{"id":58482,"date":"2024-02-27T18:38:32","date_gmt":"2024-02-27T18:38:32","guid":{"rendered":"https:\/\/medsname.com\/lukotas\/"},"modified":"2026-04-30T10:24:12","modified_gmt":"2026-04-30T10:24:12","slug":"lukotas","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/lukotas\/","title":{"rendered":"Lukotas"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 10px 0;font-size:18px;color:#1a1a1a;\">\u26a1 Quick Answer \u2014 What is Lukotas?<\/h3>\n<p><strong>Lukotas<\/strong> con\u021bine <strong>montelukast<\/strong>, an oral preventer for asthma and allergic rhinitis. Montelukast blocks <strong>cysteinyl leukotriene receptors (CysLT1)<\/strong>, mediators released by mast cells and eosinophils that drive bronchoconstriction, mucus production, and airway oedema. Used as add-on preventer therapy for asthma, especially exercise-induced and allergy-triggered asthma, and for allergic rhinitis. Each tablet contains <strong>4 \/ 5 \/ 10 mg<\/strong>, fabricat\u0103 de <strong>Intas Pharmaceuticals<\/strong>. Taken <strong>once daily in the evening<\/strong>.<\/p>\n<p><strong>Important \u2014 neuropsychiatric warning:<\/strong> the FDA added a black-box warning in 2020 noting reports of mood changes, sleep disturbance, anxiety, depression, and (rarely) suicidal ideation with montelukast. Discuss any new mood symptoms with your prescriber.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #e0e0e0;padding:12px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;text-align:center;\">\n<strong>\ud83d\udd12 Checkout criptat<\/strong> \u00b7 <strong>\ud83d\udcb3 Procesator Verificat<\/strong> \u00b7 <strong>\ud83d\ude9a Livrare Worldwide<\/strong> \u00b7 <strong>\u2b50 4,9\/5 de la peste 1.400 de clien\u021bi<\/strong>\n<\/div>\n<h2>What Is Lukotas?<\/h2>\n<p>Lukotas is a montelukast (LTRA) preparation manufactured by Intas Pharmaceuticals at WHO-GMP certified facilities. Internationally montelukast is sold as Singulair (MSD). Available as 4 mg, 5 mg, and 10 mg tablets \u2014 strengths chosen by age and indication.<\/p>\n<h2>How Does Lukotas Work?<\/h2>\n<p>Cysteinyl leukotrienes (LTC4, LTD4, LTE4) are inflammatory lipid mediators released by mast cells, eosinophils, and basophils when activated by allergen, exercise, cold air, or aspirin. They bind CysLT1 receptors on airway smooth muscle, eosinophils, and bronchial epithelium \u2014 driving bronchoconstriction, eosinophil recruitment, airway oedema, and mucus hypersecretion. Montelukast selectively blocks CysLT1, breaking this cascade.<\/p>\n<h2>Utiliz\u0103ri \u0219i indica\u021bii<\/h2>\n<ul>\n<li><strong>Astm persistent<\/strong> \u2014 add-on preventer in patients not controlled by ICS alone (alternative to LABA or LAMA add-on)<\/li>\n<li><strong>Astm indus de efort<\/strong> \u2014 particularly effective; taken 2 hours before exercise<\/li>\n<li><strong>Aspirin-exacerbated respiratory disease (AERD)<\/strong> \u2014 leukotrienes are central to this phenotype<\/li>\n<li><strong>Rinit\u0103 alergic\u0103<\/strong> \u2014 both seasonal (hay fever) and perennial<\/li>\n<li><strong>Allergic conjunctivitis adjunct<\/strong><\/li>\n<li><strong>Urti cronic\u0103<\/strong> \u2014 montelukast as adjunct to high-dose antihistamine<\/li>\n<\/ul>\n<h2>Lukotas Dosage<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Pacient<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Doza<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Frecven\u021b\u0103<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Adults &amp; children &gt;15 yr<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>10 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">O dat\u0103 pe zi seara<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Copii 6\u201314 ani<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>5 mg chewable<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">O dat\u0103 pe zi seara<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Copii 2\u20135 ani<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>4 mg chewable \/ granules<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">O dat\u0103 pe zi seara<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Children 6 mo \u2013 2 