{"id":55940,"date":"2024-02-07T05:46:49","date_gmt":"2024-02-07T05:46:49","guid":{"rendered":"https:\/\/medsname.com\/bupron-xl\/"},"modified":"2026-04-30T10:24:42","modified_gmt":"2026-04-30T10:24:42","slug":"bupron-xl","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/bupron-xl\/","title":{"rendered":"Bupron XL"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Bupron XL?<\/h3>\n<p style=\"margin:0;\"><strong>Bupron XL<\/strong> este o form\u0103 cu eliberare prelungit\u0103 <strong>bupropion hidroclorur\u0103<\/strong> comprimat utilizat pentru tratarea <strong>tulburare depresiv\u0103 major\u0103 (MDD)<\/strong>, <strong>tulburare afectiv\u0103 sezonier\u0103 (SAD)<\/strong>, \u0219i ca adjuvant \u00een <strong>renun\u021barea la fumat<\/strong>. Disponibil \u00een <strong>150 mg \u0219i 300 mg<\/strong> doze pentru administrare o dat\u0103 pe zi. Spre deosebire de SSRI, bupropionul nu <strong>provoac\u0103 disfunc\u021bii sexuale sau cre\u0219tere \u00een greutate<\/strong>, \u0219i adesea <strong>reduce apetitul<\/strong>. .. Fabricat ca echivalent generic al Wellbutrin XL de la GSK<sup>\u00ae<\/sup> \u0219i Zyban<sup>\u00ae<\/sup>.<\/p>\n<\/div>\n<p><strong>Bupron XL<\/strong> este un <strong>bupropion hidroclorur\u0103 cu eliberare prelungit\u0103<\/strong> comprimat utilizat pentru tratarea <strong>depresie<\/strong> \u0219i pentru a ajuta oamenii <strong>s\u0103 renun\u021be la fumat<\/strong>. Fiecare tablet\u0103 con\u021bine 150 mg sau 300 mg de bupropion \u00eentr-o matrice cu eliberare prelungit\u0103, conceput\u0103 pentru a asigura o dozare unic\u0103 zilnic\u0103 pe parcursul a 24 de ore. Fabricat de Sun Pharma, Bupron XL este echivalentul generic al produsului <strong>Wellbutrin XL<sup>\u00ae<\/sup><\/strong> (pentru depresie) \u0219i <strong>Zyban<sup>\u00ae<\/sup><\/strong> (pentru renun\u021barea la fumat) \u2014 la o frac\u021biune din pre\u021b.<\/p>\n<p>Bupropion este un <strong>antidepresiv atipic<\/strong> clasificat ca <strong>inhibitor al recapt\u0103rii norepinefrinei-dopaminei (NDRI)<\/strong>. Se diferen\u021biaz\u0103 de inhibitorii selectivi ai recapt\u0103rii serotoninerei (SSRI) prin profilul s\u0103u distinctiv de efecte secundare: nu provoac\u0103 disfunc\u021bii sexuale, nu induce cre\u0219tere \u00een greutate (\u0219i adesea duce la o u\u0219oar\u0103 sc\u0103dere a greut\u0103\u021bii), are un efect sedativ minim \u0219i un u\u0219or efect stimulant la mul\u021bi pacien\u021bi.<\/p>\n<h2 class=\"wp-block-heading\">Ce este Bupron XL?<\/h2>\n<p>Bupron XL este un medicament pe baz\u0103 de re\u021bet\u0103 <strong>NDRI<\/strong> care inhib\u0103 selectiv recaptarea <strong>noradrenalinei (norepinefrina)<\/strong> \u0219i <strong>dopaminei<\/strong> \u00een neuronii sistemului nervos central. Spre deosebire de SSRI, bupropionul are un efect minor asupra serotoninei \u2013 ceea ce explic\u0103 profilul s\u0103u favorabil \u00een ceea ce prive\u0219te func\u021bia sexual\u0103, greutatea \u0219i somnul.