{"id":57793,"date":"2024-02-27T18:00:17","date_gmt":"2024-02-27T18:00:17","guid":{"rendered":"https:\/\/medsname.com\/ivabrad\/"},"modified":"2026-05-01T10:49:14","modified_gmt":"2026-05-01T10:49:14","slug":"ivabrad","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/ivabrad\/","title":{"rendered":"Ivabrad"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Ivabrad?<\/h3>\n<p style=\"margin:0;\"><strong>Ivabrad<\/strong> sunt comprimate de ivabradin\u0103 7,5 mg de la un produc\u0103tor certificat WHO-GMP \u2014 un inhibitor selectiv al <strong>I<sub>f<\/sub> (\u201cfunny\u201d) curentului<\/strong> din nodul sinoatrial. Ivabradina a fost introdus\u0103 de Servier \u00een 2005 sub denumirea <strong>Procoralan<\/strong> \u2014 primul medicament care \u00eencetine\u0219te selectiv frecven\u021ba cardiac\u0103 f\u0103r\u0103 a afecta tensiunea arterial\u0103, contractilitatea miocardic\u0103 sau alte canale ionice. Ac\u021bioneaz\u0103 asupra canalelor ciclice nucleotidice hiperpolarizate (HCN) care genereaz\u0103 curentul I<sub>f<\/sub> responsabil pentru depolarizarea spontan\u0103 a nodului SA. Blocheaz\u0103 selectiv curentul I<sub>f<\/sub> \u00een nodul sinoatrial, reduc\u00e2nd panta depolariz\u0103rii diastolice spontane \u0219i \u00eencetinind frecven\u021ba cardiac\u0103. Spre deosebire de beta-blocante \u0219i antagoni\u0219tii non-DHP ai canalelor de calciu, ivabradina nu are efect asupra contractilit\u0103\u021bii cardiace, a tensiunii arteriale sau a conduc\u021biei nodului AV \u2014 este un agent \u201cpur\u201d de bradicardie. Dozare: \u00cencepe\u021bi cu 5 mg de dou\u0103 ori pe zi \u00een timpul mesei; ajusta\u021bi la 7,5 mg de dou\u0103 ori pe zi dup\u0103 2 s\u0103pt\u0103m\u00e2ni dac\u0103 frecven\u021ba cardiac\u0103 de repaus este &gt;60 bpm \u0219i este tolerat\u0103. Reduce\u021bi la 2,5 mg de dou\u0103 ori pe zi dac\u0103 frecven\u021ba cardiac\u0103 scade sub 50 bpm sau apar simptome. La pacien\u021bii \u00een v\u00e2rst\u0103 (&gt;75 ani) \u00eencepe\u021bi cu 2,5 mg de dou\u0103 ori pe zi. Managementul aritmiilor este o disciplin\u0103 condus\u0103 de cardiologi \u2014 diagnosticul, selec\u021bia medicamentelor \u0219i monitorizarea necesit\u0103 de obicei consult specializat. Acesta nu este un medicament pentru terapie autoini\u021biat\u0103.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<h2 class=\"wp-block-heading\">Ce este Ivabrad?<\/h2>\n<p>Ivabrad sunt comprimate de 7,5 mg ivabradin\u0103 de la un produc\u0103tor certificat WHO-GMP, furnizate \u00een cutii de 30-180 comprimate. Ivabradina a fost introdus\u0103 de Servier \u00een 2005 ca <strong>Procoralan<\/strong> \u2014 primul medicament care \u00eencetine\u0219te selectiv frecven\u021ba cardiac\u0103 f\u0103r\u0103 a afecta tensiunea arterial\u0103, contractilitatea miocardic\u0103 sau alte canale ionice. Ac\u021bioneaz\u0103 asupra canalelor ciclice nucleotidice hiperpolarizate (HCN) care genereaz\u0103 curentul I<sub>f<\/sub> responsabil pentru depolarizarea spontan\u0103 a nodului SA.