{"id":55088,"date":"2023-11-12T21:50:46","date_gmt":"2023-11-12T21:50:46","guid":{"rendered":"https:\/\/medsname.com\/tenof-em\/"},"modified":"2026-05-21T05:27:39","modified_gmt":"2026-05-21T05:27:39","slug":"tenof-em","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/tenof-em\/","title":{"rendered":"Tenof EM"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns Rapid \u2014 Ce este Tenof EM?<\/h3>\n<p style=\"margin:0;\"><strong>Tenof EM<\/strong> con\u021bine <strong>tenofovir disoproxil fumarat 300 mg + emtricitabin\u0103 200 mg<\/strong> \u0219i este utilizat pentru profilaxia pre-expunere (PrEP) la HIV \u2014 prevenirea infec\u021biei cu HIV-1 la adul\u021bii HIV-negativi cu risc substan\u021bial. Atunci c\u00e2nd este luat zilnic cu respectarea strict\u0103 a tratamentului, PrEP bazat pe TDF\/FTC reduce riscul de infec\u021bie cu HIV cu <strong>&gt;99% atunci c\u00e2nd este luat zilnic cu respectarea strict\u0103 a tratamentului (iPrEx, PROUD, Partners PrEP)<\/strong>. Fabricat de Hetero Drugs. Sub supraveghere medical\u0103; necesit\u0103 confirmarea st\u0103rii HIV-negative \u00eenainte de \u00eenceperea tratamentului \u0219i la fiecare 3 luni pe durata terapiei.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f6f7fb;border:1px solid #e3e5ee;border-radius:8px;padding:14px 18px;margin:18px 0;font-size:14px;line-height:1.55;\"><strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Provenit de la un produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare worldwide \u00b7 <a href=\"\/ro\/reviews\/\" rel=\"noopener\">Peste 1.400 de recenzii verificate ale clien\u021bilor<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Comand\u00e2nd de la MedsBase beneficia\u021bi de surs\u0103 de la un produc\u0103tor certificat WHO-GMP, ambalaj discret \u00een plic simplu, livrare worldwide \u0219i evalu\u0103ri de 4.9\u2605 de la peste 1.400 de clien\u021bi verifica\u021bi. Pl\u0103\u021bile cu cardul sunt procesate printr-un on-ramp crypto reglementat \u2014 descriptorul de pe extrasul de cont va afi\u0219a numele procesatorului (un procesator de pl\u0103\u021bi cu card reglementat), niciodat\u0103 \u201cMedsBase\u201d sau nume de medicamente. Fiecare colet este acoperit de <a href=\"\/ro\/medsbase-re-shipment-assurance-policy\/\" rel=\"noopener\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a>.<\/p>\n<p><strong>Tenof EM<\/strong> este un <strong>profilaxie zilnic\u0103 pre-expunere (PrEP) la HIV<\/strong> comprimat combin\u00e2nd <strong>tenofovir disoproxil fumarat 300 mg<\/strong> \u0219i <strong>emtricitabin\u0103 200 mg<\/strong> \u2014 acelea\u0219i dou\u0103 molecule antiretrovirale care compun medicamentul de marc\u0103 Truvada\u00ae dezvoltat ini\u021bial de Gilead Sciences. Fabricat de Hetero Drugs \u2014 unul dintre cei mai mari produc\u0103tori de medicamente antiretrovirale din Asia. Denumirea comercial\u0103 Tenof face referire specific\u0103 la principiul activ tenofovir; varianta EM adaug\u0103 emtricitabin\u0103 pentru utilizarea combinat\u0103 \u00een PrEP\/tratamentul HIV.<\/p>\n<p>Luat consecvent de adul\u021bi HIV-negativi cu risc substan\u021bial de expunere, PrEP bazat pe TDF\/FTC reduce riscul de a contracta HIV-1 cu <strong>peste 99%<\/strong> (extinderea iPrEx cu etichet\u0103 deschis\u0103, PROUD, Partners PrEP). Lipsa mai mult de una sau dou\u0103 doze pe s\u0103pt\u0103m\u00e2n\u0103 reduce semnificativ protec\u021bia, astfel \u00eenc\u00e2t PrEP este \u00een esen\u021b\u0103 o <strong>interven\u021bie bazat\u0103 pe respectarea tratamentului<\/strong> la fel de mult ca una farmacologic\u0103.<\/p>\n<h2 class=\"wp-block-heading\">Ce este Tenof EM?