{"id":59004,"date":"2024-02-28T05:37:46","date_gmt":"2024-02-28T05:37:46","guid":{"rendered":"https:\/\/medsname.com\/reglan\/"},"modified":"2026-04-30T10:24:05","modified_gmt":"2026-04-30T10:24:05","slug":"reglan","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/reglan\/","title":{"rendered":"Reglan"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns Rapid \u2014 Ce este Reglan?<\/h3>\n<p style=\"margin:0;\"><strong>Reglan<\/strong> este metoclopramid\u0103 10 mg \u2014 un antagonist al receptorului D2 de dopamin\u0103 cu ac\u021biune central\u0103 \u0219i periferic\u0103, utilizat ca antiemetic \u0219i prokinetic. Accelereaz\u0103 golirea gastric\u0103, cre\u0219te tonusul LES \u0219i blocheaz\u0103 zona trigger a chemoreceptorilor. Indica\u021bii includ grea\u021b\u0103\/v\u0103rs\u0103turi (post-operatorii, adjunct la chimioterapie, asociate migrenei), gastroparez\u0103 \u0219i preven\u021bia aspira\u021biei. Doz\u0103 standard: <strong>10 mg de trei ori pe zi \u00eenainte de mese, maximum 5 zile (FDA) sau 12 s\u0103pt\u0103m\u00e2ni (excep\u021bie EMA pentru gastroparez\u0103).<\/strong>. Produc\u0103tor certificat WHO-GMP.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>De ce s\u0103 comanzi de la MedsBase:<\/strong> \u2714 <strong>produc\u0103tor certificat WHO-GMP<\/strong> \u2714 Ambalaj discret \u2714 Livrare worldwide \u2714 <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">Recenzii verificate ale clien\u021bilor (peste 1.400 de clien\u021bi)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>\u26a0\ufe0f Avertisment FDA cutie neagr\u0103 \u2014 discinezie tardiv\u0103.<\/strong> Metoclopramid\u0103 poate provoca discinezie tardiv\u0103, o tulburare de mi\u0219care involuntar\u0103 care poate fi ireversibil\u0103. Riscul cre\u0219te odat\u0103 cu doza cumulativ\u0103 \u0219i durata tratamentului \u0219i este mai mare la adul\u021bii \u00een v\u00e2rst\u0103, femei \u0219i pacien\u021bi cu diabet. Utiliza\u021bi cea mai mic\u0103 doz\u0103 eficient\u0103 pentru cea mai scurt\u0103 durat\u0103. FDA limiteaz\u0103 utilizarea de rutin\u0103 la 5 zile (SUA), iar EMA la 5 zile pentru grea\u021b\u0103\/v\u0103rs\u0103turi (12 s\u0103pt\u0103m\u00e2ni pentru gastroparez\u0103 sub supraveghere specializat\u0103). Alte efecte extrapiramidale: distonie acut\u0103 (\u00een special la tinerii b\u0103rba\u021bi, trata\u021bi cu anticolinergic IV), acatisie, parkinsonism, sindrom neuroleptic malign.<\/div>\n<h3 class=\"wp-block-heading\">De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Reglan este furnizat de la <strong>produc\u0103tor certificat WHO-GMP<\/strong>. Fiecare comand\u0103 este expediat\u0103 discret \u00een \u00eentreaga lume \u0219i este acoperit\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> \u2014 dac\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, retrimitem f\u0103r\u0103 costuri. Metoclopramida r\u0103m\u00e2ne un agent de prim\u0103 linie pentru mai multe indica\u021bii de ni\u0219\u0103 (grea\u021b\u0103 asociat\u0103 migrenei, prevenirea ileusului postoperator, stimularea lacta\u021biei) unde efectul s\u0103u central D2 este util.<\/p>\n<h2 class=\"wp-block-heading\">Mecanism de ac\u021biune<\/h2>\n<p>Metoclopramida blocheaz\u0103 receptorii dopaminergici D2 central (\u00een zona trigger chemoreceptor, nigrostriatum \u0219i sistemul tuberoinfundibular) \u0219i periferic (intestin). La doze mai mari, blocheaz\u0103 \u0219i receptorii 5-HT3 \u0219i stimuleaz\u0103 receptorii 5-HT4 \u00een intestin, ceea ce contribuie la efectul s\u0103u prokinetic. P\u0103trunderea \u00een SNC o diferen\u021biaz\u0103 de domperidon \u0219i explic\u0103 at\u00e2t poten\u021ba sa antiemetic\u0103 mai mare, c\u00e2t \u0219i profilul s\u0103u de efecte secundare extrapiramidale.