{"id":57402,"date":"2024-02-27T17:40:48","date_gmt":"2024-02-27T17:40:48","guid":{"rendered":"https:\/\/medsname.com\/glisen-pm\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"glisen-pm","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/glisen-pm\/","title":{"rendered":"Glisen PM"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Glisen PM?<\/h3>\n<p style=\"margin:0;\"><strong>Glisen PM<\/strong> este un <strong>combina\u021bie fix\u0103 de trei medicamente<\/strong> de <strong>glimepirid\u0103, pioglitazon\u0103 \u0219i metformin\u0103<\/strong> (Glimepirid\u0103 1 mg (sau 2 mg) + Pioglitazon\u0103 15 mg + Metformin\u0103 500 mg) utilizat pentru <strong>diabetului de tip 2<\/strong> necontrolat la terapia dual\u0103. Ac\u021bioneaz\u0103 asupra hiperglicemiei prin trei mecanisme complementare: glimepirida stimuleaz\u0103 eliberarea de insulin\u0103 din pancreas, pioglitazona reduce rezisten\u021ba la insulin\u0103 \u00een mu\u0219chi\/\u021besut adipos\/ficat, iar metformina reduce produc\u021bia de glucoz\u0103 hepatic\u0103. Reducere tipic\u0103 a HbA1c: <strong>2,0\u20132,5 puncte<\/strong>. Doza uzual\u0103: o tablet\u0103 o dat\u0103 pe zi la micul dejun. Profilul de efecte adverse combin\u0103 riscul de hipoglicemie (de la glimepirid\u0103), cre\u0219terea \u00een greutate \u0219i edemul (de la pioglitazon\u0103), \u0219i tulbur\u0103rile gastrointestinale cauzate de metformin\u0103. Evita\u021bi \u00een insuficien\u021b\u0103 cardiac\u0103, cancer vezical activ, eGFR &lt; 30, afec\u021biuni hepatice severe \u0219i alergie la sulfamide. Aceasta este de obicei o etap\u0103 \u00eenainte de ini\u021bierea insulinoterapiei.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<h2 class=\"wp-block-heading\">Ce este Glisen PM?<\/h2>\n<p>Glisen PM este un comprimat cu doz\u0103 fix\u0103 combinat\u0103 oral care con\u021bine trei ingrediente antidiabetice active: <strong>glimepirid\u0103, pioglitazon\u0103 \u0219i clorhidrat de metformin\u0103<\/strong> (Glimepirid\u0103 1 mg (sau 2 mg) + Pioglitazon\u0103 15 mg + Metformin\u0103 500 mg). Este fabricat de un produc\u0103tor certificat WHO-GMP \u0219i este furnizat \u00een cutii de 30, 60, 90 sau 180 de comprimate.<\/p>\n<p>Terapia tripl\u0103 \u00eentr-un singur comprimat este utilizat\u0103 atunci c\u00e2nd terapia dual\u0103 (de obicei metformin\u0103 + sulfoniluree sau metformin\u0103 + TZD) nu atinge \u021bintele glicemice, iar clinicianul dore\u0219te s\u0103 intensifice tratamentul f\u0103r\u0103 a \u00eencepe \u00eenc\u0103 insulinoterapia.<\/p>\n<h2 class=\"wp-block-heading\">Cum func\u021bioneaz\u0103 Glisen PM?<\/h2>\n<p>Cele trei componente ac\u021bioneaz\u0103 asupra hiperglicemiei din trei direc\u021bii diferite:<\/p>\n<ul>\n<li><strong>Metformin\u0103<\/strong> \u2014 reduce produc\u021bia hepatic\u0103 de glucoz\u0103; \u00eembun\u0103t\u0103\u021be\u0219te sensibilitatea la insulin\u0103 periferic\u0103; nu provoac\u0103 hipoglicemie singur.<\/li>\n<li><strong>Pioglitazona<\/strong> \u2014 agonist PPAR-\u03b3; \u00eembun\u0103t\u0103\u021be\u0219te sensibilitatea la insulin\u0103 \u00een mu\u0219chi, \u021besut adipos \u0219i ficat; \u00eembun\u0103t\u0103\u021be\u0219te profilul lipidic \u0219i ficatul gras; nu provoac\u0103 hipoglicemie singur.<\/li>\n<li><strong>Glimepirid\u0103<\/strong> \u2014 sulfoniluree de genera\u021bia a treia; \u00eenchide canalele K din celulele beta<sub>Durata de ac\u021biune:<\/sub> canale pentru <em>stimularea eliber\u0103rii de insulin\u0103<\/em>. Acesta este componentul care adaug\u0103 riscul de hipoglicemie.