{"id":56102,"date":"2024-02-07T05:53:12","date_gmt":"2024-02-07T05:53:12","guid":{"rendered":"https:\/\/medsname.com\/lariago-ds\/"},"modified":"2026-04-30T10:24:40","modified_gmt":"2026-04-30T10:24:40","slug":"lariago-ds","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/lariago-ds\/","title":{"rendered":"Lariago DS"},"content":{"rendered":"

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R\u0103spuns rapid<\/h3>\n

Lariago DS<\/strong> con\u021bine fosfat de clorochin\u0103 echivalent cu 500 mg baz\u0103<\/strong> (Ipca Laboratories). Trateaz\u0103 malarie sensibil\u0103 la clorochin\u0103<\/strong> cauzat\u0103 de P. falciparum<\/em>, P. vivax<\/em>, P. ovale<\/em>, \u0219i P. malariae<\/em>, \u0219i este utilizat \u0219i pentru prevenirea \u0219i tratamentul amebiazei extra-intestinale<\/strong>. Majoritatea regiunilor endemice moderne prezint\u0103 rezisten\u021b\u0103 larg r\u0103sp\u00e2ndit\u0103 la clorochin\u0103<\/strong> (Africa subsaharian\u0103, India, Asia de Sud-Est, bazinul Amazon) \u2014 clorochina NU este profilaxia adecvat\u0103 pentru aceste destina\u021bii. Doza de tratament acut: 1 g doz\u0103 de \u00eenc\u0103rcare \u2192 500 mg la 6 \/ 24 \/ 48 h. Profilaxie (doar \u00een zone sensibile la clorochin\u0103): 500 mg o dat\u0103 pe s\u0103pt\u0103m\u00e2n\u0103, \u00eencep\u00e2nd cu 1\u20132 s\u0103pt\u0103m\u00e2ni \u00eenainte de c\u0103l\u0103torie, continu\u00e2nd timp de 4 s\u0103pt\u0103m\u00e2ni dup\u0103 \u00eentoarcere. Se administreaz\u0103 cu alimente. Screening oftalmologic obligatoriu de baz\u0103 + anual dup\u0103 5 ani de utilizare continu\u0103.<\/strong><\/p>\n<\/div>\n

\ud83c\udfed Produc\u0103tor certificat WHO-GMP<\/strong>  \u00b7  \ud83d\udce6 Ambalaj discret<\/strong>  \u00b7  \ud83c\udf0d Livrare \u00een toat\u0103 lumea<\/strong>  \u00b7  \u2b50 Peste 1.400 de recenzii ale clien\u021bilor<\/a><\/strong><\/div>\n

\ud83d\udee1\ufe0f Fiecare comand\u0103 este acoperit\u0103 de Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 if your parcel does not arrive within 20 business days we ship a free replacement on EMS or ITPS courier.<\/p>\n

De ce s\u0103 comanzi de la MedsBase<\/h3>\n

Lariago DS este procurat de la un produc\u0103tor certificat WHO-GMP \u0219i expediat \u00een toat\u0103 lumea \u00een ambalaje discrete. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> \u0219i sprijinit\u0103 de Peste 1.400 de recenzii ale clien\u021bilor<\/a>. Livrare worldwide f\u0103r\u0103 documenta\u021bie medical\u0103.<\/p>\n

Despre Lariago DS<\/h2>\n

Lariago DS este un comprimat de 500 mg de fosfat de clorochin\u0103 fabricat de Ipca Laboratories \u00een condi\u021bii certificate WHO-GMP. Clorochina este un antimalaric din clasa 4-aminochinolinei \u2014 sintetizat pentru prima dat\u0103 \u00een 1934 \u0219i a reprezentat baza tratamentului malariei pentru cea mai mare parte a secolului XX, \u00eenainte ca rezisten\u021ba s\u0103 apar\u0103 la P. falciparum \u00een anii 1960. R\u0103m\u00e2ne eficient\u0103\u0103 \u00een pu\u021binele regiuni \u00eenc\u0103 sensibile la clorochin\u0103 \u0219i este inclus\u0103 pe lista Medicamentelor Esen\u021biale ale OMS.<\/p>\n

