{"id":58205,"date":"2024-02-27T18:23:28","date_gmt":"2024-02-27T18:23:28","guid":{"rendered":"https:\/\/medsname.com\/trajenta-duo\/"},"modified":"2026-05-08T09:18:45","modified_gmt":"2026-05-08T09:18:45","slug":"trajenta-duo","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/trajenta-duo\/","title":{"rendered":"Trajenta Duo"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Trajenta Duo?<\/h3>\n<p style=\"margin:0;\"><strong>Trajenta Duo<\/strong> este un comprimat cu doz\u0103 fix\u0103 combinat\u0103 de <strong>linagliptin (2,5 mg)<\/strong> \u0219i <strong>metformin (500 mg sau 1000 mg)<\/strong> timp de <strong>diabetului de tip 2<\/strong>. Combin\u0103 mecanisme complementare: metforminul reduce produc\u021bia hepatic\u0103 de glucoz\u0103 \u0219i \u00eembun\u0103t\u0103\u021be\u0219te sensibilitatea la insulin\u0103, \u00een timp ce linagliptina (un inhibitor DPP-4) cre\u0219te nivelul hormonilor incretini pentru a stimula eliberarea de insulin\u0103 dependent\u0103 de glucoz\u0103 \u0219i a suprima glucagonul. Reducerea a\u0219teptat\u0103 a HbA1c: <strong>1,5\u20132,0 puncte<\/strong>. <strong>Neutru din punct de vedere al greut\u0103\u021bii<\/strong> \u0219i risc foarte sc\u0103zut de hipoglicemie ca combina\u021bie. Doza uzual\u0103: o tablet\u0103 de dou\u0103 ori pe zi la mese. Principalele efecte secundare sunt tulbur\u0103rile gastrointestinale cauzate de metformin \u00een primele 1\u20132 s\u0103pt\u0103m\u00e2ni. Componenta linagliptin\u0103 nu necesit\u0103 ajustare a dozei \u00een func\u021bie de func\u021bia renal\u0103; componenta metformin urmeaz\u0103 regulile standard \u2014 evita\u021bi dac\u0103 eGFR &lt; 30. Evita\u021bi \u00een cazul diabetului zaharat de tip 1, cetoacidozei diabetice, eGFR &lt; 30 \u0219i insuficien\u021bei hepatice severe.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<h2 class=\"wp-block-heading\">Ce este Trajenta Duo?<\/h2>\n<p>Trajenta Duo este un comprimat antidiabetic oral cu doz\u0103 fix\u0103 care con\u021bine <strong>linagliptin (2,5 mg)<\/strong> \u0219i <strong>clorhidrat de metformin\u0103 (500 mg sau 1000 mg)<\/strong>, fabricat de Boehringer Ingelheim. Disponibil \u00een cutii de 30, 60, 90 sau 180 de comprimate. Este utilizat atunci c\u00e2nd monoterapia cu oricare dintre componente nu este suficient\u0103 sau ca terapie combinat\u0103 ini\u021bial\u0103 atunci c\u00e2nd HbA1c este semnificativ peste \u021bint\u0103.<\/p>\n<h2 class=\"wp-block-heading\">Cum func\u021bioneaz\u0103 Trajenta Duo?<\/h2>\n<p>Trajenta Duo combin\u0103 dou\u0103 mecanisme complementare care nu se suprapun:<\/p>\n<ul>\n<li><strong>Metformin\u0103<\/strong> \u2014 activeaz\u0103 proteina kinaz\u0103 AMP-activat\u0103 (AMPK) \u00een ficat, reduc\u00e2nd produc\u021bia hepatic\u0103 de glucoz\u0103. De asemenea, \u00eembun\u0103t\u0103\u021be\u0219te sensibilitatea la insulin\u0103 la nivel periferic \u00een mu\u0219chi \u0219i \u021besut adipos. Nu stimuleaz\u0103 eliberarea de insulin\u0103 \u2014 deci nu provoac\u0103 hipoglicemie singur.<\/li>\n<li><strong>linagliptin<\/strong> \u2014 un inhibitor DPP-4 (\u201cgliptin\u0103\u201d). Blocheaz\u0103 enzima care descompune GLP-1 \u0219i GIP, cresc\u00e2nd nivelul incretinelor active. Aceasta stimuleaz\u0103 <em>dependent\u0103 de glucoz\u0103<\/em> eliberarea de insulin\u0103 \u0219i suprima glucagonul \u2014 doar atunci c\u00e2nd glicemia este crescut\u0103.