{"id":58445,"date":"2024-02-27T18:36:12","date_gmt":"2024-02-27T18:36:12","guid":{"rendered":"https:\/\/medsname.com\/lomoother\/"},"modified":"2026-04-30T10:24:13","modified_gmt":"2026-04-30T10:24:13","slug":"lomoother","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/lomoother\/","title":{"rendered":"Lomoother"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Lomoother?<\/h3>\n<p style=\"margin:0;\"><strong>Lomoother<\/strong> is an oral capsule from Beacon Pharmaceuticals containing <strong>lomustine (CCNU) 40 mg<\/strong> &mdash; a nitrosourea alkylating agent that crosses the blood-brain barrier. Used for <strong>recurrent or refractory primary brain tumours<\/strong> (high-grade glioma, ependymoma) and as part of older Hodgkin lymphoma combination regimens. Standard adult monotherapy dose: <strong>100&ndash;130 mg\/m&sup2; orally as a single dose every 6 weeks<\/strong> &mdash; the 6-week interval is mandatory because nadir is delayed (4&ndash;6 weeks) and recovery slow. Mandatory: FBC at baseline, weekly between cycles, and on day 42 before next dose. <strong>Cumulative dose limit ~1,000 mg\/m&sup2;<\/strong> because of cumulative myelotoxicity and pulmonary fibrosis risk. Pregnancy contraindication; offer fertility preservation.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Supraveghere specializat\u0103 necesar\u0103.<\/strong> Medicamentele pentru cancer trebuie prescrise de un oncolog tratant, cu un diagnostic confirmat, stadializare ini\u021bial\u0103 \u0219i un plan de tratament definit. Nu \u00eencepe\u021bi, nu opri\u021bi, nu modifica\u021bi doza \u0219i nu utiliza\u021bi medicamente pentru cancer \u00een afara unui plan de \u00eengrijire condus de oncologie. Majoritatea medicamentelor pentru cancer necesit\u0103 monitorizare regulat\u0103 prin analize de s\u00e2nge (hemoleucogram\u0103, teste hepatice, func\u021bie renal\u0103), sunt absolut contraindicate \u00een sarcin\u0103 \u0219i au interac\u021biuni medicamentoase semnificative.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 Checkout criptat<\/strong> \u00b7 <strong>\ud83d\udcb3 Procesor verificat<\/strong> \u00b7 <strong>\ud83d\ude9a Livrare worldwide<\/strong> \u00b7 <strong>\u2b50 4,9\/5 de la peste 1.400 de clien\u021bi<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Lomoother?<\/h2>\n<p>Lomoother is an oral capsule from Beacon Pharmaceuticals containing <strong>lomustine (CCNU) 40 mg<\/strong>. Lomustine is a nitrosourea alkylating agent that crosses the blood-brain barrier (CSF concentration ~30&ndash;50% of plasma), making it one of the few oral cytotoxics with meaningful CNS penetration. Used in primary brain tumours, particularly recurrent high-grade glioma after temozolomide failure.<\/p>\n<h2 class=\"wp-block-heading\">Utiliz\u0103ri \u0219i indica\u021bii<\/h2>\n<ul>\n<li><strong>Recurrent or refractory glioblastoma multiforme<\/strong> after temozolomide<\/li>\n<li><strong>Anaplastic astrocytoma, anaplastic oligodendroglioma<\/strong> (PCV regimen)<\/li>\n<li><strong>Hodgkin lymphoma<\/strong> (older CCNU-containing combinations)<\/li>\n<li><strong>Brain metastases (selected)<\/strong><\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Doza \u0219i mod de administrare<\/h2>\n<ul>\n<li><strong>Standard:<\/strong> 100&ndash;130 mg\/m&sup2; PO as a SINGLE dose every 6 weeks<\/li>\n<li><strong>PCV regimen (oligodendroglioma):<\/strong> 110 mg\/m&sup2; day 1 + procarbazine + vincristine, every 6 weeks<\/li>\n<\/ul>\n<ol>\n<li>Take as a single oral dose at bedtime, on an empty stomach (no food 2 hours before or 2 hours after).<\/li>\n<li>Antiemetic (ondansetron 8 mg) 1 hour before dose.<\/li>\n<li>Swallow capsules whole with water. Do NOT open.<\/li>\n<li><strong>Mandatory 6-week interval between doses<\/strong> &mdash; nadir is delayed (typically week 4&ndash;6), recovery slow. Dosing more frequently than every 6 weeks risks cumulative pancytopenia.<\/li>\n<li><strong>Monitorizare obligatorie:<\/strong> FBC at baseline, weekly throughout the cycle, and on day 42 before next dose. LFTs and renal function monthly. PFTs (DLCO) baseline and if dyspnoea.