{"id":55536,"date":"2024-02-07T00:02:44","date_gmt":"2024-02-07T00:02:44","guid":{"rendered":"https:\/\/medsname.com\/aprezo\/"},"modified":"2026-04-30T10:24:47","modified_gmt":"2026-04-30T10:24:47","slug":"aprezo","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/aprezo\/","title":{"rendered":"Aprezo"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Aprezo?<\/h3>\n<p style=\"margin:0;\"><strong>Aprezo<\/strong> este un <strong>apremilast 30 mg<\/strong> comprimat \u2014 a <strong>inhibitor PDE4<\/strong> utilizat pentru tratarea <strong>psoriazis \u00een pl\u0103ci de la moderat la sever<\/strong>, <strong>artrit\u0103 psoriazic\u0103 activ\u0103<\/strong>, \u0219i <strong>ulcere orale \u00een boala Beh\u00e7et<\/strong>. Este <strong>op\u021biunea oral\u0103 sistemic\u0103 de prim\u0103 inten\u021bie<\/strong> pentru pacien\u021bii care nu pot sau prefer\u0103 s\u0103 nu foloseasc\u0103 metotrexat, ciclosporin\u0103 sau biologice. Doza standard de \u00eentre\u021binere este <strong>30 mg de dou\u0103 ori pe zi<\/strong> dup\u0103 o titrare de 5 zile. Echivalent clinic cu <strong>Otezla<sup>\u00ae<\/sup><\/strong>.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<p><strong>Aprezo<\/strong> este comprimatul oral <strong>apremilast 30 mg<\/strong> \u2014 un imunomodulator care a reprezentat un adev\u0103rat progres \u00een tratamentul psoriazisului atunci c\u00e2nd a fost aprobat de FDA \u00een 2014. Apremilast este un <strong>inhibitor de fosfodiesteraz\u0103 4 (PDE4)<\/strong> care ac\u021bioneaz\u0103 exclusiv intracelular pe semnalizarea celulelor imune, f\u0103r\u0103 imunosupresia, necesitatea de monitorizare prin analize sau cerin\u021bele de injectare ale metotrexatului sau ale agen\u021bilor biologici.<\/p>\n<p>Aprezo con\u021bine acela\u0219i ingredient activ \u00een aceea\u0219i concentra\u021bie ca <strong>Otezla<sup>\u00ae<\/sup><\/strong> \u0219i este unul dintre cele mai prescrise medicamente sistematice orale pentru psoriazis din lume. Are un profil de siguran\u021b\u0103 favorabil, potrivit pentru utilizare pe termen lung \u00een regim ambulator.<\/p>\n<h2 class=\"wp-block-heading\">Ce este Aprezo?<\/h2>\n<p>Aprezo este un imunomodulator <strong>oral pe baz\u0103 de re\u021bet\u0103<\/strong> care inhib\u0103 selectiv PDE4 \u00een celulele imune \u0219i inflamatorii. Acest lucru cre\u0219te nivelul intracelular de AMP ciclic \u0219i deplaseaz\u0103 balan\u021ba citokinelor de la semnalele pro-inflamatorii (TNF-\u03b1, IL-23, IL-17, IFN-\u03b3) spre cele anti-inflamatorii (IL-10).<\/p>\n<p>Aprezo este indicat pentru:<\/p>\n<ul>\n<li><strong>Psoriazisul \u00een pl\u0103ci de la moderat la sever<\/strong> \u2014 la adul\u021bi pentru care fototerapia sau alte terapii sistematice sunt potrivite<\/li>\n<li><strong>Artrita psoriatic\u0103 activ\u0103<\/strong> \u2014 singur sau \u00een combina\u021bie cu DMARD-uri precum metotrexat<\/li>\n<li><strong>Ulcer\u0103ri orale asociate cu boala Beh\u00e7et<\/strong> \u2014 indica\u021bie aprobat\u0103 de FDA din 2019<\/li>\n<li><strong>Psoriazisul de scalp \u0219i unghii<\/strong> \u2014 adesea cu r\u0103spuns deosebit la apremilast<\/li>\n<li><strong>Psoriazisul palmoplantar \u0219i genital<\/strong> \u2014 c\u00e2nd terapia topic\u0103 este insuficient\u0103<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Cum func\u021bioneaz\u0103 Aprezo?