<\/li>\n<\/ul>\n<p>Deoarece niciuna dintre componente nu stimuleaz\u0103 eliberarea de insulin\u0103 independent de glicemie, combina\u021bia are un risc foarte sc\u0103zut de hipoglicemie. Reducere tipic\u0103 a HbA1c: <strong>1,5\u20132,0 puncte procentuale<\/strong>. Efect asupra greut\u0103\u021bii: neutru sau u\u0219or reduc\u0103tor (datorat metforminei).<\/p>\n<h2 class=\"wp-block-heading\">Doza \u0219i administrare<\/h2>\n<p><strong>Doza uzual\u0103:<\/strong> un comprimat de dou\u0103 ori pe zi, la micul dejun \u0219i la cin\u0103. Doza este individualizat\u0103 \u00een func\u021bie de terapia anterioar\u0103, \u021binta HbA1c \u0219i func\u021bia renal\u0103.<\/p>\n<ul>\n<li><strong>Lua\u021bi cu m\u00e2ncare<\/strong> \u2014 \u00eembun\u0103t\u0103\u021be\u0219te tolerabilitatea metforminei.<\/li>\n<li><strong>A\u021bi omis o doz\u0103?<\/strong> Omite\u021bi-o \u2014 lua\u021bi urm\u0103toarea la intervalul obi\u0219nuit.<\/li>\n<li><strong>Dozare renal\u0103:<\/strong> Componenta linagliptin\u0103 nu necesit\u0103 ajustare a dozei \u00een func\u021bie de func\u021bia renal\u0103; componenta metformin urmeaz\u0103 regulile standard \u2014 evita\u021bi dac\u0103 eGFR &lt; 30.<\/li>\n<li><strong>Suspendare pentru contrast IV, interven\u021bie chirurgical\u0103 sau boal\u0103 acut\u0103<\/strong> cu deshidratare.<\/li>\n<li>Verifica\u021bi nivelul de vitamina B12 anual la tratamentul pe termen lung cu metformin.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Efecte Secundare<\/h2>\n<p><strong>Efecte secundare ale metforminei (de obicei \u00een primele 1\u20132 s\u0103pt\u0103m\u00e2ni):<\/strong><\/p>\n<ul>\n<li>Diaree, grea\u021b\u0103, crampe abdominale, flatulen\u021b\u0103, gust metalic, pierderea apetitului<\/li>\n<\/ul>\n<p><strong>Efecte secundare ale inhibitorului DPP-4:<\/strong><\/p>\n<ul>\n<li>Infec\u021bie a tractului respirator superior, nazofaringit\u0103, cefalee<\/li>\n<li>Pancreatit\u0103 rar\u0103, artralgie sever\u0103, pemfigoid bulos<\/li>\n<\/ul>\n<p><strong>Pu\u021bin frecvente, dar grave:<\/strong><\/p>\n<ul>\n<li>Acidoz\u0103 lactic\u0103 cauzat\u0103 de metformin\u0103 \u2014 foarte rar\u0103; aproape \u00eentotdeauna asociat\u0103 cu IRC, septicemie sau hipoxie<\/li>\n<li>Deficit de vitamina B12 (la utilizarea pe termen lung a metforminei)<\/li>\n<li>Pancreatit\u0103 acut\u0103 \u2014 \u00eentrerupe\u021bi tratamentul \u00een caz de dureri abdominale severe<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>Inhibitori puternici ai CYP3A4\/5<\/strong> \u2014 efect hipoglicemiant aditiv; poate fi necesar\u0103 reducerea dozelor pentru a evita hipoglicemia.<\/li>\n<li><strong>Mediu de contrast iodat IV<\/strong> \u2014 \u00eentrerupe\u021bi Trajenta Duo \u00eenainte \u0219i dup\u0103 procedur\u0103 dac\u0103 eGFR &lt; 60.<\/li>\n<li><strong>Medicamente cationice<\/strong> (cimetidin\u0103, dolutegravir, ranolazin\u0103) \u2014 cresc nivelurile de metformin\u0103.<\/li>\n<li><strong>Inhibitori ai anhidrazei carbonice<\/strong> (acetazolamid\u0103, topiramat) \u2014 risc adi\u021bional de acidoz\u0103.<\/li>\n<li><strong>Inhibitori puternici ai CYP3A4<\/strong> \u2014 pot cre\u0219te nivelurile de saxagliptin\u0103 (nu este relevant pentru sitagliptin\u0103\/linagliptin\u0103\/vildagliptin\u0103).<\/li>\n<li><strong>Corticoesteroizi, tiazide, agonisti beta-2<\/strong> \u2014 pot cre\u0219te nivelul glucozei \u00een s\u00e2nge.