{"id":59010,"date":"2024-02-28T05:37:50","date_gmt":"2024-02-28T05:37:50","guid":{"rendered":"https:\/\/medsname.com\/avomine\/"},"modified":"2026-04-30T10:24:05","modified_gmt":"2026-04-30T10:24:05","slug":"avomine","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/avomine\/","title":{"rendered":"Avomine"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Avomine?<\/h3>\n<p style=\"margin:0;\"><strong>Avomine<\/strong> con\u021bine <strong>promethazine theoclate 25 mg<\/strong>, a first-generation H1 antihistamine with antiemetic, anticholinergic, and sedative properties. It is the established first-line agent for <strong>r\u0103u de mi\u0219care<\/strong>, <strong>vestibular nausea<\/strong>, \u0219i <strong>vertijului<\/strong>, and is also used for sedation and as an adjunct in allergy and pregnancy-related nausea (jurisdiction-dependent). Take <strong>30\u201360 de minute \u00eenainte de c\u0103l\u0103torie<\/strong> for motion-sickness prophylaxis. Manufactured by Wockhardt under WHO-GMP standards.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>De ce s\u0103 comanzi de la MedsBase:<\/strong> \u2714 <strong>produc\u0103tor certificat WHO-GMP<\/strong> \u2714 Ambalaj discret \u2714 Livrare worldwide \u2714 <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">Recenzii verificate ale clien\u021bilor (peste 1.400 de clien\u021bi)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>&#9888;&#65039; Strong sedation &mdash; no driving or machinery.<\/strong> {$brand} causes pronounced drowsiness in most users. Do not drive, operate machinery, or perform tasks requiring alertness for at least 24 hours after a dose. Avoid alcohol, opioids, benzodiazepines, and other CNS depressants &mdash; combination causes profound sedation and respiratory depression. Promethazine is contraindicated in <strong>children under 2 years<\/strong> (risk of fatal respiratory depression) and used cautiously in 2&ndash;5 year olds.<\/div>\n<h2 class=\"wp-block-heading\">When promethazine is the right antiemetic<\/h2>\n<p>Promethazine is the <strong>go-to drug for motion sickness<\/strong> &mdash; sea, air, car, and amusement-park motion. It is also effective for <strong>vestibular vertigo<\/strong> (acute labyrinthitis, vestibular neuritis, Meniere&rsquo;s acute attacks), and as a sedating adjunct in allergic reactions or anxiety-related nausea. It is <strong>not first-line for chemotherapy-induced nausea<\/strong> (use ondansetron\/granisetron instead) and <strong>not first-line for nausea-vomiting of pregnancy<\/strong> in most modern guidelines (NVP first-line is doxylamine+B6 &mdash; Doxinate, Pregnidoxin NU). Some jurisdictions still use promethazine for hyperemesis gravidarum after first-line failure.<\/p>\n<h3 class=\"wp-block-heading\">De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Avomine is supplied from a <strong>produc\u0103tor certificat WHO-GMP<\/strong>. Fiecare comand\u0103 este expediat\u0103 discret \u00een \u00eentreaga lume \u0219i este acoperit\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> &mdash; if it does not arrive within 20 business days, we reship at no cost. Promethazine has been the global standard for motion sickness for decades and remains a useful sedating antiemetic when histaminergic\/cholinergic vestibular nausea is the dominant problem.<\/p>\n<h2 class=\"wp-block-heading\">Mecanism de ac\u021biune<\/h2>\n<p>Promethazine is a phenothiazine-derived antihistamine. It blocks <strong>H1 histamine receptors<\/strong> (the antihistamine effect that reduces motion-induced vestibular signalling and gives sedation), <strong>receptorii muscarinici de acetilcolin\u0103<\/strong> (the anticholinergic effect that further suppresses vestibular and gut motility-driven emesis), and <strong>D2 dopamine receptors<\/strong> (a mild antiemetic effect at the chemoreceptor trigger zone). The unique value of promethazine in motion sickness is the combined H1 + anticholinergic blockade &mdash; the vestibular system depends on both pathways. The same combined blockade also explains its strong sedative and dry-mouth profile.<\/p>\n<h2 class=\"wp-block-heading\">Indica\u021bii<\/h2>\n<ul>\n<li><strong>Motion sickness:<\/strong> sea, air, car, train; especially when other agents (cinnarizine, hyoscine patch) have failed or are unavailable.<\/li>\n<li><strong>Vestibular vertigo:<\/strong> acute labyrinthitis, vestibular neuritis, Meniere&rsquo;s acute attacks.<\/li>\n<li><strong>Allergic reactions<\/strong> (urticaria, hay fever) where sedation is helpful or non-sedating antihistamines have failed.