{"id":58445,"date":"2024-02-27T18:36:12","date_gmt":"2024-02-27T18:36:12","guid":{"rendered":"https:\/\/medsname.com\/lomoother\/"},"modified":"2026-04-30T10:24:13","modified_gmt":"2026-04-30T10:24:13","slug":"lomoother","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/lomoother\/","title":{"rendered":"Lomoother"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Lomoother?<\/h3>\n<p style=\"margin:0;\"><strong>Lomoother<\/strong> este o capsul\u0103 oral\u0103 de la Beacon Pharmaceuticals care con\u021bine <strong>lomustine (CCNU) 40 mg<\/strong> \u2014 un agent alchilant nitrozoureic care trece bariera hemato-encefalic\u0103. Utilizat pentru <strong>tumori cerebrale primare recurente sau refractare<\/strong> (glioma de grad \u00eenalt, ependimom) \u0219i ca parte a regimurilor de combina\u021bie mai vechi pentru limfomul Hodgkin. Doza standard de monoterapie pentru adul\u021bi: <strong>100\u2013130 mg\/m\u00b2 oral, ca o singur\u0103 doz\u0103 la fiecare 6 s\u0103pt\u0103m\u00e2ni<\/strong> \u2014 intervalul de 6 s\u0103pt\u0103m\u00e2ni este obligatoriu deoarece nadirul este \u00eent\u00e2rziat (4\u20136 s\u0103pt\u0103m\u00e2ni) \u0219i recuperarea este lent\u0103. Obligatoriu: hemogram\u0103 complet\u0103 la baz\u0103, s\u0103pt\u0103m\u00e2nal \u00eentre cicluri \u0219i \u00een ziua 42 \u00eenaintea urm\u0103toarei doze. <strong>Limit\u0103 de doz\u0103 cumulativ\u0103 ~1.000 mg\/m\u00b2<\/strong> din cauza riscului cumulativ de mielotoxicitate \u0219i fibroz\u0103 pulmonar\u0103. Contraindica\u021bie \u00een sarcin\u0103; oferi\u021bi preservarea fertilit\u0103\u021bii.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Supraveghere specializat\u0103 necesar\u0103.<\/strong> Medicamentele pentru cancer trebuie prescrise de un oncolog tratant, cu un diagnostic confirmat, stadializare ini\u021bial\u0103 \u0219i un plan de tratament definit. Nu \u00eencepe\u021bi, nu opri\u021bi, nu modifica\u021bi doza \u0219i nu utiliza\u021bi medicamente pentru cancer \u00een afara unui plan de \u00eengrijire condus de oncologie. Majoritatea medicamentelor pentru cancer necesit\u0103 monitorizare regulat\u0103 prin analize de s\u00e2nge (hemoleucogram\u0103, teste hepatice, func\u021bie renal\u0103), sunt absolut contraindicate \u00een sarcin\u0103 \u0219i au interac\u021biuni medicamentoase semnificative.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 Checkout criptat<\/strong> \u00b7 <strong>\ud83d\udcb3 Procesor verificat<\/strong> \u00b7 <strong>\ud83d\ude9a Livrare worldwide<\/strong> \u00b7 <strong>\u2b50 4,9\/5 de la peste 1.400 de clien\u021bi<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">Ce este Lomoother?<\/h2>\n<p>Lomoother este o capsul\u0103 oral\u0103 de la Beacon Pharmaceuticals care con\u021bine <strong>lomustine (CCNU) 40 mg<\/strong>. Lomustin\u0103 este un agent alchilant nitrozoureic care trece bariera hemato-encefalic\u0103 (concentra\u021bia \u00een LCR ~30\u201350% din plasm\u0103), f\u0103c\u00e2ndu-l unul dintre pu\u021binele citotoxice orale cu penetrare semnificativ\u0103 \u00een SNC. Utilizat \u00een tumori cerebrale primare, \u00een special gliom de grad \u00eenalt recurent dup\u0103 e\u0219ecul temozolomidei.<\/p>\n<h2 class=\"wp-block-heading\">Utiliz\u0103ri \u0219i indica\u021bii<\/h2>\n<ul>\n<li><strong>Glioblastom multiform recurent sau refractar<\/strong> dup\u0103 temozolomid\u0103<\/li>\n<li><strong>Astrocitom anaplazic, oligodendrogliom anaplazic<\/strong> (regim PCV)<\/li>\n<li><strong>Limfom Hodgkin<\/strong> (combina\u021bii vechi care con\u021bin CCNU)<\/li>\n<li><strong>Metastaze cerebrale (selectate)<\/strong><\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Doza \u0219i mod de administrare<\/h2>\n<ul>\n<li><strong>Standard:<\/strong> 100\u2013130 mg\/m\u00b2 PO ca o SINGUR\u0102 doz\u0103 la fiecare 6 s\u0103pt\u0103m\u00e2ni<\/li>\n<li><strong>Regim PCV (oligodendrogliom):<\/strong> 110 mg\/m\u00b2 ziua 1 + procarbazin\u0103 + vincristin\u0103, la fiecare 6 s\u0103pt\u0103m\u00e2ni<\/li>\n<\/ul>\n<ol>\n<li>Administra\u021bi ca o singur\u0103 doz\u0103 oral\u0103 la ora de culcare, pe stomacul gol (f\u0103r\u0103 alimente 2 ore \u00eenainte sau 2 ore dup\u0103).