{"id":56581,"date":"2024-02-27T16:59:56","date_gmt":"2024-02-27T16:59:56","guid":{"rendered":"https:\/\/medsname.com\/decmax\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"decmax","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/decmax\/","title":{"rendered":"Decmax"},"content":{"rendered":"

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\u26a1 R\u0103spuns rapid \u2014 Ce este Decmax?<\/h3>\n

Decmax<\/strong> este un dexametazon\u0103 4 mg comprimat oral<\/strong> \u2014 doza standard mai mare pentru adul\u021bi a acestui corticosteroid sintetic cu ac\u021biune \u00eendelungat\u0103. Este utilizat\u0103 pentru afec\u021biuni inflamatorii, autoimune, alergice \u0219i maligne moderate p\u00e2n\u0103 la severe<\/strong>: edem cerebral, acoperire anti-emetic\u0103 pentru chimioterapie, COVID-19 sever, exacerb\u0103ri severe de astm, puseuri de boli autoimune \u0219i \u00eengrijiri paliative. Doza tipic\u0103 este de 4 p\u00e2n\u0103 la 16 mg pe zi<\/strong> \u00een func\u021bie de indica\u021bie, luat\u0103 cu alimente, preferabil diminea\u021ba.<\/p>\n<\/div>\n

\nCe beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate ale clien\u021bilor<\/a>\n<\/div>\n

\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n

De ce s\u0103 comanzi de la MedsBase<\/h3>\n

Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n

Decmax 4 mg<\/strong> este un comprimat oral de dexametazon\u0103 fabricat de Cadila\/Zydus. Doza de 4 mg este practic\u0103 pentru majoritatea indica\u021biilor la adul\u021bi unde este necesar\u0103 o doz\u0103 moderat\u0103 p\u00e2n\u0103 la ridicat\u0103 \u2014 4 mg este doza standard unic\u0103 pentru edem cerebral, profilaxia anti-emetic\u0103 \u00een chimioterapie \u0219i afec\u021biuni inflamatorii acute.<\/p>\n

Pentru ce se utilizeaz\u0103 Decmax?<\/h2>\n
    \n
  • Edem cerebral<\/strong> de la tumori cerebrale (primare sau metastatice) \u2014 de obicei 4 mg de patru ori pe zi, cu reducerea progresiv\u0103 dup\u0103 ameliorarea simptomelor<\/li>\n
  • Profilaxie anti-emetic\u0103 \u00een chimioterapie<\/strong> \u2014 8\u201312 mg \u00eenainte de chimioterapia cu emetogenicitate ridicat\u0103, de obicei \u00een asociere cu un antagonist 5-HT3<\/li>\n
  • COVID-19 sever<\/strong> care necesit\u0103 oxigenoterapie suplimentar\u0103 sau ventila\u021bie mecanic\u0103 \u2014 6 mg (o tablet\u0103 \u0219i jum\u0103tate) zilnic timp de maximum 10 zile (regimul din studiul RECOVERY)<\/li>\n
  • Astm sever acut<\/strong> \u2014 doz\u0103 unic\u0103 de 8\u201312 mg \u00een sec\u021bia de urgen\u021be<\/li>\n
  • Exacerbare sever\u0103 a BPOC<\/strong> \u2014 alternativ\u0103 la prednisolon oral<\/li>\n
  • Reac\u021bii alergice severe<\/strong><\/li>\n
  • Puseuri de boli autoimune<\/strong> \u2014 AR, LES, vasculit\u0103, polimialgie reumatic\u0103, boli inflamatorii intestinale<\/li>\n
  • Meningit\u0103 bacterian\u0103<\/strong> \u2014 adjunct la terapia antibiotic\u0103<\/li>\n
  • Maturizarea pulmonar\u0103 fetal\u0103 antenatal\u0103<\/strong> \u2014 utilizare obstetric\u0103 specializat\u0103<\/li>\n
  • Tumoare hematologic\u0103<\/strong> \u2014 parte din protocoalele de chimioterapie (LLA, mielom multiplu)<\/li>\n
  • \u00cengrijire paliativ\u0103<\/strong> \u2014 stimularea apetitului, efect anti-emetic, anti-inflamator, reducerea simptomelor legate de tumoare<\/li>\n<\/ul>\n

    Cum ac\u021bioneaz\u0103 Dexamethasonul?<\/h2>\n

    Dexamethasonul se leag\u0103 cu afinitate ridicat\u0103 de receptorii intracelulari de glucocorticoidi. Receptorul activat migreaz\u0103 \u00een nucleu \u0219i moduleaz\u0103 transcrip\u021bia a sute de gene implicate \u00een inflama\u021bie, func\u021bia imun\u0103 \u0219i metabolism. Efect clinic net: ac\u021biune anti-inflamatorie \u0219i imunosupresoare larg\u0103, reducerea permeabilit\u0103\u021bii vasculare (util\u0103 \u00een edemul cerebral), atenuarea semnalelor emetice \u00een zona postrem\u0103 (util\u0103 \u00een greata indus\u0103 de chimioterapie) \u0219i modularea furtunii de citokine observat\u0103 \u00een COVID-19 sever.<\/p>\n

