{"id":58609,"date":"2024-02-28T05:19:38","date_gmt":"2024-02-28T05:19:38","guid":{"rendered":"https:\/\/medsname.com\/oliza\/"},"modified":"2026-04-30T10:24:11","modified_gmt":"2026-04-30T10:24:11","slug":"oliza","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/oliza\/","title":{"rendered":"Oliza"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8d6;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">\u26a1 R\u0103spuns rapid<\/h3>\n<p style=\"margin-bottom:0;\">Oliza (Olanzapin\u0103 2,5 \/ 5 \/ 10 mg) este un antipsihotic atipic pentru schizofrenie, manie bipolar\u0103 \u0219i tratament de \u00eentre\u021binere, depresie rezistent\u0103 la tratament (\u00een asociere cu fluoxetin\u0103) \u0219i agita\u021bie acut\u0103. Cel mai puternic efect antipsihotic dintre atipice \u2014 dar \u0219i cel mai mare risc metabolic.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Oliza la MedsBase este furnizat\u0103 direct de la un produc\u0103tor certificat WHO-GMP \u00een ambalaje simple \u0219i discrete. Fiecare comand\u0103 este acoperit\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> \u2014 perioad\u0103 de livrare de 20 de zile lucr\u0103toare sau retrimitem f\u0103r\u0103 costuri suplimentare \u2014 \u0219i se calific\u0103 pentru <a href=\"https:\/\/medsbase.com\/ro\/loyalty-points\/\">programul nostru de loialitate pentru clien\u021bi<\/a>. Livr\u0103rile sunt disponibile \u00een majoritatea destina\u021biilor la nivel mondial.<\/p>\n<h2>Ce este Oliza \u0219i cum func\u021bioneaz\u0103<\/h2>\n<p>Oliza este un comprimat de olanzapin\u0103 furnizat de Cipla. Doze disponibile: <strong>2,5 \/ 5 \/ 10 mg<\/strong>. Olanzapina este un antipsihotic atipic tienobenzodiazepinic cu antagonism puternic D2, antagonism puternic 5-HT2A \u0219i blocaj substan\u021bial H1 (sedare, cre\u0219tere \u00een greutate), M1 (anticolinergic) \u0219i \u03b11 (ortostatism). Profilul receptorilor H1+M1 este responsabil at\u00e2t pentru efectul s\u0103u calmant\/sedativ (util \u00een agita\u021bia acut\u0103), c\u00e2t \u0219i pentru povara metabolic\u0103.<\/p>\n<h2>Indica\u021bii \u0219i dozaj<\/h2>\n<table>\n<thead>\n<tr>\n<th>Indica\u021bie<\/th>\n<th>Doza ini\u021bial\u0103<\/th>\n<th>\u021aint\u0103<\/th>\n<th>Maxim<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Schizofrenie (adul\u021bi)<\/td>\n<td>5\u201310 mg OD<\/td>\n<td>10\u201320 mg o dat\u0103 pe zi<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Schizofrenie (adolescent \u2265 13 ani)<\/td>\n<td>2,5\u20135 mg OD<\/td>\n<td>10 mg OD<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Manie bipolar\u0103 (adult)<\/td>\n<td>10\u201315 mg pe zi<\/td>\n<td>10\u201320 mg o dat\u0103 pe zi<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Agita\u021bie acut\u0103 (IM)<\/td>\n<td>10 mg IM<\/td>\n<td>\u2014<\/td>\n<td>3 doze\/24h<\/td>\n<\/tr>\n<tr>\n<td>Depresie rezistent\u0103 la tratament (cu fluoxetin\u0103)<\/td>\n<td>5 mg + 20 mg fluoxetin\u0103<\/td>\n<td>5\u201318 mg<\/td>\n<td>18 mg<\/td>\n<\/tr>\n<tr>\n<td>Pacien\u021bi v\u00e2rstnici<\/td>\n<td>2,5\u20135 mg OD<\/td>\n<td>5\u201310 mg OD<\/td>\n<td>\u00een func\u021bie de tolerabilitate<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Considera\u021bii importante de siguran\u021b\u0103<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>FDA black-box \u2014 psihoz\u0103 asociat\u0103 demen\u021bei<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Toate antipsihoticele atipice poart\u0103 un avertisment FDA black-box pentru mortalitate crescut\u0103 (\u00een principal cardiovascular\u0103 \u0219i infec\u021bioas\u0103) atunci c\u00e2nd sunt utilizate pentru tratarea tulbur\u0103rilor de comportament la adul\u021bii \u00een v\u00e2rst\u0103 cu demen\u021b\u0103. <strong>Antipsihoticele atipice nu sunt aprobate pentru psihoza sau agita\u021bia asociat\u0103 demen\u021bei<\/strong>. Utilizarea \u00een aceast\u0103 popula\u021bie este off-label, de ultim\u0103 instan\u021b\u0103, limitat\u0103 \u00een timp \u0219i necesit\u0103 o discu\u021bie explicit\u0103 despre raportul risc-beneficiu.