yr<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>4 mg granules<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">O dat\u0103 pe zi \u2014 sub supraveghere specializat\u0103<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Side Effects of Lukotas<\/h2>\n<ul>\n<li>Dureri de cap<\/li>\n<li>Dureri abdominale u\u0219oare sau grea\u021b\u0103<\/li>\n<li>Sleep disturbance (vivid dreams, insomnia)<\/li>\n<li>Mood changes \u2014 irritability, anxiety, depression (FDA black-box warning, 2020)<\/li>\n<li>Upper respiratory infection symptoms<\/li>\n<li>Erup\u021bie cutanat\u0103<\/li>\n<\/ul>\n<p><strong>Severe \u2014 \u00eentrerupe\u021bi \u0219i c\u0103uta\u021bi ajutor medical:<\/strong><\/p>\n<ul>\n<li>Reac\u021bie alergic\u0103 sever\u0103 \/ angioedem<\/li>\n<li>Suicidal ideation or severe depression \u2014 STOP and seek urgent psychiatric review<\/li>\n<li>Churg-Strauss syndrome (eosinophilic vasculitis) \u2014 rare; suspect in ICS-tapering patients with new vasculitic features (rash, neuropathy, eosinophilia)<\/li>\n<li>Hepatitis (rare)<\/li>\n<\/ul>\n<h2>Avertismente \u0219i precau\u021bii<\/h2>\n<ul>\n<li><strong>Black-box warning \u2014 neuropsychiatric events.<\/strong> If new mood changes, anxiety, sleep disturbance, agitation, depression, or suicidal thoughts occur, stop Lukotas and contact your prescriber.<\/li>\n<li><strong>Nu este un medicament de salvare.<\/strong> Do not use in acute asthma attacks \u2014 onset is too slow.<\/li>\n<li><strong>Continua\u021bi terapia cu ICS<\/strong> if previously prescribed; montelukast does not replace inhaled corticosteroids.<\/li>\n<li><strong>Afectare hepatic\u0103:<\/strong> use cautiously in moderate-to-severe disease.<\/li>\n<li><strong>Sarcin\u0103 \u0219i al\u0103ptare:<\/strong> reasonable safety data; use when benefits outweigh risks.<\/li>\n<li><strong>Copii<\/strong> may show increased risk of behavioural changes \u2014 counsel parents to monitor mood.<\/li>\n<\/ul>\n<h2>Contraindica\u021bii<\/h2>\n<ul>\n<li>Hypersensitivity to montelukast or excipients<\/li>\n<li>Severe hepatic impairment \u2014 relative<\/li>\n<li><\/li>\n<\/ul>\n<h2>Interac\u021biuni medicamentoase<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Medicament interactiv<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Efect<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Ce s\u0103 face\u021bi<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Phenobarbital, phenytoin, rifampicin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Induce CYP enzymes \u2014 reduce montelukast levels<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor asthma control<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Gemfibrozil<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Inhibits CYP2C8 \u2014 increases montelukast levels<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Utiliza\u021bi cu precau\u021bie<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Warfarin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Theoretical INR change reported in case reports<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor INR after starting\/stopping<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Depozitare<\/h2>\n<ul>\n<li>Depozita\u021bi la temperaturi sub <strong>25\u00b0C<\/strong> \u00eentr-un loc r\u0103coros \u0219i uscat, departe de lumina direct\u0103 a soarelui.<\/li>\n<li>P\u0103stra\u021bi \u00een ambalajul original p\u00e2n\u0103 la utilizare pentru a proteja de umiditate \u0219i lumin\u0103.<\/li>\n<li>Nu utiliza\u021bi dup\u0103 data de expirare tip\u0103rit\u0103 pe blister.<\/li>\n<li>P\u0103stra\u021bi la distan\u021b\u0103 de copii.<\/li>\n<\/ul>\n<h2>Alternative conexe pe MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/asthalin-inhaler\/\"><strong>Asthalin Inhaler \u2014 salbutamol pentru ameliorarea simptomelor<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/budecort-inhaler\/\"><strong>Budecort Inhaler \u2014 budesonide ICS pentru preven\u021bie<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/foracort-inhaler\/\"><strong>Foracort Inhaler \u2014 budesonide + formoterol ICS-LABA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tiova-inhaler\/\"><strong>Tiova Inhaler \u2014 tiotropium LAMA pentru BPOC<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/montair\/\"><strong>Montair \u2014 comprimat montelukast LTRA<\/strong><\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>When should I take montelukast?