<\/li>\n<li>Antiemetic (ondansetron 8 mg) 1 or\u0103 \u00eenainte de doz\u0103.<\/li>\n<li>\u00cenghi\u021bi\u021bi capsulele \u00eentregi cu ap\u0103. NU deschide\u021bi.<\/li>\n<li><strong>Interval obligatoriu de 6 s\u0103pt\u0103m\u00e2ni \u00eentre doze<\/strong> \u2014 nadirul este \u00eent\u00e2rziat (de obicei s\u0103pt\u0103m\u00e2na 4\u20136), recuperarea lent\u0103. Administrarea mai frecvent\u0103 dec\u00e2t la fiecare 6 s\u0103pt\u0103m\u00e2ni risc\u0103 panctopenie cumulativ\u0103.<\/li>\n<li><strong>Monitorizare obligatorie:<\/strong> Analiz\u0103 hematologic\u0103 complet\u0103 la ini\u021biere, s\u0103pt\u0103m\u00e2nal pe parcursul ciclului \u0219i \u00een ziua 42 \u00eenaintea urm\u0103toarei doze. Func\u021bia hepatic\u0103 \u0219i renal\u0103 lunar. Teste func\u021bionale pulmonare (DLCO) la ini\u021biere \u0219i \u00een caz de dispnee.<\/li>\n<li><strong>Limit\u0103 de doz\u0103 cumulativ\u0103 ~1.000 mg\/m\u00b2<\/strong> pe termen lung \u2014 toxicitatea mieloid\u0103 cumulativ\u0103 \u0219i fibroza pulmonar\u0103 devin factori limitan\u021bi.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Efecte Secundare<\/h2>\n<p><strong>Frecvente:<\/strong> gre\u021buri (semnificative), v\u0103rs\u0103turi, anorexie.<\/p>\n<p><strong>Important:<\/strong><\/p>\n<ul>\n<li><strong>Mielosupresie cumulativ\u0103 \u00eent\u00e2rziat\u0103<\/strong> \u2014 trombocitopenie \u0219i leucopenie la s\u0103pt\u0103m\u00e2na 4\u20136, recuperare lent\u0103<\/li>\n<li><strong>Fibroz\u0103 pulmonar\u0103<\/strong> la doze cumulative mari \u2014 teste func\u021bionale pulmonare obligatorii \u00een caz de dispnee<\/li>\n<li>Hepatotoxicitate<\/li>\n<li>Toxicitate renal\u0103<\/li>\n<li>Leucemie secundar\u0103 (pe termen lung, dependent\u0103 de doz\u0103)<\/li>\n<li>Infertilitate permanent\u0103 (gonadotoxic\u0103)<\/li>\n<li>Confuzie, letargie, ataxie (la doze mari)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Avertismente<\/h2>\n<ul>\n<li><strong>Sarcina:<\/strong> teratogen; contracep\u021bie strict\u0103 pe tot parcursul + 6 luni dup\u0103 tratament.<\/li>\n<li><strong>Al\u0103ptarea:<\/strong> evita\u021bi.<\/li>\n<li><strong>Boli pulmonare preexistente:<\/strong> DLCO de baz\u0103; evita\u021bi \u00een cazuri severe.<\/li>\n<li><strong>Insuficien\u021b\u0103 hepatic\u0103\/renal\u0103 sever\u0103:<\/strong> reduce\u021bi doza.<\/li>\n<li><strong>Vaccinuri cu virus viu:<\/strong> contraindicated.<\/li>\n<li><strong>Monitorizare doz\u0103 cumulativ\u0103<\/strong> \u2014 responsabilitate specialist.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Combina\u021bi cu<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Efect<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Ce s\u0103 face\u021bi<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Alte agente mielosupresoare<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Pancitopenie prelungit\u0103 aditiv\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Supraveghere specializat\u0103.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Cimetidina<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Cre\u0219te toxicitatea medular\u0103 a lomustinei<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Folosi\u021bi ranitidin\u0103 sau famotidin\u0103 \u00een loc.