<\/p>\n<p>Bupron XL este utilizat cel mai frecvent pentru:<\/p>\n<ul>\n<li><strong>Tulburarea depresiv\u0103 major\u0103 (MDD)<\/strong> \u2013 inclusiv depresia care nu r\u0103spunde la SSRI sau nu este tolerat\u0103 de pacien\u021bi<\/li>\n<li><strong>Tulburarea afectiv\u0103 sezonier\u0103 (SAD)<\/strong> \u2013 prevenirea episoadelor depresive \u00een toamn\u0103\/iarn\u0103 la persoanele cu antecedente de SAD<\/li>\n<li><strong>\u00cencetarea fumatului<\/strong> \u2013 reduce poftele \u0219i simptomele de sevraj; dubleaz\u0103 rata de renun\u021bare fa\u021b\u0103 de placebo<\/li>\n<li><strong>Tratament adjuvant \u00een disfunc\u021biile sexuale cauzate de SSRI<\/strong> \u2013 utilizare off-label, dar larg r\u0103sp\u00e2ndit\u0103 pentru a contracara anorgasmia \u0219i libidoul sc\u0103zut induse de SSRI<\/li>\n<li><strong>ADHD la adul\u021bi<\/strong> \u2014 utilizare off-label, o alternativ\u0103 sus\u021binut\u0103 de dovezi pentru adul\u021bii care nu pot lua stimulente<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Cum func\u021bioneaz\u0103 Bupron XL?<\/h2>\n<p>Bupropionul ac\u021bioneaz\u0103 ca un <strong>inhibitor selectiv al recapt\u0103rii norepinefrinei \u0219i dopaminei<\/strong> la nivelul sinapselor centrale:<\/p>\n<ul>\n<li>Blocheaz\u0103 <strong>transportorul de norepinefrin\u0103 (NET)<\/strong> \u0219i <strong>transportorul de dopamin\u0103 (DAT)<\/strong>, cresc\u00e2nd concentra\u021biile sinaptice ale ambelor monoamine<\/li>\n<li>Aceasta cre\u0219te activitatea \u00een regiunile cerebrale asociate cu <strong>conducere, motiva\u021bie, recompens\u0103 \u0219i aten\u021bie<\/strong> \u2014 \u00een special cortexul prefrontal \u0219i sistemul mezolimbic<\/li>\n<li>Bupropionul \u0219i metabolitul s\u0103u activ <strong>hidroxibupropion<\/strong> blocheaz\u0103 \u0219i non-competitiv receptorii nicotinici de acetilcolin\u0103, ceea ce explic\u0103 utilitatea sa \u00een renun\u021barea la fumat<\/li>\n<li>Are <strong>aproape niciun efect asupra serotoninei<\/strong>, motiv pentru care func\u021bia sexual\u0103, greutatea \u0219i somnul sunt de obicei p\u0103strate<\/li>\n<\/ul>\n<p>Efectul antidepresiv \u00eencepe de obicei s\u0103 se observe \u00een <strong>2 s\u0103pt\u0103m\u00e2ni<\/strong> \u0219i efectul complet \u00een <strong>4\u20136 s\u0103pt\u0103m\u00e2ni<\/strong>. Pentru renun\u021barea la fumat, Bupron XL este \u00eenceput <strong>1\u20132 s\u0103pt\u0103m\u00e2ni \u00eenainte de ziua planificat\u0103 pentru renun\u021bare<\/strong>, deoarece nivelurile stabile ale medicamentului necesit\u0103 acest timp pentru a se acumula.<\/p>\n<h2 class=\"wp-block-heading\">Utiliz\u0103ri \u0219i indica\u021bii<\/h2>\n<ul>\n<li><strong>Tulburarea depresiv\u0103 major\u0103 (MDD)<\/strong> \u2014 de prim\u0103 inten\u021bie \u00een multe recomand\u0103ri, \u00een special pentru pacien\u021bii care nu tolereaz\u0103 efectele secundare sexuale sau de greutate ale ISRS-urilor<\/li>\n<li><strong>Tulburarea afectiv\u0103 sezonier\u0103 (SAD)<\/strong> \u2014 utilizare preventiv\u0103 \u00eencep\u00e2nd din sf\u00e2r\u0219itul verii\/\u00eenceputul toamnei, \u00eenainte de sc\u0103derea sezonier\u0103<\/li>\n<li><strong>\u00cencetarea fumatului<\/strong> \u2014 tratamente de 7\u201312 s\u0103pt\u0103m\u00e2ni; poate fi combinat cu terapia de substitu\u021bie cu nicotin\u0103 (TSN)<\/li>\n<li><strong>disfunc\u021bia sexual\u0103 indus\u0103 de SSRI<\/strong> \u2014 ad\u0103ugat \u00een doze de 150\u2013300 mg zilnic la un tratament existent cu SSRI<\/li>\n<li><strong>ADHD la adul\u021bi<\/strong> \u2014 utilizare off-label pentru pacien\u021bii la care stimulantele sunt contraindicate sau slab tolerate<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Doza \u0219i administrare Bupron XL<\/h2>\n<table>\n<thead>\n<tr>\n<th>Indica\u021bie<\/th>\n<th>Doz\u0103 