{"id":60227,"date":"2024-02-28T06:39:39","date_gmt":"2024-02-28T06:39:39","guid":{"rendered":"https:\/\/medsname.com\/mysoline\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"mysoline","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/mysoline\/","title":{"rendered":"Mysoline"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Mysoline?<\/h3>\n<p style=\"margin:0;\"><strong>Mysoline<\/strong> este un <strong>primidon\u0103<\/strong> (250 mg) tablet\u0103 \u2014 un <strong>anticonvulsivant derivat de barbituric\u0103<\/strong> care este metabolizat \u00een dou\u0103 compu\u0219i activi: <strong>fenobarbital<\/strong> \u0219i <strong>feniletilmalonamid\u0103 (PEMA)<\/strong>. Utilizat\u0103 pentru <strong>criz\u0103 tonic\u0103-clonic\u0103 generalizat\u0103 \u0219i crize par\u021biale complexe<\/strong>, \u0219i ca <strong>tratament de prim\u0103 inten\u021bie pentru tremor esen\u021bial<\/strong>. Doz\u0103 ini\u021bial\u0103 pentru epilepsie: <strong>100\u2013125 mg la culcare<\/strong>, ajustat\u0103 progresiv pe o perioad\u0103 de 2\u20133 s\u0103pt\u0103m\u00e2ni p\u00e2n\u0103 la <strong>750\u20131.500 mg\/zi<\/strong> \u00een doze divizate. Pentru tremor esen\u021bial: <strong>25\u201350 mg la culcare<\/strong>, ajustat lent p\u00e2n\u0103 la 250\u2013750 mg\/zi. Efecte secundare frecvente: sedare, ame\u021beli, grea\u021b\u0103, ataxie (adesea mai accentuate la \u00eenceput). <strong>Nu \u00eentrerupe\u021bi brusc<\/strong> \u2014 \u00eentreruperea brusc\u0103 poate declan\u0219a stare de mal epileptic.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<h2 class=\"wp-block-heading\">Ce este Mysoline?<\/h2>\n<p>Mysoline este un comprimat oral care con\u021bine <strong>primidon\u0103 250 mg<\/strong>. Primidona este un <strong>anticonvulsivant din clasa barbituratelor<\/strong> care este utilizat \u00een clinic\u0103 din <strong>1954<\/strong>. Este metabolizat \u00een ficat \u00een doi metaboli\u021bi activi: <strong>fenobarbital<\/strong> (cu ac\u021biune prelungit\u0103) \u0219i <strong>feniletilmalonamid\u0103 (PEMA)<\/strong>.<\/p>\n<p>Primidona are dou\u0103 ni\u0219e clinice distincte: ca <strong>anticonvulsivant adjunct pentru crize focale \u0219i tonic-clonice generalizate rezistente la medicamente<\/strong>, \u0219i ca <strong>tratament de prim\u0103 inten\u021bie pentru tremor esen\u021bial<\/strong> (cu eficacitate comparabil\u0103 cu propranololul). Mysoline este marca original\u0103 \u0219i r\u0103m\u00e2ne standardul de referin\u021b\u0103 pentru formul\u0103rile de primidon\u0103.<\/p>\n<p>Deoarece primidona se transform\u0103 \u00een fenobarbital in vivo, monitorizarea terapeutic\u0103 a medicamentului ar trebui s\u0103 urm\u0103reasc\u0103 <strong>at\u00e2t nivelurile de primidon\u0103 (5\u201312 \u00b5g\/mL) c\u00e2t \u0219i cele de fenobarbital (15\u201340 \u00b5g\/mL)<\/strong> .<\/p>\n<h2 class=\"wp-block-heading\">Cum Ac\u021bioneaz\u0103 Mysoline (Primidona)?