<\/h2>\n<p>Tenof EM este un comprimat cu doz\u0103 fix\u0103 combinat\u0103 din doi inhibitori nucleozidici ai transcriptazei inverse (NRTI):<\/p>\n<ul>\n<li><strong>Tenofovir disoproxil fumarat (TDF) 300 mg<\/strong> \u2014 blocheaz\u0103 transcriptaza invers\u0103 a HIV, prevenind integrarea virusului \u00een ADN-ul gazd\u0103<\/li>\n<li><strong>Emtricitabin\u0103 (FTC) 200 mg<\/strong> \u2014 un analog de citidin\u0103 care, de asemenea, inhib\u0103 transcriptaza invers\u0103, av\u00e2nd un profil de rezisten\u021b\u0103 complementar cu TDF<\/li>\n<\/ul>\n<p>Folosite ca <strong>PrEP<\/strong>, cele dou\u0103 medicamente \u00eencarc\u0103 preemptiv celulele HIV-negative cu inhibitor, astfel \u00eenc\u00e2t orice virus introdus prin expunere sexual\u0103 sau prin injec\u021bie s\u0103 nu poat\u0103 stabili o infec\u021bie productiv\u0103. Combina\u021bia este, de asemenea, autorizat\u0103 pentru tratamentul HIV-1 (ca parte a unui regim cu 3 medicamente) \u0219i pentru hepatita B cronic\u0103, de\u0219i aceast\u0103 pagin\u0103 se concentreaz\u0103 pe utilizarea \u00een PrEP.<\/p>\n<p><strong>Echivalen\u021b\u0103 clinic\u0103:<\/strong> Tenof EM, comercializat sub denumirile Truvada, Tenvir-EM, Tenof-EM, Tavin-EM \u0219i Ricovir-EM, con\u021bin toate aceea\u0219i combina\u021bie cu doz\u0103 fix\u0103 de TDF 300 mg + FTC 200 mg. Bioechivalen\u021ba \u00eentre produc\u0103tori este stabilit\u0103 de autorit\u0103\u021bile de reglementare a medicamentelor prin teste de echivalen\u021b\u0103 farmacocinetic\u0103. Alegerea \u00eentre acestea se refer\u0103 \u00een principal la produc\u0103tor, disponibilitate \u0219i cost \u2014 nu la rezultatul clinic.<\/p>\n<h2 class=\"wp-block-heading\">Cum func\u021bioneaz\u0103 Tenof EM ca PrEP<\/h2>\n<p>Atunci c\u00e2nd este luat zilnic, tenofovirul \u0219i emtricitabina ating concentra\u021bii de echilibru \u00een s\u00e2nge, mucoasa genital\u0103 \u0219i \u021besutul rectal. C\u00e2nd are loc expunerea la HIV \u2014 \u00een timpul rela\u021biilor sexuale neprotejate, prin utilizarea comun\u0103 a echipamentelor de injec\u021bie sau prin contactul mucosal cu fluide infectate \u2014 medicamentul este deja prezent \u00een celulele neinfectate \u0219i blocheaz\u0103 etapa de transcriptaz\u0103 invers\u0103 a virusului \u00eenainte ca acesta s\u0103 se integreze \u00een ADN-ul gazd\u0103 \u0219i s\u0103 stabileasc\u0103 o infec\u021bie cronic\u0103.<\/p>\n<p>Puncte farmacocinetice cheie care afecteaz\u0103 protec\u021bia:<\/p>\n<ul>\n<li><strong>Concentra\u021bia \u00een \u021besutul rectal<\/strong> atinge niveluri protectoare dup\u0103 aproximativ <strong>7 zile<\/strong> de administrare zilnic\u0103. Acesta este motivul pentru care PrEP zilnic este eficient rapid pentru b\u0103rba\u021bii care au rela\u021bii sexuale cu b\u0103rba\u021bi<\/li>\n<li><strong>Concentra\u021bia \u00een \u021besutul cervicovaginal<\/strong> atinge niveluri protectoare mai lent \u2014 aproximativ <strong>20\u201321 de zile<\/strong> de administrare zilnic\u0103. Femeile, b\u0103rba\u021bii trans \u0219i oricine are rela\u021bii vaginale sau frontale necesit\u0103 o perioad\u0103 mai lung\u0103 de adheren\u021b\u0103 \u00eenainte de protec\u021bie complet\u0103<\/li>\n<li><strong>Tenofovirul are o semivid\u0103 intracelular\u0103 lung\u0103<\/strong> \u2014 aproximativ 4\u20135 zile. Omiterea unei singure doze nu elimin\u0103 imediat protec\u021bia, dar s\u0103ritul mai multor doze pe s\u0103pt\u0103m\u00e2n\u0103 o reduce<\/li>\n<li><strong>Acoperire post-expunere<\/strong> dup\u0103 \u00eencetarea expunerii: continua\u021bi administrarea timp de cel pu\u021bin 28 de zile dup\u0103 ultima poten\u021bial\u0103 expunere la HIV pentru a acoperi fereastra de incuba\u021bie<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u00cenainte de a \u00eencepe PrEP \u2014 Teste obligatorii<\/h2>\n<p><strong>PrEP necesit\u0103 confirmarea statutului HIV-negativ sub supraveghere specializat\u0103.<\/strong> Urm\u0103toarele teste de baz\u0103 sunt obligatorii \u00eenainte de prima doz\u0103. \u00cenceperea PrEP f\u0103r\u0103 confirmarea statutului HIV-negativ poate duce la rezisten\u021b\u0103 la medicamentele HIV dac\u0103 sunte\u021bi deja infectat \u2014 cu consecin\u021be pentru op\u021biunile viitoare de tratament.