{"id":58759,"date":"2024-02-28T05:27:04","date_gmt":"2024-02-28T05:27:04","guid":{"rendered":"https:\/\/medsname.com\/admenta\/"},"modified":"2026-05-01T10:49:14","modified_gmt":"2026-05-01T10:49:14","slug":"admenta","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/admenta\/","title":{"rendered":"Admenta"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Admenta?<\/h3>\n<p style=\"margin:0;\"><strong>Admenta<\/strong> este un comprimat oral de la Sun Pharma care con\u021bine <strong>memantin\u0103 5 mg<\/strong> \u2014 un <strong>antagonist necompetitiv al receptorilor NMDA<\/strong> utilizat pentru tratamentul simptomatic al <strong>boala Alzheimer moderat-sever\u0103<\/strong>. Memantina este <strong>prime\u0219te,<\/strong> indicat\u0103 pentru boala Alzheimer u\u0219oar\u0103. Titrare progresiv\u0103 pe parcursul a 4 s\u0103pt\u0103m\u00e2ni: <strong>5 mg s\u0103pt\u0103m\u00e2na 1, 10 mg s\u0103pt\u0103m\u00e2na 2 (5 mg de dou\u0103 ori pe zi), 15 mg s\u0103pt\u0103m\u00e2na 3, 20 mg din s\u0103pt\u0103m\u00e2na 4 \u00eencolo (10 mg de dou\u0103 ori pe zi)<\/strong>. \u00cen general bine tolerat \u2014 principalele efecte secundare sunt ame\u021beli, cefalee, constipa\u021bie \u0219i confuzie. <strong>Reduce\u021bi doza dac\u0103 eGFR &lt; 30 mL\/min<\/strong>. Adesea combinat cu donepezil \u00een boala moderat-sever\u0103 pentru beneficii cognitive aditive.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<h2 class=\"wp-block-heading\">Ce este Admenta?<\/h2>\n<p>Admenta este un comprimat oral de la Sun Pharma care con\u021bine <strong>memantin\u0103 hidroclorur\u0103 5 mg<\/strong>. Memantina este un antagonist necompetitiv al receptorului NMDA glutamat, cu afinitate sc\u0103zut\u0103 \u0219i dependen\u021b\u0103 de tensiune. Este distinct\u0103 din punct de vedere mecanic de inhibitorii de colinesteraz\u0103 (donepezil, galantamin\u0103, rivastigmin\u0103) \u0219i ac\u021bioneaz\u0103 prin cea de-a doua cale principal\u0103 implicat\u0103 \u00een boala Alzheimer \u2014 excitotoxicitatea glutamatului. <strong>Admenta de la Sun Pharma este un comprimat de memantin\u0103 5 mg \u2014 doza utilizat\u0103 \u00een timpul titr\u0103rii obligatorii de 4 s\u0103pt\u0103m\u00e2ni p\u00e2n\u0103 la doza de \u00eentre\u021binere de 20 mg\/zi. Dozarea de \u00eentre\u021binere este de dou\u0103 comprimate de 5 mg de dou\u0103 ori pe zi (4 comprimate \u00een total pe zi). Memantina este autorizat\u0103 doar pentru<\/strong>. It is mechanistically distinct from the cholinesterase inhibitors (donepezil, galantamine, rivastigmine) and works through the second major pathway implicated in Alzheimer's disease \u2014 glutamate excitotoxicity.<\/p>\n<p>Admenta from Sun Pharma is a 5 mg memantine tablet \u2014 the strength used during the mandatory 4-week up-titration to the 20 mg\/day maintenance dose. Maintenance dosing is two 5 mg tablets twice daily (4 tablets total per day). Memantine is licensed only for <strong>boala Alzheimer moderat-sever\u0103<\/strong> \u2014 nu este u\u0219oar\u0103. Este tratamentul standard adi\u021bional la un inhibitor de colinesteraz\u0103 (de obicei donepezil) c\u00e2nd pacien\u021bii progreseaz\u0103 dincolo de stadiul u\u0219or \u0219i ofer\u0103 beneficii cognitive \u0219i func\u021bionale adi\u021bionale cu o cre\u0219tere minim\u0103 a efectelor secundare.