{"id":56700,"date":"2024-02-27T17:04:40","date_gmt":"2024-02-27T17:04:40","guid":{"rendered":"https:\/\/medsname.com\/hetrazan\/"},"modified":"2026-04-30T10:24:35","modified_gmt":"2026-04-30T10:24:35","slug":"hetrazan","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/hetrazan\/","title":{"rendered":"Hetrazan"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:0 0 18px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 8px 0;font-size:1.05em;\">R\u0103spuns rapid<\/h3>\n<p><strong>Hetrazan<\/strong> con\u021bine <strong>diethylcarbamazine citrate (DEC) 100 mg<\/strong> pe tablet\u0103 \u2014 medicamentul antifilaric de prim\u0103 linie OMS pentru filarioza limfatic\u0103 (Wuchereria bancrofti, Brugia malayi, Brugia timori) \u0219i eosinofilie pulmonar\u0103 tropical\u0103. Doz\u0103 standard adult: 6 mg\/kg\/zi, unic\u0103 sau frac\u021bionat\u0103. <strong>Excludere critic\u0103:<\/strong> \u00een oncocerciaz\u0103 (orbirea de r\u00e2u) \u0219i loiaz\u0103 cu densitate mare, DEC poate declan\u0219a reac\u021bii severe Mazzotti sau encefalopatice \u2014 confirma\u021bi specia parazitului \u00eenainte de tratament.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f6f8;border:1px solid #e1e4e8;border-radius:4px;padding:14px 18px;margin:18px 0;display:flex;flex-wrap:wrap;gap:14px;font-size:0.95em;\"><span>\u2705 <strong>Certificat WHO-GMP<\/strong> produc\u0103tor<\/span><span>\ud83d\udce6 <strong>Ambalaj discret<\/strong><\/span><span>\ud83c\udf0d <strong>Livrare \u00een toat\u0103 lumea<\/strong><\/span><span>\ud83d\udcac <a href=\"\/ro\/reviews\/\">Peste 1.400 de recenzii ale clien\u021bilor<\/a><\/span><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h2>Ce este dietilcarbamazina<\/h2>\n<p>Dietilcarbamazina (DEC) este un derivat de piperazin\u0103 descoperit \u00een 1947 \u0219i microfilaricidul oral de prim\u0103 inten\u021bie al OMS pentru filarioza limfatic\u0103. Ac\u021bioneaz\u0103 prin dou\u0103 mecanisme: (1) sensibilizeaz\u0103 microfiliarele la atacul imun al gazdei prin modificarea membranelor lor de suprafa\u021b\u0103 \u0219i (2) activeaz\u0103 calea acizilor arahidonici ai gazdei, duc\u00e2nd la eliminarea rapid\u0103 din s\u00e2ngele periferic. De asemenea, are activitate macrofilaricid\u0103 lent\u0103 \u00eempotriva viermilor adul\u021bi pe parcursul mai multor cure.<\/p>\n<h2>Indica\u021bii<\/h2>\n<ul>\n<li><strong>Filarioz\u0103 limfatic\u0103<\/strong> \u2014 Wuchereria bancrofti, Brugia malayi, Brugia timori. Doz\u0103 adult 6 mg\/kg\/zi timp de 12 zile, sau doz\u0103 unic\u0103 anual\u0103 de 6 mg\/kg cu albendazol 400 mg \u00een programe de administrare \u00een mas\u0103 (MDA).<\/li>\n<li><strong>Eozinofilie pulmonar\u0103 tropical\u0103 (TPE)<\/strong> \u2014 r\u0103spuns de hipersensibilitate la antigenii filarieni. 6 mg\/kg\/zi \u00een 3 doze divizate timp de 14\u201321 de zile.<\/li>\n<li><strong>Loiaz\u0103 (Loa loa)<\/strong> \u2014 8\u201310 mg\/kg\/zi timp de 21 de zile, \u00eencep\u00e2nd cu doze mai mici sub acoperire cu steroizi. Tratament \u00een spital.<\/li>\n<li><strong>Mansonelioz\u0103 (Mansonella streptocerca, perstans)<\/strong> \u2014 r\u0103spuns variabil.