<\/p>\n<table>\n<thead>\n<tr>\n<th>Test<\/th>\n<th>De ce este important<\/th>\n<th>Calendar<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Test HIV (antigen\/anticorpi de genera\u021bia a 4-a sau ARN HIV)<\/strong><\/td>\n<td>Trebuie s\u0103 fie confirmat negativ. Dac\u0103 rezultatul este pozitiv la HIV \u0219i vi se administreaz\u0103 PrEP, regimul cu 2 medicamente este sub-terapeutic \u0219i selecteaz\u0103 muta\u021bii de rezisten\u021b\u0103 la HIV (M184V, K65R)<\/td>\n<td>\u00cen termen de 7 zile de la \u00eencepere<\/td>\n<\/tr>\n<tr>\n<td><strong>Antigenul de suprafa\u021b\u0103 al hepatitei B (HBsAg)<\/strong><\/td>\n<td>Tenofovir\/emtricitabin\u0103 trateaz\u0103 \u0219i HBV. La pacien\u021bii HBV-pozitivi, \u00eentreruperea PrEP poate provoca o exacerbare sever\u0103 a hepatitei. Pacien\u021bii HBV-pozitivi necesit\u0103 implicarea unui specialist hepatolog<\/td>\n<td>De baz\u0103<\/td>\n<\/tr>\n<tr>\n<td><strong>Func\u021bia renal\u0103 (creatinin\u0103, eGFR)<\/strong><\/td>\n<td>TDF este eliminat renal \u0219i poate provoca toxicitate renal\u0103 dependent\u0103 de doz\u0103. eGFR &lt;60 mL\/min este de obicei o contraindica\u021bie pentru PrEP bazat pe TDF (lua\u021bi \u00een considerare alternative bazate pe TAF)<\/td>\n<td>De baz\u0103, apoi la fiecare 6 luni<\/td>\n<\/tr>\n<tr>\n<td><strong>Testare IST (sifilis, clamidie, gonoree)<\/strong><\/td>\n<td>PrEP previne HIV, nu \u0219i alte IST. Testarea de baz\u0103 + screening trimestrial este standardul de \u00eengrijire<\/td>\n<td>De baz\u0103, la fiecare 3 luni<\/td>\n<\/tr>\n<tr>\n<td><strong>Test de sarcin\u0103 (dac\u0103 este cazul)<\/strong><\/td>\n<td>TDF\/FTC este categoria B \u0219i considerat sigur \u00een timpul sarcinii, dar documenta\u021bia conteaz\u0103<\/td>\n<td>De baz\u0103<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Interval de retestare:<\/strong> Test HIV repetat la fiecare 3 luni \u00een timpul PrEP. Func\u021bia renal\u0103 la fiecare 6 luni. Screening IST la fiecare 3 luni. Oricare dintre acestea \u00een afara intervalului poate necesita \u00eentreruperea PrEP.<\/p>\n<h2 class=\"wp-block-heading\">Op\u021biuni de dozare<\/h2>\n<table>\n<thead>\n<tr>\n<th>Protocol<\/th>\n<th>Pentru cine este destinat<\/th>\n<th>Regim<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>PrEP zilnic<\/strong> (prim\u0103 linie)<\/td>\n<td>To\u021bi adul\u021bii cu risc: b\u0103rba\u021bi cisgender, femei cisgender, persoane transgender, consumatori de droguri injectabile<\/td>\n<td>1 tablet\u0103 zilnic, luat\u0103 la aceea\u0219i or\u0103 \u00een fiecare zi<\/td>\n<\/tr>\n<tr>\n<td><strong>Bazat pe eveniment \/ 2-1-1 (\u201cla cerere\u201d)<\/strong> dozare<\/td>\n<td><strong>Doar pentru MSM cisgender<\/strong> \u2014 dovezi puternice din studiile IPERGAY \u0219i Prevenir. NU este recomandat pentru femei cisgender, femei transgender sau oricine are rela\u021bii vaginale\/frontale deoarece concentra\u021biile de medicament \u00een \u021besutul vaginal\/rectal difer\u0103<\/td>\n<td>2 comprimate cu 2\u201324 de ore \u00eenainte de sex, 1 comprimat la 24 de ore dup\u0103 prima pereche, 1 comprimat la 48 de ore dup\u0103 prima pereche. Pentru expunere continu\u0103, continua\u021bi cu 1 comprimat zilnic p\u00e2n\u0103 la 2 zile dup\u0103 ultima expunere sexual\u0103<\/td>\n<\/tr>\n<tr>\n<td><strong>Cre\u0219tere progresiv\u0103 zilnic\u0103<\/strong> (niveluri protectoare)<\/td>\n<td>B\u0103rba\u021bi care au sex anal receptiv<\/td>\n<td>~7 zile de administrare zilnic\u0103 pentru a atinge concentra\u021biile protectoare \u00een \u021besutul rectal<\/td>\n<\/tr>\n<tr>\n<td><strong>Cre\u0219tere progresiv\u0103 zilnic\u0103<\/strong> (niveluri protectoare, vaginal)<\/td>\n<td>Femei, b\u0103rba\u021bi transgenici care au sex vaginal\/frontal<\/td>\n<td>~21 de zile de administrare zilnic\u0103 pentru a atinge concentra\u021biile protectoare \u00een \u021besutul cervico-vaginal. Conformitatea sub acest prag reduce semnificativ eficacitatea<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Nuan\u021b\u0103 clinic\u0103 cheie:<\/strong> PrEP este <strong>protec\u021bie nu instantanee<\/strong>. Doza zilnic\u0103 trebuie luat\u0103 \u00een mod constant, iar timpul p\u00e2n\u0103 la protec\u021bie depinde de compartimentul tisular (mai rapid pentru \u021besutul rectal dec\u00e2t pentru cel cervicovaginal). Lipsa a mai mult de 1\u20132 doze pe s\u0103pt\u0103m\u00e2n\u0103 reduce semnificativ eficacitatea.