<\/p>\n<h2 class=\"wp-block-heading\">Cum func\u021bioneaz\u0103 Admenta?<\/h2>\n<p>Boala Alzheimer provoac\u0103 semnalizare cronic\u0103 excesiv\u0103 a glutamatului la receptorii NMDA \u2014 un proces numit <strong>excitotoxicitate glutamatergic\u0103<\/strong>. Activarea constant\u0103 la nivel sc\u0103zut a NMDA lezeaz\u0103 neuronii \u0219i perturb\u0103 raportul semnal-zgomot de care creierul are nevoie pentru \u00eenv\u0103\u021bare \u0219i memorie. Memantina abordeaz\u0103 acest lucru printr-un mecanism unic:<\/p>\n<ul>\n<li><strong>Blocare NMDA dependent\u0103 de tensiune<\/strong> \u2014 memantina se leag\u0103 de canalele receptorilor NMDA, dar numai atunci c\u00e2nd acestea sunt deja deschise. Blocheaz\u0103 activarea excitotoxic\u0103 cronic\u0103 la nivel sc\u0103zut, dar elibereaz\u0103 receptorul \u00een timpul semnaliz\u0103rii fiziologice de amplitudine mare necesar\u0103 pentru \u00eenv\u0103\u021bare. Aceasta este diferen\u021ba cheie dintre memantin\u0103 \u0219i blocurile mai vechi de NMDA, cum ar fi ketamina, care blocheaz\u0103 ambele moduri \u0219i provoac\u0103 deficien\u021be cognitive.<\/li>\n<li><strong>Restabile\u0219te raportul semnal-zgomot<\/strong> \u2014 prin reducerea zgomotului de fond al glutamatului, memantina \u00eembun\u0103t\u0103\u021be\u0219te capacitatea creierului de a detecta semnale semnificative \u00een timpul sarcinilor de \u00eenv\u0103\u021bare \u0219i memorie.<\/li>\n<li><strong>Efect neuroprotector<\/strong> \u2014 excitotoxicitatea redus\u0103 poate \u00eencetini progresia leziunilor neuronale, de\u0219i acest lucru nu a fost demonstrat \u00een mod clar c\u0103 se traduce \u00eentr-un efect modificator al bolii cu relevan\u021b\u0103 clinic\u0103.<\/li>\n<\/ul>\n<p>Apariere a beneficiului cognitiv: observabil\u0103 la <strong>4\u201312 s\u0103pt\u0103m\u00e2ni<\/strong> dup\u0103 atingerea dozei de \u00eentre\u021binere de 20 mg\/zi; beneficiul maxim la 6 luni.<\/p>\n<h2 class=\"wp-block-heading\">Utiliz\u0103ri \u0219i indica\u021bii<\/h2>\n<ul>\n<li><strong>Demen\u021b\u0103 Alzheimer moderat-sever\u0103<\/strong> \u2014 indica\u021bie de prim\u0103 inten\u021bie<\/li>\n<li><strong>Terapie combinat\u0103 cu un inhibitor de colinesteraz\u0103<\/strong> \u2014 standardul de \u00eengrijire \u00een boala Alzheimer moderat-sever\u0103; beneficii cognitive adi\u021bionale<\/li>\n<li><strong>Dem\u0103 vascular\u0103 (tip mixt)<\/strong> \u2014 beneficiu modest \u00een afara indica\u021biilor<\/li>\n<li><strong>Demena\u021b\u0103 cu corpii Lewy<\/strong> \u2014 utilizare off-label, util\u0103 pentru simptomele comportamentale<\/li>\n<\/ul>\n<p>Admenta este <strong>prime\u0219te,<\/strong> indicat pentru: <strong>boala Alzheimer u\u0219oar\u0103<\/strong> (inhibitorii de colinesteraz\u0103 sunt de prim\u0103 linie \u00een aceast\u0103 etap\u0103), deficien\u021b\u0103 cognitiv\u0103 u\u0219oar\u0103 f\u0103r\u0103 demen\u021b\u0103, demen\u021b\u0103 frontotemporal\u0103 sau ca stimulator cognitiv la adul\u021bii s\u0103n\u0103to\u0219i.