ini\u021bial\u0103<\/th>\n<th>Doz\u0103 \u021bint\u0103\/maxim\u0103<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Tulburare depresiv\u0103 major\u0103<\/strong><\/td>\n<td>150 mg o dat\u0103 pe zi (diminea\u021ba) \u00d7 4 zile<\/td>\n<td>300 mg o dat\u0103 pe zi; maxim 450 mg\/zi \u00een doze divizate<\/td>\n<\/tr>\n<tr>\n<td><strong>Tulburare afectiv\u0103 sezonier\u0103<\/strong><\/td>\n<td>150 mg o dat\u0103 pe zi timp de 7 zile, \u00eencep\u00e2nd toamna<\/td>\n<td>300 mg o dat\u0103 pe zi pe durata iernii; reducere treptat\u0103 prim\u0103vara<\/td>\n<\/tr>\n<tr>\n<td><strong>\u00cencetarea fumatului<\/strong><\/td>\n<td>150 mg o dat\u0103 pe zi timp de 3 zile<\/td>\n<td>150 mg de dou\u0103 ori pe zi (sau 300 mg XL o dat\u0103 pe zi) timp de 7\u201312 s\u0103pt\u0103m\u00e2ni<\/td>\n<\/tr>\n<tr>\n<td><strong>V\u00e2rstnici sau cu greutate corporal\u0103 sc\u0103zut\u0103<\/strong><\/td>\n<td>150 mg la dou\u0103 zile ini\u021bial<\/td>\n<td>Doza se ajusteaz\u0103 \u00een func\u021bie de r\u0103spuns; plafon inferior<\/td>\n<\/tr>\n<tr>\n<td><strong>Insuficien\u021b\u0103 hepatic\u0103 u\u0219oar\u0103\u2013moderat\u0103<\/strong><\/td>\n<td>Reduce\u021bi doza \u0219i\/sau frecven\u021ba<\/td>\n<td>Monitorizare atent\u0103<\/td>\n<\/tr>\n<tr>\n<td><strong>Afectare hepatic\u0103 sever\u0103 (Child-Pugh C)<\/strong><\/td>\n<td>150 mg la dou\u0103 zile<\/td>\n<td>Maxim 150 mg la dou\u0103 zile<\/td>\n<\/tr>\n<tr>\n<td><strong>Insuficien\u021b\u0103 renal\u0103<\/strong><\/td>\n<td>Lua\u021bi \u00een considerare o doz\u0103 ini\u021bial\u0103 mai mic\u0103<\/td>\n<td>Metaboli\u021bii activi se acumuleaz\u0103<\/td>\n<\/tr>\n<tr>\n<td><strong>Doza zilnic\u0103 maxim\u0103<\/strong><\/td>\n<td>450 mg (doar \u00een doze divizate cu eliberare imediat\u0103)<\/td>\n<td>Formul\u0103ri XL: maxim 300 mg o dat\u0103 pe zi<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 class=\"wp-block-heading\">Cum s\u0103 lua\u021bi corect Bupron XL<\/h3>\n<ul>\n<li>\u00cenghi\u021bi\u021bi comprimatul <strong>\u00eentreg<\/strong> \u2014 NU zdrobi\u021bi, nu mesteca\u021bi \u0219i nu desp\u0103r\u021bi\u021bi comprimatul XL. Ruperea matricei elibereaz\u0103 \u00eentreaga doz\u0103 deodat\u0103 \u0219i cre\u0219te riscul de convulsii<\/li>\n<li>Lua\u021bi <strong>diminea\u021b\u0103<\/strong> \u2014 administrarea seara poate provoca insomnie<\/li>\n<li>Poate fi luat cu sau f\u0103r\u0103 m\u00e2ncare<\/li>\n<li>Acorda\u021bi <strong>2 s\u0103pt\u0103m\u00e2ni<\/strong> pentru un r\u0103spuns antidepresiv timpuriu \u0219i <strong>4\u20136 s\u0103pt\u0103m\u00e2ni<\/strong> pentru efectul complet<\/li>\n<li>Pentru <strong>renun\u021barea la fumat<\/strong>, stabili\u021bi o dat\u0103 pentru renun\u021bare \u0219i \u00eencepe\u021bi Bupron XL <strong>1\u20132 s\u0103pt\u0103m\u00e2ni \u00eenainte<\/strong> de acea dat\u0103<\/li>\n<li>Nu <strong>nu opri\u021bi brusc<\/strong> dup\u0103 utilizare pe termen lung \u2014 reduce\u021bi treptat pe parcursul a 2\u20134 s\u0103pt\u0103m\u00e2ni sub supraveghere medical\u0103<\/li>\n<li>Acorda\u021bi <strong>14 zile<\/strong> \u00eentre \u00eentreruperea unui MAOI \u0219i \u00eenceperea bupropionului, \u0219i invers<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Efecte secundare ale Bupron XL<\/h2>\n<p>Bupropionul are un profil distinct de efecte secundare \u2014 mai pu\u021bine efecte sexuale \u0219i de greutate dec\u00e2t SSRI-urile, dar mai mult\u0103 activare, insomnie \u0219i risc de convulsii dac\u0103 nu este dozat corect.