<\/li>\n<\/ul>\n<p>Reducerea combinat\u0103 a HbA1c este de obicei <strong>2,0\u20132,5 puncte procentuale<\/strong> comparativ cu terapia dual\u0103.<\/p>\n<h2 class=\"wp-block-heading\">Doza \u0219i administrare<\/h2>\n<p><strong>Doza uzual\u0103:<\/strong> o tablet\u0103 o dat\u0103 pe zi, cu sau chiar \u00eenainte de micul dejun. Unii medici prescriu o tablet\u0103 de dou\u0103 ori pe zi la mesele mai mari dac\u0103 HbA1c nu este controlat\u0103 cu dozarea o dat\u0103 pe zi.<\/p>\n<ul>\n<li><strong>Lua\u021bi cu m\u00e2ncare<\/strong> \u2014 \u00eembun\u0103t\u0103\u021be\u0219te tolerabilitatea \u0219i sincronizeaz\u0103 eliberarea de insulin\u0103 a sulfonilureei cu cre\u0219terea glicemiei postprandiale.<\/li>\n<li><strong>Nu s\u0103ri\u021bi peste mese<\/strong> \u2014 glimepirida poate provoca hipoglicemie pe stomacul gol.<\/li>\n<li><strong>Transporta\u021bi carbohidra\u021bi cu ac\u021biune rapid\u0103<\/strong>.<\/li>\n<li>Monitoriza\u021bi glicemia, HbA1c, greutatea, edemul de glezn\u0103, ALT \u0219i func\u021bia renal\u0103.<\/li>\n<li>Verificare anual\u0103 a vitaminei B12 (metformin\u0103 pe termen lung).<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Efecte Secundare<\/h2>\n<p><strong>Frecvente:<\/strong><\/p>\n<ul>\n<li><strong>Hipoglicemie<\/strong> \u2014 din componenta glimepirid\u0103; tremur\u0103turi, transpira\u021bii, palpita\u021bii, foame, confuzie. Trata\u021bi cu 15 g de carbohidra\u021bi cu ac\u021biune rapid\u0103.<\/li>\n<li><strong>Cre\u0219terea \u00een greutate<\/strong> \u2014 2\u20134 kg \u00een medie (pioglitazon\u0103 + glimepirid\u0103 favorizeaz\u0103 cre\u0219terea; metformina o atenueaz\u0103 u\u0219or).<\/li>\n<li><strong>Edem periferic<\/strong> \u2014 din pioglitazon\u0103; cel mai frecvent motiv de \u00eentrerupere.<\/li>\n<li>Efecte secundare gastrointestinale ale metforminei \u00een primele 1\u20132 s\u0103pt\u0103m\u00e2ni (diaree, grea\u021b\u0103, gust metalic).<\/li>\n<li>Anemie u\u0219oar\u0103 (hemodilu\u021bie din cauza pioglitazonei).<\/li>\n<\/ul>\n<p><strong>Pu\u021bin frecvente, dar grave:<\/strong> hipoglicemie sever\u0103 (\u00een special la adul\u021bii \u00een v\u00e2rst\u0103, insuficien\u021b\u0103 renal\u0103); decompensare de insuficien\u021b\u0103 cardiac\u0103; cancer de vezic\u0103 (pioglitazon\u0103 pe termen lung la doze mari); edem macular; fracturi osoase la femei; acidoz\u0103 lactic\u0103 (foarte rar\u0103; insuficien\u021b\u0103 renal\u0103 acut\u0103 sau hipoxie).<\/p>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li>Multe medicamente cresc riscul de hipoglicemie: insulin\u0103, alte antidiabetice, alcool, trimetoprim\/sulfametoxazol, fluconazol, claritromicin\u0103, inhibitori ACE, salicila\u021bi la doze mari, beta-blocante neselective (de asemenea, mascheaz\u0103 simptomele).<\/li>\n<li>Corticosteroizii, tiazidele, hormonii tiroidieni, fenitoina, rifampicina, antipsihoticele atipice, contraceptivele orale reduc efectul de sc\u0103dere a glicemiei.<\/li>\n<li><strong>Gemfibrozil<\/strong> \u2014 dubleaz\u0103 nivelurile de pioglitazon\u0103; componenta de pioglitazon\u0103 limitat\u0103 la 15 mg\/zi.<\/li>\n<li><strong>Contrast IV<\/strong> \u2014 \u00eentrerupe\u021bi Glisen PM \u00eenainte \u0219i dup\u0103 procedur\u0103 dac\u0103 eGFR &lt; 60.<\/li>\n<li><strong>Medicamente cationice<\/strong> \u2014 cre\u0219te nivelurile de metformin\u0103.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Cine nu ar trebui s\u0103 ia Glisen PM?