<\/p>\n<h2 class=\"wp-block-heading\">Doza Admenta \u0219i Cum s\u0103 o Lua\u021bi \u2014 TITRARE \u00ceNCET<\/h2>\n<p>Admenta este disponibil\u0103 \u00een <strong>5 mg<\/strong> comprimate. Schema de titrare este obligatorie \u2014 trecerea direct\u0103 la 20 mg\/zi provoac\u0103 confuzie \u0219i ame\u021beli intolerabile la majoritatea pacien\u021bilor.<\/p>\n<p><strong>Titrare standard de 4 s\u0103pt\u0103m\u00e2ni:<\/strong><\/p>\n<ul>\n<li><strong>S\u0103pt\u0103m\u00e2na 1:<\/strong> 5 mg o dat\u0103 pe zi (1 comprimat diminea\u021ba)<\/li>\n<li><strong>S\u0103pt\u0103m\u00e2na 2:<\/strong> 10 mg\/zi = 5 mg de dou\u0103 ori pe zi (diminea\u021ba + seara)<\/li>\n<li><strong>S\u0103pt\u0103m\u00e2na 3:<\/strong> 15 mg\/zi = 10 mg diminea\u021ba + 5 mg seara<\/li>\n<li><strong>S\u0103pt\u0103m\u00e2na 4 \u0219i ulterior (mentenan\u021b\u0103):<\/strong> 20 mg\/zi = 10 mg de dou\u0103 ori pe zi<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\">Cum s\u0103 lua\u021bi corect Admenta<\/h3>\n<ol>\n<li><strong>Se administreaz\u0103 cu sau f\u0103r\u0103 alimente<\/strong> \u2014 alimenta\u021bia nu afecteaz\u0103 absorb\u021bia.<\/li>\n<li><strong>\u00cenghi\u021bi\u021bi \u00eentreaga tablet\u0103 cu ap\u0103.<\/strong> Comprimatele standard pot fi \u00eemp\u0103r\u021bite dac\u0103 au linie de divizare.<\/li>\n<li><strong>De dou\u0103 ori pe zi la doza de mentenan\u021b\u0103<\/strong> (10 mg diminea\u021ba + 10 mg seara), cu interval de aproximativ 12 ore.<\/li>\n<li><strong>Ajustare doz\u0103 la pacien\u021bii cu insuficien\u021b\u0103 renal\u0103:<\/strong> dac\u0103 GFR estimat este 30\u201349 mL\/min, limita\u021bi doza de mentenan\u021b\u0103 la 10 mg\/zi. Dac\u0103 eGFR este 5\u201329 mL\/min, doza de mentenan\u021b\u0103 este de 10 mg\/zi. Evita\u021bi la eGFR &lt; 5 mL\/min.<\/li>\n<li><strong>Doz\u0103 omis\u0103:<\/strong> dac\u0103 v\u0103 aminti\u021bi \u00een aceea\u0219i zi, lua\u021bi-o. Dac\u0103 v\u0103 aminti\u021bi a doua zi, omite\u021bi \u0219i relua\u021bi normal \u2014 nu dubla\u021bi doza.<\/li>\n<li><strong>Dac\u0103 tratamentul este \u00eentrerupt pentru mai multe zile<\/strong>, relua\u021bi cu 5 mg\/zi \u0219i retitra\u021bi \u00een decurs de 4 s\u0103pt\u0103m\u00e2ni. Memantina nu are sindrom de \u00eentrerupere acut\u0103, dar titrarea lent\u0103 este necesar\u0103 pentru a evita efectele secundare.<\/li>\n<li><strong>Supravegherea \u00eengrijitorului este esen\u021bial\u0103<\/strong> \u2014 pacien\u021bii cu Alzheimer moderat-sever rareori reu\u0219esc s\u0103 administreze dozele de dou\u0103 ori pe zi \u00een mod fiabil f\u0103r\u0103 sprijin. Folosi\u021bi un organizator de pastile s\u0103pt\u0103m\u00e2nal umplut de un membru al familiei sau de un \u00eengrijitor.<\/li>\n<li><strong>Reevaluare dup\u0103 6 luni<\/strong> cu teste cognitive formale (MMSE sau MoCA). Continua\u021bi dac\u0103 exist\u0103 beneficii sau stabilizare; opri\u021bi treptat dac\u0103 se \u00eenregistreaz\u0103 o deteriorare clar\u0103 \u00een ciuda tratamentului la doza maxim\u0103.