<\/h2>\n<p>Primidona \u00een sine are activitate anticonvulsivant\u0103, dar este \u0219i metabolizat\u0103 extensiv hepatic \u00een <strong>doi metaboli\u021bi activi<\/strong>:<\/p>\n<ul>\n<li><strong>Fenobarbital<\/strong> \u2014 un barbiturat cu ac\u021biune prelungit\u0103 care intensific\u0103 activitatea receptorilor GABA<sub>A<\/sub> \u0219i prelunge\u0219te deschiderea canalelor de clorur\u0103<\/li>\n<li><strong>PEMA (feniletilmalonamida)<\/strong> \u2014 are propriet\u0103\u021bi anticonvulsivante independente<\/li>\n<\/ul>\n<p>Ac\u021biunea combinat\u0103 a medicamentului p\u0103rinte \u0219i a metaboli\u021bilor s\u0103i asigur\u0103 controlul crizelor prin multiple mecanisme inhibitorii. Pentru tremorul esen\u021bial, mecanismul este mai pu\u021bin \u00een\u021beles, dar poate implica suprima\u021bia nucleului olivar \u0219i cerebelar.<\/p>\n<h2 class=\"wp-block-heading\">Indica\u021bii<\/h2>\n<ul>\n<li><strong>Crize generalizate tonic-clonice (grand mal)<\/strong><\/li>\n<li><strong>Crize par\u021biale complexe (focale)<\/strong><\/li>\n<li><strong>Tremor esen\u021bial<\/strong> \u2014 de prim\u0103 linie \u00eempreun\u0103 cu propranolol (conform ghidului AAN)<\/li>\n<li>Tremur familial benign<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dozare \u0219i administrare<\/h2>\n<h3 class=\"wp-block-heading\" style=\"font-size:15px;\">Epilepsie<\/h3>\n<table style=\"width:100%;border-collapse:collapse;margin:0 0 24px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px 14px;\">S\u0103pt\u0103m\u00e2na<\/th>\n<th style=\"padding:10px 14px;\">Doza zilnic\u0103<\/th>\n<th style=\"padding:10px 14px;\">Program<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px 14px;\">S\u0103pt\u0103m\u00e2na 1<\/td>\n<td style=\"padding:10px 14px;\">100\u2013125 mg<\/td>\n<td style=\"padding:10px 14px;\">La culcare<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px 14px;\">S\u0103pt\u0103m\u00e2na 2<\/td>\n<td style=\"padding:10px 14px;\">200\u2013250 mg<\/td>\n<td style=\"padding:10px 14px;\">\u00cemp\u0103r\u021bit\u0103 \u00een dou\u0103 doze zilnice<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px 14px;\">S\u0103pt\u0103m\u00e2na 3<\/td>\n<td style=\"padding:10px 14px;\">500\u2013750 mg<\/td>\n<td style=\"padding:10px 14px;\">\u00cemp\u0103r\u021bit\u0103 \u00een trei doze zilnice<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px 14px;\">Doz\u0103 de \u00eentre\u021binere<\/td>\n<td style=\"padding:10px 14px;\">750\u20131,500 mg<\/td>\n<td style=\"padding:10px 14px;\">\u00cemp\u0103r\u021bit\u0103 \u00een trei doze zilnice<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 class=\"wp-block-heading\" style=\"font-size:15px;\">Tremor esen\u021bial<\/h3>\n<p>\u00cencepe\u021bi cu <strong>25\u201350 mg la culcare<\/strong> (mai mic dec\u00e2t epilepsia). Cre\u0219te\u021bi cu 25\u201350 mg la fiecare 1\u20132 s\u0103pt\u0103m\u00e2ni. Interval eficace: <strong>250\u2013750 mg\/zi<\/strong>. Mul\u021bi pacien\u021bi r\u0103spund la 250 mg\/zi sau mai pu\u021bin. Efectele secundare ale dozei ini\u021biale (sedare, ame\u021beli, grea\u021b\u0103) dispar adesea \u2014 \u00eenceperea cu doze foarte mici reduce abandonul tratamentului.<\/p>\n<h2 class=\"wp-block-heading\">Efecte Secundare<\/h2>\n<p><strong>Frecvente (\u00een special la \u00eenceput):<\/strong> sedare, ame\u021beli, grea\u021b\u0103\/v\u0103rs\u0103turi, ataxie, vertij \u2014 adesea numite \u201creac\u021bia la primidon\u201d. Acestea tind s\u0103 se diminueze \u00een primele 1\u20132 s\u0103pt\u0103m\u00e2ni.<\/p>\n<p><strong>Pe termen lung:<\/strong> \u00eencetinire cognitiv\u0103, modific\u0103ri de dispozi\u021bie, disfunc\u021bii sexuale, osteomalacie (prin metabolismul vitaminei D \u2014 acela\u0219i mecanism ca fenitoina\/fenobarbitalul), anemie megaloblastic\u0103 (epuizare folat\u0103).