<\/h2>\n<p>Mecanismul apremilastului este distinct de alte sistematice pentru psoriazis:<\/p>\n<ul>\n<li><strong>Inhib\u0103 PDE4<\/strong> \u00een interiorul celulelor imune \u2014 PDE4 este enzima care degradeaz\u0103 normal cAMP intracelular<\/li>\n<li>Niveluri crescute de cAMP <strong>activeaz\u0103 proteina kinaza A<\/strong> \u0219i <strong>suprim\u0103 factorul de transcrip\u021bie NF-\u03baB<\/strong><\/li>\n<li>Efect downstream: <strong>produc\u021bie redus\u0103 de TNF-\u03b1, IL-23, IL-17, IL-8 \u0219i IFN-\u03b3<\/strong>, cu <strong>cre\u0219tere a IL-10<\/strong><\/li>\n<li>F\u0103r\u0103 imunosupresie direct\u0103 \u2014 pacien\u021bii nu sunt imunocompromi\u0219i \u0219i nu necesit\u0103 screening de infec\u021bii de rutin\u0103 ca \u00een cazul biologicelor<\/li>\n<li>Efectul clinic este gradual \u2014 majoritatea pacien\u021bilor observ\u0103 o \u00eembun\u0103t\u0103\u021bire semnificativ\u0103 a psoriazisului p\u00e2n\u0103 la <strong>16 s\u0103pt\u0103m\u00e2ni<\/strong>; unele mai devreme<\/li>\n<\/ul>\n<p>Deoarece medicamentul nu vizeaz\u0103 un singur citokin\u0103, ci moduleaz\u0103 \u00eentregul mediu de semnalizare \u00een amonte, eficacitatea este mai moderat\u0103 dec\u00e2t a biologicelor anti-TNF sau anti-IL-17, dar marja de siguran\u021b\u0103 este mai larg\u0103 \u2014 deosebit de atractiv\u0103 pentru pacien\u021bii care nu tolereaz\u0103 biologicele sau doresc s\u0103 evite injec\u021biile.<\/p>\n<h2 class=\"wp-block-heading\">Dozarea \u0219i administrarea Aprezo<\/h2>\n<p>Apremilast folose\u0219te o <strong>titrare de 5 zile<\/strong> pentru a reduce efectele secundare gastrointestinale ini\u021biale.<\/p>\n<table>\n<thead>\n<tr>\n<th>Ziua<\/th>\n<th>Diminea\u021ba<\/th>\n<th>Seara<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>1<\/td>\n<td>10 mg<\/td>\n<td>\u2014<\/td>\n<\/tr>\n<tr>\n<td>2<\/td>\n<td>10 mg<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>3<\/td>\n<td>10 mg<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>4<\/td>\n<td>20 mg<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>5<\/td>\n<td>20 mg<\/td>\n<td>30 mg<\/td>\n<\/tr>\n<tr>\n<td>ziua 6 \u00eencolo<\/td>\n<td><strong>30 mg<\/strong><\/td>\n<td><strong>30 mg<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Not\u0103:<\/strong> pachetul de titrare con\u021bine de obicei comprimate de 10 mg \u0219i 20 mg pentru zilele 1\u20135. Comprimatul de 30 mg (Aprezo) este doza de \u00eentre\u021binere \u00eencep\u00e2nd cu ziua 6 \u00eencolo.<\/p>\n<table>\n<thead>\n<tr>\n<th>Scenariu<\/th>\n<th>Doza<\/th>\n<th>Note<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Psoriazis \u00een pl\u0103ci\/artrit\u0103 psoriazic\u0103 (\u00eentre\u021binere)<\/strong><\/td>\n<td>30 mg de dou\u0103 ori pe zi<\/td>\n<td>Continua\u021bi pe termen nedefinit at\u00e2ta timp c\u00e2t este eficace<\/td>\n<\/tr>\n<tr>\n<td><strong>Afte orale Beh\u00e7et<\/strong><\/td>\n<td>30 mg de dou\u0103 ori pe zi<\/td>\n<td>Titrare similar\u0103<\/td>\n<\/tr>\n<tr>\n<td><strong>Insuficien\u021b\u0103 renal\u0103 sever\u0103 (CrCl &lt;30 