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Cea mai mare povar\u0103 metabolic\u0103 a antipsihoticelor atipice<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Olanzapina produce cea mai mare cre\u0219tere \u00een greutate (de obicei 4\u201310 kg \u00een primele 6 luni, uneori mult mai mult), cea mai mare rezisten\u021b\u0103 la insulin\u0103 \u0219i cea mai mare perturbare lipidic\u0103 dintre toate antipsihoticele utilizate \u00een mod obi\u0219nuit. Pacien\u021bii pot dezvolta diabet de tip 2 \u00een c\u00e2teva luni de la \u00eenceperea tratamentului. <strong>Monitorizare obligatorie: greutate la fiecare vizit\u0103; glicemie \u00een stare de post \/ HbA1c \u0219i lipide \u00een stare de post la \u00eenceput, la 12 s\u0103pt\u0103m\u00e2ni, apoi la fiecare 6 luni.<\/strong> Consiliere privind dieta \u0219i exerci\u021biile fizice de la \u00eenceput.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Sedare \u0219i povar\u0103 anticolinergic\u0103<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Sedare puternic\u0103 \u00een primele 1\u20132 s\u0103pt\u0103m\u00e2ni. Efectele anticolinergice (gur\u0103 uscat\u0103, constipa\u021bie, dificultate la urinare) sunt universale. Ambele se atenueaz\u0103, dar nu dispar complet.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Olanzapin\u0103 + benzodiazepin\u0103 IM \u2014 precau\u021bie<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Combinarea olanzapinei IM cu benzodiazepinele parenterale a produs cazuri de hipotensiune sever\u0103, depresie respiratorie \u0219i deces. Dac\u0103 ambele sunt necesare clinic \u00een agita\u021bia acut\u0103, administra\u021bi-le la interval de \u2265 1 or\u0103 \u0219i monitoriza\u021bi \u00eendeaproape.<\/p>\n<\/div>\n<h2>Efecte secundare frecvente<\/h2>\n<ul>\n<li><strong>Cre\u0219tere \u00een greutate \u0219i sindrom metabolic<\/strong> \u2014 principiul \u00eengrijorare pe termen lung dominant.<\/li>\n<li><strong>Sedare<\/strong> \u2014 universal la \u00eenceput.<\/li>\n<li><strong>Hipotensiune ortostatic\u0103<\/strong> \u2014 frecvent la \u00eenceput; titra\u021bi lent la adul\u021bii \u00een v\u00e2rst\u0103.<\/li>\n<li><strong>Anticolinergic<\/strong> \u2014 gur\u0103 uscat\u0103, constipa\u021bie, dificultate la urinare.<\/li>\n<li><strong>Acatisie, EPS<\/strong> \u2014 mai pu\u021bin frecvent dec\u00e2t risperidonul, mai frecvent dec\u00e2t aripiprazolul.<\/li>\n<li><strong>Prolactina<\/strong> \u2014 cre\u0219tere moderat\u0103; mai mic\u0103 dec\u00e2t risperidonul.<\/li>\n<li><strong>Hepatic<\/strong> \u2014 cre\u0219teri tranzitorii ale AST\/ALT frecvente.<\/li>\n<\/ul>\n<h2>Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>Inhibitori CYP1A2<\/strong> (fluvoxamin\u0103, ciprofloxacin\u0103) \u2014 cresc nivelurile de olanzapin\u0103 semnificativ.<\/li>\n<li><strong>Fumatul<\/strong> \u2014 induce CYP1A2; fum\u0103torii au niveluri mai sc\u0103zute \u0219i necesit\u0103 doze mai mari; renun\u021barea la fumat poate produce toxicitate.<\/li>\n<li><strong>Carbamazepin\u0103<\/strong> \u2014 induc\u021bie puternic\u0103 a CYP1A2; cre\u0219te clearance-ul de olanzapin\u0103.<\/li>\n<li><strong>Depresante ale SNC<\/strong> \u2014 sedare aditiv\u0103.