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vaccinuri cu virus viu<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Infec\u021bie diseminat\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Contraindicated.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Depozitare<\/h2>\n<ul>\n<li>Se p\u0103streaz\u0103 la frigider <strong>2\u20138\u00b0C<\/strong>.<\/li>\n<li>Depozita\u021bi \u00een afara accesului copiilor, femeilor \u00een v\u00e2rst\u0103 de reproducere, animalelor de companie.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Alternative conexe pe MedsBase<\/h2>\n<p>Alte medicamente oncologice disponibile \u00eempreun\u0103 cu acest produs:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/endoxan\/\"><strong>Endoxan (ciclosfosfamid\u0103 50 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/celkeran\/\"><strong>Celkeran (clorambucil 2 \/ 5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/temotero\/\"><strong>Temotero (temozolomid\u0103 20\/100 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/temozol-20\/\"><strong>Temozol (temozolomid\u0103 20 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/endace\/\"><strong>Endace (megestrol 40\/160 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/ro\/anti-cancer-medication\/\">R\u0103sfoi\u021bi toate medicamentele anti-cancer \u2192<\/a><\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">De ce trebuie s\u0103 fie dozele administrate la interval de 6 s\u0103pt\u0103m\u00e2ni?<\/h3>\n<p>Lomustina provoac\u0103 <strong>mielosupresie cumulativ\u0103 \u00eent\u00e2rziat\u0103<\/strong>. Nadirul num\u0103rului de celule sanguine apare de obicei la <strong>s\u0103pt\u0103m\u00e2na 4\u20136<\/strong> dup\u0103 administrare, cu recuperare lent\u0103 ulterioar\u0103. Administrarea mai frecvent\u0103 dec\u00e2t la fiecare 6 s\u0103pt\u0103m\u00e2ni acumuleaz\u0103 toxicitatea m\u0103duvei osoase \u0219i risc\u0103 de panctiopenie sever\u0103. Intervalul de 6 s\u0103pt\u0103m\u00e2ni este strict \u2014 chiar dac\u0103 v\u0103 sim\u021bi\u021bi bine, nu administra\u021bi mai devreme f\u0103r\u0103 instruc\u021biuni specializate.<\/p>\n<h3 class=\"wp-block-heading\">De ce exist\u0103 o limit\u0103 de doz\u0103 cumulativ\u0103?<\/h3>\n<p>Fibroza pulmonar\u0103 cumulativ\u0103 \u0219i trombocitopenie persistent\u0103 devin limitative la expunerea total\u0103 dep\u0103\u0219ind ~1.000 mg\/m\u00b2 (pe via\u021b\u0103). Speciali\u0219tii monitorizeaz\u0103 doza cumulativ\u0103 \u0219i opresc sau extind intervalul pe m\u0103sur\u0103 ce se apropie de limit\u0103. Spune\u021bi fiec\u0103rui medic despre fiecare curs anterior de chimioterapie.<\/p>\n<h3 class=\"wp-block-heading\">Pot lua Lomustina cu m\u00e2ncare?<\/h3>\n<p>Nu \u2014 lua\u021bi pe stomacul gol (f\u0103r\u0103 m\u00e2ncare 2 ore \u00eenainte \u0219i 2 ore dup\u0103). Majoritatea pacien\u021bilor iau doza la culcare, cu \u2265 2 ore dup\u0103 cin\u0103. Premedica\u021bi cu ondansetron 8 mg cu aproximativ 1 or\u0103 \u00eenainte pentru a preveni grea\u021ba \u0219i v\u0103rs\u0103turile semnificative caracteristice nitrozoureelor.<\/p>\n<h3 class=\"wp-block-heading\">Ce analize de s\u00e2nge am nevoie?<\/h3>\n<p>Analiz\u0103 hemoleucogram\u0103 la baz\u0103, s\u0103pt\u0103m\u00e2nal \u00eentre cicluri \u0219i \u00een ziua 42 \u00eenaintea fiec\u0103rei doze urm\u0103toare. Func\u021bie hepatic\u0103 \u0219i renal\u0103 lunar. Teste func\u021bionale pulmonare (cu DLCO) la baz\u0103 \u0219i oric\u00e2nd apare dispnee nou\u0103 sau tuse uscat\u0103 persistent\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Va func\u021biona Lomustina pentru tumoarea mea cerebral\u0103?