{"id":56643,"date":"2024-02-27T17:02:18","date_gmt":"2024-02-27T17:02:18","guid":{"rendered":"https:\/\/medsname.com\/dompewal-tablet\/"},"modified":"2026-04-30T10:24:36","modified_gmt":"2026-04-30T10:24:36","slug":"dompewal-tablet","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/dompewal-tablet\/","title":{"rendered":"Dompewal Tablet"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Dompewal?<\/h3>\n<p style=\"margin:0;\"><strong>Dompewal<\/strong> este un comprimat oral de domperidon\u0103 10 mg \u2014 un antagonist periferic al receptorului D2 de dopamin\u0103 utilizat pe termen scurt pentru <strong>gre\u021buri, v\u0103rs\u0103turi \u0219i gastroparez\u0103<\/strong>. Accelereaz\u0103 golirea gastric\u0103, cre\u0219te tonusul sfincterului esofagian inferior \u0219i antagonizeaz\u0103 receptorii D2 din zona trigger a chemoreceptorilor. Spre deosebire de metoclopramid\u0103, nu traverseaz\u0103 bariera hemato-encefalic\u0103 \u00een cantit\u0103\u021bi semnificative \u0219i, prin urmare, nu produce simptome extrapiramidale. Doz\u0103 standard: <strong>10 mg de p\u00e2n\u0103 la trei ori pe zi, luate cu 15\u201330 de minute \u00eenainte de mese<\/strong>, pentru maximum 7 zile la un maxim de 30 mg\/zi conform restric\u021biei EMA 2014. Produc\u0103tor certificat WHO-GMP.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>De ce s\u0103 comanzi de la MedsBase:<\/strong> \u2714 <strong>produc\u0103tor certificat WHO-GMP<\/strong> \u2714 Ambalaj discret \u2714 Livrare worldwide \u2714 <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">Recenzii verificate ale clien\u021bilor (peste 1.400 de clien\u021bi)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>\u26a0\ufe0f Regula EMA 2014 pentru tratamente de scurt\u0103 durat\u0103.<\/strong> Domperidonul este restric\u021bionat la cea mai mic\u0103 doz\u0103 eficient\u0103 pentru cea mai scurt\u0103 durat\u0103 (de obicei \u2264 7 zile, max 30 mg\/zi). Prezint\u0103 un semnal mic dar real pentru prelungirea intervalului QT \u0219i aritmii ventriculare grave. Evita\u021bi la v\u00e2rsta &gt; 60 de ani, prelungire cunoscut\u0103 a QT, dezechilibru electrolitic, insuficien\u021b\u0103 hepatic\u0103 sever\u0103 sau cu medicamente care prelungesc QT sau inhib\u0103 puternic CYP3A4 (claritromicin\u0103, ketoconazol, ritonavir). Evita\u021bi \u00een boala Parkinson \u2014 chiar \u0219i blocarea periferic\u0103 D2 poate \u00eenr\u0103ut\u0103\u021bi fluctua\u021biile motorii.<\/div>\n<h3 class=\"wp-block-heading\">De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Dompewal este furnizat de la un <strong>produc\u0103tor certificat WHO-GMP<\/strong>. Fiecare comand\u0103 este expediat\u0103 discret \u00een \u00eentreaga lume \u0219i este acoperit\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> \u2014 dac\u0103 nu ajunge \u00een 20 de zile lucr\u0103toare, retrimitem f\u0103r\u0103 costuri suplimentare. Domperidonul este utilizat pe scar\u0103 larg\u0103 pentru ameliorarea simptomelor pe termen scurt \u0219i reprezint\u0103 o alternativ\u0103 util\u0103 la metoclopramid\u0103 la pacien\u021bii care experimenteaz\u0103 efecte extrapiramidale cu aceasta din urm\u0103.<\/p>\n<h2 class=\"wp-block-heading\">Mecanism de ac\u021biune<\/h2>\n<p>Domperidonul este un derivat de benzimidazol care blocheaz\u0103 selectiv receptorii dopaminergici D2 din peretele intestinal (antrul gastric \u0219i duoden) \u0219i din zona trigger a chemoreceptorilor (CTZ) a zonei postreme, care se afl\u0103 \u00een afara barierei hemato-encefalice. Blocarea periferic\u0103 D2 cre\u0219te eliberarea de acetilcolin\u0103 din neuronii colinergici din plexul mienteric, acceler\u00e2nd golirea gastric\u0103 \u0219i \u00eent\u0103rind tonusul LES. Blocarea CTZ produce efect antiemetic. Deoarece molecula are o penetrare slab\u0103 a BHE, blocarea central\u0103 D2 \u0219i efectele secundare extrapiramidale rezultate sunt minime.