{"id":58464,"date":"2024-02-27T18:37:02","date_gmt":"2024-02-27T18:37:02","guid":{"rendered":"https:\/\/medsname.com\/mirzacan\/"},"modified":"2026-04-30T10:24:13","modified_gmt":"2026-04-30T10:24:13","slug":"mirzacan","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/mirzacan\/","title":{"rendered":"Mirzacan"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8d6;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">\u26a1 R\u0103spuns rapid<\/h3>\n<p style=\"margin-bottom:0;\">Mirzacan (Mirtazapin\u0103 15 \/ 30 mg) este un antidepresiv tetraciclic (NaSSA) pentru depresia major\u0103, \u00een special atunci c\u00e2nd insomnia, anxietatea, pierderea \u00een greutate sau anorexia sunt simptome dominante. Puternic sedativ la doze mici, mai pu\u021bin sedativ la doze mai mari (contraintuitiv \u2014 vezi mai jos).<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Mirzacan de la MedsBase este furnizat direct de la un produc\u0103tor certificat WHO-GMP \u00een ambalaj simplu \u0219i discret. Fiecare comand\u0103 este acoperit\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> \u2014 perioad\u0103 de livrare de 20 de zile lucr\u0103toare sau retrimitem f\u0103r\u0103 costuri suplimentare \u2014 \u0219i se calific\u0103 pentru <a href=\"https:\/\/medsbase.com\/ro\/loyalty-points\/\">programul nostru de loialitate pentru clien\u021bi<\/a>. Livr\u0103rile sunt disponibile \u00een majoritatea destina\u021biilor la nivel mondial.<\/p>\n<h2>Ce este Mirzacan \u0219i cum func\u021bioneaz\u0103<\/h2>\n<p>Mirzacan este un comprimat de mirtazapin\u0103 15 \/ 30 mg furnizat de Cadila. Mirtazapina este distinct\u0103 structural \u0219i mecanistic de SSRI\/SNRI\/TCA. Este un antidepresiv noradrenergic \u0219i serotoninergic specific (NaSSA): blocheaz\u0103 autoreceptorii \u03b12-adrenergici centrali (cre\u0219te eliberarea de NA \u0219i 5-HT indirect), receptorii 5-HT2A \u0219i 5-HT2C (anxiolitic, promoveaz\u0103 somnul, f\u0103r\u0103 disfunc\u021bii sexuale) \u0219i receptorii H1 histaminici (sedare \u0219i stimulare a apetitului).<\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Curb\u0103 contraintuitiv\u0103 a dozei-sedare<\/strong><\/p>\n<p style=\"margin-bottom:0;\">La 7,5\u201315 mg, mirtazapina are cel mai puternic efect sedativ. La doze de 30 mg+, componenta noradrenergic\u0103 (care are o rela\u021bie mai liniar\u0103 cu doza dec\u00e2t componenta antihistaminic\u0103 H1) \u00eencepe s\u0103 contrabalanseze seda\u021bia H1. Mul\u021bi pacien\u021bi descriu doza de 30 mg ca \u201coferind mai mult\u0103 energie\u201d dec\u00e2t 15 mg. Dac\u0103 un pacient dore\u0219te mai mult somn, doza trebuie redus\u0103 \u2014 nu crescut\u0103.<\/p>\n<\/div>\n<h2>Indica\u021bii \u0219i dozaj<\/h2>\n<table>\n<thead>\n<tr>\n<th>Indica\u021bie<\/th>\n<th>Doza ini\u021bial\u0103<\/th>\n<th>\u021aint\u0103<\/th>\n<th>Maxim<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Depresie major\u0103<\/td>\n<td>15 mg la culcare<\/td>\n<td>30 mg la culcare<\/td>\n<td>45 mg<\/td>\n<\/tr>\n<tr>\n<td>Depresie cu insomnie<\/td>\n<td>7,5\u201315 mg la culcare<\/td>\n<td>15 mg la culcare (adesea suficient)<\/td>\n<td>30 mg<\/td>\n<\/tr>\n<tr>\n<td>Depresie cu pierdere \u00een greutate\/anorexie<\/td>\n<td>15 mg la culcare<\/td>\n<td>30\u201345 mg la culcare<\/td>\n<td>45 mg<\/td>\n<\/tr>\n<tr>\n<td>Augmentare cu SSRI<\/td>\n<td>7,5\u201315 mg la culcare ad\u0103ugat la SSRI<\/td>\n<td>15 mg la culcare<\/td>\n<td>30 