<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 8px 0;font-size:1.05em;\">NU utiliza\u021bi f\u0103r\u0103 confirmarea speciei \u00een<\/h3>\n<ul>\n<li><strong>Onchocerciaz\u0103 (orbirea de r\u00e2u)<\/strong> \u2014 DEC ucide microfilarele rapid, eliber\u00e2nd antigen \u0219i declan\u0219\u00e2nd o inflama\u021bie sever\u0103 <strong>reac\u021bia Mazzotti<\/strong> cu prurit intens, febr\u0103, limfadenopatie, hipotensiune \u0219i leziuni oculare ireversibile. Utiliza\u021bi ivermectina \u00een schimb.<\/li>\n<li><strong>Loiaz\u0103 cu densitate mare (num\u0103r de microfilare &gt; 8.000\/ml)<\/strong> \u2014 DEC poate declan\u0219a encefalopatie fatal\u0103. Este necesar\u0103 num\u0103rarea prealabil\u0103 a microfilarelor \u0219i aferez\u0103 sau pretratament cu albendazol.<\/li>\n<li>Confirma\u021bi \u00eentotdeauna specia parazitului prin frotiu sanguin gros, test antigenic (ICT pentru W. bancrofti) sau serologie de anticorpi \u00eenainte de \u00eenceperea tratamentului.<\/li>\n<\/ul>\n<\/div>\n<h2>Doza<\/h2>\n<table>\n<thead>\n<tr>\n<th>Indica\u021bie<\/th>\n<th>Doza pentru adul\u021bi<\/th>\n<th>Durat\u0103<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Filarioz\u0103 limfatic\u0103 (curs curativ)<\/td>\n<td>6 mg\/kg\/zi, \u00eemp\u0103r\u021bit \u00een 3 doze<\/td>\n<td>12 zile<\/td>\n<\/tr>\n<tr>\n<td>Filarioz\u0103 limfatic\u0103 (MDA, cu albendazol)<\/td>\n<td>6 mg\/kg doz\u0103 unic\u0103 + albendazol 400 mg doz\u0103 unic\u0103<\/td>\n<td>O dat\u0103 pe an timp de 5\u20136 ani<\/td>\n<\/tr>\n<tr>\n<td>Eozinofilie pulmonar\u0103 tropical\u0103<\/td>\n<td>6 mg\/kg\/zi, \u00eemp\u0103r\u021bit \u00een 3 doze<\/td>\n<td>14\u201321 de zile<\/td>\n<\/tr>\n<tr>\n<td>Loiasis (\u00eengrijire specializat\u0103)<\/td>\n<td>Ini\u021biere cu 1 mg\/kg ziua 1, cre\u0219tere progresiv\u0103 p\u00e2n\u0103 la 8\u201310 mg\/kg\/zi<\/td>\n<td>21 de zile, cu terapie de sus\u021binere cu steroizi<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Efecte secundare<\/h2>\n<p>DEC are DOU\u0102 categorii de reac\u021bii adverse:<\/p>\n<h3>Efecte directe ale medicamentului (u\u0219oare, tranzitorii)<\/h3>\n<ul>\n<li>Cefalee, stare general\u0103 slab\u0103, anorexie, grea\u021b\u0103 u\u0219oar\u0103<\/li>\n<li>Disconfort abdominal minor<\/li>\n<li>Dureri articulare \u0219i musculare<\/li>\n<\/ul>\n<h3>Reac\u021bie de distrugere a microfilariei (asem\u0103n\u0103toare cu Mazzotti, dependent\u0103 de doz\u0103 \u0219i \u00eenc\u0103rc\u0103tur\u0103 parazitar\u0103)<\/h3>\n<ul>\n<li>Febr\u0103 (adesea \u00een c\u00e2teva ore de la prima doz\u0103)<\/li>\n<li>Prurit generalizat, urticarie, erup\u021bie papuloas\u0103<\/li>\n<li>Limfadenit\u0103 \u0219i ganglioni limfatici sensibili (inflamare a limfaticelor scrotale la b\u0103rba\u021bii cu W. bancrofti)<\/li>\n<li>Cefalee, ame\u021beli, stare general\u0103 slab\u0103<\/li>\n<li>Recrudescen\u021ba eozinofiliei<\/li>\n<li>\u00cen filarioza ocular\u0103 sau onchocerciasis: inflamaama\u021bie ocular\u0103 sever\u0103, poate duce la orbire<\/li>\n<li>\u00cen zonele cu inciden\u021b\u0103 ridicat\u0103 a Loa loa: encefalopatie sever\u0103, com\u0103 \u2014 prevenibile prin screening pre-tratament<\/li>\n<\/ul>\n<p>Gestiona\u021bi reac\u021biile de tip Mazzotti cu paracetamol, antihistaminice \u0219i cursuri scurte de corticosteroide orale (prednisolon 0,5\u20131 mg\/kg\/zi) pentru cazurile severe. NU \u00eentrerupe\u021bi DEC pentru reac\u021biile u\u0219oare \u2014 acestea reflect\u0103 eliminarea parazitului \u0219i vor disp\u0103rea.