<\/p>\n<p><strong>Grave:<\/strong> dizcrazii sanguine (rare \u2014 agranulocitoz\u0103, anemie aplastic\u0103), hepatotoxicitate, sindrom asem\u0103n\u0103tor SLE (foarte rar).<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:16px 0;border-radius:4px;\"><strong>\u26a0 Avertisment privind \u00eentreruperea tratamentului:<\/strong> Nu \u00eentrerupe\u021bi brusc primidonul \u2014 metabolitul s\u0103u activ, fenobarbitalul, are o semivia\u021b\u0103 lung\u0103 (~80\u2013120 ore), iar \u00eentreruperea brusc\u0103 poate precipita <strong>stare epileptic\u0103<\/strong>. Reduce\u021bi progresiv pe parcursul s\u0103pt\u0103m\u00e2nilor sau lunilor sub supraveghere medical\u0103.<\/div>\n<h2 class=\"wp-block-heading\">Avertismente \u0219i precau\u021bii<\/h2>\n<ul>\n<li><strong>Comportament suicidal \u2014 avertizare de clas\u0103.<\/strong> Toate medicamentele anticonvulsivante poart\u0103 un avertisment FDA privind riscul crescut de idei suicidare. Monitoriza\u021bi modific\u0103rile de dispozi\u021bie.<\/li>\n<li><strong>Sedare \u2014 deosebit de sever\u0103 la \u00eenceput.<\/strong> Prima doz\u0103 de primidon poate provoca sedare dramatic\u0103, ame\u021beli, grea\u021b\u0103 \u0219i ataxie (\u201cvertijul primidonic\u201d). \u00cencepe\u021bi cu o doz\u0103 de noapte de 50\u2013125 mg \u0219i titra\u021bi foarte \u00eencet pe 2\u20134 s\u0103pt\u0103m\u00e2ni.<\/li>\n<li><strong>Induc\u021bie enzimatic\u0103.<\/strong> Primidonul\/fenobarbitalul induce puternic CYP3A4, CYP2C9, CYP2C19 \u0219i enzimele UGT. Aceasta reduce eficacitatea contraceptivelor orale, warfarinei, corticosteroidelor, lamotriginei \u0219i a multor alte medicamente. Utiliza\u021bi contraceptive non-hormonale sau formul\u0103ri cu doze mari de estrogen.<\/li>\n<li><strong>\u00centrerupere brusc\u0103.<\/strong> \u00centreruperea brusc\u0103 poate precipita status epilepticus. Reduce\u021bi treptat doza pe o perioad\u0103 de minim 2\u20134 s\u0103pt\u0103m\u00e2ni.<\/li>\n<li><strong>Deple\u021bie de vitamina D \u0219i osteoporoz\u0103.<\/strong> Utilizarea cronic\u0103 accelereaz\u0103 catabolismul vitaminei D prin induc\u021bie enzimatic\u0103. Suplimenta\u021bi cu vitamina D 1.000\u20132.000 UI\/zi. Monitoriza\u021bi scan\u0103rile DEXA la pacien\u021bii care urmeaz\u0103 terapia de peste 2 ani.<\/li>\n<li><strong>Deple\u021bie de acid folic.<\/strong> Primidonul epuizeaz\u0103 acidul folic, cresc\u00e2nd riscul de homocistein\u0103 ridicat\u0103 \u0219i anemie megaloblastic\u0103. Suplimenta\u021bi cu acid folic 1\u20135 mg\/zi, \u00een special la femeile \u00een v\u00e2rst\u0103 fertil\u0103.<\/li>\n<li><strong>Sarcina \u2014 categoria D.<\/strong> Fenobarbitalul (metabolit activ) este teratogen. Sindromul barbituric fetal include anomalii craniofaciale, restric\u021bie de cre\u0219tere \u0219i \u00eent\u00e2rziere neurodezvoltamental\u0103. De asemenea, exist\u0103 riscuri de sevraj neonatal \u0219i s\u00e2nger\u0103ri (deple\u021bie de vitamina K). Utiliza\u021bi numai dac\u0103 nu exist\u0103 alternative pentru controlul crizelor.<\/li>\n<li><strong>Afectare hepatic\u0103.<\/strong> Primidonul este metabolizat hepatic. Utiliza\u021bi doze mai mici \u0219i monitoriza\u021bi nivelurile \u00een cazul afec\u021biunilor hepatice.