mL\/min)<\/strong><\/td>\n<td>30 mg o dat\u0103 pe zi (doar diminea\u021ba)<\/td>\n<td>\u00cenjum\u0103t\u0103\u021bi\u021bi doza de \u00eentre\u021binere; titrarea utilizeaz\u0103 doar dozele de diminea\u021b\u0103<\/td>\n<\/tr>\n<tr>\n<td><strong>Insuficien\u021b\u0103 hepatic\u0103<\/strong><\/td>\n<td>Doza standard<\/td>\n<td>Nu este necesar\u0103 ajustare<\/td>\n<\/tr>\n<tr>\n<td><strong>Sarcin\u0103<\/strong><\/td>\n<td>Evita\u021bi<\/td>\n<td>Contraindica\u021bii<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 class=\"wp-block-heading\">Cum s\u0103 lua\u021bi corect Aprezo<\/h3>\n<ul>\n<li>\u00cenghi\u021bi\u021bi comprimatul \u00eentreg cu ap\u0103; poate fi luat cu sau f\u0103r\u0103 m\u00e2ncare<\/li>\n<li>Lua\u021bi la aproximativ acelea\u0219i ore \u00een fiecare zi (diminea\u021ba \u0219i seara, la aproximativ 12 ore distan\u021b\u0103)<\/li>\n<li>Finaliza\u021bi \u00eentreaga titrare de 5 zile, chiar dac\u0103 tolera\u021bi bine dozele ini\u021biale \u2014 programul de titrare reduce semnificativ efectele secundare gastrointestinale<\/li>\n<li>Dac\u0103 greata sau diareea sunt deranjante la doza de \u00eentre\u021binere, lua\u021bi medicamentul cu m\u00e2ncare \u00een loc s\u0103 \u00eentrerupe\u021bi<\/li>\n<li>Acorda\u021bi <strong>cel pu\u021bin 16 s\u0103pt\u0103m\u00e2ni<\/strong> \u00eenainte de a evalua eficacitatea \u2014 majoritatea pacien\u021bilor care vor r\u0103spunde o fac p\u00e2n\u0103 atunci<\/li>\n<li>Monitoriza\u021bi greutatea lunar \u2014 pierderea involuntar\u0103 de greutate apare la o minoritate de pacien\u021bi<\/li>\n<li>Monitoriza\u021bi activ starea de spirit \u2014 au fost raportate cazuri de depresie nou\u0103 sau agravat\u0103<\/li>\n<li>Nu \u00eentrerupe\u021bi brusc f\u0103r\u0103 consult medical \u2014 psoriazisul poate se agrava<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Efecte secundare ale Aprezo<\/h2>\n<table>\n<thead>\n<tr>\n<th>Severitate<\/th>\n<th>Efect Secundar<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Frecvente (\u22651 din 10)<\/strong><\/td>\n<td>Diaree, grea\u021b\u0103, cefalee (\u00een special s\u0103pt\u0103m\u00e2nile 1\u20134)<\/td>\n<\/tr>\n<tr>\n<td><strong>Frecvente (\u22651 din 100)<\/strong><\/td>\n<td>Durere abdominal\u0103, v\u0103rs\u0103turi, infec\u021bii ale tractului respirator superior, oboseal\u0103, pierdere \u00een greutate (\u22655% din greutatea corporal\u0103 la ~10% dintre utilizatori)<\/td>\n<\/tr>\n<tr>\n<td><strong>Pu\u021bin frecvente<\/strong><\/td>\n<td>Modific\u0103ri ale st\u0103rii de spirit\/depresie, migren\u0103, insomnie, reac\u021bii de hipersensibilitate<\/td>\n<\/tr>\n<tr>\n<td><strong>Rare<\/strong><\/td>\n<td>Diarhee severe care necesit\u0103 spitalizare, pierdere semnificativ\u0103 \u00een greutate, idei suicidare, angioedem<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Efectele secundare gastrointestinale sunt de obicei autolimitate<\/strong> \u2014 majoritatea se rezolv\u0103 \u00een primele 2\u20134 s\u0103pt\u0103m\u00e2ni pe m\u0103sur\u0103 ce organismul se adapteaz\u0103. Diarhea persistent\u0103 sever\u0103 necesit\u0103 evaluare medical\u0103.<\/p>\n<h2 class=\"wp-block-heading\">Avertismente \u0219i precau\u021bii<\/h2>\n<ul>\n<li><strong>Risc de depresie.