<\/p>\n<table>\n<thead>\n<tr>\n<th>Severitate<\/th>\n<th>Efect Secundar<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Frecvente (\u22651 din 10)<\/strong><\/td>\n<td>Gura uscat\u0103, insomnie, dureri de cap, grea\u021b\u0103<\/td>\n<\/tr>\n<tr>\n<td><strong>Frecvente (\u22651 din 100)<\/strong><\/td>\n<td>Agita\u021bie, anxietate, tremur, ame\u021beli, constipa\u021bie, transpira\u021bie, tinnitus, vedere \u00eence\u021bo\u0219at\u0103, modific\u0103ri ale gustului, sc\u0103dere a apetitului \/ pierdere u\u0219oar\u0103 \u00een greutate<\/td>\n<\/tr>\n<tr>\n<td><strong>Pu\u021bin frecvente<\/strong><\/td>\n<td>Tahicardie, tensiune arterial\u0103 crescut\u0103, erup\u021bii cutanate, urticarie, palpita\u021bii<\/td>\n<\/tr>\n<tr>\n<td><strong>Rare, dar grave<\/strong><\/td>\n<td>Convulsii (dependente de doz\u0103), sindrom asem\u0103n\u0103tor bolii serice, sindromul Stevens-Johnson, hipertensiune sever\u0103, g\u00e2nduri suicidare (\u00een special la tineri adul\u021bi), psihoz\u0103 sau manie la pacien\u021bii susceptibili<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Riscul de convulsii este cel mai important efect secundar legat de doz\u0103.<\/strong> La doze de p\u00e2n\u0103 la 300 mg XL zilnic, inciden\u021ba este de aproximativ 0,1% \u2014 comparabil\u0103 cu alte antidepresive. Peste 450 mg\/zi sau cu comprimate zdrobite\/despicate, riscul cre\u0219te brusc. Nu dep\u0103\u0219i\u021bi niciodat\u0103 doza recomandat\u0103 \u0219i nu despica\u021bi sau zdrobi\u021bi forma XL.<\/p>\n<h2 class=\"wp-block-heading\">Avertismente \u0219i precau\u021bii<\/h2>\n<ul>\n<li><strong>Riscul de convulsii<\/strong> este legat de doz\u0103. Nu dep\u0103\u0219i\u021bi 300 mg XL o dat\u0103 pe zi (sau 450 mg pe zi dac\u0103 folosi\u021bi forma IR). Evita\u021bi la pacien\u021bii cu istoric de convulsii, leziuni cerebrale sau factori care scad pragul convulsiilor.<\/li>\n<li><strong>G\u00e2nduri suicidare.<\/strong> Ca toate antidepresivele, bupropionul are un avertisment de cutie neagr\u0103 pentru g\u00e2nduri suicidare la pacien\u021bii sub 25 de ani. Monitoriza\u021bi \u00eendeaproape \u00een primele 2\u20134 s\u0103pt\u0103m\u00e2ni de tratament \u0219i dup\u0103 orice modificare de doz\u0103.<\/li>\n<li><strong>Simptome neuropsihiatrice la renun\u021barea la fumat.<\/strong> Au fost raportate cazuri de agita\u021bie, stare depresiv\u0103 \u0219i, rareori, psihoz\u0103. Pacien\u021bii trebuie avertiza\u021bi s\u0103 raporteze astfel de simptome imediat.<\/li>\n<li><strong>Hipertensiune.<\/strong> Verifica\u021bi tensiunea arterial\u0103 \u00eenainte de \u00eenceperea tratamentului \u0219i la urm\u0103rirea medical\u0103; poate provoca o u\u0219oar\u0103 cre\u0219tere a tensiunii arteriale, \u00een special atunci c\u00e2nd este combinat cu terapia de \u00eenlocuire a nicotinei<\/li>\n<li><strong>Activare\/anxietate\/insomnie.<\/strong> \u00cencepe\u021bi cu 150 mg; dac\u0103 insomnia este predominant\u0103, administra\u021bi mai devreme \u00een cursul zilei sau lua\u021bi \u00een considerare sprijin hipnotic pe termen scurt<\/li>\n<li><strong>Alcool.<\/strong> Evita\u021bi consumul excesiv de alcool \u2014 alcoolul scade pragul convulsiilor \u0219i poate declan\u0219a efecte neuropsihiatrice<\/li>\n<li><strong>Sarcina\/al\u0103ptare.