mg<\/td>\n<\/tr>\n<tr>\n<td>Pacien\u021bi v\u00e2rstnici<\/td>\n<td>7,5 mg la culcare<\/td>\n<td>15 mg la culcare<\/td>\n<td>30 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Considera\u021bii importante de siguran\u021b\u0103<\/h2>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Cre\u0219terea \u00een greutate \u0219i efectele metabolice<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Mirtazapina este unul dintre antidepresivele cu cel mai puternic efect de cre\u0219tere a greut\u0103\u021bii \u2014 de obicei 4\u20137 kg \u00een 6 luni. Util\u0103 la pacien\u021bii cu pierdere \u00een greutate asociat\u0103 depresiei; problematic\u0103 la pacien\u021bii obezi sau cu sindrom metabolic. Verifica\u021bi lipidele \u00een stare de post \u0219i HbA1c la 6 luni.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Agranulocitoz\u0103 (rar\u0103)<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Neutropenie reversibil\u0103 \u0219i agranulocitoz\u0103 rar\u0103 descrise \u2014 inciden\u021b\u0103 de aproximativ 1 la 1000. <strong>\u00centrerupe\u021bi imediat \u0219i verifica\u021bi hemoleucograma (FBC) dac\u0103 apar febr\u0103, durere \u00een g\u00e2t, ulcera\u021bii bucale sau alte semne de infec\u021bie \u00een primele 8 s\u0103pt\u0103m\u00e2ni.<\/strong> Nu este necesar\u0103 verificarea de rutin\u0103 a hemoleucogramei (FBC).<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Picioarele agitate \u0219i mi\u0219c\u0103ri periodice ale membrelor (PLM)<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Mirtazapina agraveaz\u0103 frecvent sindromul picioarelor agitate \u0219i mi\u0219c\u0103rile periodice ale membrelor \u00een timpul somnului \u2014 relevant pentru pacien\u021bii cu antecedente de RLS sau tulbur\u0103ri de somn.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Avertisment cutie neagr\u0103 privind riscul de suicid (sub 25 de ani)<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Toate antidepresivele poart\u0103 un avertisment cutie neagr\u0103 FDA privind cre\u0219terea g\u00e2ndurilor suicidare la pacien\u021bii sub 25 de ani.<\/p>\n<\/div>\n<h2>Efecte secundare frecvente<\/h2>\n<ul>\n<li><strong>Sedare:<\/strong> universal la doza de 15 mg; se atenueaz\u0103 la 30+ mg; administrarea la ora de culcare o transform\u0103 \u00eentr-un beneficiu.<\/li>\n<li><strong>Cre\u0219terea \u00een greutate \u0219i apetit crescut:<\/strong> 4\u20137 kg tipic la 6 luni.<\/li>\n<li><strong>Gur\u0103 uscat\u0103:<\/strong> comune, u\u0219oare.<\/li>\n<li><strong>Constipa\u021bie:<\/strong> ac\u021biune anticolinergic\u0103 u\u0219oar\u0103.<\/li>\n<li><strong>F\u0103r\u0103 disfunc\u021bii sexuale:<\/strong> avantaj distinct fa\u021b\u0103 de SSRI.<\/li>\n<li><strong>Vise vii:<\/strong> unii pacien\u021bi descriu vise neobi\u0219nuit de intense.<\/li>\n<li><strong>Colesterol \/ trigliceride:<\/strong> cre\u0219tere medie mic\u0103.<\/li>\n<\/ul>\n<h2>Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>MAOI<\/strong> \u2014 perioad\u0103 de eliminare de 14 zile \u00een fiecare direc\u021bie.<\/li>\n<li><strong>Inhibitori \/ inductori puternici ai CYP3A4<\/strong> \u2014 efect moderat asupra nivelurilor de mirtazapin\u0103.<\/li>\n<li><strong>Depresante ale SNC<\/strong> (alcool, benzodiazepine, opioide, Z-medicamente) \u2014 sedare aditiv\u0103.<\/li>\n<li><strong>Alte medicamente serotoninergice<\/strong> \u2014 sindrom serotoninergic descris dar neobi\u0219nuit (antagonismul 5-HT2A al mirtazapinei este par\u021bial protector).