<\/h3>\n<p>Lomustina are o istorie lung\u0103 \u00een tumori cerebrale primare. \u00cen glioblastomul recurent dup\u0103 e\u0219ecul temozolomidei, lomustina ofer\u0103 un beneficiu modest de control al bolii la unii pacien\u021bi. \u00cen oligodendrogliom, regimul PCV (procarbazin\u0103 + lomustin\u0103 + vincristin\u0103) a demonstrat beneficiu \u00een supravie\u021buirea global\u0103 atunci c\u00e2nd este combinat cu radioterapia \u00een cazurile cu co-dele\u021bie 1p\/19q. Discuta\u021bi beneficiul a\u0219teptat specific tumorii dumneavoastr\u0103 cu neuro-oncologul.<\/p>\n<h3 class=\"wp-block-heading\">De ce trebuie p\u0103strat\u0103 Lomustina la frigider?<\/h3>\n<p>Lomustina este sensibil\u0103 la c\u0103ldur\u0103 \u0219i se degradeaz\u0103 la temperatura camerei, mai ales \u00een climatul cald. Refrigerarea (2\u20138\u00b0C) p\u0103streaz\u0103 poten\u021ba. P\u0103stra\u021bi \u00een blisterul original.<\/p>\n<h3 class=\"wp-block-heading\">\u00cengrijitorii care manipuleaz\u0103 Lomoother?<\/h3>\n<p>Purta\u021bi m\u0103nu\u0219i atunci c\u00e2nd manipula\u021bi capsulele \u0219i fluidele corporale ale pacientului \u00een primele 48 de ore dup\u0103 administrare. Sp\u0103la\u021bi-v\u0103 m\u00e2inile dup\u0103 aceea. \u00cengrijitorii gravizi ar trebui s\u0103 evite manipularea.<\/p>\n<h3 class=\"wp-block-heading\">Pot primi vaccinuri cu virus viu?<\/h3>\n<p>Nu \u2014 contraindicat \u00een timpul tratamentului cu lomustin\u0103 \u0219i pentru cel pu\u021bin 6 luni dup\u0103 ultima doz\u0103. Vaccinurile inactivate sunt sigure \u0219i recomandate.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Fiecare lot este procurat de la un <strong>produc\u0103tor certificat WHO-GMP<\/strong>. Comenzile sunt expediate \u00een ambalaje simple, f\u0103r\u0103 marc\u0103, de la partenerii no\u0219tri de onorare \u0219i acoperite de <a href=\"\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a>: dac\u0103 un colet nu ajunge \u00een 20 de zile lucr\u0103toare, trimitem gratuit o nou\u0103 comand\u0103, f\u0103r\u0103 \u00eentreb\u0103ri.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Medicamente Anticanceroase Asem\u0103n\u0103toare<\/h3>\n<p>Alte medicamente oncologice disponibile \u00eempreun\u0103 cu acest produs:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/endoxan\/\">Endoxan (ciclosfosfamid\u0103 50 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/celkeran\/\">Celkeran (clorambucil 2 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/temozol-20\/\">Temozol 20 (temozolomid\u0103 20 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/temotero\/\">Temotero (temozolomid\u0103 100\/250 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/hydrosar\/\">Hydrosar (hidroxiuree 500 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Tratament tumori cerebrale<br \/>\n\u2705 Medicament chimioterapic<br \/>\n\u2705 \u00cencetine\u0219te cre\u0219terea tumorii<br \/>\n\u2705 Agent alchilant<br \/>\n\u2705 Medica\u021bie oral\u0103<\/p>\n<p>Lomoother con\u021bine Lomustine.<\/p>","protected":false},"featured_media":58446,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[4493,4494],"class_list":{"0":"post-58445","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-lomoother","10":"product_tag-lomustine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/58445","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=58445"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/58446"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=58445"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=58445"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=58445"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=58445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}