<\/p>\n<h2 class=\"wp-block-heading\">Cum func\u021bioneaz\u0103 Ivabradina<\/h2>\n<p>Ivabradina blocheaz\u0103 selectiv curentul I<sub>f<\/sub> \u00een nodul sinoatrial, reduc\u00e2nd panta depolariz\u0103rii diastolice spontane \u0219i \u00eencetinind frecven\u021ba cardiac\u0103. Spre deosebire de beta-blocante \u0219i antagoni\u0219tii non-DHP ai canalelor de calciu, ivabradina nu are efect asupra contractilit\u0103\u021bii cardiace, a tensiunii arteriale sau a conduc\u021biei nodului AV \u2014 este un agent \u201cpur\u201d de bradicardie.<\/p>\n<h2 class=\"wp-block-heading\">Utiliz\u0103ri aprobate<\/h2>\n<ul>\n<li><strong>Insuficien\u021b\u0103 cardiac\u0103 cronic\u0103 simptomatic\u0103 cu frac\u021bie de ejec\u021bie redus\u0103 (HF-REF)<\/strong> \u2014 la pacien\u021bii cu FE \u226435%, ritm sinusal \u0219i frecven\u021b\u0103 cardiac\u0103 &gt;70 bpm \u00een ciuda beta-blocantului la doza maxim\u0103 tolerat\u0103 (sau intoleran\u021b\u0103 la beta-blocante). <strong>Dovezile din studiul SHIFT.<\/strong><\/li>\n<li><strong>Angin\u0103 cronic\u0103 stabil\u0103<\/strong> \u2014 adi\u021bional la beta-blocant sau singur acolo unde beta-blocantele sunt contraindicate. <strong>Studiile BEAUTIFUL \u0219i SIGNIFY.<\/strong><\/li>\n<li>Tahicardie sinusal\u0103 inadecvat\u0103 (off-label)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Doza \u0219i Monitorizare<\/h2>\n<p><strong>Doza:<\/strong> \u00cencepe\u021bi cu 5 mg de dou\u0103 ori pe zi \u00een timpul mesei; titra\u021bi la 7,5 mg de dou\u0103 ori pe zi dup\u0103 2 s\u0103pt\u0103m\u00e2ni dac\u0103 frecven\u021ba cardiac\u0103 (FC) de repaus este &gt;60 bpm \u0219i este tolerat. Reduce\u021bi la 2,5 mg de dou\u0103 ori pe zi dac\u0103 FC scade sub 50 bpm sau apar simptome. La v\u00e2rstnici (&gt;75 ani) \u00eencepe\u021bi cu 2,5 mg de dou\u0103 ori pe zi.<\/p>\n<p><strong>Monitorizare:<\/strong><\/p>\n<ul>\n<li><strong>Valori ini\u021biale:<\/strong> ECG cu 12 deriva\u021bii (confirma\u021bi ritm sinusal, evalua\u021bi FC \u0219i intervalul QT), TA, electroli\u021bi serici.<\/li>\n<li><strong>La 2-4 s\u0103pt\u0103m\u00e2ni:<\/strong> Evaluare FC; titra\u021bi \u00een sus sau \u00een jos.<\/li>\n<li><strong>Continuu:<\/strong> monitorizare periodic\u0103 a FC \u0219i ECG; FC de repaus \u021bint\u0103 50-60 bpm \u00een IC-FER.<\/li>\n<li><strong>Interrup\u021bie la:<\/strong> bradicardie simptomatic\u0103 (FC &lt;50 cu simptome), FA nou\u0103 (eficacitatea ivabradinei depinde de men\u021binerea ritmului sinusal), fenomene vizuale suficient de severe pentru a afecta conducerea\/munca.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Efecte Secundare<\/h2>\n<ul>\n<li><strong>Fenomene luminoase (fosfene)<\/strong> \u2014 cre\u0219tere tranzitorie a luminozit\u0103\u021bii \u00een vederea periferic\u0103 (15%); de obicei se amelior\u0103 spontan. Mecanism: ivabradina blocheaz\u0103 slab \u0219i curentul I<sub>h<\/sub> \u00een fotoreceptorii retiniani.<\/li>\n<li><strong>Bradicardie<\/strong> \u2014 limitare de doz\u0103 (5-10%)<\/li>\n<li><strong>Fibrila\u021bie atrial\u0103<\/strong> \u2014 exces moderat fa\u021b\u0103 de placebo \u00een studii; medicamentul nu este eficient odat\u0103 ce se pierde ritmul sinusal<\/li>\n<li><strong>Dureri de cap, ame\u021beli<\/strong><\/li>\n<li><strong>Bloc AV de gradul I, extrasistole ventriculare<\/strong><\/li>\n<li><strong>Erup\u021bie cutanat\u0103<\/strong><\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindica\u021bii<\/h2>\n<ul>\n<li>FC