{"id":56116,"date":"2024-02-07T05:53:44","date_gmt":"2024-02-07T05:53:44","guid":{"rendered":"https:\/\/medsname.com\/orzine\/"},"modified":"2026-04-30T10:24:40","modified_gmt":"2026-04-30T10:24:40","slug":"orzine","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/orzine\/","title":{"rendered":"Orzine"},"content":{"rendered":"

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\u26a1 R\u0103spuns rapid<\/h3>\n

Orzine (Clorpromazin\u0103 10 \/ 100 mg) este un antipsihotic fenotiazinic de prim\u0103 genera\u021bie. Utilizat pentru schizofrenie, agita\u021bie sever\u0103, sughituri refractare, grea\u021b\u0103\/v\u0103rs\u0103turi severe \u0219i sedare pre-anestezie. Tipicele (FGA) sunt acum \u00een general pe locul doi \u00een spatele atipicelor.<\/p>\n<\/div>\n

\nCe beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate ale clien\u021bilor<\/a>\n<\/div>\n

\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n

De ce s\u0103 comanzi de la MedsBase<\/h3>\n

Orzine la MedsBase este furnizat direct de la un produc\u0103tor certificat WHO-GMP \u00een ambalaj simplu, discret. Fiecare comand\u0103 este acoperit\u0103 de Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> \u2014 perioad\u0103 de livrare de 20 de zile lucr\u0103toare sau retrimitem f\u0103r\u0103 costuri suplimentare \u2014 \u0219i se calific\u0103 pentru programul nostru de loialitate pentru clien\u021bi<\/a>. Livr\u0103rile sunt disponibile \u00een majoritatea destina\u021biilor la nivel mondial.<\/p>\n

Ce este Orzine \u0219i cum func\u021bioneaz\u0103<\/h2>\n

Orzine este un comprimat de Clorpromazin\u0103 furnizat de Sun Pharma. Concentra\u021bii disponibile: 10 \/ 100 mg<\/strong>.<\/p>\n

Clorpromazina a fost primul antipsihotic (1952) \u0219i r\u0103m\u00e2ne util\u0103 pentru agita\u021bie sever\u0103, sughituri refractare \u0219i psihoz\u0103 acut\u0103. Fenotiazina original\u0103 \u2014 sedare puternic\u0103, ac\u021biune anticolinergic\u0103 puternic\u0103, blocaj \u03b11 puternic \u0219i risc semnificativ de EPS \/ discinez\u0103 tardiv\u0103.<\/p>\n

Indica\u021bii \u0219i dozaj<\/h2>\n\n\n\n\n\n\n\n\n\n
Indica\u021bie<\/th>\nDoza ini\u021bial\u0103<\/th>\n\u021aint\u0103<\/th>\nMaxim<\/th>\n<\/tr>\n<\/thead>\n
Schizofrenie (adul\u021bi)<\/td>\n25\u201350 mg de 3 ori pe zi<\/td>\n200\u2013800 mg\/zi<\/td>\n1000 mg<\/td>\n<\/tr>\n
Agita\u021bie sever\u0103 (IM)<\/td>\n25\u201350 mg IM<\/td>\n\u2014<\/td>\n3 doze\/24h<\/td>\n<\/tr>\n
Hipc persistent<\/td>\n25\u201350 mg de 3-4 ori\/zi pe cale oral\u0103<\/td>\n\u2014<\/td>\n50 mg de 4 ori\/zi<\/td>\n<\/tr>\n
Grea\u021b\u0103\/v\u0103rs\u0103turi severe<\/td>\n10\u201325 mg la fiecare 4-6 ore pe cale oral\u0103<\/td>\n\u2014<\/td>\n\u2014<\/td>\n<\/tr>\n
Pacien\u021bi v\u00e2rstnici\/demen\u021b\u0103 (off-label, ultim\u0103 solu\u021bie)<\/td>\n10 mg HS<\/td>\n10\u201325 mg\/zi<\/td>\n\u00een func\u021bie de tolerabilitate<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Considera\u021bii importante de siguran\u021b\u0103<\/h2>\n
\nFDA avertizare cutie neagr\u0103 pentru demen\u021b\u0103<\/strong><\/p>\n

La fel ca atipicele, toate antipsihoticele poart\u0103 avertizarea privind mortalitatea \u00een psihoza asociat\u0103 demen\u021bei.<\/p>\n<\/div>\n

\nPrelungire QT, EPS, discinezie tardiv\u0103<\/strong><\/p>\n

Clorpromazina prelunge\u0219te QT (mai pu\u021bin dec\u00e2t tioridazina). EPS \u0219i discinezia tardiv\u0103 sunt mai frecvente dec\u00e2t la atipice. Riscul cumulativ de DT este de aproximativ 5%\/an de expunere.<\/p>\n<\/div>\n

\n\u00cenc\u0103rc\u0103tur\u0103 anticolinergic\u0103, sedare, hipotensiune ortostatic\u0103<\/strong><\/p>\n

Toate fenotiazinele au activitate anticolinergic\u0103, antihistaminic\u0103 \u0219i de blocare \u03b11 semnificativ\u0103. Deosebit de problematice la adul\u021bii \u00een v\u00e2rst\u0103 \u2014 c\u0103deri, delir, reten\u021bie urinar\u0103 \u0219i constipa\u021bie sunt frecvente. Evita\u021bi \u00een demen\u021b\u0103, HBP, glaucom cu unghi \u00eengust, afec\u021biuni hepatice severe.<\/p>\n<\/div>\n

\nFotosensibilitate \u0219i pigmentare cutanat\u0103<\/strong><\/p>\n

Fenotiazinele cauzeaz\u0103 fotosensibilitate (arsuri solare severe) \u0219i, la utilizarea pe termen lung, pigmentare cutanat\u0103 alb\u0103strui-gri, precum \u0219i pigmentare rar\u0103 a cristalinului\/corneei (clorpromazina \u00een special). Protec\u021bia solar\u0103 este obligatorie.<\/p>\n<\/div>\n

Efecte secundare frecvente<\/h2>\n