<\/li>\n<li><strong>Conducere auto.<\/strong> Nu conduce\u021bi p\u00e2n\u0103 c\u00e2nd nu a\u021bi fost pe o doz\u0103 stabil\u0103 timp de cel pu\u021bin 2 s\u0103pt\u0103m\u00e2ni. Sedarea este frecvent\u0103.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindica\u021bii \u2014 Cine NU ar trebui s\u0103 ia Mysoline<\/h2>\n<ul>\n<li>Hipersensibilitate cunoscut\u0103 la primidon, fenobarbital sau orice excipient<\/li>\n<li>Porfirie (barbituratele sunt absolut contraindicate)<\/li>\n<li>Insuficien\u021b\u0103 respiratorie sever\u0103<\/li>\n<li>Pacien\u021bi cu antecedente de dependen\u021b\u0103 sau abuz de barbiturate (contraindica\u021bie relativ\u0103)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>Depresante ale SNC:<\/strong> Sedare aditiv\u0103 (opioide, benzodiazepine, alcool)<\/li>\n<li><strong>Inducerea enzimelor CYP:<\/strong> Primidona (prin fenobarbital) induce CYP3A4, CYP2C \u0219i CYP1A2 \u2014 reduce nivelul contraceptivelor orale, warfarinei, corticosteroidelor, imunosupresoarelor \u0219i multor alte medicamente<\/li>\n<li><strong>Valproat:<\/strong> Inhib\u0103 metabolismul fenobarbitalului \u2192 risc de toxicitate; de asemenea, displace din legarea proteinelor<\/li>\n<li><strong>Isoniazid:<\/strong> Inhib\u0103 metabolismul primidonei \u2192 cre\u0219tere a nivelurilor<\/li>\n<li><strong>Carbamazepin\u0103:<\/strong> Inducere reciproc\u0103 \u2014 interac\u021biune bidirec\u021bional\u0103 complex\u0103<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Instruc\u021biuni de Depozitare<\/h2>\n<ul>\n<li>Se p\u0103streaz\u0103 la temperatura camerei, <strong>15\u201330\u00b0C<\/strong>. Proteja\u021bi de umiditate.<\/li>\n<li>P\u0103stra\u021bi \u00een ambalajul original p\u00e2n\u0103 la utilizare.<\/li>\n<li>P\u0103stra\u021bi \u00een afara reachii copiilor \u2014 supradoza de primidon\u0103\/fenobarbital este periculoas\u0103 pentru via\u021b\u0103.<\/li>\n<li>Nu utiliza\u021bi dup\u0103 data de expirare.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Categorii conexe pe MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/neurological-conditions-and-epilepsy\/\">R\u0103sfoi\u021bi toate medicamentele neurologice \u0219i antiepileptice<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/mental-health-and-psychiatric-medications\/\">R\u0103sfoi\u021bi medicamentele pentru s\u0103n\u0103tatea mintal\u0103 \u0219i psihiatrie<\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">Pentru ce se utilizeaz\u0103 Mysoline?<\/h3>\n<p>Mysoline con\u021bine <strong>primidon\u0103 250 mg<\/strong> \u0219i este utilizat pentru controlul <strong>crizelor tonico-clonice \u0219i a celor par\u021biale complexe<\/strong> \u00een epilepsie. De asemenea, este un <strong>tratament de prim\u0103 inten\u021bie pentru tremor esen\u021bial<\/strong> (tremur al m\u00e2inilor \u0219i al capului care se agraveaz\u0103 cu mi\u0219carea).<\/p>\n<h3 class=\"wp-block-heading\">Primidonul este un barbituric?<\/h3>\n<p>Primidonul este un <strong>derivat de barbituric<\/strong> (deoxibarbiturat). Nu este \u00een sine un barbituric, dar unul dintre cei doi metaboli\u021bi activi \u2014 <strong>fenobarbital<\/strong> \u2014 este. Aceasta \u00eenseamn\u0103 c\u0103 primidonul poart\u0103 avertismentele specifice clasei de barbiturice (poten\u021bial de dependen\u021b\u0103, crize de sevraj, depresie CNS).