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Efectele Secundare ale Admenta<\/h2>\n<p><strong>Frecvente (cele mai accentuate \u00een perioada de titrare, se atenueaz\u0103 odat\u0103 cu doza de \u00eentre\u021binere):<\/strong><\/p>\n<ul>\n<li>Ame\u021beli<\/li>\n<li>Dureri de cap<\/li>\n<li>Confuzie sau agravarea confuziei (adesea se \u00eembun\u0103t\u0103\u021be\u0219te odat\u0103 cu doza stabil\u0103 de \u00eentre\u021binere)<\/li>\n<li>Constipa\u021bie<\/li>\n<li>Somnolen\u021b\u0103 sau oboseal\u0103<\/li>\n<li>Hipertensiune (cre\u0219tere u\u0219oar\u0103 a tensiunii arteriale)<\/li>\n<\/ul>\n<p><strong>Mai pu\u021bin frecvente:<\/strong><\/p>\n<ul>\n<li>Halucina\u021bii sau agravarea halucina\u021biilor existente<\/li>\n<li>Agita\u021bie sau agresivitate (paradoxal, \u00een special \u00een perioada de titrare)<\/li>\n<li>C\u0103deri (din cauza ame\u021belii)<\/li>\n<li>Infec\u021bii ale tractului urinar<\/li>\n<\/ul>\n<p><strong>Rare, dar necesit\u0103 evaluare medical\u0103:<\/strong><\/p>\n<ul>\n<li>Criz\u0103 epileptic\u0103<\/li>\n<li>Simptome psihiatrice severe (psihoz\u0103, manie)<\/li>\n<li>Pancreatit\u0103<\/li>\n<li>Hepatit\u0103<\/li>\n<li>Sindromul Stevens-Johnson (cazuri raportate)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Avertismente \u0219i precau\u021bii<\/h2>\n<ul>\n<li><strong>Afectare renal\u0103:<\/strong> reducerea dozei este obligatorie. Limita\u021bi la 10 mg\/zi dac\u0103 eGFR este 5\u201349 mL\/min. Evita\u021bi dac\u0103 eGFR &lt; 5 mL\/min. Memantina se acumuleaz\u0103 \u00een insuficien\u021ba renal\u0103 \u0219i provoac\u0103 toxicitate.<\/li>\n<li><strong>Alcalinizare urinar\u0103:<\/strong> afec\u021biuni care cresc pH-ul urinar (infec\u021bii urinare severe, acidoz\u0103 tubular\u0103 renal\u0103, diet\u0103 vegetarian\u0103 cu doze mari de medicamente alcalinizante, bicarbonat de sodiu) reduc eliminarea memantinei \u0219i cresc nivelul sanguin \u2014 monitoriza\u021bi apari\u021bia efectelor adverse.<\/li>\n<li><strong>Istoric de crize epileptice:<\/strong> utiliza\u021bi cu precau\u021bie \u2014 memantina poate sc\u0103dea pragul convulsiilor.<\/li>\n<li><strong>Infarct miocardic recent, hipertensiune arterial\u0103 necontrolat\u0103, insuficien\u021b\u0103 cardiac\u0103 sever\u0103:<\/strong> precau\u021bie \u2014 date insuficiente privind siguran\u021ba \u00een aceste popula\u021bii.<\/li>\n<li><strong>Afectare hepatic\u0103:<\/strong> nu este necesar\u0103 ajustarea dozei \u00een cazul afec\u021biunilor u\u0219oare p\u00e2n\u0103 la moderate; se recomand\u0103 precau\u021bie \u00een cazul afec\u021biunilor severe.<\/li>\n<li><strong>Halucina\u021bii \u0219i idei delirante:<\/strong> pot agrava simptomele psihiatrice preexistente la unii pacien\u021bi cu demen\u021b\u0103. Monitoriza\u021bi modific\u0103rile comportamentale.<\/li>\n<li><strong>Suport pentru \u00eengrijitor:<\/strong> pacien\u021bii din popula\u021bia cu boala Alzheimer moderat-sever\u0103 pentru care memantina este indicat\u0103 rareori \u00ee\u0219i administreaz\u0103 singuri medicamentele. Implicarea \u00eengrijitorului \u00een preg\u0103tirea dozei, supraveghere \u0219i respectarea tratamentului este esen\u021bial\u0103.