<\/strong> Au fost raportate cazuri de depresie nou\u0103 sau agravat\u0103, g\u00e2nduri suicidare sau sinucidere la unii pacien\u021bi. Monitoriza\u021bi starea emo\u021bional\u0103; raporta\u021bi prompt orice modific\u0103ri ale dispozi\u021biei<\/li>\n<li><strong>Pierdere \u00een greutate.<\/strong> 10% dintre pacien\u021bi pierd \u22655% din greutatea corporal\u0103. Monitoriza\u021bi greutatea lunar \u2014 \u00een cazul pierderii semnificative neinten\u021bionate, lua\u021bi \u00een considerare reducerea dozei sau \u00eentreruperea tratamentului<\/li>\n<li><strong>Diarhee \u0219i grea\u021b\u0103.<\/strong> Cele mai frecvente \u00een primele 2\u20134 s\u0103pt\u0103m\u00e2ni \u2014 schema de titrare pe 5 zile reduce semnificativ severitatea<\/li>\n<li><strong>Sarcina.<\/strong> Teratogen \u00een studii pe animale \u2014 evita\u021bi. Folosi\u021bi metode contraceptive sigure \u00een timpul \u0219i 30 de zile dup\u0103 \u00eentreruperea tratamentului<\/li>\n<li><strong>Al\u0103ptare.<\/strong> Nu este recomandat<\/li>\n<li><strong>Alcool.<\/strong> Nu exist\u0103 interac\u021biune direct\u0103, dar agraveaz\u0103 efectele adverse gastrointestinale \u00een primele s\u0103pt\u0103m\u00e2ni<\/li>\n<li><strong>Vaccin\u0103ri.<\/strong> Vaccinurile cu microorganisme vii sunt permise cu apremilast (spre deosebire de biologice) deoarece apremilastul nu este imunosupresor<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindica\u021bii \u2014 Cine NU ar trebui s\u0103 ia Aprezo<\/h2>\n<ul>\n<li>Sarcin\u0103<\/li>\n<li>Hipersensibilitate cunoscut\u0103 la apremilast sau la orice excipient<\/li>\n<li>Depresie sever\u0103 activ\u0103 cu tendin\u021be suicidare (evalua\u021bi cu aten\u021bie)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<table>\n<thead>\n<tr>\n<th>Medicament \/ Clas\u0103<\/th>\n<th>Interac\u021biune<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Inductori puternici ai CYP3A4 (rifampicin\u0103, fenitoin\u0103, carbamazepin\u0103, fenobarbital, iarba Sf\u00e2ntului Ioan)<\/strong><\/td>\n<td><strong>Evita\u021bi combina\u021bia<\/strong> \u2014 poate reduce nivelurile de apremilast cu 72% \u0219i poate compromite eficacitatea<\/td>\n<\/tr>\n<tr>\n<td><strong>Inhibitori ai CYP3A4 (ketoconazol, ritonavir, claritromicin\u0103)<\/strong><\/td>\n<td>Cre\u0219tere moderat\u0103 a nivelurilor de apremilast \u2014 de obicei gestionabil\u0103 clinic<\/td>\n<\/tr>\n<tr>\n<td><strong>Metotrexat<\/strong><\/td>\n<td>Frecvent prescrise \u00eempreun\u0103 \u00een artrita psoriazic\u0103 \u2014 f\u0103r\u0103 interac\u021biune farmacocinetic\u0103 advers\u0103<\/td>\n<\/tr>\n<tr>\n<td><strong>Agente biologice (inhibitori TNF, IL-17, IL-23)<\/strong><\/td>\n<td>De obicei utilizate secven\u021bial \u0219i nu \u00een combina\u021bie \u2014 datele pentru coprescriere sunt limitate<\/td>\n<\/tr>\n<tr>\n<td><strong>Alcool<\/strong><\/td>\n<td>Agravarea efectelor adverse gastrointestinale la \u00eenceput; moderate ulterior<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Instruc\u021biuni de Depozitare<\/h2>\n<ul>\n<li>P\u0103stra\u021bi la sub 25 \u00b0C \u00eentr-un loc uscat, departe de lumina direct\u0103 a