<\/h2>\n<ul>\n<li>Insuficien\u021b\u0103 cardiac\u0103 (NYHA III\u2013IV)<\/li>\n<li>Cancer vezical activ sau hematurie neexplicat\u0103<\/li>\n<li>Insuficien\u021b\u0103 renal\u0103 sever\u0103 (eGFR &lt; 30)<\/li>\n<li>Insuficien\u021b\u0103 hepatic\u0103 sever\u0103; ALT &gt; 2,5\u00d7 ULN<\/li>\n<li>Cetoacidoz\u0103 diabetic\u0103; diabet zaharat tip 1<\/li>\n<li>Alergie la sulfonamide (sulfa)<\/li>\n<li>Boal\u0103 acut\u0103 cu risc de hipoxie tisular\u0103<\/li>\n<li>Sarcin\u0103, al\u0103ptare<\/li>\n<li>Hipersipersensibilitate cunoscut\u0103 la orice component\u0103<\/li>\n<\/ul>\n<p><strong>La persoanele \u00een v\u00e2rst\u0103 (&gt; 65 de ani):<\/strong> terapia tripl\u0103 care include o sulfoniluree prezint\u0103 un risc crescut de hipoglicemie. Mul\u021bi clinicieni prefer\u0103 un inhibitor DPP-4 sau un inhibitor SGLT-2 \u00een loc de glimepirid\u0103 \u00een acest grup.<\/p>\n<h2 class=\"wp-block-heading\">Depozitare<\/h2>\n<p>P\u0103stra\u021bi Glisen PM la o temperatur\u0103 sub 30\u00b0C, \u00eentr-un loc uscat. Depozita\u021bi \u00een afara accesului copiilor.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">C\u00e2nd este prescris un comprimat triplu pentru diabet, cum ar fi Glisen PM?<\/h3>\n<p>De obicei, atunci c\u00e2nd terapia dual\u0103 (de obicei metformin\u0103 + sulfoniluree sau metformin\u0103 + TZD) nu atinge \u021bintele HbA1c, iar clinicianul dore\u0219te s\u0103 intensifice terapia oral\u0103 \u00eenainte de a \u00eencepe insulina. Este, de asemenea, convenabil pentru pacien\u021bii care iau deja aceste trei medicamente separat \u2014 un singur comprimat \u00een loc de trei \u00eembun\u0103t\u0103\u021be\u0219te aderen\u021ba.<\/p>\n<h3 class=\"wp-block-heading\">Glisen PM este acela\u0219i lucru cu luarea celor trei medicamente separat?<\/h3>\n<p>Din punct de vedere clinic, da \u2014 acelea\u0219i molecule la acelea\u0219i doze. Combina\u021bia cu doz\u0103 fix\u0103 \u00eembun\u0103t\u0103\u021be\u0219te aderen\u021ba \u0219i cost\u0103 de obicei mai pu\u021bin, dar ofer\u0103 mai pu\u021bin\u0103 flexibilitate dac\u0103 o component\u0103 necesit\u0103 o modificare a dozei.<\/p>\n<h3 class=\"wp-block-heading\">Glisen PM va provoca sc\u0103dere a glicemiei?<\/h3>\n<p>Da \u2014 con\u021bine glimepirid\u0103, o sulfoniluree. S\u0103rirea meselor, exerci\u021biul neobi\u0219nuit, consumul de alcool f\u0103r\u0103 m\u00e2ncare \u0219i insuficien\u021ba renal\u0103 cresc riscul de hipoglicemie. Lua\u021bi \u00eentotdeauna cu m\u00e2ncare \u0219i purta\u021bi tablete de glucoz\u0103 la dumneavoastr\u0103.<\/p>\n<h3 class=\"wp-block-heading\">C\u00e2t de mult voi c\u00e2\u0219tiga \u00een greutate cu Glisen PM?<\/h3>\n<p>De obicei, 2\u20134 kg \u00een primul an \u2014 datorit\u0103 pioglitazonei (redistribuirea fluidelor \u0219i a gr\u0103similor) \u0219i glimepiridei (efect anabolic al mai mult\u0103 insulin\u0103). Metformina contrabalanseaz\u0103 par\u021bial acest efect. Dieta \u0219i exerci\u021biul fizic sunt cele mai bune contram\u0103suri.<\/p>\n<h3 class=\"wp-block-heading\">Ar trebui s\u0103 trec la insulin\u0103 \u00een schimb?<\/h3>\n<p>Aceasta este o decizie care v\u0103 apar\u021bine vou\u0103 \u0219i medicului dumneavoastr\u0103. Insulina ofer\u0103 un control mai predictibil al glicemiei \u0219i este esen\u021bial\u0103 odat\u0103 ce rezerva de celule beta este epuizat\u0103, dar necesit\u0103 injec\u021bii \u0219i are propriul profil de hipoglicemie \u0219i cre\u0219tere \u00een greutate. Terapia tripl\u0103 oral\u0103 este adesea \u00eencercat\u0103 mai \u00eent\u00e2i la pacien\u021bii motiva\u021bi care doresc s\u0103 evite injec\u021biile.<\/p>\n<h3 class=\"wp-block-heading\">Unde pot cump\u0103ra Glisen PM online?