<\/p>\n<h2 class=\"wp-block-heading\">Indica\u021bii<\/h2>\n<ul>\n<li>Grea\u021b\u0103 \u0219i v\u0103rs\u0103turi (induse de chimioterapie, postoperatorii, asociate migrenei)<\/li>\n<li>Gastroparez\u0103 diabetic\u0103 \u0219i idiopatic\u0103 (maximum 12 s\u0103pt\u0103m\u00e2ni conform EMA)<\/li>\n<li>Prevenirea aspira\u021biei pre-anestezie (adjuvant \u00een induc\u021bia secven\u021bei rapide)<\/li>\n<li>Adjuvant \u00een radiologie pentru accelerarea tranzitului bariului<\/li>\n<li>Off-label: galactagog<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Doza<\/h2>\n<p>Adul\u021bi: 10 mg de p\u00e2n\u0103 la trei ori pe zi, cu 30 de minute \u00eenainte de mese \u0219i la culcare, dac\u0103 este necesar. Durata maxim\u0103 cumulativ\u0103: 5 zile pentru grea\u021b\u0103\/v\u0103rs\u0103turi (FDA), 12 s\u0103pt\u0103m\u00e2ni pentru gastroparez\u0103 (EMA, specialist). CrCl  1 an pentru grea\u021b\u0103 indus\u0103 de chimioterapie sau postoperatorie, pe baz\u0103 de greutate.<\/p>\n<h2 class=\"wp-block-heading\">Efecte secundare<\/h2>\n<ul>\n<li>Frecvente: somnolen\u021b\u0103, agita\u021bie, oboseal\u0103, diaree<\/li>\n<li>Extrapiramidale: distonie acut\u0103, acatisie, parkinsonism, discinezie tardiv\u0103 (AVERTISMENT \u00ceN CUTIE NEAGR\u0102)<\/li>\n<li>Hiperprolactinemie: galactoree, ginecomastie, tulbur\u0103ri menstruale<\/li>\n<li>Rare: sindrom neuroleptic malign, convulsii, methemoglobinemie (la sugari cu deficit de G6PD)<\/li>\n<li>Cardiace: bradicardie \u0219i hipotensiune dup\u0103 administrare rapid\u0103 IV<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li>Anticolinergice, opioide: contracareaz\u0103 efectul prokinetic.<\/li>\n<li>Al\u021bi antagoni\u0219ti ai dopaminei (haloperidol, risperidon, proclorperazin\u0103): risc adi\u021bional extrapiramidal \u2014 evita\u021bi asocierea.<\/li>\n<li>Inhibitorii MAO: criz\u0103 hipertensiv\u0103 \u2014 evita\u021bi.<\/li>\n<li>SSRI, SNRI: sindrom serotoninergic (rar).<\/li>\n<li>Levodopa: fiecare blocheaz\u0103 efectul celuilalt \u2014 nu co-prescrie\u021bi.<\/li>\n<li>Digoxin: accelerarea golirii gastrice poate reduce absorb\u021bia digoxinului.<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">Cum difer\u0103 Reglan de domperidon?<\/h3>\n<p>Ambele blocheaz\u0103 receptorii D2. Metoclopramid\u0103 trece bariera hemato-encefalic\u0103 \u0219i este mai puternic\u0103 ca antiemetic, dar provoac\u0103 efecte secundare extrapiramidale (avertisment FDA \u00een cutie neagr\u0103). Domperidonul ac\u021bioneaz\u0103 doar periferic cu efecte extrapiramidale minime, dar are un semnal de prelungire a intervalului QT.<\/p>\n<h3 class=\"wp-block-heading\">Ce \u00eenseamn\u0103 avertismentul FDA \u00een cutie neagr\u0103 pentru mine?<\/h3>\n<p>Utiliza\u021bi cea mai mic\u0103 doz\u0103 pentru cea mai scurt\u0103 perioad\u0103 de timp. Informa\u021bi imediat medicul prescriptor despre orice mi\u0219care involuntar\u0103 a limbii, maxilarului, buzelor sau membrelor \u2014 acestea pot fi semne timpurii de discinezie tardiv\u0103 \u0219i medicamentul trebuie \u00eentrerupt.<\/p>\n<h3 class=\"wp-block-heading\">Pot s\u0103-l iau pentru r\u0103u de mi\u0219care?<\/h3>\n<p>Exist\u0103 alternative mai bine tolerate (cinnarizin\u0103, hioscin\u0103, antihistaminice). Metoclopramida nu este de prim\u0103 inten\u021bie pentru r\u0103ul de mi\u0219care deoarece nu ac\u021bioneaz\u0103 asupra sistemului vestibular.<\/p>\n<h3 class=\"wp-block-heading\">Este sigur \u00een sarcin\u0103?<\/h3>\n<p>Categoria B \u00een SUA. Utilizat \u00een sarcin\u0103 pentru grea\u021b\u0103\/v\u0103rs\u0103turi \u0219i este de a doua inten\u021bie dup\u0103 piridoxin\u0103-doxilamin\u0103 c\u00e2nd prima linie e\u0219ueaz\u0103. Discuta\u021bi cu medicul obstetrician.<\/p>\n<h3 class=\"wp-block-heading\">Pot s\u0103 conduc sub influen\u021ba acestui medicament?