<\/li>\n<li><strong>Anticolinergice<\/strong> \u2014 povar\u0103 aditiv\u0103.<\/li>\n<\/ul>\n<h2>Sarcina, al\u0103ptare, pediatric<\/h2>\n<p>Sarcina: date limitate; evalua\u021bi \u00een raport cu boala netratat\u0103; expunerea \u00een sarcin\u0103 t\u00e2rzie poate produce EPS neonatal sau sevraj. Al\u0103ptare: trece \u00een lapte; de obicei necesit\u0103 alternativ\u0103 sau monitorizare atent\u0103. Pediatric: autorizat de la 13 ani (schizofrenie, bipolar).<\/p>\n<h2>Depozitare<\/h2>\n<p>P\u0103strare la 15\u201330 \u00b0C \u00een ambalajul original.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>De ce provoac\u0103 Oliza o cre\u0219tere at\u00e2t de mare a greut\u0103\u021bii?<\/h3>\n<p>Olanzapina, prin combina\u021bia de efecte antihistaminice H1, antagonism 5-HT2C \u0219i alte efecte receptoriale, produce o stimulare puternic\u0103 a apetitului, \u00eencetinirea satiet\u0103\u021bii \u0219i o preferin\u021b\u0103 modificat\u0103 pentru carbohidra\u021bi. Cre\u0219terea \u00een greutate este dependent\u0103 de doz\u0103, dar apare chiar \u0219i la doze mici. Consilierea privind dieta \u0219i exerci\u021biile fizice din prima s\u0103pt\u0103m\u00e2n\u0103, plus monitorizarea regulat\u0103 a greut\u0103\u021bii, sunt obligatorii.<\/p>\n<h3>Cum difer\u0103 Oliza de risperidon sau aripiprazol?<\/h3>\n<p>Olanzapina are cel mai puternic efect antipsihotic acut \u0219i cea mai rapid\u0103 ac\u021biune calmant\u0103 \u2014 util\u0103 \u00een agita\u021bia acut\u0103. Compromisul este cea mai mare povar\u0103 metabolic\u0103. Risperidonul este mai eficient pentru unele simptome pozitive, dar cre\u0219te prolactina substan\u021bial. Aripiprazolul este cel mai neutru metabolic, dar produce mai mult\u0103 acatisie.<\/p>\n<h3>Trebuie s\u0103 monitorizez nivelul zah\u0103rului din s\u00e2nge c\u00e2nd iau Oliza?<\/h3>\n<p>Da \u2014 glicemia la stomacul gol sau HbA1c la \u00eenceput, dup\u0103 12 s\u0103pt\u0103m\u00e2ni \u0219i apoi la fiecare 6 luni. Olanzapina poate provoca diabet \u00een c\u00e2teva luni de la \u00eenceperea tratamentului, uneori prezent\u00e2ndu-se cu cetoacidoz\u0103 diabetic\u0103. Nu s\u0103ri\u021bi peste monitorizare.<\/p>\n<h3>Oliza poate fi utilizat\u0103 pe termen lung?<\/h3>\n<p>Da \u2014 \u00een special pentru men\u021binerea schizofreniei, unde olanzapina dep\u0103\u0219e\u0219te adesea alte medicamente atipice \u00een ceea ce prive\u0219te rata de recidiv\u0103. Povara metabolic\u0103 este principalul motiv pentru care utilizarea pe termen lung necesit\u0103 monitorizare atent\u0103 a greut\u0103\u021bii, glicemiei \u0219i lipidelor, plus gestionarea activ\u0103 a riscului cardiometabolic.<\/p>\n<h3>C\u00e2t dureaz\u0103 p\u00e2n\u0103 \u00eencepe s\u0103 ac\u021bioneze Oliza?<\/h3>\n<p>Efectul calmant apare \u00een 1\u20132 ore de la prima doz\u0103 oral\u0103. Efectul antipsihotic se dezvolt\u0103 \u00een 1\u20132 s\u0103pt\u0103m\u00e2ni; efectul antipsihotic \u0219i stabilizator de dispozi\u021bie complet la 4\u20136 s\u0103pt\u0103m\u00e2ni.<\/p>\n<h3>Cum stau lucrurile cu condusul sub influen\u021ba Olizei?<\/h3>\n<p>Evita\u021bi condusul \u00een primele 1\u20132 s\u0103pt\u0103m\u00e2ni de titrare. Majoritatea pacien\u021bilor la doze stabile conduc normal, dar sedarea poate persista la doze mai mari.<\/p>\n<h3>Forma orodispersibil\u0103 este diferit\u0103?<\/h3>\n<p>Da \u2014 exist\u0103 versiuni orodispersibile (ODT) de olanzapin\u0103 (Zyprexa Zydis, Olimelt) care se dizolv\u0103 pe limb\u0103 f\u0103r\u0103 ap\u0103. Bioechivalente cu comprimatele standard, dar utile la pacien\u021bii cu probleme de adheren\u021b\u0103 sau disfagie.