<\/li>\n<li><strong>Cumulative dose limit ~1,000 mg\/m&sup2;<\/strong> over the lifetime &mdash; cumulative myelotoxicity and pulmonary fibrosis become rate-limiting.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Efecte Secundare<\/h2>\n<p><strong>Frecvente:<\/strong> nausea (significant), vomiting, anorexia.<\/p>\n<p><strong>Important:<\/strong><\/p>\n<ul>\n<li><strong>Delayed cumulative myelosuppression<\/strong> &mdash; thrombocytopenia and leucopenia at week 4&ndash;6, recovery slow<\/li>\n<li><strong>Pulmonary fibrosis<\/strong> at high cumulative dose &mdash; mandatory PFTs if dyspnoea<\/li>\n<li>Hepatotoxicitate<\/li>\n<li>Toxicitate renal\u0103<\/li>\n<li>Secondary leukaemia (long-term, dose-related)<\/li>\n<li>Infertilitate permanent\u0103 (gonadotoxic\u0103)<\/li>\n<li>Confusion, lethargy, ataxia (high doses)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Avertismente<\/h2>\n<ul>\n<li><strong>Sarcina:<\/strong> teratogenic; strict contraception throughout + 6 months after.<\/li>\n<li><strong>Al\u0103ptarea:<\/strong> evita\u021bi.<\/li>\n<li><strong>Pre-existing pulmonary disease:<\/strong> baseline DLCO; avoid in severe.<\/li>\n<li><strong>Insuficien\u021b\u0103 hepatic\u0103\/renal\u0103 sever\u0103:<\/strong> reduce\u021bi doza.<\/li>\n<li><strong>Vaccinuri cu virus viu:<\/strong> contraindicated.<\/li>\n<li><strong>Cumulative dose tracking<\/strong> &mdash; specialist responsibility.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Combina\u021bi cu<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Efect<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Ce s\u0103 face\u021bi<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Other myelosuppressives<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive prolonged pancytopenia<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Supraveghere specializat\u0103.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Cimetidina<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Increases lomustine marrow toxicity<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Use ranitidine or famotidine instead.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vaccinuri cu virus viu<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Infec\u021bie diseminat\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Contraindicated.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Depozitare<\/h2>\n<ul>\n<li>Se p\u0103streaz\u0103 la frigider <strong>2\u20138\u00b0C<\/strong>.<\/li>\n<li>Depozita\u021bi \u00een afara accesului copiilor, femeilor \u00een v\u00e2rst\u0103 de reproducere, animalelor de companie.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Alternative conexe pe MedsBase<\/h2>\n<p>Alte medicamente oncologice disponibile \u00eempreun\u0103 cu acest produs:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/endoxan\/\"><strong>Endoxan (ciclosfosfamid\u0103 50 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/celkeran\/\"><strong>Celkeran (clorambucil 2 \/ 5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/temotero\/\"><strong>Temotero (temozolomid\u0103 20\/100 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/temozol-20\/\"><strong>Temozol (temozolomid\u0103 20 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/endace\/\"><strong>Endace (megestrol 40\/160 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/ro\/anti-cancer-medication\/\">R\u0103sfoi\u021bi toate medicamentele anti-cancer \u2192<\/a><\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">Why must doses be 6 weeks apart?<\/h3>\n<p>Lomustine causes <strong>delayed cumulative myelosuppression<\/strong>. The blood count nadir typically occurs at <strong>week 4&ndash;6<\/strong> after a dose, with slow recovery thereafter. Dosing more frequently than every 6 weeks stacks the marrow toxicity and risks severe pancytopenia. The 6-week interval is rigid &mdash; even if you feel well, do not dose-advance without specialist instruction.<\/p>\n<h3 class=\"wp-block-heading\">Why is there a cumulative dose limit?