{"id":59908,"date":"2024-02-28T06:23:19","date_gmt":"2024-02-28T06:23:19","guid":{"rendered":"https:\/\/medsname.com\/ondem-injection\/"},"modified":"2026-04-30T10:23:53","modified_gmt":"2026-04-30T10:23:53","slug":"ondem-injection","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/ondem-injection\/","title":{"rendered":"Injectabil Ondem"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Ondem Injection?<\/h3>\n<p style=\"margin:0;\"><strong>Injectabil Ondem<\/strong> con\u021bine <strong>ondansetron 2 mg\/ml<\/strong> in 2 ml ampoules (4 mg total) &mdash; a selective serotonin <strong>5-HT3 receptor antagonist<\/strong> used in hospitals to prevent and treat <strong>indus\u0103 de chimioterapie<\/strong>, <strong>indus\u0103 de radioterapie<\/strong>, \u0219i <strong>post-operative nausea and vomiting (PONV)<\/strong>. Administered by a healthcare professional intravenously (slow push or short infusion) or intramuscularly. Onset within 5&ndash;10 minutes IV. Manufactured by Alkem Laboratories &mdash; the generic equivalent of Zofran injection. <strong>FDA single-dose cap 16 mg IV<\/strong> due to QT signal at higher doses.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>De ce s\u0103 comanzi de la MedsBase:<\/strong> \u2714 <strong>produc\u0103tor certificat WHO-GMP<\/strong> \u2714 Ambalaj discret \u2714 Livrare worldwide \u2714 <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">Recenzii verificate ale clien\u021bilor (peste 1.400 de clien\u021bi)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>&#9888;&#65039; Hospital-only injection &mdash; not for self-administration.<\/strong> Parenteral ondansetron is administered by a healthcare professional in a clinical setting (chemotherapy unit, hospital theatre, emergency department) where ECG and resuscitation equipment are available. Self-administration is not appropriate. Single doses &gt; 16 mg IV have been associated with QT prolongation and torsades-de-pointes &mdash; the FDA dose cap is 16 mg per dose. Avoid in <strong>congenital long-QT syndrome<\/strong>, hypokalaemia, hypomagnesaemia, and with concurrent QT-prolonging drugs (azithromycin, citalopram, methadone, amiodarone, fluoroquinolones, antipsychotics, hydroxychloroquine). Apomorphine is an absolute contraindication.<\/div>\n<h3 class=\"wp-block-heading\">De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Ondem Injection is supplied from a <strong>produc\u0103tor certificat WHO-GMP<\/strong>. Fiecare comand\u0103 este expediat\u0103 discret \u00een \u00eentreaga lume \u0219i este acoperit\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> &mdash; if it does not arrive within 20 business days, we reship at no cost. Ondem Injection is the global standard parenteral 5-HT3 antagonist for inpatient antiemesis. Alkem is one of India&rsquo;s largest WHO-GMP injectable manufacturers and the formulation is bioequivalent to the reference brand.<\/p>\n<h2 class=\"wp-block-heading\">Mecanism de ac\u021biune<\/h2>\n<p>Chemotherapy, radiation, and surgical stress damage gut enterochromaffin cells, releasing massive amounts of <strong>serotonin (5-HT)<\/strong>. The serotonin binds 5-HT3 receptors on vagal afferents and on the chemoreceptor trigger zone (area postrema), generating the strongest known oral\/intestinal emetic stimulus. Ondansetron is a highly selective antagonist at the 5-HT3 receptor &mdash; it interrupts this signal at both peripheral and central sites without affecting D2, H1, muscarinic, or alpha-adrenergic receptors. The clean receptor profile explains the absence of sedation, extrapyramidal reactions, and anticholinergic side effects that limit older antiemetics like prochlorperazine and metoclopramide.<\/p>\n<h2 class=\"wp-block-heading\">Indica\u021bii<\/h2>\n<ul>\n<li><strong>CINV:<\/strong> moderately or highly emetogenic chemotherapy &mdash; usually with dexamethasone &plusmn; aprepitant for highly emetogenic regimens.<\/li>\n<li><strong>Grea\u021b\u0103 indus\u0103 de radioterapie:<\/strong> total body irradiation, high-dose abdominal\/pelvic radiation.<\/li>\n<li><strong>Grea\u021b\u0103 \u0219i v\u0103rs\u0103turi postoperatorii (PONV):<\/strong> single 4 mg dose at induction or end of surgery; prophylaxis for high-risk patients (Apfel score &ge; 2).<\/li>\n<li><strong>Severe gastroenteritis<\/strong> in patients unable to retain oral fluids.