<\/p>\n<h2>Contraindica\u021bii<\/h2>\n<ul>\n<li>Oncocercoz\u0103 confirmat\u0103 (utiliza\u021bi ivermectin\u0103)<\/li>\n<li>Loa loa cu densitate microfilare &gt; 8.000\/ml f\u0103r\u0103 \u00eengrijire specializat\u0103 \u00een spital<\/li>\n<li>Sarcin\u0103 (relativ\u0103 \u2014 am\u00e2na\u021bi tratamentul dup\u0103 na\u0219tere, acolo unde este posibil)<\/li>\n<li>Afectare renal\u0103 sau hepatic\u0103 sever\u0103 f\u0103r\u0103 ajustare de doz\u0103<\/li>\n<li>Copii sub 18 luni<\/li>\n<\/ul>\n<h2>Interac\u021biuni medicamentoase<\/h2>\n<p>Pu\u021bine interac\u021biuni semnificative. Monitoriza\u021bi INR la pacien\u021bii sub tratament cu warfarin\u0103. Co-administrarea cu albendazol 400 mg doz\u0103 unic\u0103 este standardul OMS pentru filarioza limfatic\u0103 \u0219i este bine tolerat\u0103.<\/p>\n<h2>Sarcin\u0103 \u0219i al\u0103ptare<\/h2>\n<ul>\n<li>Sarcin\u0103 \u2014 date limitate. OMS am\u00e2n\u0103 tratamentul p\u00e2n\u0103 dup\u0103 na\u0219tere; tratamentul pentru boal\u0103 activ\u0103 \u00een timpul sarcinii se decide caz cu caz.<\/li>\n<li>Al\u0103ptare \u2014 cantit\u0103\u021bi mici eliminate \u00een lapte; de obicei compatibil dac\u0103 tratamentul este necesar.<\/li>\n<\/ul>\n<h2>Depozitare<\/h2>\n<p>P\u0103stra\u021bi la temperatur\u0103 sub 25 \u00b0C, \u00een ambalajul original blister, uscat. Comprimatele sunt stabile pe \u00eentreaga durat\u0103 de valabilitate indicat\u0103, dac\u0103 sunt p\u0103strate uscate.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Hetrazan este furnizat de un produc\u0103tor certificat WHO-GMP cu documenta\u021bie COA complet\u0103. Livr\u0103m \u00een toat\u0103 lumea \u00een ambalaje discrete \u0219i simple, iar fiecare comand\u0103 este acoperit\u0103 de asigurarea noastr\u0103 Reshipment Assurance. <a href=\"\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a>. Descrierea tranzac\u021biei la plata cu cardul afi\u0219eaz\u0103 procesatorul de pl\u0103\u021bi reglementat (un procesator de pl\u0103\u021bi cu card reglementat), niciodat\u0103 \"MedsBase\" sau numele vreunui medicament.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>C\u00e2t de repede omoar\u0103 Hetrazan viermii?<\/h3>\n<p>Microfilarele (stadiul larval care circul\u0103 \u00een s\u00e2nge) sunt eliminate din s\u00e2ngele periferic \u00een c\u00e2teva ore p\u00e2n\u0103 la zile. Viermii adul\u021bi sunt redu\u0219i mai \u00eencet, pe parcursul s\u0103pt\u0103m\u00e2nilor; sunt de obicei necesare mai multe cursuri sau doze MDA anuale repetate pentru a elimina complet o infec\u021bie instalat\u0103.<\/p>\n<h3>De ce unor persoane li se recomand\u0103 s\u0103 ia Hetrazan \u00eempreun\u0103 cu albendazol?<\/h3>\n<p>\u00cen programele de administrare \u00een mas\u0103 a medicamentelor (MDA) ale WHO pentru filarioza limfatic\u0103, se administreaz\u0103 anual o doz\u0103 unic\u0103 de DEC 6 mg\/kg + albendazol 400 mg timp de 5\u20136 ani pentru a \u00eentrerupe transmiterea. Combina\u021bia este mai eficient\u0103 \u00een suprimarea microfilarelor dec\u00e2t DEC singur.