<\/strong> Folosi\u021bi numai dac\u0103 beneficiile dep\u0103\u0219esc clar riscurile. Bupropionul trece \u00een laptele matern \u00een cantit\u0103\u021bi mici<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindica\u021bii \u2014 Cine NU ar trebui s\u0103 ia Bupron XL<\/h2>\n<ul>\n<li><strong>Orice istoric de tulbur\u0103ri convulsive<\/strong><\/li>\n<li><strong>Bulimie sau anorexie nervoas\u0103 prezent\u0103 sau trecut\u0103<\/strong> \u2014 risc crescut de convulsii la pacien\u021bii cu tulbur\u0103ri electrolitice<\/li>\n<li><strong>Sevraj acut de alcool sau benzodiazepine<\/strong><\/li>\n<li><strong>Utilizare MAOI \u00een ultimele 14 zile<\/strong> (inclusiv linezolid, albastru de metilen)<\/li>\n<li><strong>Utilizarea unui alt produs care con\u021bine bupropion<\/strong> (risc aditiv de convulsii)<\/li>\n<li><strong>Insuficien\u021b\u0103 hepatic\u0103 sever\u0103<\/strong> (cu excep\u021bia cazului \u00een care doza este redus\u0103 conform recomand\u0103rilor specialistului)<\/li>\n<li>Hipersensibilitate cunoscut\u0103 la bupropion sau la orice excipient<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<table>\n<thead>\n<tr>\n<th>Medicament \/ Clas\u0103<\/th>\n<th>Interac\u021biune<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>IMAO (fenelzin\u0103, trancilcipromin\u0103, moclobemid\u0103, linezolid)<\/strong><\/td>\n<td><strong>Contraindica\u021bie absolut\u0103<\/strong> \u2014 risc de criz\u0103 serotoninergic\u0103\/noradrenergic\u0103. Perioad\u0103 de eliminare de 14 zile \u00een ambele direc\u021bii<\/td>\n<\/tr>\n<tr>\n<td><strong>Alte medicamente care scad pragul convulsiilor<\/strong> (tramadol, teofilin\u0103, steroizi sistemici, antipsihotice)<\/td>\n<td>Risc crescut de convulsii \u2014 utiliza\u021bi cu precau\u021bie<\/td>\n<\/tr>\n<tr>\n<td><strong>Inhibitori CYP2B6 (ticlopidin\u0103, clopidogrel)<\/strong><\/td>\n<td>Cre\u0219te nivelul de bupropion\u0103 \u2014 poate fi necesar\u0103 reducerea dozei<\/td>\n<\/tr>\n<tr>\n<td><strong>Inductori CYP2B6 (carbamazepin\u0103, fenitoin\u0103, rifampicin\u0103, ritonavir)<\/strong><\/td>\n<td>Scade nivelul de bupropion\u0103 \u2014 poate reduce eficacitatea<\/td>\n<\/tr>\n<tr>\n<td><strong>Substrate CYP2D6 (tamoxifen, codein\u0103, beta-blocante, multe antidepresive, atomoxetin\u0103)<\/strong><\/td>\n<td>Bupropionul este un <strong>inhibitor puternic al CYP2D6<\/strong> \u2014 substraturile se acumuleaz\u0103. Importan\u021b\u0103 clinic\u0103 \u00een cazul tamoxifenului (reduce eficacitatea) \u0219i codeinei (reduce analgezia)<\/td>\n<\/tr>\n<tr>\n<td><strong>Pl\u0103ci de nicotin\u0103 \/ gum\u0103 \/ vareniclin\u0103<\/strong><\/td>\n<td>Pot fi combinate pentru renun\u021barea la fumat \u2014 monitoriza\u021bi tensiunea arterial\u0103<\/td>\n<\/tr>\n<tr>\n<td><strong>Alcool<\/strong><\/td>\n<td>Scade pragul convulsiilor \u2014 limita\u021bi strict<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00centotdeauna furniza\u021bi o list\u0103 complet\u0103 a medicamentelor cu \u0219i f\u0103r\u0103 prescrip\u021bie, inclusiv droguri recrea\u021bionale, suplimente herbale \u0219i produse cu nicotin\u0103, medicului dumneavoastr\u0103 \u00eenainte de a \u00eencepe tratamentul cu Bupron XL.