    Doza Decmax<\/h2>\n
      \n
    • Edem cerebral:<\/strong> 16 mg\/zi \u00een 4 doze divizate (4 mg de 4 ori pe zi), cu reducere treptat\u0103 dup\u0103 3\u20135 zile<\/li>\n
    • Anti-emetic pentru chimioterapie:<\/strong> 8\u201312 mg (2\u20133 comprimate) o dat\u0103 \u00eenainte de chimioterapie; continuat timp de 2\u20134 zile<\/li>\n
    • COVID-19 sever:<\/strong> 6 mg o dat\u0103 pe zi p\u00e2n\u0103 la 10 zile<\/li>\n
    • Puseu sever de astm:<\/strong> 8\u201312 mg ca o singur\u0103 doz\u0103 sau \u00een dou\u0103 administr\u0103ri<\/li>\n
    • Puseu autoimun:<\/strong> 4\u201316 mg\/zi \u00een doze divizate, apoi reducere treptat\u0103<\/li>\n
    • Lua\u021bi cu m\u00e2ncare<\/strong>, preferabil diminea\u021ba<\/li>\n<\/ul>\n

      Poten\u021ba \u0219i echivalen\u021ba corticosteroidelor<\/h2>\n

      Diferite corticosteroide difer\u0103 \u00een principal prin poten\u021b\u0103, durat\u0103 de ac\u021biune \u0219i activitate mineralocorticoid\u0103 (de re\u021binere a s\u0103rurilor). Tabelul de mai jos ofer\u0103 echivalen\u021ba clinic\u0103 util\u0103 \u2014 v\u0103 permite s\u0103 converti\u021bi o doz\u0103 dintr-un steroid \u00een doza echivalent\u0103 a altuia.<\/p>\n\n\n\n\n\n\n\n\n\n
      Corticosteroid<\/th>\nPoten\u021b\u0103 glucocorticoid\u0103<\/th>\nDoza echivalent\u0103<\/th>\nMineralocorticoid<\/th>\nDurat\u0103<\/th>\n<\/tr>\n<\/thead>\n
      Hidrocortizon<\/td>\n1 (de referin\u021b\u0103)<\/td>\n20 mg<\/td>\nSubstan\u021bial\u0103<\/td>\n8\u201312 h<\/td>\n<\/tr>\n
      Prednisolon<\/td>\n4<\/td>\n5 mg<\/td>\nSc\u0103zut<\/td>\n12\u201336 h<\/td>\n<\/tr>\n
      Methylprednisolone<\/td>\n5<\/td>\n4 mg<\/td>\nMinim\u0103<\/td>\n12\u201336 h<\/td>\n<\/tr>\n
      Dexametazon\u0103<\/strong><\/td>\n25\u201330<\/td>\n0,75 mg<\/td>\nNiciuna<\/td>\n36\u201354 h<\/td>\n<\/tr>\n
      Betametazon\u0103<\/td>\n25\u201330<\/td>\n0,75 mg<\/td>\nNiciuna<\/td>\n36\u201354 h<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      Cine nu ar trebui s\u0103 ia Decmax?<\/h2>\n
        \n
      • Infec\u021bie fungic\u0103 sistemic\u0103 (cu excep\u021bia terapiei de substitu\u021bie \u00een insuficien\u021ba adrenal\u0103)<\/li>\n
      • Vaccinuri cu virus viu \u00een timpul dozelor imunosupresoare (consulta\u021bi un specialist \u00eenainte de BCG, MMR, febr\u0103 galben\u0103, varicel\u0103, tifos oral)<\/li>\n
      • Infec\u021bie bacterian\u0103 activ\u0103 netratat\u0103 (\u00eencepe\u021bi mai \u00eent\u00e2i cu antibioticele)<\/li>\n
      • Tuberculoz\u0103 activ\u0103 f\u0103r\u0103 acoperire anti-TB<\/li>\n
      • Hipersensibilitate cunoscut\u0103 la molecula activ\u0103 sau la orice excipient<\/li>\n
      • Folosi\u021bi cu precau\u021bie \u00een: diabet zaharat, insuficien\u021b\u0103 cardiac\u0103 congestiv\u0103, hipertensiune arterial\u0103, osteoporoz\u0103, ulcer peptic, tulbur\u0103ri psihiatrice, glaucom, herpes simplex oftalmic<\/li>\n
      • Sarcina: folosi\u021bi numai dac\u0103 este clar necesar \u2014 prednisolonul \u0219i hidrocortizonul trec mai pu\u021bin prin placent\u0103 dec\u00e2t dexametazonul\/betametazonul, care sunt preferate atunci c\u00e2nd se dore\u0219te un efect fetal (de ex. maturarea pl\u0103m\u00e2nilor)<\/li>\n<\/ul>\n

        Efecte Secundare ale Corticosteroidelor<\/h2>\n

        Efectele secundare ale corticosteroidelor depind de doz\u0103 \u0219i de durat\u0103. Tratamentele scurte (< 2 s\u0103pt\u0103m\u00e2ni) la doze moderate sunt de obicei bine tolerate. Terapiile mai lungi sau la doze mai mari produc profilul clasic \u201cCushingoid\u201d.<\/p>\n

        Pe termen scurt (primele 1\u20132 s\u0103pt\u0103m\u00e2ni):<\/strong><\/p>\n