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindica\u021bii \u2014 Cine NU ar trebui s\u0103 ia Admenta<\/h2>\n<ul>\n<li>Hipersensibilitate cunoscut\u0103 la memantin\u0103 sau la orice excipient din compozi\u021bia tabletelor<\/li>\n<li>Insuficien\u021b\u0103 renal\u0103 sever\u0103 (eGFR &lt; 5 mL\/min)<\/li>\n<li>Demen\u021b\u0103 Alzheimer u\u0219oar\u0103 (utiliza\u021bi mai \u00eent\u00e2i un inhibitor de colinesteraz\u0103)<\/li>\n<li>Deteriorare cognitiv\u0103 u\u0219oar\u0103 f\u0103r\u0103 demen\u021b\u0103<\/li>\n<li>Demen\u021b\u0103 frontotemporal\u0103 (nu ofer\u0103 beneficii \u0219i poate agrava simptomele comportamentale)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Combina\u021bi cu<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Efect<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Ce s\u0103 face\u021bi<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Al\u021bi antagoni\u0219ti NMDA (amantadin\u0103, ketamin\u0103, dextrometorfan)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Efecte psihotomimetice aditive (confuzie, halucina\u021bii, disociere)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Evita\u021bi combina\u021bia. Informa\u021bi anestezistul despre memantin\u0103 \u00eenaintea oric\u0103rei proceduri care implic\u0103 ketamin\u0103.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Inhibitori de colinesteraz\u0103 (donepezil, galantamin\u0103, rivastigmin\u0103)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Combina\u021bie standard \u2014 beneficiu cognitiv aditiv, f\u0103r\u0103 interac\u021biuni semnificative<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Terapie adjunctiv\u0103 standard \u00een Alzheimer moderat-sever. Vezi <a href=\"https:\/\/medsbase.com\/ro\/aricep\/\">Aricep<\/a>.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Hidroclorotiazid\u0103 \u0219i alte diuretice tiazidice<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Memantina reduce efectul diuretic; tiazidele cresc nivelurile de memantin\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitoriza\u021bi TA \u0219i verifica\u021bi efectele adverse ale memantinei.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Bicarbonat de sodiu, acetazolamid\u0103, alcalinizante urinare<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduc clearance-ul renal al memantinei \u2014 cresc nivelurile sanguine<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitoriza\u021bi toxicitatea memantinei (confuzie, ame\u021beal\u0103, somnolen\u021b\u0103).<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Levodopa, agonisti dopaminergici (medicamente pentru Parkinson)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Memantina poate poten\u021ba efectele dopaminergice<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitoriza\u021bi discinezii \u0219i efectele adverse psihiatrice.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Barbiturice, neuroleptice (antipsihotice)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Memantina poate reduce efectul acestora<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitoriza\u021bi controlul simptomelor; ajusta\u021bi doza dup\u0103 necesitate.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Warfarin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Exist\u0103 cazuri raportate de INR crescut cu terapia combinat\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Verifica\u021bi INR mai frecvent dup\u0103 ini\u021bierea memantinei.