<\/p>\n<h3>Am river blindness (onchocerciaz\u0103) \u2014 pot lua Hetrazan?<\/h3>\n<p>Nu. DEC declan\u0219eaz\u0103 o reac\u021bie Mazzotti sever\u0103 \u00een onchocerciaz\u0103, cu reac\u021bie cutanat\u0103 intens\u0103 \u0219i leziuni oculare ireversibile. Ivermectina (Mectizan) este standardul WHO pentru onchocerciaz\u0103. Confirma\u021bi \u00eentotdeauna specia \u00eenainte de a \u00eencepe tratamentul cu DEC.<\/p>\n<h3>Sunt din Africa Central\u0103 \u2014 ar trebui s\u0103 fiu testat pentru Loa loa mai \u00eent\u00e2i?<\/h3>\n<p>Da, dac\u0103 v\u0103 afla\u021bi sau provine\u021bi din Africa Central\u0103 (Camerun, Congo, Gabon etc.). Microfilaremia cu densitate mare de Loa loa + DEC poate declan\u0219a encefalopatie fatal\u0103. Este esen\u021bial un frotiu de s\u00e2nge diurn \u00eenainte de tratament pentru num\u0103rarea microfilarelor.<\/p>\n<h3>La ce s\u0103 m\u0103 a\u0219tept \u00een primele zile de tratament?<\/h3>\n<p>Febr\u0103 u\u0219oar\u0103, cefalee, m\u00e2nc\u0103rime \u0219i ganglioni limfatici sensibili sunt frecvente din cauza elimin\u0103rii microfilarelor \u2014 acestea ating apogeul \u00een primele 24\u201372 de ore \u0219i apoi se atenueaz\u0103. Lua\u021bi paracetamol; nu \u00eentrerupe\u021bi DEC dec\u00e2t dac\u0103 reac\u021biile sunt severe (febr\u0103 mare, dificult\u0103\u021bi de respira\u021bie, durere ocular\u0103). Reac\u021biile severe necesit\u0103 evaluare medical\u0103 \u0219i un scurt tratament cu steroid oral.<\/p>\n<h3>Cum difer\u0103 eosinofilia pulmonar\u0103 tropical\u0103 de astmul obi\u0219nuit?<\/h3>\n<p>TPE este un r\u0103spuns de hipersensibilitate la antigenii filariali \u2014 tuse cronic\u0103 uscat\u0103, dispnee \u0219i eosinofilie foarte mare (adesea &gt; 3.000\/\u03bcL) la cineva dintr-o zon\u0103 endemic\u0103 pentru filarioz\u0103. Func\u021bia pulmonar\u0103 sugereaz\u0103 restric\u021bie sau obstruc\u021bie; radiografia toracic\u0103 arat\u0103 opacit\u0103\u021bi reticulonodulare. DEC la 6 mg\/kg\/zi timp de 14\u201321 de zile rezolv\u0103 at\u00e2t simptomele, c\u00e2t \u0219i eosinofilia \u00een majoritatea cazurilor.<\/p>\n<h3>C\u00e2t dureaz\u0103 tratamentul pentru filarioz\u0103 p\u00e2n\u0103 la vindecarea complet\u0103?<\/h3>\n<p>Un tratament curativ de 12 zile elimin\u0103 adesea microfilaria \u0219i reduce \u00eenc\u0103rc\u0103tura de viermi adul\u021bi, dar leziunile limfatice stabilite (limfedem, hidrocel) nu sunt reversate de DEC \u0219i necesit\u0103 \u00eengrijire limfatic\u0103 de sus\u021binere. Eliminarea viermilor adul\u021bi poate necesita mai multe cursuri de tratament pe parcursul anilor.<\/p>\n<h3>Exist\u0103 o modalitate de a preveni filarioza?<\/h3>\n<p>Controlul vectorilor (plase pentru \u021b\u00e2n\u021bari, pulveriz\u0103ri reziduale \u00een interior) plus administrarea anual\u0103 de DEC + albendazol a eliminat transmiterea \u00een multe zone \u021bint\u0103 ale OMS. Preven\u021bia personal\u0103 \u00een zonele endemice: m\u00e2neci lungi la amurg, repelent, plase pentru pat.<\/p>\n<h3>Pot s\u0103-l iau \u00een timpul sarcinii?