{"id":58277,"date":"2024-02-27T18:26:33","date_gmt":"2024-02-27T18:26:33","guid":{"rendered":"https:\/\/medsname.com\/pentasa-suppositories\/"},"modified":"2026-04-30T10:24:16","modified_gmt":"2026-04-30T10:24:16","slug":"pentasa-suppositories","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/pentasa-suppositories\/","title":{"rendered":"Pentasa Supozitoare"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce sunt supozitoarele Pentasa?<\/h3>\n<p style=\"margin:0;\"><strong>Pentasa Supozitoare<\/strong> sunt <strong>supozitoare rectale de mesalazin\u0103 1 g<\/strong> \u2014 un 5-aminosalicilat (5-ASA) topic pentru puseuri de colit\u0103 ulceroas\u0103 distal\u0103 (proctit\u0103, proctosigmoidit\u0103 distal\u0103), proctit\u0103 Crohn \u0219i pouchit\u0103 postchirurgical\u0103. Mesalazina ac\u021bioneaz\u0103 local pe mucosa colonic\u0103 inflamat\u0103, cu absorb\u021bie sistemic\u0103 neglijabil\u0103. Regim standard: <strong>1 supozitor la culcare timp de 4\u20138 s\u0103pt\u0103m\u00e2ni pentru induc\u021bie<\/strong> \u00een caz de puseu de proctit\u0103, apoi \u00eentre\u021binere cu 1 supozitor de trei ori pe s\u0103pt\u0103m\u00e2n\u0103 sau zilnic, \u00een func\u021bie de tiparul bolii. Fabricat conform standardelor WHO-GMP.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>De ce s\u0103 comanzi de la MedsBase:<\/strong> \u2714 <strong>produc\u0103tor certificat WHO-GMP<\/strong> \u2714 Ambalaj discret \u2714 Livrare worldwide \u2714 <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">Recenzii verificate ale clien\u021bilor (peste 1.400 de clien\u021bi)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>\ud83d\udca1 Linie primar\u0103 pentru proctit\u0103 \u0219i CU distal\u0103.<\/strong> At\u00e2t ECCO 2022 c\u00e2t \u0219i ACG 2019 plaseaz\u0103 mesalazina topic\u0103 (supozitoare pentru proctit\u0103 \u2264 15 cm; clisme pentru proctosigmoidit\u0103 distal\u0103 \u2264 30\u201340 cm) ca tratament de prim\u0103 linie pentru inducerea \u0219i \u00eentre\u021binerea CU distale u\u0219oar\u0103-p\u00e2n\u0103-la-moderat\u0103. Combinarea mesalazinei topice + orale este superioar\u0103 fiec\u0103reia separat pentru colita st\u00e2ng\u0103. Se adaug\u0103 steroid topic (spum\u0103 de budesonid\u0103) c\u00e2nd 5-ASA e\u0219ueaz\u0103.<\/div>\n<h3 class=\"wp-block-heading\">De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Supozitoarele Pentasa sunt furnizate de la <strong>produc\u0103tor certificat WHO-GMP<\/strong>. Fiecare comand\u0103 este expediat\u0103 discret \u00een \u00eentreaga lume \u0219i este acoperit\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> \u2014 dac\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, retrimitem f\u0103r\u0103 costuri suplimentare. Mesalazina topic\u0103 asigur\u0103 concentra\u021bie local\u0103 ridicat\u0103 \u00een rect, cu absorb\u021bie sistemic\u0103 neglijabil\u0103, f\u0103c\u00e2nd-o piatra de temelie a remisiei CU distale \u2014 mai sigur\u0103 dec\u00e2t cursurile de steroid oral sau sistemic.<\/p>\n<h2 class=\"wp-block-heading\">Mecanism de ac\u021biune<\/h2>\n<p>Mesalazina (acid 5-aminosalicilic, 5-ASA) este componenta antiinflamatorie activ\u0103 a vechiului medicament sulfasalazin\u0103 (care este hidrolizat de bacteriile colonice \u00een 5-ASA + sulfapiridin\u0103; sulfapiridina este responsabil\u0103 pentru efectele adverse ale sulfasalazinei). 5-ASA ac\u021bioneaz\u0103 pe mucosa colonic\u0103 prin mai multe mecanisme: agonism PPAR-\u03b3 (transcrip\u021bie antiinflamatorie), inhibarea c\u0103ilor prostaglandine COX\/LOX, eliminarea speciilor reactive de oxigen \u0219i inhibarea activ\u0103rii NF-\u03baB. Forma de supozitor asigur\u0103 administrarea direct\u0103 \u00een rect (acoperind 15 cm) cu absorb\u021bie sistemic\u0103 foarte mic\u0103.