<\/p>\n<h2 class=\"wp-block-heading\">Ce s\u0103 Face\u021bi \u00een Caz de Supradozare<\/h2>\n<p>Supradozarea de bupropion poate provoca convulsii, anomalii ale conduc\u021biei cardiace, hipertensiune sever\u0103 \u0219i alterarea con\u0219tiin\u021bei. Nu exist\u0103 un antidot specific \u2014 managementul este de sus\u021binere cu protec\u021bie a c\u0103ilor respiratorii, benzodiazepine pentru convulsii \u0219i monitorizare cardiac\u0103. Contacta\u021bi imediat serviciul local de toxicoze sau departamentul de urgen\u021be dac\u0103 suspecta\u021bi o supradozare.<\/p>\n<h2 class=\"wp-block-heading\">Instruc\u021biuni de Depozitare<\/h2>\n<ul>\n<li>P\u0103stra\u021bi la sub 25 \u00b0C \u00eentr-un loc uscat, departe de lumina direct\u0103 a soarelui<\/li>\n<li>P\u0103stra\u021bi \u00een ambalajul original blister<\/li>\n<li>Se p\u0103streaz\u0103 \u00een afara accesului copiilor<\/li>\n<li>Nu utiliza\u021bi dup\u0103 data de expirare tip\u0103rit\u0103 pe ambalaj<\/li>\n<li>Elimina\u021bi comprimatele neutilizate prin programele de colectare disponibile \u00een farmacii<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Alternative conexe pe MedsBase<\/h2>\n<p>C\u0103uta\u021bi op\u021biuni conexe de antidepresive sau pentru renun\u021barea la fumat?<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/champix\/\" rel=\"noopener\">Champix<\/a> \u2014 vareniclin\u0103, o alt\u0103 op\u021biune pentru renun\u021barea la fumat care ac\u021bioneaz\u0103 pe receptorii nicotinici<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/mirtaz\/\" rel=\"noopener\">Mirtaz<\/a> \u2014 mirtazapin\u0103, un antidepresiv atipic cu efecte puternice asupra somnului \u0219i apetitului (profil contrar bupropionului)<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/sertima\/\" rel=\"noopener\">Sertima<\/a> \u2014 sertralin\u0103, un SSRI comun; adesea considerat al\u0103turi de bupropion sau combinat cu acesta<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/mental-health-and-psychiatric-medications\/\" rel=\"noopener\">Vizualiza\u021bi toate medicamentele pentru S\u0103n\u0103tate Mintal\u0103 \u2192<\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">C\u00e2t dureaz\u0103 p\u00e2n\u0103 \u00eencepe s\u0103 ac\u021bioneze Bupron XL?<\/h3>\n<p>Pentru depresie, majoritatea persoanelor observ\u0103 un r\u0103spuns timpuriu \u00een termen de <strong>2 s\u0103pt\u0103m\u00e2ni<\/strong> (energie, concentrare, apetit) cu efect antidepresiv complet p\u00e2n\u0103 \u00een <strong>4\u20136 s\u0103pt\u0103m\u00e2ni<\/strong>. Pentru renun\u021barea la fumat, efectul de reducere a poftei este de obicei prezent p\u00e2n\u0103 \u00een ziua \u00eencet\u0103rii, motiv pentru care tratamentul \u00eencepe <strong>1\u20132 s\u0103pt\u0103m\u00e2ni \u00eenainte<\/strong> renun\u021barea la fumat.<\/p>\n<h3 class=\"wp-block-heading\">Bupron XL provoac\u0103 efecte secundare sexuale?<\/h3>\n<p><strong>Nu<\/strong> \u2014 acesta este unul dintre avantajele definitorii ale bupropionului fa\u021b\u0103 de SSRI. Bupropionul are un efect minim asupra serotoninei \u0219i p\u0103streaz\u0103 libidoul, excitarea \u0219i orgasmul. Este adesea prescris special pentru a contracara disfunc\u021bia sexual\u0103 indus\u0103 de SSRI.<\/p>\n<h3 class=\"wp-block-heading\">Bupron XL provoac\u0103 cre\u0219tere \u00een greutate?