<\/p>\n<h2 class=\"wp-block-heading\">Efecte Secundare<\/h2>\n<p>Majoritatea efectelor secundare apar \u00een primele 2\u20134 s\u0103pt\u0103m\u00e2ni (\u201csindromul de \u00eenceput\u201d) \u0219i se rezolv\u0103 cu utilizarea continu\u0103.<\/p>\n<table>\n<thead>\n<tr>\n<th>Severitate<\/th>\n<th>Efect Secundar<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Comune, tranzitorii (primele 2\u20134 s\u0103pt\u0103m\u00e2ni)<\/strong><\/td>\n<td>Grea\u021b\u0103, diaree, disconfort abdominal, cefalee, oboseal\u0103. De obicei se rezolv\u0103 f\u0103r\u0103 interven\u021bie<\/td>\n<\/tr>\n<tr>\n<td><strong>Mai pu\u021bin frecvent\u0103<\/strong><\/td>\n<td>Ame\u021beli, erup\u021bii cutanate, sc\u0103derea apetitului, pierdere \u00een greutate, insomnie<\/td>\n<\/tr>\n<tr>\n<td><strong>Dependent de doz\u0103 (monitorizare pe termen lung)<\/strong><\/td>\n<td>Sc\u0103dere u\u0219oar\u0103 a densit\u0103\u021bii minerale osoase (reversibil\u0103 la \u00eentrerupere), sc\u0103dere mic\u0103 a func\u021biei renale (reversibil\u0103 la majoritatea b\u0103rba\u021bilor)<\/td>\n<\/tr>\n<tr>\n<td><strong>Rare, dar grave<\/strong><\/td>\n<td>Insuficien\u021b\u0103 renal\u0103 acut\u0103 (sindrom Fanconi), acidoz\u0103 lactic\u0103, cre\u0219tere sever\u0103 a enzimelor hepatice, steatoz\u0103 hepatic\u0103. C\u0103uta\u021bi ajutor medical urgent pentru oboseal\u0103 sever\u0103, dureri musculare neexplicate, grea\u021b\u0103 persistent\u0103 sau icter<\/td>\n<\/tr>\n<tr>\n<td><strong>Specific HBV (dac\u0103 pacientul este HBV-pozitiv)<\/strong><\/td>\n<td>\u00centreruperea TDF\/FTC la un pacient HBV-pozitiv poate declan\u0219a o exacerbare acut\u0103 de hepatit\u0103 \u2014 poten\u021bial letal\u0103. Pacien\u021bii HBV-pozitivi care folosesc PrEP <strong>nu trebuie s\u0103 \u00eentrerup\u0103 brusc<\/strong> f\u0103r\u0103 implicarea unui hepatolog<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Contraindica\u021bii \u0219i precau\u021bii<\/h2>\n<ul>\n<li><strong>Statut HIV-pozitiv confirmat<\/strong> \u2014 TDF\/FTC este un regim cu 2 medicamente care este sub-terapeutic pentru tratamentul HIV; utilizarea lui selecteaz\u0103 muta\u021bii de rezisten\u021b\u0103 care compromit tratamentul viitor<\/li>\n<li><strong>Insuficien\u021b\u0103 renal\u0103 sever\u0103 (eGFR &lt;60 mL\/min)<\/strong> \u2014 TDF necesit\u0103 o func\u021bionare renal\u0103 adecvat\u0103; PrEP bazat pe TAF este o alternativ\u0103 pentru eGFR 30\u201359<\/li>\n<li><strong>Medicamente nefrotocice concomitente<\/strong> \u2014 aminoglicozide, AINS \u00een doze mari, contrast intravenos, adefovir, cidofovir. Consulta\u021bi un clinician \u00eenainte de asociere<\/li>\n<li><strong>Hepatit\u0103 acut\u0103<\/strong> \u2014 utiliza\u021bi cu precau\u021bie \u0219i consulta\u021bi un hepatolog<\/li>\n<li><strong>Al\u0103ptare<\/strong> \u2014 tenofovirul este secretat \u00een laptele matern. Este recomandat\u0103 evaluarea risc\/beneficiu cu un clinician dac\u0103 nou-n\u0103scutul este HIV-negativ \u0219i exist\u0103 alte op\u021biuni de prevenire a HIV<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>Medicamente nefrotoxice<\/strong> (aminoglicozide, amfotericin\u0103 B, cidofovir, pentamidin\u0103 intravenoas\u0103, AINS \u00een doze mari sau cronice) \u2014 toxicitate renal\u0103 aditiv\u0103<\/li>\n<li><strong>Didanosine (ddI)<\/strong> \u2014 cre\u0219te expunerea \u0219i toxicitatea didanozinei; evita\u021bi asocierea<\/li>\n<li><strong>Ledipasvir\/sofosbuvir (Harvoni)<\/strong> \u2014 cre\u0219te expunerea la tenofovir. \u00cen general, poate fi gestionat cu monitorizare renal\u0103, dar este recomandat\u0103 consultarea unui clinician<\/li>\n<li><strong>Adefovir<\/strong> \u2014 