<\/p>\n<h2 class=\"wp-block-heading\">Indica\u021bii<\/h2>\n<ul>\n<li>Proctit\u0103 ulceroas\u0103 u\u0219oar\u0103-p\u00e2n\u0103-la-moderat\u0103 (induc\u021bie \u0219i \u00eentre\u021binere)<\/li>\n<li>Proctosigmoidit\u0103 distal\u0103 (combinat cu 5-ASA oral)<\/li>\n<li>Proctit\u0103 Crohn<\/li>\n<li>Pouchit\u0103 postchirurgical\u0103 (off-label)<\/li>\n<li>Proctit\u0103 postradioterapie (off-label, linie secundar\u0103)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Doza<\/h2>\n<p>Induc\u021bie: 1 supozitor (1 g) o dat\u0103 pe zi, ideal la culcare, timp de 4\u20138 s\u0103pt\u0103m\u00e2ni. \u00centre\u021binere: 1 supozitor de trei ori pe s\u0103pt\u0103m\u00e2n\u0103 sau zilnic, \u00een func\u021bie de tiparul bolii. Copii &gt; 12 ani: la fel ca adul\u021bii. Insuficien\u021b\u0103 hepatic\u0103 sau renal\u0103 sever\u0103: precau\u021bie.<\/p>\n<h2 class=\"wp-block-heading\">Cum se utilizeaz\u0103<\/h2>\n<ol>\n<li>Goli\u021bi intestinul \u0219i vezica dac\u0103 este posibil.<\/li>\n<li>Sp\u0103la\u021bi-v\u0103 m\u00e2inile; r\u0103ci\u021bi supozitorul (5\u201310 minute la frigider dac\u0103 s-a \u00eenmuiat).<\/li>\n<li>\u00centinde\u021bi-v\u0103 pe partea st\u00e2ng\u0103 cu genunchiul drept \u00eendoit.<\/li>\n<li>Introduce\u021bi mai \u00eent\u00e2i cap\u0103tul rotunjit, \u00eempinge\u021bi u\u0219or la 2\u20133 cm \u00een rect.<\/li>\n<li>R\u0103m\u00e2ne\u021bi \u00eentin\u0219i 15\u201330 de minute pentru a permite supozitorului s\u0103 se men\u021bin\u0103 \u00een loc.<\/li>\n<li>Aplicarea la ora de culcare maximizeaz\u0103 reten\u021bia pe durata nop\u021bii.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Efecte secundare<\/h2>\n<ul>\n<li>Local: arsur\u0103 anal\u0103, scurgere, m\u00e2nc\u0103rime u\u0219oar\u0103<\/li>\n<li>Sistemic (rar): durere de cap, grea\u021b\u0103, durere abdominal\u0103<\/li>\n<li>Idiosincratic: hipersensibilitate (erup\u021bie cutanat\u0103, febr\u0103, eozinofilie), nefrit\u0103 intersti\u021bial\u0103 (rar\u0103; se recomand\u0103 creatinina de baz\u0103 \u0219i analiza de urin\u0103 anual\u0103 pentru mesalazina oral\u0103 cronic\u0103, op\u021bional pentru supozitor)<\/li>\n<li>Sindromul acut de intoleran\u021b\u0103 la mesalazin\u0103 \u2014 agravare paradoxal\u0103 a colitei (rar; \u00eentrerupe\u021bi medicamentul \u0219i consulta\u021bi)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li>Azathioprine, mercaptopurine: mesalazine inhib\u0103 TPMT \u0219i cre\u0219te nivelurile de 6-MP \u2014 monitoriza\u021bi str\u00e2ns hemograma.<\/li>\n<li>Warfarin: raportat\u0103 cre\u0219tere rar\u0103 a INR.<\/li>\n<li>Vaccin oral viu contra tifoidului: evita\u021bi.<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">C\u00e2t de repede voi \u00eembun\u0103t\u0103\u021bi?<\/h3>\n<p>Tenismul \u0219i s\u00e2ngerarea rectal\u0103 se \u00eembun\u0103t\u0103\u021besc adesea \u00een 1\u20132 s\u0103pt\u0103m\u00e2ni. Vindecarea complet\u0103 a mucoasei dureaz\u0103 4\u20138 s\u0103pt\u0103m\u00e2ni. Continua\u021bi \u00eentregul tratament de induc\u021bie chiar dac\u0103 simptomele se amelior\u0103 mai devreme.<\/p>\n<h3 class=\"wp-block-heading\">De ce la ora de culcare?<\/h3>\n<p>Un supozitor administrat la ora de culcare r\u0103m\u00e2ne \u00een rect peste noapte \u00een timp ce dormi\u021bi, maximiz\u00e2nd timpul de contact cu mucoasa. Aplica\u021biile din timpul zilei tind s\u0103 se scurg\u0103 dup\u0103 activitate.<\/p>\n<h3 class=\"wp-block-heading\">Nu am \u00eenregistrat nicio \u00eembun\u0103t\u0103\u021bire dup\u0103 4 s\u0103pt\u0103m\u00e2ni. Ce fac acum?<\/h3>\n<p>Trece\u021bi la mesalazina oral\u0103 (Asacol, Mesacol sau Pentasa) ad\u0103ugat\u0103 la supozitor sau escalada\u021bi la spum\u0103 de budesonid\u0103 topic\u0103. Dac\u0103 tot nu exist\u0103 r\u0103spuns dup\u0103 8 s\u0103pt\u0103m\u00e2ni, consult gastroenterologic pentru steroid sistemic, imunomodulator sau biologic.<\/p>\n<h3 class=\"wp-block-heading\">Este sigur \u00een sarcin\u0103?<\/h3>\n<p>Da. Mesalazina topic\u0103 are absorb\u021bie sistemic\u0103 minim\u0103 \u0219i este considerat\u0103 sigur\u0103 pe tot parcursul sarcinii \u0219i al\u0103pt\u0103rii. Puseurile active de colit\u0103 ulceroas\u0103 \u00een sine reprezint\u0103 un risc pentru sarcin\u0103; controlul puseului este prioritar.