Hart\u0103 a rezisten\u021bei \u2014 citi\u021bi \u00eenainte de cump\u0103rare.<\/strong> Clorochina nu mai este eficient\u0103 \u00eempotriva P. falciparum \u00een Africa subsaharian\u0103, India, Asia de Sud-Est (Thailanda, Cambodgia, Vietnam, Myanmar, Laos), bazinul Amazon (Brazilia, Peru, Columbia, Venezuela, Bolivia, Guyana), Papua Noua Guinee, Insulele Solomon<\/strong>, \u0219i majoritatea altor destina\u021bii tropicale. Utiliza\u021bi mefloquin\u0103, doxiciclin\u0103 sau atovaquon-proguanil pentru aceste zone. Clorochina r\u0103m\u00e2ne eficient\u0103 \u00een pu\u021binele zone sensibile la clorochin\u0103 r\u0103mase: Mexic (zonele vestice \u0219i nordice ale Canalului Panama), p\u0103r\u021bi din America Central\u0103 (Belize, zonele \u00eenalte din Guatemala, Honduras, Nicaragua, Panama vestul canalului), Hispaniola (Haiti, Republica Dominican\u0103), o mare parte din Orientul Mijlociu<\/strong>, \u0219i \u00een anumite destina\u021bii din Pacific. Confirma\u021bi modelul actual de rezisten\u021b\u0103 la CDC Yellow Book<\/a> \u00eenainte de c\u0103l\u0103torie.<\/div>\n

Cum func\u021bioneaz\u0103 cloroquina<\/h2>\n

Parazitul malariei diger\u0103 hemoglobina gazdei \u00een interiorul unei vacuole alimentare acide, eliber\u00e2nd hem liber (toxic pentru parazit). \u00cen mod normal, parazitul polimerizeaz\u0103 hemul \u00een hemozoin\u0103 inert\u0103 (pigment de malarie). Cloroquina se acumuleaz\u0103 \u00een vacuola alimentar\u0103 datorit\u0103 naturii sale de baz\u0103 slab\u0103, care o captureaz\u0103 \u00een compartimentele acide, unde se leag\u0103 de hemul liber \u0219i \u00eempiedic\u0103 polimerizarea. Hemul toxic liber se acumuleaz\u0103 \u0219i omoar\u0103 parazitul. Rezisten\u021ba la cloroquin\u0103 apare din cauza muta\u021biilor PfCRT (transportorul de rezisten\u021b\u0103 la cloroquin\u0103 P. falciparum) care pompeaz\u0103 cloroquina \u00eenapoi din vacuola alimentar\u0103.<\/p>\n

Timpul de \u00eenjum\u0103t\u0103\u021bire este de 1\u20132 luni \u2014 cloroquina se acumuleaz\u0103 \u00een \u021besut \u0219i este eliberat\u0103 lent. Acesta este motivul pentru care profilaxia este administrat\u0103 s\u0103pt\u0103m\u00e2nal \u0219i continu\u0103 timp de 4 s\u0103pt\u0103m\u00e2ni dup\u0103 expunere.<\/p>\n