<\/h3>\n<p>Pute\u021bi comanda Glisen PM (Glimepirid\u0103 1 mg (sau 2 mg) + Pioglitazon\u0103 15 mg + Metformin\u0103 500 mg) de la MedsBase \u00een cutii de 30, 60, 90 sau 180 de comprimate. Livr\u0103m \u00een \u00eentreaga lume, cu ambalaj discret \u0219i stoc autentic certificat WHO-GMP de la produc\u0103tor.<\/p>\n<h2 class=\"wp-block-heading\">Medicamente \u00eenrudite pentru Diabet<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/pioglit-mf-forte\/\">Pioglit MF Forte \u2014 Combina\u021bie dual\u0103 Pioglitazon\u0103 + Metformin\u0103<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/glycomet-gp\/\">Glycomet-GP \u2014 Metformin\u0103 + Glimepirid\u0103<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/amaryl\/\">Amaryl \u2014 Monoterapie cu Glimepirid\u0103<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/glycomet-sr\/\">Glycomet SR \u2014 Metformin cu eliberare prelungit\u0103<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/januvia\/\">Januvia \u2014 Sitagliptin\u0103 (alternativ\u0103 inhibitor DPP-4)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/jardiance-empagliflozin\/\">Jardiance \u2014 Empagliflozin\u0103 (alternativ\u0103 SGLT-2)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/diabetes-medication\/\"><strong>Vizualiza\u021bi toate Medicamentele pentru Diabet<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are doar scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui profesionist calificat din domeniul s\u0103n\u0103t\u0103\u021bii. Terapia tripl\u0103 pentru diabet are un profil cumulativ de efecte secundare (hipoglicemie, cre\u0219tere \u00een greutate, edem, acidoz\u0103 lactic\u0103) \u2014 utiliza\u021bi \u00eentotdeauna sub supraveghere medical\u0103 atent\u0103.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alternative conexe<\/h3>\n<p>Alte produse din <strong>Afec\u021biuni cronice<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/methimez\/\">Methimez<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/betapro-sr\/\">Betapro-SR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/biodib-30\/\">Biodib 30<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/brufen\/\">Brufen<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/duovir-n\/\">Duovir N<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Men\u021bine nivelul zah\u0103rului din s\u00e2nge<br \/>\n\u2705 Controlul diabetului<br \/>\n\u2705 \u00cembun\u0103t\u0103\u021be\u0219te sensibilitatea la insulin\u0103<br \/>\n\u2705 Reduce nivelul de glucoz\u0103<br \/>\n\u2705 \u00cembun\u0103t\u0103\u021be\u0219te controlul glicemic<\/p>\n<p>Glisen PM con\u021bine Glimepirid\u0103, Metformin\u0103 \u0219i Pioglitazon\u0103.<\/p>","protected":false},"featured_media":57403,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3230,3231],"product_tag":[3251,4296,3255,4297],"class_list":{"0":"post-57402","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-diabetes","9":"product_cat-diabetes-medication","10":"product_tag-glimepiride","11":"product_tag-glisen-pm","12":"product_tag-metformin","13":"product_tag-pioglitazone","15":"first","16":"instock","17":"shipping-taxable","18":"purchasable","19":"product-type-variable","20":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/57402","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=57402"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/57403"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=57402"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=57402"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=57402"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=57402"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}