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Instruc\u021biuni de Depozitare<\/h2>\n<ul>\n<li>Se p\u0103streaz\u0103 la temperatura camerei, <strong>15\u201325\u00b0C<\/strong>. Proteja\u021bi de lumin\u0103 \u0219i umiditate.<\/li>\n<li>P\u0103stra\u021bi comprimatele \u00een ambalajul original blister p\u00e2n\u0103 la utilizare.<\/li>\n<li>Nu depozita\u021bi \u00een baie \u2014 umiditatea reduce durata de via\u021b\u0103.<\/li>\n<li>P\u0103stra\u021bi departe de copii \u0219i de pacien\u021bii care pot s\u0103 nu \u00een\u021beleag\u0103 c\u0103 acestea sunt medicamente.<\/li>\n<li>Nu utiliza\u021bi dup\u0103 data de expirare tip\u0103rit\u0103 pe ambalaj.<\/li>\n<li>Returna\u021bi comprimatele nefolosite la o farmacie pentru eliminare.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Alternative conexe pe MedsBase<\/h2>\n<p>Alte medicamente pentru Alzheimer \u0219i demen\u021b\u0103 disponibile pe MedsBase:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/aricep\/\"><strong>Aricep (donepezil 5 \/ 10 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/donect\/\"><strong>Donect (donepezil 10 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/donemax\/\"><strong>Donemax (donepezil 10 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/galamer\/\"><strong>Galamer (galantamin\u0103 4 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/rivamer-2\/\"><strong>Rivamer (rivastigmine 1.5 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p>Lectur\u0103 util\u0103: <a href=\"https:\/\/medsbase.com\/ro\/everything-you-need-to-know-about-alzheimers-disease\/\">Tot ce trebuie s\u0103 \u0219tii despre boala Alzheimer<\/a> \u00b7 <a href=\"https:\/\/medsbase.com\/ro\/everything-to-know-about-dementia\/\">Tot ce trebuie s\u0103 \u0219tii despre demen\u021b\u0103<\/a> \u00b7 <a href=\"https:\/\/medsbase.com\/ro\/7-ways-to-protect-your-brain-health-as-you-age\/\">7 moduri de a-\u021bi proteja s\u0103n\u0103tatea creierului odat\u0103 cu \u00eenaintarea \u00een v\u00e2rst\u0103<\/a> \u00b7 <a href=\"https:\/\/medsbase.com\/ro\/best-foods-for-a-healthy-brain-and-improved-memory\/\">Cele mai bune alimente pentru un creier s\u0103n\u0103tos \u0219i o memorie \u00eembun\u0103t\u0103\u021bit\u0103<\/a>.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">De ce Admenta este indicat\u0103 doar pentru Alzheimer moderat-sever?<\/h3>\n<p>Studiile nu au demonstrat un beneficiu cognitiv semnificativ clinic al memantinei \u00een Alzheimer u\u0219or \u2014 calea excitotoxicit\u0103\u021bii glutamatice devine un factor dominant al simptomelor doar \u00een fazele tardive ale bolii. Pentru Alzheimer u\u0219or, un inhibitor de colinesteraz\u0103 (donepezil, galantamin\u0103, rivastigmin\u0103) este de prim\u0103 inten\u021b\u0103. Memantina se adaug\u0103 c\u00e2nd pacientul progreseaz\u0103 c\u0103tre stadiul moderat sau sever.<\/p>\n<h3 class=\"wp-block-heading\">Poate fi Admenta combinat\u0103 cu donepezil?