{"id":55317,"date":"2024-01-30T10:07:16","date_gmt":"2024-01-30T10:07:16","guid":{"rendered":"https:\/\/medsname.com\/agoprex\/"},"modified":"2026-04-30T10:24:49","modified_gmt":"2026-04-30T10:24:49","slug":"agoprex","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/agoprex\/","title":{"rendered":"Agoprex"},"content":{"rendered":"

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\u26a1 R\u0103spuns rapid<\/h3>\n

Agoprex (Agomelatin\u0103 25 mg) este un agonist al receptorilor de melatonin\u0103 MT1\/MT2 \u0219i antagonist 5-HT2C utilizat \u00een tratamentul depresiei majore. Profil distinct: nu provoac\u0103 disfunc\u021bii sexuale, cre\u0219tere \u00een greutate sau sindrom de \u00eentrerupere, dar necesit\u0103 monitorizarea func\u021biei hepatice (LFT).<\/p>\n<\/div>\n

\nCe beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate ale clien\u021bilor<\/a>\n<\/div>\n

\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n

De ce s\u0103 comanzi de la MedsBase<\/h3>\n

Agoprex la MedsBase este furnizat direct de la un produc\u0103tor certificat WHO-GMP \u00een ambalaje discrete, simple. Fiecare comand\u0103 este acoperit\u0103 de Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> \u2014 perioad\u0103 de livrare de 20 de zile lucr\u0103toare sau retrimitem f\u0103r\u0103 costuri suplimentare \u2014 \u0219i se calific\u0103 pentru programul nostru de loialitate pentru clien\u021bi<\/a>. Livr\u0103rile sunt disponibile \u00een majoritatea destina\u021biilor la nivel mondial.<\/p>\n

Ce este Agoprex \u0219i cum func\u021bioneaz\u0103<\/h2>\n

Agoprex este un comprimat de agomelatin\u0103 25 mg furnizat de Sun Pharma. Agomelatina este unic\u0103 din punct de vedere mecanic printre antidepresive: ac\u021bioneaz\u0103 ca agonist la receptorii de melatonin\u0103 MT1 \u0219i MT2 \u0219i ca antagonist la receptorii serotoninici 5-HT2C. Mecanismul dublu resincronizeaz\u0103 ritmurile circadiene perturbate (o caracteristic\u0103 a depresiei majore) \u00een timp ce cre\u0219te indirect eliberarea de dopamin\u0103 \u0219i noradrenalin\u0103 \u00een cortexul frontal.<\/p>\n

Agomelatina nu are activitate SERT, nu are efecte anticolinergice \u0219i nici efecte histaminergice \u2014 ceea ce explic\u0103 profilul s\u0103u de efecte secundare foarte diferit fa\u021b\u0103 de SSRI \u0219i TCA.<\/p>\n

Indica\u021bii \u0219i dozaj<\/h2>\n\n\n\n\n\n\n
Indica\u021bie<\/th>\nDoza ini\u021bial\u0103<\/th>\n\u021aint\u0103<\/th>\nMaxim<\/th>\n<\/tr>\n<\/thead>\n
Depresie major\u0103<\/td>\n25 mg HS<\/td>\n25 mg HS<\/td>\n50 mg HS<\/td>\n<\/tr>\n
Pacien\u021bi \u00een v\u00e2rst\u0103 \/ probleme hepatice<\/td>\nDoar 25 mg HS<\/td>\n\u2014<\/td>\nnu cre\u0219te\u021bi doza<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Se administreaz\u0103 \u00eentotdeauna seara (v\u00e2rf la 1 or\u0103, timp de \u00eenjum\u0103t\u0103\u021bire 1\u20132 ore, dar efectul receptor asupra ritmului circadian necesit\u0103 administrare seara).<\/p>\n

Considera\u021bii importante de siguran\u021b\u0103<\/h2>\n
\nMonitorizare obligatorie a testelor hepatice<\/strong><\/p>\n

Agomelatina are un semnal clinic semnificativ de hepatotoxicitate \u2014 inclusiv cazuri rare de hepatit\u0103 fulminant\u0103. Teste hepatice obligatorii<\/strong> la ini\u021biere, apoi la 3, 6, 12 \u0219i 24 de s\u0103pt\u0103m\u00e2ni, apoi la fiecare cre\u0219tere de doz\u0103. \u00centrerupe\u021bi imediat dac\u0103 AST sau ALT > 3\u00d7 ULN, sau dac\u0103 icterul, urina \u00eenchis\u0103 la culoare, durere \u00een cadranul superior drept sau oboseala sugereaz\u0103 afectare hepatic\u0103. Contraindicate \u00een orice afec\u021biune hepatic\u0103 preexistent\u0103<\/strong> (Child-Pugh B sau C), \u00een cazul transaminazelor > 3\u00d7 ULN la ini\u021biere \u0219i \u00een cazul consumului ridicat de alcool.<\/p>\n<\/div>\n

\nInterac\u021biuni medicamentoase \u2014 inhibitori puternici ai CYP1A2<\/strong><\/p>\n

Evita\u021bi administrarea concomitent\u0103 cu fluvoxamin\u0103, ciprofloxacin\u0103, enoxacin\u0103 \u2014 acestea cresc nivelurile de agomelatin\u0103 de mai multe ori. Renun\u021barea la fumat poate cre\u0219te nivelurile (CYP1A2 este indus de fumat).<\/p>\n<\/div>\n

\nAvertisment cutie neagr\u0103 privind riscul de suicid (sub 25 de ani)<\/strong><\/p>\n

Toate antidepresivele poart\u0103 un avertisment cutie neagr\u0103 FDA privind cre\u0219terea g\u00e2ndurilor suicidare la pacien\u021bii sub 25 de ani.<\/p>\n<\/div>\n

Efecte secundare frecvente<\/h2>\n