<\/p>\n<h3 class=\"wp-block-heading\">Cum se compar\u0103 Mysoline cu propranololul pentru tremurul esen\u021bial?<\/h3>\n<p>Ambele sunt <strong>linia \u00eent\u00e2i<\/strong> pentru tremurul esen\u021bial (conform ghidurilor AAN\/EFNS). Propranololul func\u021bioneaz\u0103 mai bine pentru tremurul membrelor \u0219i are un profil de efecte adverse mai cunoscut. Primidonul este mai eficient pentru unii pacien\u021bi \u0219i poate fi combinat cu propranolol atunci c\u00e2nd monoterapia este insuficient\u0103. Alegerea depinde de comorbidit\u0103\u021bi, tolerabilitate \u0219i preferin\u021bele pacientului.<\/p>\n<h3 class=\"wp-block-heading\">De ce este at\u00e2t de nepl\u0103cut\u0103 ini\u021bierea tratamentului cu Mysoline?<\/h3>\n<p>Reac\u021bia \u201cprimidon\u0103\u201d (gre\u021buri severe, ame\u021beli, sedare) apare deoarece compusul parental atinge concentra\u021bia maxim\u0103 \u00eenainte de dezvoltarea toleran\u021bei. \u00cenceperea cu <strong>25\u201350 mg la culcare<\/strong> (t\u0103ierea tabletei de 250 mg) reduce dramatic aceast\u0103 reac\u021bie. Majoritatea pacien\u021bilor tolereaz\u0103 bine medicamentul dup\u0103 prima s\u0103pt\u0103m\u00e2n\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Mysoline necesit\u0103 monitorizarea nivelului sanguin?<\/h3>\n<p>At\u00e2t primidona, c\u00e2t \u0219i metabolitul s\u0103u, fenobarbitalul, pot fi m\u0103surate. <strong>Niveluri de fenobarbital<\/strong> (terapeutice: 15\u201340 \u00b5g\/mL) sunt un ghid clinic mai util pentru epilepsie, deoarece fenobarbitalul este metabolitul activ cu ac\u021biune \u00eendelungat\u0103. Pentru tremorul esen\u021bial, dozarea este de obicei ghidat\u0103 de r\u0103spunsul clinic mai degrab\u0103 dec\u00e2t de niveluri.<\/p>\n<h3 class=\"wp-block-heading\">Pot opri Mysoline brusc?<\/h3>\n<p><strong>Nu.<\/strong> Deoarece fenobarbitalul (un metabolit major) are o semivie foarte lung\u0103, \u00eentreruperea brusc\u0103 dup\u0103 utilizare cronic\u0103 poate provoca <strong>criz\u0103 epileptic\u0103 de rebond sau status epilepticus<\/strong>. Reducerea treptat\u0103 ar trebui s\u0103 se fac\u0103 pe parcursul s\u0103pt\u0103m\u00e2nilor sau lunilor.<\/p>\n<h3 class=\"wp-block-heading\">Primidona afecteaz\u0103 contraceptivele orale?<\/h3>\n<p>Da \u2014 primidona (prin fenobarbital) induce puternic CYP3A4, care accelereaz\u0103 metabolismul estrogenului \u0219i progestagenului. <strong>Contraceptivele hormonale pot e\u0219ua.<\/strong> Utiliza\u021bi o metod\u0103 non-hormonal\u0103 (DIU de cupru) sau o metod\u0103 neafectat\u0103 de induc\u021bia enzimatic\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Mysoline este sigur \u00een timpul sarcinii?<\/h3>\n<p>Primidonul este <strong>teratogen<\/strong> (prin metabolitul fenobarbital). Este asociat cu defecte cardiace congenitale \u0219i anomalii faciale. Schimba\u021bi la un anticonvulsivant mai sigur \u00eenainte de concep\u021bie, atunci c\u00e2nd este posibil. Dac\u0103 primidonul trebuie continuat, doze mari de acid folic \u0219i monitorizarea de specialitate sunt esen\u021biale.<\/p>\n<h3 class=\"wp-block-heading\">Care este diferen\u021ba dintre Mysoline \u0219i fenobarbital?