aceea\u0219i clas\u0103 de medicamente, nu combina\u021bi<\/li>\n<li><strong>Regimuri de profilaxie post-expunere la HIV (PEP)<\/strong> \u2014 dac\u0103 PEP este prescris dup\u0103 o expunere la risc ridicat \u00een timp ce sunte\u021bi pe PrEP, regimurile sunt gestionate \u00eempreun\u0103 de un specialist \u00een HIV<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Cum s\u0103 lua\u021bi \u2014 Ghid practic<\/h2>\n<ul>\n<li>\u00cenghi\u021bi\u021bi comprimatul \u00eentreg cu ap\u0103, <strong>la aceea\u0219i or\u0103 \u00een fiecare zi<\/strong>. Regularitatea este esen\u021bial\u0103 pentru eficacitatea PrEP - omiterea a mai mult de 1-2 doze pe s\u0103pt\u0103m\u00e2n\u0103 reduce semnificativ protec\u021bia<\/li>\n<li>Poate fi luat cu sau f\u0103r\u0103 m\u00e2ncare. Dac\u0103 greata este o problem\u0103 \u00een primele s\u0103pt\u0103m\u00e2ni, administrarea cu m\u00e2ncare ajut\u0103<\/li>\n<li>Dac\u0103 a\u021bi uitat o doz\u0103 \u0219i v\u0103 aminti\u021bi \u00een 24 de ore, lua\u021bi-o c\u00e2t mai cur\u00e2nd posibil. Dac\u0103 au trecut mai mult de 24 de ore, omite\u021bi doza uitat\u0103 \u0219i continua\u021bi cu urm\u0103toarea programat\u0103 - nu lua\u021bi o doz\u0103 dubl\u0103<\/li>\n<li>Nu \u00eentrerupe\u021bi brusc PrEP dac\u0103 sunte\u021bi HBV-pozitiv - consulta\u021bi-v\u0103 mai \u00eent\u00e2i cu medicul<\/li>\n<li>Dup\u0103 ultimul contact sexual, continua\u021bi PrEP timp de cel pu\u021bin 28 de zile (coad\u0103 de 2 doze) pentru a acoperi orice virus \u00een perioada de incuba\u021bie<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Depozitare<\/h2>\n<ul>\n<li>P\u0103stra\u021bi la sub 30\u00b0C \u00eentr-un loc r\u0103coros \u0219i uscat<\/li>\n<li>P\u0103stra\u021bi \u00een ambalajul original blister p\u00e2n\u0103 la utilizare<\/li>\n<li>Nu utiliza\u021bi dup\u0103 data de expirare tip\u0103rit\u0103 pe ambalaj<\/li>\n<li>Depozita\u021bi \u00eentr-un loc inaccesibil copiilor \u0219i animalelor de companie<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Tenof EM vs Truvada de marc\u0103, PrEP bazat pe TAF \u0219i alte generice<\/h2>\n<table>\n<thead>\n<tr>\n<th>Op\u021biune<\/th>\n<th>Ingrediente<\/th>\n<th>Siguran\u021b\u0103 renal\u0103\/osuar\u0103<\/th>\n<th>Date de eficacitate specifice sexului<\/th>\n<th>Nivel de cost<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Tenof EM<\/strong> (acest produs)<\/td>\n<td>TDF 300 + FTC 200<\/td>\n<td>Monitorizare standard TDF<\/td>\n<td>Toate expunerile (vaginal\u0103 + anal\u0103 + injectare)<\/td>\n<td>Cel mai sc\u0103zut<\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/medsbase.com\/ro\/tenvir-em\/\" rel=\"noopener\">Tenvir EM<\/a> (Cipla)<\/td>\n<td>TDF 300 + FTC 200<\/td>\n<td>Monitorizare standard TDF<\/td>\n<td>Toate expunerile<\/td>\n<td>Sc\u0103zut<\/td>\n<\/tr>\n<tr>\n<td>Truvada\u00ae original (Gilead)<\/td>\n<td>TDF 300 + FTC 200<\/td>\n<td>Monitorizare standard TDF<\/td>\n<td>Toate expunerile<\/td>\n<td>Cel mai ridicat<\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/medsbase.com\/ro\/tenvir-af\/\" rel=\"noopener\">Tenvir AF<\/a> \/ Descovy\u00ae<\/td>\n<td>TAF 25 + FTC 200<\/td>\n<td>Semnificativ mai bl\u00e2nd pe rinichi \u0219i densitatea mineral\u0103 osoas\u0103<\/td>\n<td>Autorizat doar pentru b\u0103rba\u021bii care au rela\u021bii sexuale cu b\u0103rba\u021bi (MSM) \u0219i femei transgen \u2014 datele pentru femeile cisgen sunt incomplete<\/td>\n<td>Moderate<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Pe care ar trebui s\u0103 o alegi?<\/strong> Dac\u0103 ai func\u021bie renal\u0103 normal\u0103 \u0219i nu ai probleme de densitate osoas\u0103, TDF\/FTC (produsul de pe aceast\u0103 pagin\u0103) este de prim\u0103 linie \u00een toate directivele majore (CDC, WHO, BHIVA, IAS-USA). Dac\u0103 ai eGFR 30\u201359 mL\/min, osteoporoz\u0103 sau alte motive pentru a evita TDF, PrEP-ul bazat pe TAF (Tenvir AF \/ Descovy) este mai sigur, dar aprobat doar pentru expunerea la HIV prin contact anal. Discut\u0103 situa\u021bia ta specific\u0103 cu un clinician care prescrie tratamente pentru HIV.