<\/li>\n<li><strong>Warfarin<\/strong> \u2014 cre\u0219tere mic\u0103 a INR; monitorizare necesar\u0103.<\/li>\n<\/ul>\n<h2>Sarcina, al\u0103ptare, pediatric<\/h2>\n<p>Sarcina: date limitate; evalua\u021bi \u00een raport cu depresia matern\u0103 netratat\u0103. Al\u0103ptare: trece \u00een lapte; uneori utilizat \u00een depresia postnatal\u0103 c\u00e2nd insomniile \u0219i pierderea \u00een greutate sunt preocup\u0103ri. Pediatric: nu de prim\u0103 inten\u021b\u0103.<\/p>\n<h2>Depozitare<\/h2>\n<p>P\u0103strare la 15\u201330 \u00b0C \u00een ambalajul original.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>De ce Mirzacan este mai sedativ la 15 mg dec\u00e2t la 30 mg?<\/h3>\n<p>Mirtazapina are efecte dependente de doz\u0103 asupra diferitelor receptori. La 15 mg, ac\u021biunea antihistaminic\u0103 H1 domin\u0103 \u2014 puternic sedativ\u0103. La 30 mg+, ac\u021biunea noradrenergic\u0103 cre\u0219te \u0219i contrabalanseaz\u0103 seda\u021bia. Acest lucru este contrar intui\u021biei \u0219i reprezint\u0103 cea mai frecvent\u0103 \u00eentrebare despre mirtazapin\u0103. Dac\u0103 somnul este prea profund, cre\u0219te\u021bi doza; dac\u0103 dori\u021bi mai mult somn, reduce\u021bi-o.<\/p>\n<h3>Mirzacan m\u0103 va face s\u0103 iau \u00een greutate?<\/h3>\n<p>Da \u2014 de obicei 4\u20137 kg \u00een 6 luni. Acesta este unul dintre cele mai fiabile efecte secundare. La pacien\u021bii cu pierdere \u00een greutate cauzat\u0103 de depresie, este un beneficiu; la pacien\u021bii obezi, reprezint\u0103 o problem\u0103. Discuta\u021bi explicit acest compromis \u00eenainte de a \u00eencepe tratamentul.<\/p>\n<h3>De ce Mirzacan se ia la culcare?<\/h3>\n<p>Seda\u021bia antihistaminic\u0103 H1 atinge maximul la 2\u20133 ore dup\u0103 administrare. Administrarea la ora de culcare utilizeaz\u0103 seda\u021bia ca beneficiu pentru somn, \u00een loc de somnolen\u021b\u0103 diurn\u0103. Administrarea diminea\u021ba produce somnolen\u021b\u0103 inacceptabil\u0103 la majoritatea pacien\u021bilor.<\/p>\n<h3>Cum difer\u0103 Mirzacan de un SSRI?<\/h3>\n<p>Mecanism diferit (blocare \u03b12 + 5-HT2A\/2C + H1 vs inhibi\u021bie SERT) se traduce prin: mai mult\u0103 seda\u021bie, mai mult\u0103 poft\u0103 de m\u00e2ncare, mai mult\u0103 cre\u0219tere \u00een greutate, f\u0103r\u0103 disfunc\u021bii sexuale, mai pu\u021bine tulbur\u0103ri gastrointestinale, mai pu\u021bin\u0103 cre\u0219tere a anxiet\u0103\u021bii. Util c\u00e2nd aceste efecte secundare ale SSRI sunt problematice sau c\u00e2nd insomnia\/pierderea \u00een greutate sunt simptome dominante.<\/p>\n<h3>Mirzacan poate fi combinat cu un SSRI?<\/h3>\n<p>Da \u2014 a\u0219a-numitul \u201ccombustibil rachet\u0103 California\u201d (SSRI\/SNRI + mirtazapin\u0103) este o combina\u021bie recunoscut\u0103 pentru depresia sever\u0103 sau cu r\u0103spuns par\u021bial. Mirtazapina se adaug\u0103 de obicei la 7,5\u201315 mg HS. Se recomand\u0103 supraveghere specializat\u0103.<\/p>\n<h3>C\u00e2t dureaz\u0103 p\u00e2n\u0103 \u00eencepe s\u0103 actioneze Mirzacan?<\/h3>\n<p>Somnul \u0219i pofta de m\u00e2ncare se \u00eembun\u0103t\u0103\u021besc adesea \u00een 1\u20132 s\u0103pt\u0103m\u00e2ni; efectul asupra st\u0103rii de spirit se construie\u0219te \u00een 4\u20136 s\u0103pt\u0103m\u00e2ni la 15\u201330 mg.<\/p>\n<h3>Cum pot \u00eentrerupe tratamentul cu Mirzacan?