<\/h3>\n<p><strong>Nu<\/strong> \u2014 \u0219i la mul\u021bi pacien\u021bi produce o sc\u0103dere u\u0219oar\u0103 \u00een greutate (de obicei 2\u20135 lb \/ 1\u20132 kg). Reduce apetitul \u00een primele s\u0103pt\u0103m\u00e2ni \u0219i nu provoac\u0103 cre\u0219terea metabolic\u0103 \u00een greutate observat\u0103 cu SSRI, triciclice sau mirtazapin\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Bupron XL este acela\u0219i lucru cu Wellbutrin \u0219i Zyban?<\/h3>\n<p>Da, \u00een ceea ce prive\u0219te ingredientele active \u2014 Bupron XL este bupropion clorhidrat cu eliberare prelungit\u0103, identic cu Wellbutrin XL<sup>\u00ae<\/sup> (pentru depresie) \u0219i cu Zyban<sup>\u00ae<\/sup> (pentru renun\u021barea la fumat; de obicei formula\u021bia SR cu ac\u021biune mai scurt\u0103). Echivalent clinic, pre\u021b mult mai mic.<\/p>\n<h3 class=\"wp-block-heading\">Pot s\u0103 despic sau s\u0103 zdrobesc comprimatele Bupron XL?<\/h3>\n<p><strong>Nu, niciodat\u0103.<\/strong> Matricea de eliberare prelungit\u0103 este esen\u021bial\u0103. Spargerea, zdrobirea sau mestecarea tabletei elibereaz\u0103 \u00eentreaga doz\u0103 simultan \u0219i cre\u0219te semnificativ riscul de convulsii.<\/p>\n<h3 class=\"wp-block-heading\">Pot s\u0103 combin Bupron XL cu un SSRI?<\/h3>\n<p>Da \u2014 aceast\u0103 combina\u021bie este frecvent utilizat\u0103 \u00een practica clinic\u0103 pentru pacien\u021bii care r\u0103spund par\u021bial la SSRI dar prezint\u0103 energie sc\u0103zut\u0103 rezidual\u0103, motiva\u021bie redus\u0103 sau disfunc\u021bii sexuale. Riscul de sindrom serotoninergic este foarte sc\u0103zut deoarece bupropionul are o activitate serotoninergic\u0103 minimal\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Cum folosesc Bupron XL pentru renun\u021barea la fumat?<\/h3>\n<p>Stabili\u021bi o dat\u0103 pentru renun\u021bare cu 1\u20132 s\u0103pt\u0103m\u00e2ni \u00eenainte. \u00cencepe\u021bi Bupron XL cu 150 mg o dat\u0103 pe zi timp de 3 zile, apoi 150 mg de dou\u0103 ori pe zi (sau 300 mg XL o dat\u0103 pe zi). Continua\u021bi pentru <strong>7\u201312 s\u0103pt\u0103m\u00e2ni<\/strong> \u00een total. Poate fi combinat cu terapia de substitu\u021bie cu nicotin\u0103 (pl\u0103ci, gum\u0103, pastile) pentru rate mai mari de renun\u021bare. Dac\u0103 nu a\u021bi renun\u021bat la fumat p\u00e2n\u0103 la 7 s\u0103pt\u0103m\u00e2ni, tratamentul poate fi prelungit.<\/p>\n<h3 class=\"wp-block-heading\">Pot consuma alcool \u00een timpul tratamentului cu Bupron XL?<\/h3>\n<p>Consumul excesiv de alcool ar trebui evitat \u2014 scade pragul convulsiilor \u0219i poate declan\u0219a efecte adverse neuropsihiatrice. <strong>Sevrajul alcoolic acut \u00een timpul administr\u0103rii bupropionului este periculos<\/strong> deoarece riscul de convulsii se acumuleaz\u0103. Consumul social moderat este de obicei tolerat, dar discuta\u021bi cu medicul prescriptor.<\/p>\n<h3 class=\"wp-block-heading\">Care este diferen\u021ba dintre Bupron SR \u0219i Bupron XL?<\/h3>\n<p>Ambele con\u021bin bupropion HCl, dar difer\u0103 prin profilul de eliberare. <strong>SR (eliberare prelungit\u0103)<\/strong> se administreaz\u0103 de dou\u0103 ori pe zi. <strong>XL (eliberare prelungit\u0103)<\/strong> se administreaz\u0103 o dat\u0103 pe zi. XL este forma preferat\u0103 pentru comoditate \u0219i niveluri plasmatice mai stabile.<\/p>\n<h3 class=\"wp-block-heading\">Bupron XL provoac\u0103 dependen\u021b\u0103?