<\/p>\n<h2 class=\"wp-block-heading\">Op\u021biuni conexe de PrEP<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tenvir-em\/\" rel=\"noopener\"><strong>Tenvir EM<\/strong><\/a> \u2014 Genericul Truvada de la Cipla (cel mai mare produc\u0103tor indian, precalificat de WHO)<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tenvir-af\/\" rel=\"noopener\"><strong>Tenvir AF<\/strong><\/a> \u2014 Genericul Descovy bazat pe TAF de la Cipla (mai bl\u00e2nd pe rinichi \u0219i oase)<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/ricovir-em\/\" rel=\"noopener\"><strong>Ricovir EM<\/strong><\/a> \u2014 Genericul Truvada de la Mylan<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tavin-em\/\" rel=\"noopener\"><strong>Tavin EM<\/strong><\/a> \u2014 Genericul Truvada de la Emcure<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/std-protection-pack\/\" rel=\"noopener\"><strong>Pachet Protec\u021bie IST<\/strong><\/a> \u2014 Stiva de s\u0103n\u0103tate sexual\u0103 TDF\/FTC + doxiciclin\u0103 + azitromicrin\u0103<\/li>\n<\/ul>\n<p>Vezi \u0219i: <a href=\"\/ro\/tenvir-em\/\">pagina complet\u0103 Tenvir EM<\/a> (produsul nostru TDF\/FTC cel mai des referen\u021biat), \u0219i mai larg <a href=\"\/ro\/hiv-medication\/\">Medicamente HIV<\/a> \u0219i <a href=\"\/ro\/sexual-health\/\">S\u0103n\u0103tate sexual\u0103<\/a> categorii.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">Este Tenof EM acela\u0219i lucru cu Truvada?<\/h3>\n<p>Echivalent clinic. Tenof EM con\u021bine exact acelea\u0219i ingrediente active ca Truvada (tenofovir disoproxil fumarat 300 mg + emtricitabin\u0103 200 mg) \u0219i este produs conform standardelor de bioechivalen\u021b\u0103 farmaceutic\u0103. Dovezile clinice care sus\u021bin PrEP se bazeaz\u0103 pe aceste dou\u0103 molecule, astfel \u00eenc\u00e2t protec\u021bia oferit\u0103 de un generic bioechivalent este aceea\u0219i cu cea a medicamentului original.<\/p>\n<h3 class=\"wp-block-heading\">C\u00e2t de eficient este Tenof EM \u00een prevenirea HIV?<\/h3>\n<p>PrEP bazat pe TDF\/FTC reduce achizi\u021bia HIV-1 cu <strong>peste 99%<\/strong> la persoanele care men\u021bin o adheren\u021b\u0103 ridicat\u0103 (cel pu\u021bin 4 doze pe s\u0103pt\u0103m\u00e2n\u0103 pentru b\u0103rba\u021bii care au rela\u021bii sexuale cu b\u0103rba\u021bi; dozare zilnic\u0103 pentru femeile cisgender \u0219i b\u0103rba\u021bii trans). Cele mai solide dovezi provin din studiile randomizate controlate iPrEx, PROUD \u0219i Partners PrEP.<\/p>\n<h3 class=\"wp-block-heading\">C\u00e2t dureaz\u0103 p\u00e2n\u0103 devii protejat?<\/h3>\n<p>Depinde de calea de expunere. Pentru expunerea rectal\u0103 la HIV (sex anal), dozarea zilnic\u0103 atinge niveluri protectoare \u00een tisue \u00een aproximativ. Pentru expunerea cervicovaginal\u0103 (sex vaginal\/frontal), sunt necesare aproximativ <strong>7 zile<\/strong>. de dozare zilnic\u0103. Pentru protocolul la cerere 2-1-1 (doar pentru MSM cisgender), prima doz\u0103 dubl\u0103 asigur\u0103 acoperire farmacologic\u0103 acut\u0103. <strong>20\u201321 de zile<\/strong> Trebuie s\u0103 consult un medic \u00eenainte de a \u00eencepe?.<\/p>\n<h3 class=\"wp-block-heading\">Da.<\/h3>\n<p><strong>Yes.<\/strong> PrEP necesit\u0103 confirmarea statutului de HIV-negativ sub supraveghere specializat\u0103 \u00eenainte de \u00eencepere. \u00cenceperea PrEP \u00een timp ce sunte\u021bi HIV-pozitiv f\u0103r\u0103 s\u0103 \u0219ti\u021bi poate provoca rezisten\u021b\u0103 la medicamente care limiteaz\u0103 viitoarele tratamente pentru HIV. De asemenea, ave\u021bi nevoie de teste de baz\u0103 pentru func\u021bia renal\u0103, HBV \u0219i infec\u021bii cu transmitere sexual\u0103 (ITS). La fiecare 3 luni este necesar\u0103 repetarea test\u0103rii pentru HIV \u0219i ITS; la fiecare 6 luni, evaluarea func\u021biei renale.<\/p>\n<h3 class=\"wp-block-heading\">Pot lua Tenof EM doar c\u00e2nd cred c\u0103 voi avea nevoie?