<\/h3>\n<p>Reduce\u021bi progresiv doza \u00een 2\u20134 s\u0103pt\u0103m\u00e2ni. Sindromul de sevraj este \u00een general mai bl\u00e2nd dec\u00e2t la SSRI\/SNRI, dar s-au descris insomnie \u0219i disforie de rebond.<\/p>\n<h3>Mirzacan afecteaz\u0103 capacitatea de a conduce?<\/h3>\n<p>Da \u2014 \u00een primele 1\u20132 s\u0103pt\u0103m\u00e2ni, seda\u021bia poate afecta timpul de reac\u021bie. Evita\u021bi condusul p\u00e2n\u0103 c\u00e2nd v\u0103 cunoa\u0219te\u021bi toleran\u021ba. Dup\u0103 aceea, majoritatea pacien\u021bilor conduc normal la doze stabile.<\/p>\n<h3>Mirzacan ajut\u0103 \u00een cazul anxiet\u0103\u021bii?<\/h3>\n<p>Da \u2014 antagonismul 5-HT2A \u0219i 5-HT2C contribuie cu un efect anxiolitic semnificativ, adesea vizibil \u00een primele 1-2 s\u0103pt\u0103m\u00e2ni. Util atunci c\u00e2nd depresia \u0219i anxietatea coexist\u0103.<\/p>\n<h3>Mirzacan poate crea dependen\u021b\u0103?<\/h3>\n<p>Nu \u2014 nu produce euforie, nu induce utilizare compulsiv\u0103, nu are toleran\u021b\u0103 cresc\u00e2nd\u0103. Dependen\u021ba fizic\u0103 este u\u0219oar\u0103 \u0219i mai scurt\u0103 dec\u00e2t cea a SSRI.<\/p>\n<h2>Alte Medicamente pentru S\u0103n\u0103tatea Mintal\u0103<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/agoprex\/\">Agoprex (Agomelatin\u0103 \u2014 melatonergic)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/flunil\/\">Flunil (Fluoxetine SSRI)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/duvanta\/\">Duvanta (Duloxetine SNRI)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/bupron-xl\/\">Bupron XL (Bupropion XL \u2014 NDRI)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/lexaheal\/\">Lexaheal (Escitalopram SSRI)<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:0.9em;\">\n<strong>Not\u0103 medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are scop educa\u021bional \u0219i nu \u00eenlocuie\u0219te sfatul medical personalizat. Farmacoterapia pentru s\u0103n\u0103tatea mintal\u0103 ar trebui ini\u021biat\u0103, monitorizat\u0103 \u0219i ajustat\u0103 de c\u0103tre un clinician calificat. Dac\u0103 tu sau cineva cunoscut se afl\u0103 \u00eentr-o criz\u0103 suicidal\u0103, contacteaz\u0103 imediat serviciile de urgen\u021b\u0103 locale sau sun\u0103 la linia de preven\u021bie a suicidului din \u021bara ta (SUA\/Canada: 988; UK: Samaritans 116 123; list\u0103 interna\u021bional\u0103: <a href=\"https:\/\/findahelpline.com\/\" rel=\"nofollow noopener\" target=\"_blank\">findahelpline.com<\/a>).\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mirzacan (Mirtazapin\u0103 15\/30 mg) \u2014 antidepresiv tetraciclic NaSSA pentru TDM cu insomnie, anxietate sau pierdere \u00een greutate. Adesea ad\u0103ugat la SSRI ca \u201ccombustibil rachet\u0103 California\u201d.<\/p>","protected":false},"featured_media":58465,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[4487,4497],"class_list":{"0":"post-58464","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-mirtazapine","10":"product_tag-mirzacan","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/58464","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=58464"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/58465"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=58464"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=58464"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=58464"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=58464"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}