<\/li>\n<li><strong>Refractory hyperemesis gravidarum<\/strong> &mdash; second\/third-line after doxylamine+B6 and metoclopramide.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Doza<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;\">Indica\u021bie<\/th>\n<th style=\"padding:8px;text-align:left;\">Doza<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">CINV (highly emetogenic)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">8 mg slow IV (over &gt; 15 min) 30 min before chemo, then 8 mg every 4 h &times; 2 doses, then transition to oral 8 mg every 12 h<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">CINV (moderately emetogenic)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">8 mg slow IV 30 min before chemo, then transition to oral<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">PONV (adult)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">4 mg slow IV at induction or end of surgery (single dose); some protocols 8 mg for high-risk<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Pediatric (CINV)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">5 mg\/m&sup2; IV before chemo (max 8 mg per dose); weight-based for gastroenteritis<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Single-dose maximum<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">16 mg IV (FDA cap due to QT signal); slow IV push over 30 sec or short infusion 15 min<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Insuficien\u021b\u0103 hepatic\u0103 sever\u0103<\/td>\n<td style=\"padding:8px;\">Maximum 8 mg\/day (Child-Pugh C)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Compatible with 0.9% sodium chloride and 5% dextrose; do not mix in the same syringe with other drugs. Administer slow IV (over 30 seconds for push or 15 min for infusion) &mdash; rapid bolus increases the QT signal.<\/p>\n<h2 class=\"wp-block-heading\">Efecte secundare<\/h2>\n<ul>\n<li><strong>Frecvente:<\/strong> headache (often within minutes of injection), constipation, mild flushing, transient AST\/ALT rise, fatigue<\/li>\n<li><strong>Mai pu\u021bin frecvente:<\/strong> dizziness, hot flushes, hiccups, mild bradycardia, hypotension after rapid IV<\/li>\n<li><strong>Rare dar grave:<\/strong> QT prolongation\/torsades (especially with single doses &gt; 16 mg), serotonin syndrome (with SSRIs\/SNRIs\/triptans), severe hypersensitivity, transient blindness (very rare), arrhythmia<\/li>\n<li><strong>Mai pu\u021bin frecvente:<\/strong> extrapyramidal reactions (rare with ondansetron unlike older antiemetics)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>Apomorphine:<\/strong> ABSOLUTE contraindication &mdash; severe hypotension and loss of consciousness reported.<\/li>\n<li><strong>Alte medicamente care prelungesc intervalul QT<\/strong> (azithromycin, clarithromycin, citalopram, escitalopram, methadone, amiodarone, sotalol, fluoroquinolones, hydroxychloroquine, antipsychotics): avoid combination or monitor ECG.<\/li>\n<li><strong>Medicamente serotoninergice<\/strong> (SSRIs, SNRIs, MAOIs, triptans, tramadol, fentanyl, linezolid, methylene blue): rare serotonin syndrome reported.<\/li>\n<li><strong>Inductori puternici ai CYP3A4<\/strong> (rifampicin, phenytoin, carbamazepine): may lower ondansetron levels and reduce efficacy.<\/li>\n<li><strong>Tramadol:<\/strong> ondansetron may reduce tramadol analgesic effect (5-HT3 blockade interferes with descending pain inhibition).<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">How quickly does Ondem Injection work?<\/h3>\n<p>Onset is within 5&ndash;10 minutes after slow IV push and 15&ndash;30 minutes after IM injection. Antiemetic effect lasts 8&ndash;12 hours. The IV form is preferred for active vomiting where oral routes are unreliable.<\/p>\n<h3 class=\"wp-block-heading\">Why is the IV ondansetron dose capped at 16 mg?<\/h3>\n<p>FDA review of cardiac safety data found that single IV doses &gt; 16 mg significantly increase the risk of QT prolongation and torsades-de-pointes. The 16 mg cap applies to single doses; total daily dose can still be 24 mg given as 8 mg every 8 hours.<\/p>\n<h3 class=\"wp-block-heading\">Can Ondem Injection be given IM?<\/h3>\n<p>Yes &mdash; IM is a reasonable route when IV access is difficult, with onset 15&ndash;30 minutes (slower than IV but faster than oral). The standard IM dose is 4 mg; do not exceed 16 mg per single dose.<\/p>\n<h3 class=\"wp-block-heading\">Can Ondem Injection be used in pregnancy?