<\/h3>\n<p>Da \u2014 aceasta este combina\u021bia standard pentru <strong>boala Alzheimer moderat-sever\u0103<\/strong>. Cele dou\u0103 medicamente ac\u021bioneaz\u0103 pe c\u0103i diferite (colinergice + glutamatergice) \u0219i ofer\u0103 beneficii cognitive \u0219i func\u021bionale aditive. Nu exist\u0103 o interac\u021biune farmacocinetic\u0103 semnificativ\u0103. Terapia combinat\u0103 este mai eficient\u0103 dec\u00e2t fiecare medicament separat \u00een stadiul moderat-sever. <a href=\"https:\/\/medsbase.com\/ro\/aricep\/\">Aricep (donepezil)<\/a> este partenerul standard.<\/p>\n<h3 class=\"wp-block-heading\">De ce necesit\u0103 Admenta o titrare pe 4 s\u0103pt\u0103m\u00e2ni?<\/h3>\n<p>Trecerea direct\u0103 la doza de \u00eentre\u021binere de 20 mg\/zi \u00een prima zi provoac\u0103 confuzie intolerabil\u0103, ame\u021beli \u0219i uneori halucina\u021bii \u2014 suficient de grave pentru ca majoritatea pacien\u021bilor s\u0103 \u00eentrerup\u0103 tratamentul. Titrarea pe 4 s\u0103pt\u0103m\u00e2ni (5 \u2192 10 \u2192 15 \u2192 20 mg\/zi) permite creierului s\u0103 se adapteze treptat la blocarea NMDA. Omiterea titr\u0103rii este cel mai frecvent motiv pentru care pacien\u021bii \u201cnu tolereaz\u0103\u201d memantina.<\/p>\n<h3 class=\"wp-block-heading\">C\u00e2nd voi sau membru al familiei mele vom vedea rezultate?<\/h3>\n<p>Beneficiu cognitiv vizibil la <strong>4\u201312 s\u0103pt\u0103m\u00e2ni<\/strong> dup\u0103 atingerea dozei de \u00eentre\u021binere de 20 mg\/zi; beneficiul maxim la 6 luni. Ca \u0219i donepezilul, memantina este o terapie simptomatic\u0103, nu modificatoare de boal\u0103. Reevalua\u021bi cu teste cognitive formale la 6 luni.<\/p>\n<h3 class=\"wp-block-heading\">Admenta necesit\u0103 ajustarea dozei \u00een cazul problemelor renale?<\/h3>\n<p>Da. Memantina este eliminat\u0103 renal \u0219i se acumuleaz\u0103 \u00een cazul insuficien\u021bei renale. Limite de doz\u0103: <strong>eGFR 30\u201349 mL\/min<\/strong> \u2014 doza de \u00eentre\u021binere maxim\u0103 de 10 mg\/zi. <strong>eGFR 5\u201329 mL\/min<\/strong> \u2014 doz\u0103 de \u00eentre\u021binere de 10 mg\/zi. <strong>eGFR &lt; 5 mL\/min<\/strong> \u2014 evita\u021bi complet memantina. Verifica\u021bi func\u021bia renal\u0103 \u00eenainte de \u00eencepere \u0219i la orice semn de toxicitate (confuzie, somnolen\u021b\u0103, ame\u021beli la o doz\u0103 anterior stabil\u0103).<\/p>\n<h3 class=\"wp-block-heading\">Admenta este un vindec\u0103tor sau \u00eencetine\u0219te progresia bolii Alzheimer?<\/h3>\n<p><strong>Niciuna dintre acestea.<\/strong> Memantina este o terapie simptomatic\u0103 \u2014 stabilizeaz\u0103 func\u021bia pentru o perioad\u0103 tipic de 6\u201318 luni. Neurodegenerarea subiacent\u0103 continu\u0103. Noile medicamente modificatoare de boal\u0103 (anticorpi anti-amiloizi precum lecanemab \u0219i donanemab) vizeaz\u0103 patologia subiacent\u0103, dar necesit\u0103 perfuzie intravenoas\u0103, monitorizare regulat\u0103 prin RMN \u0219i supraveghere specializat\u0103 \u2014 nu sunt disponibile aici.<\/p>\n<h3 class=\"wp-block-heading\">Admenta ajut\u0103 la simptomele comportamentale (agitare, agresivitate, halucina\u021bii)?<\/h3>\n<p>Beneficiu moderat asupra agita\u021biei \u0219i agresivit\u0103\u021bii \u00een Alzheimer moderat-sever \u2014 unul dintre motivele pentru care memantina este preferat\u0103 ca tratament adi\u021bional \u00een aceast\u0103 etap\u0103, \u00een locul unui al doilea inhibitor de colinesteraz\u0103. Memantina poate agrava paradoxal halucina\u021biile la o minoritate de pacien\u021bi \u2014 monitoriza\u021bi \u0219i \u00eentrerupe\u021bi tratamentul dac\u0103 acest lucru se \u00eent\u00e2mpl\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Pot s\u0103 opresc Admenta dac\u0103 nu ajut\u0103?