<\/h3>\n<p><strong>Nu<\/strong> \u2014 bupropionul nu provoac\u0103 dependen\u021b\u0103 \u0219i nu are poten\u021bial de abuz, \u00een ciuda efectului s\u0103u dopaminergic, deoarece cre\u0219terea dopaminei extracelulare este moderat\u0103 \u0219i lent\u0103. Nu este o substan\u021b\u0103 controlat\u0103 \u00een majoritatea jurisdic\u021biilor.<\/p>\n<h3 class=\"wp-block-heading\">Pot \u00eentrerupe brusc Bupron XL?<\/h3>\n<p>Tratamentele scurte (de ex., cursul de 7\u201312 s\u0103pt\u0103m\u00e2ni pentru renun\u021barea la fumat) pot fi de obicei \u00eentrerupte f\u0103r\u0103 reducere treptat\u0103. Pentru tratamentul depresiei care dureaz\u0103 c\u00e2teva luni, <strong>reduce\u021bi treptat pe parcursul a 2\u20134 s\u0103pt\u0103m\u00e2ni<\/strong> pentru a minimiza reapari\u021bia st\u0103rii depresive sau a simptomelor asem\u0103n\u0103toare sevrajului. Discuta\u021bi reducerea treptat\u0103 cu medicul prescriptor.<\/p>\n<p><!-- medsbase-faq-h3-converted --><\/p>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Bupron XL la MedsBase este furnizat direct de la un produc\u0103tor certificat WHO-GMP \u00een ambalaje simple \u0219i discrete. Fiecare comand\u0103 este acoperit\u0103 de asigurarea noastr\u0103. <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> \u2014 perioad\u0103 de livrare de 20 de zile lucr\u0103toare sau retrimitem f\u0103r\u0103 costuri suplimentare \u2014 \u0219i se calific\u0103 pentru <a href=\"https:\/\/medsbase.com\/ro\/loyalty-points\/\">programul nostru de loialitate pentru clien\u021bi<\/a>. Livr\u0103rile sunt disponibile \u00een majoritatea destina\u021biilor la nivel mondial.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alternative conexe<\/h3>\n<p>Alte produse din <strong>S\u0103n\u0103tate general\u0103<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/erythromycin\/\">Eritromicina<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/orzine\/\">Orzine<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/reglan\/\">Reglan<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/dulcoflex\/\">Dulcoflex<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/lurakem\/\">Lurakem<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Bupron XL (Bupropion 150\/300 mg XL) \u2014 antidepresiv NDRI pentru depresia major\u0103 \u0219i renun\u021barea la fumat. XL o dat\u0103 pe zi \u2014 f\u0103r\u0103 disfunc\u021bii sexuale, neutru din punct de vedere al greut\u0103\u021bii.<\/p>","protected":false},"featured_media":55941,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[5684,4015,4014,5677,5681,5682,5683,5680,5678,5679],"class_list":{"0":"post-55940","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-atypical-antidepressant","10":"product_tag-bupron-xl","11":"product_tag-bupropion","12":"product_tag-bupropion-hcl","13":"product_tag-major-depression","14":"product_tag-mdd","15":"product_tag-ndri","16":"product_tag-smoking-cessation","17":"product_tag-wellbutrin-generic","18":"product_tag-zyban","20":"first","21":"instock","22":"shipping-taxable","23":"purchasable","24":"product-type-variable","25":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/55940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=55940"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/55941"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=55940"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=55940"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=55940"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=55940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}