<\/h3>\n<p>Cumulative pulmonary fibrosis and persistent thrombocytopenia become limiting at total exposure above ~1,000 mg\/m&sup2; (lifetime). Specialists track cumulative dose and stop or extend the interval as the limit is approached. Tell every doctor about every previous chemotherapy course.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Lomoother with food?<\/h3>\n<p>No &mdash; take on an empty stomach (no food for 2 hours before or 2 hours after). Most patients take the dose at bedtime &ge; 2 hours after dinner. Pre-medicate with ondansetron 8 mg about 1 hour before to prevent the significant nausea and vomiting characteristic of nitrosoureas.<\/p>\n<h3 class=\"wp-block-heading\">Ce analize de s\u00e2nge am nevoie?<\/h3>\n<p>FBC at baseline, weekly between cycles, and on day 42 before each next dose. LFTs and renal function monthly. PFTs (with DLCO) at baseline and any time you develop new dyspnoea or persistent dry cough.<\/p>\n<h3 class=\"wp-block-heading\">Will Lomoother work for my brain tumour?<\/h3>\n<p>Lomustine has a long history in primary brain tumours. In recurrent glioblastoma after temozolomide failure, lomustine produces modest disease-control benefit in some patients. In oligodendroglioma, the PCV regimen (procarbazine + lomustine + vincristine) has documented overall survival benefit when combined with radiotherapy in 1p\/19q co-deleted disease. Discuss expected benefit specific to your tumour with the neuro-oncologist.<\/p>\n<h3 class=\"wp-block-heading\">Why must Lomoother be refrigerated?<\/h3>\n<p>Lomustine is heat-sensitive and degrades at room temperature, especially in warmer climates. Refrigeration (2&ndash;8&deg;C) preserves potency. Keep in original blister.<\/p>\n<h3 class=\"wp-block-heading\">Caregivers handling Lomoother?<\/h3>\n<p>Wear gloves when handling capsules and patient body fluids in the first 48 hours after a dose. Wash hands afterwards. Pregnant caregivers should avoid handling.<\/p>\n<h3 class=\"wp-block-heading\">Pot primi vaccinuri cu virus viu?<\/h3>\n<p>No &mdash; contraindicated during lomustine and for at least 6 months after the last dose. Inactivated vaccines safe and recommended.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Fiecare lot este procurat de la un <strong>produc\u0103tor certificat WHO-GMP<\/strong>. Comenzile sunt expediate \u00een ambalaje simple, f\u0103r\u0103 marc\u0103, de la partenerii no\u0219tri de onorare \u0219i acoperite de <a href=\"\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a>: dac\u0103 un colet nu ajunge \u00een 20 de zile lucr\u0103toare, trimitem gratuit o nou\u0103 comand\u0103, f\u0103r\u0103 \u00eentreb\u0103ri.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Medicamente Anticanceroase Asem\u0103n\u0103toare<\/h3>\n<p>Alte medicamente oncologice disponibile \u00eempreun\u0103 cu acest produs:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/endoxan\/\">Endoxan (ciclosfosfamid\u0103 50 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/celkeran\/\">Celkeran (clorambucil 2 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/temozol-20\/\">Temozol 20 (temozolomide 20 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/temotero\/\">Temotero (temozolomide 100\/250 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/hydrosar\/\">Hydrosar (hidroxiuree 500 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Brain tumor treatment<br \/>\n\u2705 Chemotherapy drug<br \/>\n\u2705 Slows tumor growth<br \/>\n\u2705 Alkylating agent<br \/>\n\u2705 Medica\u021bie oral\u0103<\/p>\n<p>Lomoother contains Lomustine.<\/p>","protected":false},"featured_media":58446,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[4493,4494],"class_list":{"0":"post-58445","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-lomoother","10":"product_tag-lomustine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/58445","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=58445"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/58446"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=58445"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=58445"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=58445"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=58445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}