soarelui<\/li>\n<li>P\u0103stra\u021bi \u00een ambalajul original blister<\/li>\n<li>Se p\u0103streaz\u0103 \u00een afara accesului copiilor<\/li>\n<li>Nu utiliza\u021bi dup\u0103 data de expirare<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Alternative conexe pe MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/dapsone\/\" rel=\"noopener\">Dapsone<\/a> \u2014 imunomodulator oral alternativ pentru anumite boli inflamatorii ale pielii<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/eczema-psoriasis-treatment\/\" rel=\"noopener\">R\u0103sfoi\u021bi toate tratamentele pentru eczem\u0103 \u0219i psoriazis \u2192<\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">Pentru ce se utilizeaz\u0103 Aprezo?<\/h3>\n<p>Aprezo (apremilast) trateaz\u0103 <strong>psoriazisul \u00een pl\u0103ci moderat p\u00e2n\u0103 la sever, artrita psoriazic\u0103 activ\u0103 \u0219i ulcera\u021biile orale ale bolii Beh\u00e7et<\/strong>. Este adesea prescris pentru pacien\u021bii care nu pot sau prefer\u0103 s\u0103 nu foloseasc\u0103 injec\u021bii biologice sau metotrexat.<\/p>\n<h3 class=\"wp-block-heading\">C\u00e2t de repede ac\u021bioneaz\u0103 Aprezo?<\/h3>\n<p>\u00cembun\u0103t\u0103\u021biri timpurii la 4\u20136 s\u0103pt\u0103m\u00e2ni; r\u0103spuns semnificativ de obicei p\u00e2n\u0103 la <strong>16 s\u0103pt\u0103m\u00e2ni<\/strong>. Simptomele articulare \u00een artrita psoriazic\u0103 pot r\u0103spunde mai repede dec\u00e2t leziunile cutanate.<\/p>\n<h3 class=\"wp-block-heading\">De ce exist\u0103 un pachet de titrare?<\/h3>\n<p>Cre\u0219terea treptat\u0103 pe 5 zile de la 10 mg la doza de \u00eentre\u021binere de 30 mg de dou\u0103 ori pe zi reduce semnificativ greata, diareea \u0219i cefaleea ini\u021bial\u0103. Nu s\u0103ri\u021bi niciodat\u0103 titrarea \u2014 \u00eenceperea direct cu 30 mg de dou\u0103 ori pe zi este mult mai pu\u021bin tolerabil\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Este Aprezo un biologic?<\/h3>\n<p><strong>Nu<\/strong> \u2014 apremilast este un medicament cu molecul\u0103 mic\u0103 <strong>oral<\/strong> , nu un biologic. Nu necesit\u0103 injec\u021bii, perfuzii, depozitare \u00een lan\u021b frigorific sau screening pre-tratament pentru tuberculoz\u0103\/hepatit\u0103. Acesta este unul dintre principalele sale avantaje practice.<\/p>\n<h3 class=\"wp-block-heading\">Voi sl\u0103bi dac\u0103 iau Aprezo?<\/h3>\n<p>Aproximativ 10% dintre utilizatori pierd \u22655% din greutatea corporal\u0103. La pacien\u021bii cu exces de greutate, acest lucru poate fi binevenit, dar orice pierdere semnificativ\u0103 neinten\u021bionat\u0103 ar trebui discutat\u0103 cu medicul dumneavoastr\u0103. Monitoriza\u021bi greutatea lunar.<\/p>\n<h3 class=\"wp-block-heading\">Pot consuma alcool \u00een timp ce iau Aprezo?<\/h3>\n<p>Un consum moderat este acceptabil. Consumul excesiv de alcool poate agrava efectele secundare gastrointestinale, \u00een special \u00een primele s\u0103pt\u0103m\u00e2ni.<\/p>\n<h3 class=\"wp-block-heading\">Pot r\u0103m\u00e2ne \u00eens\u0103rcinat\u0103 \u00een timp ce iau Aprezo?<\/h3>\n<p><strong>Nu<\/strong> \u2014 apremilast este contraindiat \u00een timpul sarcinii. Folosi\u021bi metode contraceptive sigure \u00een timpul tratamentului \u0219i pentru cel pu\u021bin 30 de zile dup\u0103 \u00eentrerupere.