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Cine nu ar trebui s\u0103 ia Trajenta Duo?<\/h2>\n<ul>\n<li>Diabet zaharat tip 1 sau cetoacidoz\u0103 diabetic\u0103<\/li>\n<li>Insuficien\u021b\u0103 renal\u0103 sever\u0103 (eGFR &lt; 30)<\/li>\n<li>Insuficien\u021b\u0103 hepatic\u0103 sever\u0103<\/li>\n<li>Boal\u0103 acut\u0103 cu risc de hipoxie tisular\u0103<\/li>\n<li>Istoric de hipersensibilitate la oricare dintre componente<\/li>\n<li>Istoric de pancreatit\u0103 (relativ)<\/li>\n<li>Sarcin\u0103 \u0219i al\u0103ptare<\/li>\n<li>\u00cenainte \u0219i la 48 de ore dup\u0103 administrarea de contrast iodat IV dac\u0103 eGFR &lt; 60<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Depozitare<\/h2>\n<p>P\u0103stra\u021bi Trajenta Duo la o temperatur\u0103 sub 30\u00b0C, \u00eentr-un loc uscat, \u00een ambalajul original blister. Depozita\u021bi \u00eentr-un loc inaccesibil copiilor.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">Este Trajenta Duo acela\u0219i lucru cu luarea separat\u0103 a Trajenta \u0219i metforminei?<\/h3>\n<p>Din punct de vedere clinic, da \u2014 acelea\u0219i molecule la acelea\u0219i doze. Combina\u021bia cu doz\u0103 fix\u0103 \u00eembun\u0103t\u0103\u021be\u0219te aderen\u021ba, reduce num\u0103rul de comprimate \u0219i cost\u0103 de obicei mai pu\u021bin dec\u00e2t cele dou\u0103 componente cump\u0103rate separat. Dezavantajul este flexibilitatea redus\u0103 a dozei.<\/p>\n<h3 class=\"wp-block-heading\">Va provoca Trajenta Duo hipoglicemie?<\/h3>\n<p>Singur, foarte rar. Nici inhibitorii DPP-4, nici metformina nu stimuleaz\u0103 eliberarea de insulin\u0103 independent de glucoz\u0103. Hipoglicemia devine o problem\u0103 doar atunci c\u00e2nd Trajenta Duo este combinat\u0103 cu o sulfoniluree, meglitinid\u0103 sau insulin\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Voi lua \u00een greutate dac\u0103 iau Trajenta Duo?<\/h3>\n<p>Nu. Combina\u021bia este neutr\u0103 din punct de vedere al greut\u0103\u021bii sau u\u0219or reduc\u0103toare de greutate, ceea ce este un motiv major pentru care este preferat\u0103 \u00een locul combina\u021biilor bazate pe sulfoniluree la pacien\u021bii cu exces de greutate.<\/p>\n<h3 class=\"wp-block-heading\">C\u00e2t timp dureaz\u0103 p\u00e2n\u0103 \u00eencepe s\u0103 ac\u021bioneze Trajenta Duo?<\/h3>\n<p>Glicemia \u00een post scade \u00een decurs de o s\u0103pt\u0103m\u00e2n\u0103. Efectul maxim asupra HbA1c se ob\u021bine la 12 s\u0103pt\u0103m\u00e2ni. Dac\u0103 HbA1c nu a sc\u0103zut cu cel pu\u021bin 0,5% dup\u0103 3 luni la doza \u021bint\u0103, poate fi necesar\u0103 terapie suplimentar\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Pot consuma alcool \u00een timp ce iau Trajenta Duo?<\/h3>\n<p>Consumul moderat de alcool \u00een combina\u021bie cu m\u00e2ncare este de obicei sigur. Evita\u021bi consumul excesiv \u2014 acesta cre\u0219te riscul de acidoz\u0103 lactic\u0103 (metformin\u0103) \u0219i poate afecta func\u021bia hepatic\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Unde pot cump\u0103ra Trajenta Duo online?<\/h3>\n<p>Pute\u021bi comanda Trajenta Duo (Linagliptin 2.5 mg + Metformin 500\/1000 mg (de dou\u0103 ori pe zi)) de la MedsBase \u00een cutii de 30, 60, 90 sau 180 de comprimate. Livr\u0103m \u00een \u00eentreaga lume, cu ambalaj discret \u0219i stoc original certificat WHO-GMP.