<\/h3>\n<p>Pentru <strong>b\u0103rba\u021bi cisgender care au rela\u021bii sexuale cu b\u0103rba\u021bi<\/strong>, protocolul \u201c2-1-1\u201d (bazat pe eveniment) are dovezi puternice din studii (IPERGAY, Prevenir). Pentru <strong>femei cisgender, femei transgender \u0219i oricine are rela\u021bii vaginale\/frontale<\/strong>, dozarea la cerere este <strong>nerecomandat\u0103<\/strong> \u2014 farmacocinetica \u00een \u021besuturi difer\u0103 \u0219i este necesar\u0103 dozarea zilnic\u0103 pentru o protec\u021bie fiabil\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Ce se \u00eent\u00e2mpl\u0103 dac\u0103 \u00eencetez s\u0103-l mai iau?<\/h3>\n<p>Dac\u0103 sunte\u021bi HIV-negativ \u0219i HBV-negativ, pute\u021bi opri \u00een siguran\u021b\u0103 dup\u0103 completarea unei <strong>perioade de 28 de zile<\/strong> dup\u0103 ultima expunere la HIV. Dac\u0103 sunte\u021bi HBV-pozitiv, <strong>nu opri\u021bi f\u0103r\u0103 implicarea clinicianului<\/strong> \u2014 \u00eentreruperea brusc\u0103 a TDF \u00een HBV cronic poate declan\u0219a o exacerbare acut\u0103 a hepatitei.<\/p>\n<h3 class=\"wp-block-heading\">PrEP m\u0103 va proteja de alte ITS?<\/h3>\n<p><strong>Nu.<\/strong> PrEP previne doar HIV. Ave\u021bi \u00een continuare nevoie de prezervative, vaccin\u0103ri (HPV, HepA, HepB dac\u0103 nu sunte\u021bi imun) \u0219i screening trimestrial pentru clamidie, gonoree \u0219i sifilis. Consulta\u021bi <a href=\"\/ro\/std-protection-pack\/\" rel=\"noopener\">Pachet Protec\u021bie IST<\/a> pentru un set mai larg de medicamente pentru s\u0103n\u0103tatea sexual\u0103, inclusiv DoxyPEP.<\/p>\n<h3 class=\"wp-block-heading\">Are Tenof EM efecte secundare?<\/h3>\n<p>Majoritatea b\u0103rba\u021bilor experimenteaz\u0103 grea\u021b\u0103 u\u0219oar\u0103, dureri de cap sau diaree \u00een primele 2-4 s\u0103pt\u0103m\u00e2ni (\u201csindromul de \u00eenceput\u201d), care se rezolv\u0103 cu utilizarea continu\u0103. Pe termen lung, TDF provoac\u0103 o mic\u0103 sc\u0103dere a densit\u0103\u021bii minerale osoase \u0219i o u\u0219oar\u0103 sc\u0103dere a func\u021biei renale \u2014 ambele fiind de obicei reversibile la oprire. Toxicitatea renal\u0103 grav\u0103 (sindromul Fanconi, insuficien\u021b\u0103 renal\u0103 acut\u0103) este rar\u0103, dar necesit\u0103 aten\u021bie medical\u0103 urgent\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Pot combina Tenof EM cu alte medicamente?<\/h3>\n<p>Da, majoritatea medicamentelor. Evita\u021bi medicamentele nefrotoxice concomitente (aminoglicozide, AINS \u00een doze mari, cidofovir, adefovir). Majoritatea medicamentelor de uz obi\u0219nuit, inclusiv contracep\u021bia hormonal\u0103, SSRI, statine, inhibitori PDE5 \u0219i antibiotice, sunt sigure. Dezv\u0103luie\u021bi \u00eentotdeauna utilizarea PrEP medicului care v\u0103 prescrie.<\/p>\n<h3 class=\"wp-block-heading\">Am nevoie de re\u021bet\u0103 pentru a cump\u0103ra Tenof EM?<\/h3>\n<p>La MedsBase pute\u021bi comanda Tenof EM online f\u0103r\u0103 re\u021bet\u0103. PrEP este cel mai eficient atunci c\u00e2nd este supravegheat de un clinician care confirm\u0103 statutul HIV-negativ cu un test antigen\/anticorp de genera\u021bia a 4-a \u00eenainte de \u00eencepere, efectueaz\u0103 un screening HIV \u0219i pentru BTS la fiecare 3 luni \u0219i monitorizeaz\u0103 func\u021bia renal\u0103 (eGFR, protein\u0103 \u00een urin\u0103) la baz\u0103 \u0219i la fiecare 6 luni. Recomand\u0103m cu t\u0103rie un parteneriat cu un clinician pentru PrEP sigur \u0219i eficient \u2014 chiar \u0219i atunci c\u00e2nd medicamentul \u00een sine este furnizat f\u0103r\u0103 re\u021bet\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Ce este protocolul \u201c2-1-1\u201d la cerere?<\/h3>\n<p>Regimul bazat pe evenimente studiat \u00een procesul IPERGAY: 2 comprimate luate cu 2\u201324 de ore \u00eenainte de rela\u021bia sexual\u0103 anticipat\u0103, 1 comprimat la 24 de ore dup\u0103 prima doz\u0103 \u0219i 1 comprimat la 48 de ore dup\u0103 prima doz\u0103. Dac\u0103 activitatea sexual\u0103 continu\u0103, continua\u021bi cu 1 comprimat pe zi p\u00e2n\u0103 la 48 de ore dup\u0103 ultima expunere. Dovede\u021bile sus\u021bin acest protocol \u00een <strong>doar la MSM cisgender<\/strong>.