<\/h3>\n<p>Discuta\u021bi cu medicul prescriptor. Dac\u0103 testele cognitive formale la 6 luni nu arat\u0103 niciun beneficiu \u0219i starea pacientului s-a \u00eenr\u0103ut\u0103\u021bit evident, memantina poate fi \u00eentrerupt\u0103. Spre deosebire de donepezil, memantina nu are un sindrom de \u00eentrerupere semnificativ \u2014 dar o reducere progresiv\u0103 pe 1\u20132 s\u0103pt\u0103m\u00e2ni r\u0103m\u00e2ne practica standard.<\/p>\n<h3 class=\"wp-block-heading\">Este Admenta sigur\u0103 cu medicamentele pentru tensiune sau inim\u0103 ale p\u0103rintelui meu?<\/h3>\n<p>Memantina este \u00een general sigur\u0103 cu majoritatea medicamentelor cardiovasculare. Nu exist\u0103 interac\u021biuni semnificative cu beta-blocantele, inhibitorii ACE, ARB, blocatele de canale de calciu, statinele sau aspirina. Diureticele tiazidice pot cre\u0219te u\u0219or nivelul memantinei \u2014 monitoriza\u021bi efectele adverse, dar de obicei nu este necesar\u0103 ajustarea dozei. Memantina poate provoca o u\u0219oar\u0103 cre\u0219tere a tensiunii arteriale la unii pacien\u021bi \u2014 verifica\u021bi tensiunea la vizitele de la 6 s\u0103pt\u0103m\u00e2ni \u0219i 3 luni.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alternative conexe<\/h3>\n<p>Alte produse din <strong>Afec\u021biuni cronice<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/duovir-n\/\">Duovir N<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/neomercazole\/\">Neomercazole<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/venish-sr\/\">Venish SR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/syndopa\/\">Syndopa<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/pregastar\/\">Pregastar 75 mg (Pregabalin\u0103) \u2014 Durere neuropatic\u0103 \u0219i anxietate<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 \u00cembun\u0103t\u0103\u021be\u0219te func\u021biile cognitive<br \/>\n\u2705 \u00cembun\u0103t\u0103\u021be\u0219te memoria<br \/>\n\u2705 \u00cencetine\u0219te neurodegenerarea<br \/>\n\u2705 Reduce confuzia<br \/>\n\u2705 Trateaz\u0103 boala Alzheimer<\/p>\n<p>Admenta con\u021bine Memantin\u0103.<\/p>","protected":false},"featured_media":58760,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3772,3141,3223],"product_tag":[4562,4563],"class_list":{"0":"post-58759","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-alzheimers-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-admenta","10":"product_tag-memantine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/58759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=58759"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/58760"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=58759"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=58759"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=58759"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=58759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}