<\/p>\n<h2 class=\"wp-block-heading\">Medicamente \u00eenrudite pentru Diabet<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/januvia\/\">Januvia \u2014 monoterapie cu Sitagliptin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/trajenta\/\">Trajenta \u2014 monoterapie cu Linagliptin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/glycomet-sr\/\">Glycomet SR \u2014 Metformin cu eliberare prelungit\u0103<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/jardiance-empagliflozin\/\">Jardiance \u2014 Empagliflozin\u0103 (alternativ\u0103 SGLT-2)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/forxiga-dapagliflozin\/\">Forxiga \u2014 Dapagliflozin\u0103 (alternativ\u0103 SGLT-2)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/diabetes-medication\/\"><strong>Vizualiza\u021bi toate Medicamentele pentru Diabet<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are doar scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui profesionist calificat din domeniul s\u0103n\u0103t\u0103\u021bii. Utiliza\u021bi \u00eentotdeauna combina\u021biile fixe pentru diabet sub \u00eendrumare medical\u0103, cu monitorizare renal\u0103, hepatic\u0103 \u0219i a nivelului de vitamina B12.<\/div>\n<p class=\"medsbase-link-boost-2026-05-08\" data-marker=\"mb-link-boost-glycomet-sr\">Pacien\u021bii care \u00eentrerup componenta de linagliptin\u0103 din <a href=\"https:\/\/medsbase.com\/ro\/trajenta-duo\/\">Trajenta Duo<\/a> \u00een timp ce continu\u0103 metformina pot trece direct la <a href=\"https:\/\/medsbase.com\/ro\/glycomet-sr\/\">Glycomet SR (clorhidrat de metformin\u0103 500\u20131000 mg SR)<\/a>, disponibil \u00een acelea\u0219i doze de 500 mg \u0219i 1000 mg SR ca \u0219i comprimatul original combinat.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alternative conexe<\/h3>\n<p>Alte produse din <strong>Afec\u021biuni cronice<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/prazopill-xl\/\">Prazopill XL<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/paracip\/\">Paracip<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/lasix\/\">Lasix<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/domin-injection\/\">Domin Injection<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/aziderm-cream\/\">Aziderm Cream<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Control dublu ac\u021biune<br \/>\n\u2705 Regleaz\u0103 glicemia<br \/>\n\u2705 Combin\u0103 dou\u0103 medicamente<br \/>\n\u2705 \u00cembun\u0103t\u0103\u021be\u0219te sensibilitatea la insulin\u0103<br \/>\n\u2705 Gestioneaz\u0103 diabetul de tip 2<\/p>\n<p>Trajenta Duo con\u021bine Linagliptin &amp; Metformin.<\/p>","protected":false},"featured_media":58206,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3230,3231],"product_tag":[3278,3255,4443],"class_list":{"0":"post-58205","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-diabetes","9":"product_cat-diabetes-medication","10":"product_tag-linagliptin","11":"product_tag-metformin","12":"product_tag-trajenta-duo","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/58205","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=58205"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/58206"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=58205"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=58205"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=58205"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=58205"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}