<\/p>\n<h3 class=\"wp-block-heading\">Pot combina Aprezo cu metotrexat?<\/h3>\n<p>Da \u2014 aceast\u0103 combina\u021bie este frecvent utilizat\u0103 \u00een artrita psoriazic\u0103 \u0219i este bine tolerat\u0103. Nu exist\u0103 interac\u021biuni farmacocinetice adverse.<\/p>\n<h3 class=\"wp-block-heading\">Aprezo afecteaz\u0103 sistemul imunitar?<\/h3>\n<p>Spre deosebire de medicamentele biologice, apremilast nu provoac\u0103 imunosupresie. Nu sunt necesare teste de screening pentru tuberculoz\u0103 sau hepatit\u0103, iar vaccinurile cu virus vii sunt permise.<\/p>\n<h3 class=\"wp-block-heading\">Ce se \u00eent\u00e2mpl\u0103 dac\u0103 Aprezo nu func\u021bioneaz\u0103 dup\u0103 16 s\u0103pt\u0103m\u00e2ni?<\/h3>\n<p>Eficacitatea este mai moderat\u0103 dec\u00e2t a biologicelor. Dac\u0103 r\u0103spunsul este insuficient, dermatologul sau reumatologul dumneavoastr\u0103 v\u0103 poate prescrie un biologic (adalimumab, secukinumab, ixekizumab, guselkumab) sau medicamente sistemice tradi\u021bionale (metotrexat, ciclosporin\u0103).<\/p>\n<p><!-- medsbase-faq-h3-converted --><\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alternative conexe<\/h3>\n<p>Alte produse din <strong>Afec\u021biuni cronice<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/inderal\/\">Inderal<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/lipaglyn\/\">Lipaglyn<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/triohale-rotacaps\/\">Triohale Rotacaps<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/seroflo-rotacaps\/\">Seroflo Rotacaps<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/amlip\/\">Amlip<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Reduce simptomele psoriazisului<br \/>\n\u2705 Controleaz\u0103 artrita psoriatic\u0103<br \/>\n\u2705 Minimizeaz\u0103 inflama\u021bia pielii<br \/>\n\u2705 Amelioreaz\u0103 durerea articular\u0103<br \/>\n\u2705 \u00cembun\u0103t\u0103\u021be\u0219te claritatea pielii<\/p>\n<p>Aprezo con\u021bine Apremilast.<\/p>","protected":false},"featured_media":55537,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3942],"product_tag":[3943,3944,5765,5767,5766,5761,5762,5763,5764],"class_list":{"0":"post-55536","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-eczema-psoriasis-treatment","9":"product_tag-apremilast","10":"product_tag-aprezo","11":"product_tag-behcet-disease","12":"product_tag-glenmark","13":"product_tag-immunomodulator","14":"product_tag-otezla-generic","15":"product_tag-pde4-inhibitor","16":"product_tag-plaque-psoriasis","17":"product_tag-psoriatic-arthritis","19":"first","20":"instock","21":"shipping-taxable","22":"purchasable","23":"product-type-variable","24":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/55536","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=55536"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/55537"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=55536"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=55536"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=55536"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=55536"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}