de repaus &lt;70 bpm \u00eenainte de ini\u021biere<\/li>\n<li>\u0218oc cardiogen, IM acut<\/li>\n<li>Hipotenziune sever\u0103<\/li>\n<li>Sindromul sinusului bolnav, bloc sinoatrial, bloc AV de gradul III f\u0103r\u0103 stimulator<\/li>\n<li>Insuficien\u021b\u0103 cardiac\u0103 instabil\u0103 sau acut\u0103<\/li>\n<li>Fibrila\u021bie atrial\u0103 (ineficient\u0103; poate agrava controlul frecven\u021bei)<\/li>\n<li>Pacien\u021bi dependen\u021bi de stimulator cardiac<\/li>\n<li>Insuficien\u021b\u0103 hepatic\u0103 sever\u0103<\/li>\n<li>Terapie concomitent\u0103 cu inhibitori puternici ai CYP3A4<\/li>\n<li>Sarcin\u0103 \u0219i al\u0103ptare<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>Inhibitori puternici ai CYP3A4 \u2014 CRITIC.<\/strong> Contraindicate: claritromicina, itraconazol, ketoconazol, ritonavir, nefazodon\u0103, nelfinavir. Precau\u021bie cu inhibitori moderati (diltiazem, verapamil \u2014 aten\u021bie, acestea pot induce bradicardie independent).<\/li>\n<li><strong>Diltiazem, verapamil<\/strong> \u2014 evita\u021bi (bradicardie aditiv\u0103 + inhibi\u021bie CYP3A4).<\/li>\n<li><strong>Medicamente care prelungesc intervalul QT<\/strong> \u2014 precau\u021bie; ivabradina are efect QT minim intrinsec, dar riscul combinat cre\u0219te.<\/li>\n<li><strong>Suc de grapefruit<\/strong> \u2014 cre\u0219te nivelurile de ivabradin\u0103.<\/li>\n<li><strong>Beta-blocante<\/strong> \u2014 combina\u021bia este standard \u00een IC-FER c\u00e2nd beta-blocantul singur este insuficient; monitoriza\u021bi bradicardia aditiv\u0103.<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">Ce sunt fosfenele vizuale?<\/h3>\n<p>Aproximativ 15% dintre pacien\u021bi experimenteaz\u0103 o luminozitate crescut\u0103 tranzitorie \u00een vederea periferic\u0103 \u2014 mai ales la trecerea de la lumin\u0103 slab\u0103 la una puternic\u0103. Acestea sunt benigne (ivabradina blocheaz\u0103 slab un curent similar \u00een fotoreceptorii retiniani) \u0219i de obicei se atenueaz\u0103 \u00een c\u00e2teva s\u0103pt\u0103m\u00e2ni. Fenomene severe care afecteaz\u0103 conducerea sau activitatea profesional\u0103 reprezint\u0103 indica\u021bie de \u00eentrerupere a tratamentului.<\/p>\n<h3 class=\"wp-block-heading\">Pot lua ivabradin\u0103 dac\u0103 am fibrila\u021bie atrial\u0103?<\/h3>\n<p>Nu \u2014 ivabradina \u00eencetine\u0219te doar nodul sinoatrial, a\u0219adar nu are efect asupra FA \u0219i poate chiar \u00eenr\u0103ut\u0103\u021bi controlul frecven\u021bei cardiace. \u00cen FA se folosesc beta-blocante, antagoni\u0219ti non-DHP ai canalelor de calciu sau digoxin.<\/p>\n<h3 class=\"wp-block-heading\">Pot lua Ivabrad \u00een timpul sarcinii?<\/h3>\n<p>\u00cen general nu. Ivabradina are date de teratogenitate \u00een animale; sarcina este contraindicat\u0103 \u00een indica\u021biile aprobate.<\/p>\n<h3 class=\"wp-block-heading\">Unde pot cump\u0103ra Ivabrad online?<\/h3>\n<p>Pute\u021bi cump\u0103ra Ivabrad (ivabradin\u0103 7,5 mg, 30-180 comprimate) de la MedsBase cu ambalaj discret \u0219i livrare la nivel mondial.