<\/p>\n<h3 class=\"wp-block-heading\">Voi avea nevoie de ea pe termen lung?<\/h3>\n<p>Mul\u021bi pacien\u021bi au nevoie pentru men\u021binere. Dozarea de trei ori pe s\u0103pt\u0103m\u00e2n\u0103 este adesea suficient\u0103 odat\u0103 ce se ob\u021bine remisia. Scopul este prevenirea puseurilor, care au propriile riscuri de complica\u021bii \u0219i interven\u021bii chirurgicale.<\/p>\n<h3 class=\"wp-block-heading\">Pot lua alte medicamente pentru CU \u00een acela\u0219i timp?<\/h3>\n<p>Da, regimul tipic pentru CU distal moderat este mesalazina oral\u0103 (Asacol\/Mesacol) 2,4\u20134,8 g\/zi plus un supozitor sau clism\u0103 de mesalazin\u0103 topic\u0103. Ad\u0103ugarea unui 5-ASA topic accelereaz\u0103 remisia comparativ cu administrarea doar oral\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Ce se \u00eent\u00e2mpl\u0103 cu rinichii mei?<\/h3>\n<p>Nefrita intersti\u021bial\u0103 este rar\u0103 cu mesalazina oral\u0103 \u0219i foarte rar\u0103 cu terapia exclusiv topic\u0103. Dac\u0103 lua\u021bi mesalazin\u0103 oral\u0103 cronic \u00een plus, se recomand\u0103 creatinin\u0103 \u0219i analize de urin\u0103 de baz\u0103 \u0219i anuale.<\/p>\n<h3 class=\"wp-block-heading\">Pot s\u0103-l tai \u00een dou\u0103?<\/h3>\n<p>Nu \u2014 supozitorul este conceput s\u0103 elibereze mesalazin\u0103 treptat pe m\u0103sur\u0103 ce se dizolv\u0103. T\u0103ierea modific\u0103 suprafa\u021ba \u0219i rata de eliberare.<\/p>\n<h3 class=\"wp-block-heading\">Depozitare<\/h3>\n<p>Sub 30\u00b0C \u00een ambalajul original sigilat. Supozitoarele care s-au \u00eenmuiat sau s-au fragmentat nu trebuie utilizate.<\/p>\n<h3 class=\"wp-block-heading\">Ce fac dac\u0103 uit o doz\u0103?<\/h3>\n<p>Introduce\u021bi-l imediat ce v\u0103 aminti\u021bi. Dac\u0103 este aproape de urm\u0103toarea doz\u0103, omite\u021bi \u0219i continua\u021bi. Nu dubla\u021bi doza.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alte Medicamente pentru S\u0103n\u0103tatea Gastrointestinal\u0103<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/asacol\/\">Asacol \u2014 Mesalamin\u0103 oral\u0103 400 mg DR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/mesacol\/\">Mesacol \u2014 Mesalamin\u0103 oral\u0103 400 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/saaz\/\">Saaz \u2014 Sulfasalazina 500 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/budez-cr\/\">Budez CR \u2014 Budesonid CR (boala Crohn ileal\u0103 terminal\u0103)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/rifagut\/\">Rifagut \u2014 Rifaximin (antibiotic selectiv intestinal)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/gastro-health\/\"><strong>Vede\u021bi toate Medicamentele pentru S\u0103n\u0103tatea Gastrointestinal\u0103<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui profesionist calificat din domeniul s\u0103n\u0103t\u0103\u021bii. Colit\u0103 agravat\u0103, febr\u0103, pierdere \u00een greutate, hemoragii severe sau manifest\u0103ri extra-intestinale (ochi, articula\u021bii, piele) necesit\u0103 consult gastroenterologic urgent.<\/div>","protected":false},"excerpt":{"rendered":"<p>Supozitoare Pentasa (Mesalazin\u0103 1 g rectal) \u2014 5-ASA topic pentru proctita ulcerativ\u0103, UC distal \u0219i proctita Crohn. ECCO\/ACG recomandare de prim\u0103 linie pentru induc\u021bia \u0219i men\u021binerea UC distal. Livrare worldwide de la MedsBase.<\/p>","protected":false},"featured_media":58278,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[4458,4459],"class_list":{"0":"post-58277","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","9":"product_tag-mesalazine","10":"product_tag-pentasa-suppositories","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/58277","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=58277"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/58278"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=58277"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=58277"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=58277"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=58277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}