Indica\u021bii \u0219i dozaj<\/h2>\n
\n\n\n\n\n\n\n\n\n\n
Indica\u021bie<\/th>\nDoza (\u00een mg de baz\u0103)<\/th>\nNote<\/th>\n<\/tr>\n<\/thead>\n
Malarie sensibil\u0103 la cloroquin\u0103 \u2014 tratament acut, adult<\/td>\n1 000 mg de baz\u0103 ini\u021bial \u2192 500 mg de baz\u0103 la 6, 24 \u0219i 48 h (total 2 500 mg de baz\u0103 \u00een 48 h)<\/td>\nAd\u0103uga\u021bi primaquin\u0103 pentru vindecarea radical\u0103 a P. vivax \/ P. ovale (dup\u0103 testul G6PD).<\/td>\n<\/tr>\n
Profilaxie pentru malarie sensibil\u0103 la cloroquin\u0103, adult<\/td>\n500 mg de baz\u0103 o dat\u0103 pe s\u0103pt\u0103m\u00e2n\u0103<\/td>\n\u00cencepe\u021bi cu 1\u20132 s\u0103pt\u0103m\u00e2ni \u00eenainte de c\u0103l\u0103torie; continua\u021bi s\u0103pt\u0103m\u00e2nal \u00een timpul expunerii; continua\u021bi 4 s\u0103pt\u0103m\u00e2ni dup\u0103 \u00eentoarcere.<\/td>\n<\/tr>\n
Tratament pediatric<\/td>\n10 mg\/kg de baz\u0103 ini\u021bial \u2192 5 mg\/kg la 6, 24, 48 h<\/td>\nAcela\u0219i total \u00een 48 h. Comprimatele pot fi zdrobite \u0219i amestecate cu m\u00e2ncare.<\/td>\n<\/tr>\n
Profilaxie pediatric\u0103<\/td>\n5 mg\/kg baz\u0103 o dat\u0103 pe s\u0103pt\u0103m\u00e2n\u0103 (max 500 mg)<\/td>\nAceea\u0219i schem\u0103 de \u00eencepere\/continuare\/\u00eentrerupere ca la adul\u021bi.<\/td>\n<\/tr>\n
Amebiaz\u0103 extraintestinal\u0103 (abces hepatic amebian)<\/td>\n1 g\/zi timp de 2 zile, apoi 500 mg\/zi timp de 2\u20133 s\u0103pt\u0103m\u00e2ni<\/td>\nAdjuvant la metronidazol.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
Conversie de concentra\u021bie.<\/strong> Fosfat de clorochin\u0103 500 mg sare = ~ 300 mg baz\u0103 de clorochin\u0103. Lariago DS con\u021bine o doz\u0103 mai mare pe tablet\u0103 pentru o dozare profilactic\u0103 s\u0103pt\u0103m\u00e2nal\u0103 simplificat\u0103 \u2014 majoritatea adul\u021bilor iau 1 tablet\u0103 s\u0103pt\u0103m\u00e2nal pentru a atinge \u021binta profilactic\u0103 de 500 mg baz\u0103. Citi\u021bi eticheta \u0219i verifica\u021bi cu informa\u021biile de prescriere; multe referin\u021be men\u021bioneaz\u0103 clorochina baz\u0103, \u00een timp ce comprimatele sunt etichetate dup\u0103 concentra\u021bia de sare.<\/div>\n
Avertisment toxicitate retinal\u0103.<\/strong> La fel ca hidroxiclorochina, clorochina se acumuleaz\u0103 \u00een epiteliul pigmentar retinal la utilizare cronic\u0103. Riscul de maculopatie \u00een form\u0103 de ochi de bou este MAI MARE cu cloroquina dec\u00e2t cu hidroxicloroquina<\/strong>. Utilizatorii pe termen lung (boal\u0103 autoimun\u0103, profilaxie > 5 ani) necesit\u0103 evaluare oftalmologic\u0103 de baz\u0103 + screening anual \u00eencep\u00e2nd cu anul 5 cu OCT spectral, camp vizual automat 10-2 \u0219i autofluorescen\u021b\u0103 fundic\u0103. Tratamentele acute (c\u00e2teva zile) nu prezint\u0103 risc retinal semnificativ.<\/div>\n
Not\u0103 G6PD.<\/strong> Cloroquina are un semnal de hemoliz\u0103 mult mai sc\u0103zut dec\u00e2t primaquina, dar exist\u0103 cazuri raportate \u00een deficien\u021b\u0103 sever\u0103 de G6PD. Dac\u0103 administra\u021bi cloroquin\u0103 pe perioade \u00eendelungate unui pacient cu deficien\u021b\u0103 cunoscut\u0103 de G6PD, monitoriza\u021bi hemoliza.<\/div>\n

Efecte secundare<\/h2>\n