<\/p>\n<p><!-- medsbase-faq-h3-converted --><\/p>\n<p class=\"medsbase-bundle-link-2026-05-01\" data-marker=\"mb-bundle-link-prep-starter-pack\">Tenof-EM ofer\u0103 PrEP pentru HIV, dar nu acoper\u0103 BTS bacteriene; pentru regimul stratificat de PrEP + doxy-PEP, consulta\u021bi oferta noastr\u0103 <a href='\/ro\/prep-starter-pack\/'>Pachetul de pornire PrEP (Tenvir-EM + doxiciclin\u0103 100 mg)<\/a> \u2014 ambele molecule \u00een niveluri de aprovizionare corespunz\u0103toare cu un singur ATC, o singur\u0103 expediere.<\/p>\n<p class=\"medsbase-link-boost-2026-05-21\" data-marker=\"mb-link-boost-tavin-em\">Dac\u0103 compara\u021bi produc\u0103torii de TDF\/FTC pentru PrEP zilnic, <a href=\"https:\/\/medsbase.com\/ro\/tenof-em\/\">Tenof EM<\/a> \u0219i <a href=\"https:\/\/medsbase.com\/ro\/tavin-em\/\">Tavin EM (tenofovir disoproxil 300 mg + emtricitabin\u0103 200 mg)<\/a> ambele con\u021bin acelea\u0219i ingrediente active \u0219i doz\u0103; alegerea se reduce de obicei la preferin\u021ba produc\u0103torului, economiile de dimensiune a ambalajului \u0219i disponibilitatea stocului.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2 id=\"related-alts\">Alte Medicamente pentru S\u0103n\u0103tate Sexual\u0103<\/h2>\n<ul>\n<li><a href=\"\/ro\/tenvir-em\/\">Tenvir EM (TDF\/FTC 300+200 mg)<\/a><\/li>\n<li><a href=\"\/ro\/ricovir-em\/\">Ricovir EM (TDF\/FTC 300+200 mg)<\/a><\/li>\n<li><a href=\"\/ro\/tavin-em\/\">Tavin EM (TDF\/FTC 300+200 mg)<\/a><\/li>\n<li><a href=\"\/ro\/taficita\/\">Taficita (TAF\/FTC 25+200 mg, generic Descovy)<\/a><\/li>\n<li><a href=\"\/ro\/std-protection-pack\/\">Pachet Protec\u021bie IST<\/a><\/li>\n<\/ul>\n<p style=\"font-size:13px;color:#555;margin:14px 0;font-style:italic;\"><strong>Disclaimer medical:<\/strong> Informa\u021biile de pe aceast\u0103 pagin\u0103 au doar scop educa\u021bional \u0219i nu \u00eenlocuiesc sfatul medical. Consulta\u021bi \u00eentotdeauna un medic calificat \u00eenainte de a \u00eencepe, \u00eentrerupe sau modifica orice tratament medicamentos.<\/p>","protected":false},"excerpt":{"rendered":"<h5>\u2705 Protejeaz\u0103 \u00eempotriva infec\u021biei cu HIV<br \/>\n\u2705 Previne multiplicarea virusului<br \/>\n\u2705 Poten\u021bial pentru tratamentul hepatitei B<br \/>\n\u2705 \u00cembun\u0103t\u0103\u021be\u0219te calitatea vie\u021bii<br \/>\n\u2705 Versiune generic\u0103 a Truvada \u00ae<\/h5>\n<p><span style=\"color: #808080;\"><strong>Tenof EM<\/strong> con\u021bine <strong>Emtricitabine<\/strong> \u0219i <strong>Tenofovir.<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>","protected":false},"featured_media":55089,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3334,3304,3338,3337],"product_tag":[3339,5820,5815,5816,5354,5814,3854,3335,5670],"class_list":{"0":"post-55088","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-hepatitis-medication","9":"product_cat-hiv-medication","10":"product_cat-prep-medication-pre-exposure-prophylaxis","11":"product_cat-sexual-health","12":"product_tag-emtricitabine","13":"product_tag-hetero-drugs","14":"product_tag-hiv-prevention","15":"product_tag-pre-exposure-prophylaxis","16":"product_tag-prep","17":"product_tag-tdf-ftc","18":"product_tag-tenof-em","19":"product_tag-tenofovir","20":"product_tag-truvada-generic","22":"first","23":"instock","24":"featured","25":"shipping-taxable","26":"purchasable","27":"product-type-variable","28":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/55088","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=55088"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/55089"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=55088"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=55088"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=55088"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=55088"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}