<\/p>\n<h3>Oliza poate fi combinat\u0103 cu fluoxetina?<\/h3>\n<p>Da \u2014 combina\u021bia de olanzapin\u0103-fluoxetin\u0103 (OFC, Symbyax) este aprobat\u0103 de FDA pentru depresia rezistent\u0103 la tratament \u0219i depresia bipolar\u0103. Fluoxetina abordeaz\u0103 par\u021bial lipsa efectului antidepresiv al olanzapinei; olanzapina adaug\u0103 o component\u0103 puternic\u0103 de stabilizare a dispozi\u021biei.<\/p>\n<h3>De ce conteaz\u0103 fumatul?<\/h3>\n<p>Fumatul induce puternic CYP1A2, care este principalul enzim metabolic al olanzapinei. Fum\u0103torii metabolizeaz\u0103 olanzapina mai repede \u0219i au nevoie de doze mai mari; \u00eencetarea brusc\u0103 a fumatului (de ex. la internare) poate provoca toxicitate de olanzapin\u0103 dac\u0103 doza nu este ajustat\u0103. Spune\u021bi medicului prescriptor dac\u0103 statutul de fum\u0103tor se schimb\u0103.<\/p>\n<h3>Oliza poate fi \u00eentrerupt\u0103 brusc?<\/h3>\n<p>\u00cen general nu \u2014 reduce\u021bi treptat pe parcursul a 2\u20134 s\u0103pt\u0103m\u00e2ni. \u00centreruperea brusc\u0103 poate provoca rebound colinergic (gre\u021buri, transpira\u021bii, insomnie) \u0219i recidiv\u0103 psihotic\u0103. Nu \u00eenceta\u021bi niciodat\u0103 f\u0103r\u0103 acordul medicului prescriptor.<\/p>\n<h2>Alte Medicamente pentru S\u0103n\u0103tatea Mintal\u0103<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/aripicon\/\">Aripicon (Aripiprazol \u2014 agonist par\u021bial D2)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/olanzap\/\">Olanzap (Olanzapin\u0103 \u2014 antipsihotic puternic)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/risdone\/\">Risdone (Risperidon\u0103)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/seroquit\/\">Seroquit (Quetiapin\u0103 \u2014 depresie bipolar\u0103)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/atlura\/\">Atlura (Lurasidon\u0103 \u2014 metabolic neutru)<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:0.9em;\">\n<strong>Not\u0103 medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are scop educa\u021bional \u0219i nu \u00eenlocuie\u0219te sfatul medical personalizat. Farmacoterapia pentru s\u0103n\u0103tatea mintal\u0103 ar trebui ini\u021biat\u0103, monitorizat\u0103 \u0219i ajustat\u0103 de c\u0103tre un clinician calificat. Dac\u0103 tu sau cineva cunoscut se afl\u0103 \u00eentr-o criz\u0103 suicidal\u0103, contacteaz\u0103 imediat serviciile de urgen\u021b\u0103 locale sau sun\u0103 la linia de preven\u021bie a suicidului din \u021bara ta (SUA\/Canada: 988; UK: Samaritans 116 123; list\u0103 interna\u021bional\u0103: <a href=\"https:\/\/findahelpline.com\/\" rel=\"nofollow noopener\" target=\"_blank\">findahelpline.com<\/a>).\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Oliza (Olanzapin\u0103 2,5\/5\/10 mg) \u2014 tienobenzodiazepin\u0103 atipic\u0103 pentru schizofrenie \u0219i manie bipolar\u0103. Efect calmant puternic \u00een agita\u021bie sever\u0103.<\/p>","protected":false},"featured_media":58610,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[4527,4529],"class_list":{"0":"post-58609","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-olanzapine","10":"product_tag-oliza","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/58609","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=58609"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/58610"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=58609"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=58609"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=58609"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=58609"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}