<\/p>\n<h2 class=\"wp-block-heading\">Medicamente cardio-vasculare conexe<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/abana\/\">Abana \u2014 formul\u0103 ayurvedic\u0103 cardiac\u0103<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/aldactone\/\">Aldactone \u2014 Spironolacton\u0103<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/cardace\/\">Cardace \u2014 Ramipril (inhibitor ACE)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/ecosprin\/\">Ecosprin \u2014 Aspirin\u0103 75\/150 mg (antiagregant plachetar)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/lonitab\/\">Lonitab \u2014 Minoxidil 5 mg (vasodilatator oral)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/vymada\/\">Vymada \u2014 Sacubitril\/Valsartan ARNI<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/high-blood-pressure-medication\/\"><strong>R\u0103sfoi\u021bi toate medicamentele pentru hipertensiune arterial\u0103<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui medic calificat. Hipertensiunea, insuficien\u021ba cardiac\u0103 \u0219i aritmiile necesit\u0103 diagnostic, monitorizare \u0219i individualizarea dozei de c\u0103tre un medic \u2014 utiliza\u021bi \u00eentotdeauna beta-blocante sub \u00eendrumare medical\u0103.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alternative conexe<\/h3>\n<p>Alte produse din <strong>Afec\u021biuni cronice<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/prilox-cream\/\">Prilox Cream<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/rozucor\/\">Rozucor<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/lasix\/\">Lasix<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/meftal\/\">Meftal<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/carvego\/\">Carvego<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Ivabrad sunt comprimate de ivabradin\u0103 7,5 mg \u2014 primul inhibitor selectiv al curentului I-f, ac\u021bion\u00e2nd la nivelul nodului sinoatrial pentru a \u00eencetini frecven\u021ba cardiac\u0103 f\u0103r\u0103 a afecta tensiunea arterial\u0103, contractilitatea sau conduc\u021bia AV. Ini\u021bial comercializat sub denumirea Servier Procoralan (2005). Studiul SHIFT a validat eficacitatea \u00een insuficien\u021b\u0103 cardiac\u0103 cu frac\u021bie de ejec\u021bie redus\u0103 (HF-REF) cu FC &gt;70 \u00een ciuda tratamentului cu beta-blocante; studiile BEAUTIFUL\/SIGNIFY au extins dovezile pentru angina pectoral\u0103 stabil\u0103 cronic\u0103. Eficace doar \u00een ritm sinusal \u2014 nu este indicat \u00een fibrila\u021bie atrial\u0103. Contraindicat cu inhibitori puternici ai CYP3A4.<\/p>","protected":false},"featured_media":57794,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3260,3356],"product_tag":[4359,4360],"class_list":{"0":"post-57793","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-heart-blood-pressure","9":"product_cat-high-blood-pressure-medication","10":"product_tag-ivabrad","11":"product_tag-ivabradine","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/57793","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=57793"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/57794"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=57793"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=57793"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=57793"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=57793"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}