<\/h3>\n<p>OMS am\u00e2n\u0103 administrarea MDA \u00een timpul sarcinii. Boala activ\u0103 \u00een sarcin\u0103 este decis\u0103 caz cu caz cu consult specializat. Date limitate de siguran\u021b\u0103; tratamentul este de obicei am\u00e2nat acolo unde este posibil.<\/p>\n<h3>Cum difer\u0103 DEC de ivermectin\u0103?<\/h3>\n<p>DEC este de prim\u0103 inten\u021bie pentru filarioza limfatic\u0103 (Wuchereria, Brugia) \u0219i eosinofilia pulmonar\u0103 tropical\u0103. Ivermectina este de prim\u0103 inten\u021bie pentru oncocerciaz\u0103 (orbirea de r\u00e2u) \u0219i strongiloidiaz\u0103 \u0219i este preferat\u0103 \u00een locul DEC \u00een zonele cu infec\u021bii mixte deoarece nu declan\u0219eaz\u0103 reac\u021bia periculoas\u0103 Mazzotti \u00een oncocerciaz\u0103. Cele dou\u0103 medicamente acoper\u0103 parazi\u021bi diferi\u021bi.<\/p>\n<h2>Alte Medicamente Antiparazitare \u0219i Anthelmintice<\/h2>\n<ul>\n<li><a href=\"\/ro\/threadworm-treatment\/\">Toate Tratamentele Antiparazitare \u0219i Anthelmintice<\/a><\/li>\n<li><a href=\"\/ro\/vermact\/\">Vermact (ivermectin\u0103) \u2014 de prim\u0103 inten\u021bie pentru oncocerciaz\u0103 \u0219i strongiloidiaz\u0103<\/a><\/li>\n<li><a href=\"\/ro\/ivecop\/\">Ivecop (ivermectin\u0103) \u2014 marc\u0103 alternativ\u0103 de ivermectin\u0103<\/a><\/li>\n<li><a href=\"\/ro\/wormentel\/\">Wormentel \u2014 antihelmintic cu spectru larg<\/a><\/li>\n<li><a href=\"\/ro\/prazihet\/\">Prazihet (praziquantel) \u2014 pentru schistosomiaz\u0103 \u0219i teniaz\u0103<\/a><\/li>\n<li><a href=\"\/ro\/ivermectin-fenbendazole-combo-pack\/\">Pachet Combinat Ivermectin\u0103 + Fenbendazol<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0 0 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 8px 0;font-size:1.05em;\">Declinare de responsabilitate medical\u0103<\/h3>\n<p style=\"margin:0;\">Aceast\u0103 informa\u021bie este furnizat\u0103 \u00een scop educa\u021bional \u0219i nu \u00eenlocuie\u0219te sfatul medical. Consulta\u021bi \u00eentotdeauna un profesionist calificat \u00een s\u0103n\u0103tate \u00eenainte de a \u00eencepe, modifica sau \u00eentrerupe orice tratament medicamentos.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Hetrazan (diethylcarbamazine 100 mg) \u2014 antifilaric oral de prim\u0103 linie pentru filarioza limfatic\u0103 (Wuchereria bancrofti, Brugia malayi), loiaz\u0103 \u0219i eosinofilie pulmonar\u0103 tropical\u0103. Medicament esen\u021bial pe lista OMS.<\/p>","protected":false},"featured_media":56701,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3856],"product_tag":[4152,4153],"class_list":{"0":"post-56700","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-threadworm-treatment","9":"product_tag-diethylcarbamazine","10":"product_tag-hetrazan","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/56700","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=56700"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/56701"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=56700"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=56700"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=56700"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=56700"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}