<\/h3>\n<p>Somnen\u021ba este frecvent\u0103, mai ales \u00een primele zile. Nu conduce\u021bi sau opera\u021bi utilaje p\u00e2n\u0103 nu \u0219ti\u021bi cum v\u0103 afecteaz\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Ce fac dac\u0103 dezvolt o rigiditate a g\u00e2tului sau mi\u0219c\u0103ri ciudate ale maxilarului?<\/h3>\n<p>\u00centrerupe\u021bi medicamentul \u0219i c\u0103uta\u021bi ajutor medical. Distonia acut\u0103 se trateaz\u0103 cu anticolinergic IV (procilidin\u0103 sau benztropin\u0103) \u0219i este complet reversibil\u0103.<\/p>\n<h3 class=\"wp-block-heading\">De ce am s\u00e2nge care curge sub influen\u021ba acestui medicament?<\/h3>\n<p>Metoclopramida cre\u0219te prolactina prin blocarea receptorilor D2 hipofizari. Efectul este reversibil la \u00eentreruperea tratamentului.<\/p>\n<h3 class=\"wp-block-heading\">Poate interac\u021biona cu medicamentele mele pentru Parkinson?<\/h3>\n<p>Da \u2014 metoclopramida blocheaz\u0103 receptorii D2 centrali \u0219i poate \u00eenr\u0103ut\u0103\u021bi dramatic simptomele motorii ale Parkinsonului. Evita\u021bi \u00een boala Parkinson.<\/p>\n<h3 class=\"wp-block-heading\">Depozitare<\/h3>\n<p>P\u0103stra\u021bi la sub 25\u00b0C \u00eentr-un loc uscat. Depozita\u021bi \u00een afara accesului copiilor.<\/p>\n<h3 class=\"wp-block-heading\">Ce fac dac\u0103 uit o doz\u0103?<\/h3>\n<p>Lua\u021bi-o \u00eenainte de urm\u0103toarea mas\u0103, apoi continua\u021bi. Nu dubla\u021bi doza.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alte Medicamente pentru S\u0103n\u0103tatea Gastrointestinal\u0103<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/dompewal-tablet\/\">Dompewal \u2014 Domperidon (antagonist D2 periferic)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/stemetil\/\">Stemetil \u2014 Proclorperazin\u0103 (antiemetic)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/doxinate\/\">Doxinate \u2014 Doxilamin\u0103 + B6 (primul tratament pentru grea\u021b\u0103 \u0219i v\u0103rs\u0103turi la gravide)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/omez-d\/\">Omez D \u2014 Omeprazol + Domperidon SR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/gr8-od\/\">GR8-OD \u2014 Pantoprazol + Domperidon SR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/gastro-health\/\"><strong>Vede\u021bi toate Medicamentele pentru S\u0103n\u0103tatea Gastrointestinal\u0103<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfaturile medicale ale unui medic calificat. Informa\u021bi prescriptorul despre toate medicamentele neurologice sau psihiatrice pe care le lua\u021bi. Evita\u021bi \u00een boala Parkinson \u0219i \u00een caz de istoric personal\/familial de discinez\u0103 tardiv\u0103.<\/div>","protected":false},"excerpt":{"rendered":"<p>Reglan (Metoclopramid\u0103 10 mg) \u2014 antagonist D2 prokinetic \u0219i antiemetic central + periferic. Are avertizare FDA pentru discinezii tardive (maxim 12 s\u0103pt\u0103m\u00e2ni). Pentru grea\u021b\u0103, v\u0103rs\u0103turi, gastroparez\u0103, grea\u021b\u0103 asociat\u0103 migrenei. Livrare worldwide de la MedsBase.<\/p>","protected":false},"featured_media":59005,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[4610,4611],"class_list":{"0":"post-59004","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","9":"product_tag-metoclopramide","10":"product_tag-reglan","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/59004","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=59004"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/59005"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=59004"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=59004"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=59004"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=59004"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}