<\/li>\n<li><strong>Pre-medication for anaesthesia<\/strong> (sedation + antiemetic + drying of secretions).<\/li>\n<li><strong>Insomnie<\/strong> short-term occasional use.<\/li>\n<li><strong>Hiperemez\u0103 gravidic\u0103<\/strong> (jurisdiction-dependent, after first-line doxylamine+B6 failure).<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Doza<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;\">Indica\u021bie<\/th>\n<th style=\"padding:8px;text-align:left;\">Doza<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Motion sickness (adult)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">25 mg the night before, repeat 25 mg morning of travel; or 25 mg 1&ndash;2 h pre-travel; max 75 mg\/day<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Vestibular vertigo (adult)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">25 mg every 8&ndash;12 h during acute episode; taper after 2&ndash;3 days (long-term use slows vestibular compensation)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Children 5&ndash;10 y<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">12.5 mg the night before travel and again the morning of travel<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Children 2&ndash;5 y<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Use only if essential under medical supervision; 6.25 mg twice daily maximum<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Children &lt; 2 y<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">CONTRAINDICATED &mdash; risk of fatal respiratory depression<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Older adults (&gt; 65)<\/td>\n<td style=\"padding:8px;\">Use cautiously &mdash; high anticholinergic burden; risk of confusion, falls, urinary retention<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Efecte secundare<\/h2>\n<ul>\n<li><strong>Foarte frecvente:<\/strong> sedation, dry mouth, blurred vision, urinary hesitancy, constipation<\/li>\n<li><strong>Frecvente:<\/strong> dizziness, hypotension on standing, palpitation, mild confusion (especially older adults)<\/li>\n<li><strong>Mai pu\u021bin frecvente:<\/strong> photosensitivity, rash, paradoxical excitation in children, extrapyramidal reactions (low frequency vs other phenothiazines)<\/li>\n<li><strong>Rare dar grave:<\/strong> agranulocytosis, neuroleptic malignant syndrome (very rare), severe respiratory depression in young children, seizures in overdose<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>Depresante ale SNC<\/strong> (alcohol, opioids, benzodiazepines, gabapentinoids, sleep medication): additive sedation and respiratory depression &mdash; avoid combination.<\/li>\n<li><strong>Anticolinergice<\/strong> (TCAs, oxybutynin, atropine, hyoscine patch, antipsychotics): additive dry mouth, urinary retention, cognitive impairment &mdash; especially in older adults.<\/li>\n<li><strong>MAO inhibitors:<\/strong> may prolong and intensify sedation &mdash; avoid combination.<\/li>\n<li><strong>Adrenaline (epinephrine):<\/strong> promethazine may reverse the pressor effect (use noradrenaline if vasopressor needed during anaphylaxis on promethazine).<\/li>\n<li><strong>Pregnancy test interference:<\/strong> may cause false positive\/negative immunological pregnancy tests.<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">How long before travel should I take Avomine?<\/h3>\n<p>For best motion-sickness protection, take 25 mg the <strong>night before travel<\/strong> and a second 25 mg dose 1&ndash;2 hours before departure. Once the journey is underway and you are already nauseated, prevention is much harder &mdash; take the dose proactively.<\/p>\n<h3 class=\"wp-block-heading\">Will Avomine make me sleepy?<\/h3>\n<p>Yes &mdash; pronounced drowsiness is the dominant side effect. Do not drive, fly an aircraft, scuba dive, or operate machinery for 24 hours after a dose. Many users find this useful for long-haul flights but it is dangerous before active tasks.<\/p>\n<h3 class=\"wp-block-heading\">Can Avomine be used in pregnancy?<\/h3>\n<p>Promethazine has been used historically for hyperemesis gravidarum but is no longer first-line in most modern guidelines. First-line for nausea-vomiting of pregnancy (NVP) is <strong>doxylamine + B6<\/strong> (Doxinate, Pregnidoxin NU); ondansetron, metoclopramide, and promethazine are reserved for refractory cases under specialist supervision.<\/p>\n<h3 class=\"wp-block-heading\">Can children take Avomine?