<\/h3>\n<p>Primidonul este un <strong>prodrog<\/strong> care este convertit \u00een fenobarbital plus PEMA. Unii pacien\u021bi care nu r\u0103spund la fenobarbital singur r\u0103spund la primidon, suger\u00e2nd c\u0103 compusul p\u0103rinte \u0219i PEMA contribuie independent. Primidonul poate avea \u0219i un efect mai rapid asupra tremorului, deoarece nivelurile maxime ale medicamentului p\u0103rinte apar \u00eenainte de acumularea fenobarbitalului.<\/p>\n<h3 class=\"wp-block-heading\">Pot s\u0103 consum alcool \u00een timp ce iau Mysoline?<\/h3>\n<p><strong>Evita\u021bi alcoolul.<\/strong> At\u00e2t primidonul\/fenobarbitalul, c\u00e2t \u0219i alcoolul sunt depresante ale SNC \u2014 utilizarea combinat\u0103 cre\u0219te semnificativ sedarea, tulbur\u0103rile de coordonare, riscul de depresie respiratorie \u0219i deteriorarea cognitiv\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Mysoline provoac\u0103 cre\u0219tere \u00een greutate?<\/h3>\n<p>O u\u0219oar\u0103 cre\u0219tere \u00een greutate este posibil\u0103 cu utilizarea pe termen lung (efect de clas\u0103 barbituric), de\u0219i este mai pu\u021bin frecvent\u0103 dec\u00e2t \u00een cazul valproatului sau gabapentinei. Reducerea activit\u0103\u021bii fizice legate de sedare poate contribui.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Avertizare medical\u0103:<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical profesionist. Consulta\u021bi \u00eentotdeauna un furnizor de servicii medicale calificat \u00eenainte de a \u00eencepe, modifica sau \u00eentrerupe orice medica\u021bie. Informa\u021biile privind dozarea reflect\u0103 eticheta produc\u0103torului \u0219i ghidurile clinice publicate \u2014 cerin\u021bele individuale pot diferi.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alternative conexe<\/h3>\n<p>Alte produse din <strong>Afec\u021biuni cronice<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/topaheal\/\">Topaheal<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/lorfast-meltab\/\">Lorfast Meltab<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/modin-2-5\/\">Modin 2.5<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/carloc\/\">Carloc<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/lox-10-spray\/\">Spray Lox 10%<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Controlul crizelor<br \/>\n\u2705 Managementul epilepsiei<br \/>\n\u2705 Reducerea convulsiilor<br \/>\n\u2705 Calitate de via\u021b\u0103 \u00eembun\u0103t\u0103\u021bit\u0103<br \/>\n\u2705 \u00cembun\u0103t\u0103\u021birea func\u021biei motorii<\/p>\n<p>Mysoline con\u021bine Primidon.<\/p>","protected":false},"featured_media":60228,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3468],"product_tag":[4826,4827],"class_list":{"0":"post-60227","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-neurological-conditions-and-epilepsy","9":"product_tag-mysoline","10":"product_tag-primidone","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/60227","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=60227"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/60228"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=60227"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=60227"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=60227"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=60227"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}