong>Medicamente bradicardizante:<\/strong> beta-blocante, CCB non-DHP (verapamil\/diltiazem), digoxin \u2014 risc crescut de bradicardie\/bloc AV; monitoriza\u021bi<\/li>\n<li><strong>AINS:<\/strong> risc crescut de s\u00e2ngerare gastrointestinal\u0103<\/li>\n<li><strong>inhibitori CYP2D6 + CYP3A4:<\/strong> ketoconazol, paroxetin\u0103, fluoxetin\u0103 \u2014 cre\u0219tere moderat\u0103 a nivelurilor de donepezil; de obicei nesemnificativ\u0103 clinic<\/li>\n<li><strong>Succinilcolin\u0103 (anestezie):<\/strong> bloc neuromuscular prelungit \u2014 informa\u021bi anestezistul despre utilizarea donepezilului \u00eenaintea oric\u0103rei interven\u021bii chirurgicale<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>C\u00e2t de repede voi observa \u00eembun\u0103t\u0103\u021biri?<\/h3>\n<p>Beneficiile cognitive \u0219i comportamentale, atunci c\u00e2nd apar, sunt de obicei modeste \u0219i se manifest\u0103 pe parcursul a 6-12 s\u0103pt\u0103m\u00e2ni. Unii pacien\u021bi nu prezint\u0103 beneficii m\u0103surabile; acest lucru este normal \u0219i nu reprezint\u0103 un e\u0219ec al tratamentului.<\/p>\n<h3>C\u00e2nd ar trebui oprit?<\/h3>\n<p>\u00centrerupe\u021bi tratamentul dac\u0103 nu se observ\u0103 beneficii dup\u0103 3-6 luni la doza maxim\u0103 tolerat\u0103 sau dac\u0103 efectele adverse (\u00een special pierderea \u00een greutate) dep\u0103\u0219esc beneficiile. Unii clinici continu\u0103 tratamentul \u00een stadiile avansate ale bolii \u2014 dovezile sunt mixte.<\/p>\n<h3>Poate fi combinat cu memantin\u0103?<\/h3>\n<p>Da \u2014 terapia combinat\u0103 (donepezil + memantin\u0103) este aprobat\u0103 \u0219i utilizat\u0103 frecvent \u00een boala moderat p\u00e2n\u0103 la sever\u0103. Memantina ac\u021bioneaz\u0103 asupra receptorilor de glutamat (NMDA), iar donepezilul asupra acetilcolinei \u2014 mecanisme diferite, beneficii aditive, f\u0103r\u0103 interac\u021biuni medicamentoase majore.<\/p>\n<h3>Insomnie?<\/h3>\n<p>Donepezilul poate cauza vise vii \u0219i insomnie. Dac\u0103 persist\u0103, trece\u021bi la administrare diminea\u021ba.<\/p>\n<h3>Va \u00eencetini boala Alzheimer?<\/h3>\n<p>Nu. Este un tratament simptomatic. Neurodegenerarea subiacent\u0103 continu\u0103. Noile agen\u021bi modificatori ai bolii (lecanemab, donanemab) reduc pl\u0103cile amiloide, dar sunt terapii separate, costisitoare, bazate pe perfuzii, cu propriile riscuri.<\/p>\n<h3>Dar bradicardia?<\/h3>\n<p>Ob\u021bine\u021bi un ECG de baz\u0103 \u00eenainte de a \u00eencepe dac\u0103 ave\u021bi probleme de conducere cardiac\u0103 cunoscute, lua\u021bi beta-blocante sau ave\u021bi sincop\u0103 neexplicat\u0103. Donepezilul intensific\u0103 tonusul vagal \u0219i rareori provoac\u0103 bloc AV.<\/p>\n<h3>Partenerul meu poate \u00eenceta s\u0103 foloseasc\u0103 medicamente anticholinergice pentru vezic\u0103 hiperactiv\u0103?<\/h3>\n<p>Dac\u0103 persoana drag\u0103 este sub tratament cu donepezil pentru Alzheimer, medicamentele anticholinergice pentru vezic\u0103 hiperactiv\u0103 (oxibutinin\u0103, tolterodin\u0103) se opun direct efectului donepezilului \u0218I \u00eenr\u0103ut\u0103\u021besc independent cogni\u021bia. Mirabegronul (agonist beta-3) este preferat pentru vezica hiperactiv\u0103 la pacien\u021bii cu demen\u021b\u0103.<\/p>\n<h3>Ce se \u00eent\u00e2mpl\u0103 dac\u0103 uita\u021bi o doz\u0103?<\/h3>\n<p>Omite\u021bi doza ratat\u0103 \u0219i relua\u021bi programul normal. Nu lua\u021bi o doblur\u0103. Dac\u0103 sunt ratate mai multe doze (mai mult de c\u00e2teva zile), relua\u021bi la doza mai mic\u0103 de 5 mg pentru a evita efectele secundare gastrointestinale.<\/p>\n<h3>Pot consuma alcool?<\/h3>\n<p>Consumul moderat de alcool este acceptabil. Consumul excesiv de alcool \u00eenr\u0103ut\u0103\u021be\u0219te declinul cognitiv independent de donepezil \u0219i ar trebui descurajat.<\/p>\n<h3>Interven\u021bie chirurgical\u0103 \u0219i anestezie?<\/h3>\n<p>Spune\u021bi anestezistului despre donepezil \u2014 prelunge\u0219te ac\u021biunea succinilcolinei \u0219i a altor blocante neuromusculare. Unii chirurgi prefer\u0103 s\u0103 \u00eentrerup\u0103 donepezilul cu 24-48 de ore \u00eenainte de interven\u021biile chirurgicale elective; face\u021bi acest lucru doar la recomandarea specialistului.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Alte medicamente pentru Alzheimer \u0219i demen\u021b\u0103<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/nemdaa\/\">Nemdaa<\/a> \u2014 memantin\u0103 5\/10 mg \u2014 antagonist NMDA pentru boal\u0103 moderat-sever\u0103<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/donamem\/\">Donamem<\/a> \u2014 combina\u021bie fix\u0103 de donepezil + memantin\u0103<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/alzil\/\">Alzil<\/a> \u2014 donepezil 5\/10 mg \u2014 marc\u0103 alternativ\u0103<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/donecept\/\">Donecept<\/a> \u2014 donepezil 5\/10 mg \u2014 marca Cipla<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/donep\/\">Donep<\/a> \u2014 donepezil 5\/10 mg \u2014 marca Alkem<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>Disclaimer medical:<\/strong> Aceast\u0103 pagin\u0103 este doar informativ\u0103 \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui clinician calificat. Discuta\u021bi orice medicament nou cu medicul sau farmacistul dumneavoastr\u0103.<\/div>","protected":false},"excerpt":{"rendered":"<p>Alzil (Donepezil 5\/10 mg) \u2014 Intas Pharma inhibitor de colinesteraz\u0103 pentru boala Alzheimer u\u0219oar\u0103, moderat\u0103 \u0219i sever\u0103 \u0219i demen\u021ba \u00een boala Parkinson. Administrare o dat\u0103 pe zi la ora de culcare. Beneficiu simptomatic modest.<\/p>","protected":false},"featured_media":54916,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3772,3141,3223],"product_tag":[3848,3849],"class_list":{"0":"post-54915","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-alzheimers-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-alzil","10":"product_tag-donepezil","12":"first","13":"outofstock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/54915","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=54915"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/54916"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=54915"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=54915"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=54915"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=54915"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}