<\/p>\n<h2 class=\"wp-block-heading\">Indica\u021bii<\/h2>\n<ul>\n<li>Gre\u021buri \u0219i v\u0103rs\u0103turi (acute, pe termen scurt)<\/li>\n<li>Adjuvant \u00een gastropareza diabetic\u0103 (ini\u021biere de c\u0103tre specialist)<\/li>\n<li>Dispepsie func\u021bional\u0103 cu disconfort postprandial<\/li>\n<li>Off-label: galactagog (inducerea lacta\u021biei)<\/li>\n<li>Adjuvant la levodopa pentru controlul gre\u021burilor periferice \u00een boala Parkinson f\u0103r\u0103 a antagoniza efectele centrale<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Doza<\/h2>\n<p>Adul\u021bi: 10 mg de p\u00e2n\u0103 la trei ori pe zi, cu 15\u201330 de minute \u00eenainte de mese. Maxim 30 mg\/zi. Maxim 7 zile. Copii &gt; 12 ani \u0219i &gt; 35 kg: la fel ca adul\u021bii. Copii &lt; 35 kg: doz\u0103 \u00een func\u021bie de greutate 250 mcg\/kg de p\u00e2n\u0103 la 3 ori pe zi, max 750 mcg\/kg\/zi. Insuficien\u021b\u0103 hepatic\u0103 sever\u0103: evita\u021bi. CrCl &lt; 30: nu este contraindicated, dar prelungi\u021bi intervalul.<\/p>\n<h2 class=\"wp-block-heading\">Efecte secundare<\/h2>\n<ul>\n<li>Frecvente: gur\u0103 uscat\u0103, cefalee, crampe abdominale<\/li>\n<li>Hiperprolactinemie: galactoree, ginecomastie, tulbur\u0103ri menstruale, libido sc\u0103zut, disfunc\u021bie erectil\u0103<\/li>\n<li>Prelungire QT, torsade de pointes (rar, dependent de doz\u0103 \u0219i factori de risc)<\/li>\n<li>Reac\u021bii cutanate alergice<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>Substan\u021be care prelungesc intervalul QT:<\/strong> azitromicin\u0103, ondansetron, fluorochinolone, citalopram, metadon\u0103 \u2014 evita\u021bi asocierea.<\/li>\n<li><strong>Inhibitori puternici ai CYP3A4:<\/strong> ketoconazol, ritonavir, claritromicin\u0103, suc de grapefruit \u2014 cresc nivelurile de 4\u20138 ori; evita\u021bi.<\/li>\n<li><strong>Medicamente anticholinergice<\/strong> contracaraz\u0103 efectul prokinetic.<\/li>\n<li><strong>Levodopa:<\/strong> poate fi prescris\u0103 \u00een mod deliberat pentru a gestiona greata indus\u0103 de levodopa f\u0103r\u0103 a afecta efectul levodopei \u00een SNC.<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">C\u00e2nd ar trebui s\u0103 iau Dompewal?<\/h3>\n<p>15\u201330 de minute \u00eenainte de mese pe stomacul gol. Alimentele \u00eent\u00e2rzie absorb\u021bia \u0219i sl\u0103besc efectul prokinetic.<\/p>\n<h3 class=\"wp-block-heading\">Pot s\u0103 o iau pentru gastroparezie cronic\u0103?<\/h3>\n<p>Utilizarea pe termen lung necesit\u0103 supraveghere specializat\u0103 cu ECG de baz\u0103 \u0219i periodic. Regula EMA privind tratamentul pe termen scurt se aplic\u0103 prescrierilor din medicina general\u0103; este permis\u0103 excep\u021bia specializat\u0103 atunci c\u00e2nd beneficiile dep\u0103\u0219esc riscurile \u0219i monitorizarea este asigurat\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Care este diferen\u021ba dintre domperidon \u0219i metoclopramid?<\/h3>\n<p>Ambele sunt antagoni\u0219ti D2 \u0219i prokinetice. Metoclopramida traverseaz\u0103 BHE \u0219i poate provoca simptome extrapiramidale (distonie acut\u0103, discinezie tardiv\u0103 \u2014 avertizare FDA) \u0219i are propria limit\u0103 de 12 s\u0103pt\u0103m\u00e2ni. Domperidonul are penetrare minim\u0103 \u00een SNC, dar un semnal cardiac (QT) mai clar \u0219i o regul\u0103 de 7 zile.<\/p>\n<h3 class=\"wp-block-heading\">De ce am senza\u021bie de durere la s\u00e2n la acest medicament?<\/h3>\n<p>Domperidonul cre\u0219te prolactina prin blocarea D2 hipofizar\u0103. Acest efect este reversibil la \u00eentrerupere. Simptomele persistente necesit\u0103 verificarea prolactinei serice \u0219i reevaluare.<\/p>\n<h3 class=\"wp-block-heading\">Este sigur \u00een sarcin\u0103?<\/h3>\n<p>Date umane limitate. Evita\u021bi, cu excep\u021bia cazului \u00een care prescriptorul decide c\u0103 beneficiile dep\u0103\u0219esc riscurile. Al\u0103ptare: cantit\u0103\u021bi mici \u00een laptele matern; uneori utilizat off-label pentru a stimula lacta\u021bia, dar este recomandat consult specializat.