<\/h3>\n<p>Once daily in the evening, with or without food. Evening dosing matches the typical overnight rise in leukotriene mediators and gives best protection against early-morning symptoms.<\/p>\n<h3>How long until montelukast works?<\/h3>\n<p>Some symptom relief within 24\u201348 hours. Full effect on asthma exacerbation rate develops over 4\u20138 weeks.<\/p>\n<h3>Should I worry about the FDA black-box warning?<\/h3>\n<p>The 2020 FDA black-box warning highlighted reports of mood changes, sleep disturbance, anxiety, depression, and rarely suicidal ideation \u2014 particularly in children. The absolute risk is low but real. Watch for any new mood symptoms in yourself or your child; stop the drug and contact your prescriber if they appear.<\/p>\n<h3>Can montelukast replace my inhaler?<\/h3>\n<p>No \u2014 montelukast is an add-on preventer. It does not replace inhaled corticosteroids (Budecort, Beclate, Foracort, Seretide). Continue ICS as prescribed.<\/p>\n<h3>Is montelukast a rescue medication?<\/h3>\n<p>No \u2014 onset is too slow. Use a SABA (Asthalin, Levolin) for acute attacks.<\/p>\n<h3>Can children take montelukast?<\/h3>\n<p>Yes from 6 months of age in age-appropriate strengths (4 mg granules, 4 mg or 5 mg chewable, 10 mg tablet). Counsel parents to monitor mood and behaviour.<\/p>\n<h3>Is montelukast safe in pregnancy?<\/h3>\n<p>Reasonable observational data; use when benefits outweigh risks, particularly in patients whose asthma is well-controlled on it.<\/p>\n<h3>Does montelukast help allergic rhinitis?<\/h3>\n<p>Yes \u2014 montelukast is licensed for both asthma and allergic rhinitis. Particularly useful when both coexist (United Airways disease).<\/p>\n<h3>Should I stop montelukast if I feel better?<\/h3>\n<p>No \u2014 continue daily for as long as your prescriber advises. Stopping leads to gradual return of symptoms over days-to-weeks.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Avertizare medical\u0103:<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical profesionist. Consult\u0103 \u00eentotdeauna un profesionist calificat \u00een s\u0103n\u0103tate \u00eenainte de a \u00eencepe, \u00eentrerupe sau schimba orice inhalator sau medicament respirator, mai ales dac\u0103 ai alte afec\u021biuni medicale, iei alte re\u021bete, e\u0219ti gravid\u0103 sau al\u0103ptezi, sau ai peste 65 de ani.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alternative conexe<\/h3>\n<p>Alte produse din <strong>Afec\u021biuni cronice<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/calpol\/\">Calpol<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/hivus-lr\/\">Hivus LR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/rami-race\/\">Rami Race<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/dynapar\/\">Dynapar<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/indicid-75-sr\/\">Indicid-75 SR<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Trateaz\u0103 alergiile<br \/>\n\u2705 Amelioreaz\u0103 simptomele astmului<br \/>\n\u2705 Reduces bronchoconstriction<br \/>\n\u2705 Controls wheezing<br \/>\n\u2705 Prevents airway inflammation<\/p>\n<p>Lukotas contains Montelukast.<\/p>","protected":false},"featured_media":58483,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3681,3141,3223],"product_tag":[4501,4499],"class_list":{"0":"post-58482","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-asthma-copd-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-lukotas","10":"product_tag-montelukast","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/58482","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=58482"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/58483"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=58482"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=58482"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=58482"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=58482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}