<\/h3>\n<p><strong>Children under 2 years must NOT take promethazine<\/strong> &mdash; risk of fatal respiratory depression. For ages 2&ndash;5 use only if essential under medical supervision. Standard motion-sickness dosing starts from age 5 with 12.5 mg the night before and morning of travel.<\/p>\n<h3 class=\"wp-block-heading\">What is the difference between Avomine and ondansetron?<\/h3>\n<p>Avomine is a sedating H1 antihistamine + anticholinergic &mdash; ideal for <strong>motion sickness and vestibular vertigo<\/strong> where the histaminergic and cholinergic pathways are dominant. Ondansetron is a 5-HT3 antagonist &mdash; ideal for <strong>chemo, radiation, surgery, severe gastroenteritis<\/strong> where the serotonin pathway is dominant. They are not interchangeable.<\/p>\n<h3 class=\"wp-block-heading\">Is Avomine addictive?<\/h3>\n<p>No, promethazine is not a controlled substance and does not cause physical dependence. However, the strong sedation makes it occasionally misused for sleep or to potentiate opioids &mdash; the latter is dangerous because of respiratory depression.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol with Avomine?<\/h3>\n<p>No &mdash; combination causes profound sedation and respiratory depression. Avoid alcohol, sleeping pills, and opioids while on promethazine.<\/p>\n<h3 class=\"wp-block-heading\">Ce se \u00eent\u00e2mpl\u0103 dac\u0103 uit o doz\u0103?<\/h3>\n<p>Promethazine is usually used for prevention &mdash; take the next dose at the next planned time. If you miss the pre-travel dose, taking it once travel-induced nausea has already started is less effective; an ODT 5-HT3 (Ondem MD) or a cinnarizine alternative may give better breakthrough control.<\/p>\n<h3 class=\"wp-block-heading\">How does Avomine differ from cinnarizine and meclozine?<\/h3>\n<p>All three are anti-vertigo\/motion-sickness antihistamines. <strong>Cinarizina<\/strong> has additional calcium-channel blocking action (useful in Meniere&rsquo;s) and is less sedating. <strong>Meclozine<\/strong> is intermediate &mdash; less sedating than promethazine, longer-acting than cinnarizine. <strong>Promethazine<\/strong> is the most strongly sedating and is preferred when sedation is a benefit (long flights, severe vertigo).<\/p>\n<h3 class=\"wp-block-heading\">How is Avomine stored?<\/h3>\n<p>Store tablets at room temperature (below 25&deg;C), protected from light and moisture. Keep out of reach of children &mdash; accidental paediatric ingestion can cause severe respiratory depression.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alte tratamente pentru grea\u021b\u0103<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/stemetil-md\/\">Stemetil MD (prochlorperazine &mdash; vestibular nausea ODT)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/dompewal-tablet\/\">Dompewal (domperidone &mdash; gastric-emptying nausea)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/ondem\/\">Ondem (ondansetron &mdash; chemo\/PONV)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/doxinate\/\">Doxinate (doxilamin\u0103 + B6 \u2014 grea\u021b\u0103 gravidic\u0103)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/metopar\/\">Metopar (paracetamol + metoclopramid\u0103 \u2014 grea\u021b\u0103 de migren\u0103)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/nausea-treatment\/\"><strong>Vizualiza\u021bi toate tratamentele pentru grea\u021b\u0103<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui profesionist calificat. V\u0103rs\u0103turi persistente, s\u00e2nge \u00een vom\u0103, dureri abdominale severe, semne de deshidratare, suspiciuni de complica\u021bii ale sarcinii sau simptome legate de chimioterapie necesit\u0103 evaluare medical\u0103.<\/div>","protected":false},"excerpt":{"rendered":"<p>Avomine (Promethazine theoclate 25 mg) \u2014 sedating H1 antihistamine + anticholinergic for motion sickness, vestibular vertigo, and Meniere&#8217;s acute attacks.<\/p>","protected":false},"featured_media":59011,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3543],"product_tag":[4612,4613],"class_list":{"0":"post-59010","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-nausea-treatment","9":"product_tag-avomine","10":"product_tag-promethazine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/59010","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=59010"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/59011"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=59010"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=59010"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=59010"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=59010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}