<\/p>\n<h3 class=\"wp-block-heading\">Pot s\u0103 o iau cu medicamentele pentru inim\u0103?<\/h3>\n<p>Spune\u021bi prescriptorului despre fiecare medicament pe care \u00eel lua\u021bi, \u00een special antibiotice (azitromicin\u0103\/claritromicin\u0103), antifungice (ketoconazol\/itraconazol), antidepresive (citalopram), antimalarice (clorochin\u0103) \u0219i metadon\u0103. Prolungarea QT indus\u0103 de domperidon se adaug\u0103 la efectul acestora.<\/p>\n<h3 class=\"wp-block-heading\">De ce EMA limiteaz\u0103 la 7 zile?<\/h3>\n<p>Semnal de farmacovigilan\u021b\u0103 privind decesul cardiac subit asociat cu doze mari \u0219i tratamente \u00eendelungate, \u00een special la adul\u021bii \u00een v\u00e2rst\u0103. Limita de 7 zile echilibreaz\u0103 ameliorarea simptomelor fa\u021b\u0103 de riscul de aritmie.<\/p>\n<h3 class=\"wp-block-heading\">Ce se \u00eent\u00e2mpl\u0103 dac\u0103 am Parkinson?<\/h3>\n<p>Evita\u021bi. Chiar \u0219i blocarea periferic\u0103 a receptorilor D2 poate agrava simptomele motorii la pacien\u021bii vulnerabili. Discuta\u021bi alternative cu un neurolog.<\/p>\n<h3 class=\"wp-block-heading\">Depozitare<\/h3>\n<p>Sub 30\u00b0C, proteja\u021bi de umiditate. P\u0103stra\u021bi departe de copii.<\/p>\n<h3 class=\"wp-block-heading\">Ce fac dac\u0103 uit o doz\u0103?<\/h3>\n<p>Lua\u021bi-o \u00eenainte de urm\u0103toarea mas\u0103, apoi continua\u021bi conform programului. Nu lua\u021bi o dobl\u0103.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alte Medicamente pentru S\u0103n\u0103tatea Gastrointestinal\u0103<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/reglan\/\">Reglan \u2014 Metoclopramid\u0103 10 mg (alt prokinetic)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/stemetil\/\">Stemetil \u2014 Proclorperazin\u0103 5 mg (antiemetic)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/doxinate\/\">Doxinate \u2014 Doxilamin\u0103 + B6 (specific pentru gre\u021buri \u00een sarcin\u0103)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/omez-d\/\">Omez D \u2014 Omeprazol + Domperidon SR combinate<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/gr8-od\/\">GR8-OD \u2014 Pantoprazol + Domperidon SR combinate<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/gastro-health\/\"><strong>Vede\u021bi toate Medicamentele pentru S\u0103n\u0103tatea Gastrointestinal\u0103<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui profesionist calificat. Grea\u021b\u0103 persistent\u0103, v\u0103rs\u0103turi de s\u00e2nge, dureri abdominale severe, deshidratare sau pierdere \u00een greutate necesit\u0103 evaluare urgent\u0103.<\/div>","protected":false},"excerpt":{"rendered":"<p>Comprimat Dompewal (Domperidon\u0103 10 mg) \u2014 antagonist periferic al receptorului D2 de dopamin\u0103 pentru scurt\u0103 durat\u0103 a gre\u021burilor, v\u0103rs\u0103turilor, regurgit\u0103rilor \u0219i gastropareziei. Gr\u0103be\u0219te golirea gastric\u0103.<\/p>","protected":false},"featured_media":0,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342,3543],"product_tag":[3609,4137],"class_list":{"0":"post-56643","1":"product","2":"type-product","3":"status-publish","5":"product_cat-category-overview","6":"product_cat-gastro-health","7":"product_cat-general-health","8":"product_cat-nausea-treatment","9":"product_tag-domperidone","10":"product_tag-dompewal-tablet","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/56643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=56643"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=56643"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=56643"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=56643"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=56643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}