<\/h3>\n<p>Reserved for refractory hyperemesis gravidarum after doxylamine+B6 and metoclopramide have failed. Some observational studies suggest a small first-trimester cardiac and cleft-palate signal &mdash; weigh against the maternal risk of severe untreated hyperemesis. Specialist supervision recommended.<\/p>\n<h3 class=\"wp-block-heading\">Is Ondem Injection safe in children?<\/h3>\n<p>Yes &mdash; weight or BSA-based dosing is well established for paediatric chemotherapy and severe gastroenteritis. The dose is typically 5 mg\/m&sup2; IV before chemo (max 8 mg) or weight-based (0.15 mg\/kg) for gastroenteritis.<\/p>\n<h3 class=\"wp-block-heading\">Why does Ondem Injection cause constipation?<\/h3>\n<p>5-HT3 receptors in the gut wall regulate gut motility &mdash; blocking them reduces peristalsis and slows colonic transit. Constipation is the most clinically meaningful side effect; pre-empt with hydration, fibre, and prophylactic laxatives during multi-day chemo courses.<\/p>\n<h3 class=\"wp-block-heading\">Does Ondem Injection cause sedation?<\/h3>\n<p>No. Unlike promethazine, prochlorperazine, and metoclopramide, ondansetron does not cause sedation, extrapyramidal reactions, or anticholinergic side effects.<\/p>\n<h3 class=\"wp-block-heading\">Can Ondem Injection be mixed with chemotherapy in the same line?<\/h3>\n<p>Ondansetron is incompatible with several chemotherapy agents in the same syringe; flush the line with normal saline between drugs. Compatibility is product-specific and should be checked against pharmacy guidelines for each chemotherapy combination.<\/p>\n<h3 class=\"wp-block-heading\">What if a single dose &gt; 16 mg is needed?<\/h3>\n<p>For highly emetogenic chemotherapy, give 8 mg slow IV every 4 hours rather than a single high dose. Switching to a different 5-HT3 (granisetron, palonosetron) or adding an NK1 antagonist (aprepitant) is usually a better strategy than exceeding the 16 mg single-dose cap.<\/p>\n<h3 class=\"wp-block-heading\">How is Ondem Injection stored?<\/h3>\n<p>Store ampoules at room temperature (15&ndash;25&deg;C), protect from light. Do not freeze. Inspect the solution before use &mdash; it should be clear and colourless.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alte tratamente pentru grea\u021b\u0103<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/ondem\/\">Ondem (ondansetron oral tablet &mdash; oral switch after IV)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/emeset-4-odt\/\">Emeset 4 ODT (oral disintegrating &mdash; transition from IV)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/granicip\/\">Granicip (granisetron &mdash; once-daily 5-HT3)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/dompewal-tablet\/\">Dompewal (domperidone &mdash; alternative class)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/stemetil-md\/\">Stemetil MD (prochlorperazine ODT &mdash; rescue antiemetic)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/nausea-treatment\/\"><strong>Vizualiza\u021bi toate tratamentele pentru grea\u021b\u0103<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui profesionist calificat. V\u0103rs\u0103turi persistente, s\u00e2nge \u00een vom\u0103, dureri abdominale severe, semne de deshidratare, suspiciuni de complica\u021bii ale sarcinii sau simptome legate de chimioterapie necesit\u0103 evaluare medical\u0103.<\/div>","protected":false},"excerpt":{"rendered":"<p>Ondem Injection (Ondansetron 2 mg\/ml, 4 mg per 2 ml ampoule) \u2014 hospital-administered IV\/IM 5-HT3 antagonist for chemotherapy, radiation, and post-operative nausea. Alkem generic of Zofran injection.<\/p>","protected":false},"featured_media":59909,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3543],"product_tag":[3613,4766],"class_list":{"0":"post-59908","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-nausea-treatment","9":"product_tag-ondansetron","10":"product_tag-ondem-injection","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/59908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=59908"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/59909"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=59908"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=59908"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=59908"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=59908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}