{"id":60357,"date":"2024-02-28T06:45:27","date_gmt":"2024-02-28T06:45:27","guid":{"rendered":"https:\/\/medsname.com\/rcifax\/"},"modified":"2026-04-30T10:23:48","modified_gmt":"2026-04-30T10:23:48","slug":"rcifax","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/rcifax\/","title":{"rendered":"Rcifax"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Rcifax?<\/h3>\n<p style=\"margin:0;\"><strong>Rcifax<\/strong> este <strong>rifaximin 400 mg or 550 mg<\/strong> &mdash; a non-absorbable rifamycin antibiotic that acts almost entirely within the gut lumen. Three validated indications: <strong>traveller&#8217;s diarrhoea (non-invasive E. coli), prevention of overt hepatic encephalopathy in cirrhosis, and IBS-D (diarrhoea-predominant irritable bowel)<\/strong>. Less than 0.4 percent of an oral dose is absorbed systemically, so off-target side effects, drug interactions, and resistance pressure on commensal bacteria are minimal. WHO-GMP certified manufacturer.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>De ce s\u0103 comanzi de la MedsBase:<\/strong> \u2714 <strong>produc\u0103tor certificat WHO-GMP<\/strong> \u2714 Ambalaj discret \u2714 Livrare worldwide \u2714 <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">Recenzii verificate ale clien\u021bilor (peste 1.400 de clien\u021bi)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>&#128161; Why &#8220;gut-selective&#8221;?<\/strong> Rifaximin is a structural analogue of rifamycin SV with an additional pyridoimidazole ring that prevents intestinal absorption. The compound therefore reaches very high concentrations in the gut lumen but does not enter the systemic circulation in significant amounts. This explains its safety profile and its preferential effect on enteric bacteria.<\/div>\n<h3 class=\"wp-block-heading\">De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Rcifax is supplied from a <strong>produc\u0103tor certificat WHO-GMP<\/strong>. Fiecare comand\u0103 este expediat\u0103 discret \u00een \u00eentreaga lume \u0219i este acoperit\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> &mdash; if it does not arrive within 20 business days, we reship at no cost. Rifaximin is endorsed by AASLD 2021 for hepatic encephalopathy prevention and by ACG 2021 for traveller&#8217;s diarrhoea and IBS-D &mdash; one of the few antibiotics with strong evidence in functional GI disorders.<\/p>\n<h2 class=\"wp-block-heading\">Mecanism de ac\u021biune<\/h2>\n<p>Rifaximin binds the &beta;-subunit of bacterial DNA-dependent RNA polymerase (rpoB), inhibiting bacterial RNA synthesis. Spectrum covers Gram-positive and Gram-negative aerobes and anaerobes including E. coli, Shigella, Salmonella, Campylobacter, and many enteric anaerobes. Because absorption is &lt; 0.4 percent of the oral dose, the drug acts effectively only on intra-luminal organisms.<\/p>\n<h2 class=\"wp-block-heading\">Indica\u021bii &amp; doze<\/h2>\n<table border=\"1\" cellpadding=\"6\" style=\"border-collapse:collapse;width:100%;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th>Indica\u021bie<\/th>\n<th>Doza<\/th>\n<th>Durat\u0103<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Traveller&#8217;s diarrhoea (non-invasive)<\/td>\n<td>200&ndash;400 mg three times daily<\/td>\n<td>3 zile<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Hepatic encephalopathy &mdash; prevention<\/td>\n<td>550 mg twice daily<\/td>\n<td>Long-term, with lactulose<\/td>\n<\/tr>\n<tr>\n<td>IBS-D<\/td>\n<td>550 mg three times daily<\/td>\n<td>14 days; can be re-dosed up to 2 more times if symptoms recur<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Small-intestinal bacterial overgrowth (SIBO)<\/td>\n<td>550 mg three times daily<\/td>\n<td>14 days (off-label)<\/td>\n<\/tr>\n<tr>\n<td>Diverticulitis (mild)<\/td>\n<td>400 mg de dou\u0103 ori pe zi<\/td>\n<td>7 days (off-label, with diet)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">When it is NOT the right drug<\/h2>\n<ul>\n<li>Invasive enteric infection (fever, bloody stool, severe systemic illness) &mdash; needs ciprofloxacin or azithromycin systemically.<\/li>\n<li>Pseudomembranous colitis (C. difficile) &mdash; oral vancomycin or fidaxomicin is first-line; rifaximin has limited evidence as a relapse-prevention adjunct.<\/li>\n<li>Suspected typhoid &mdash; needs systemic antibiotic.<\/li>\n<li>Suspected appendicitis \/ cholangitis \/ pyelonephritis &mdash; needs systemic.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Efecte secundare<\/h2>\n<ul>\n<li>Gastrointestinal: nausea, abdominal pain, flatulence (mostly mild)<\/li>\n<li>Dureri de cap, ame\u021beli<\/li>\n<li>Peripheral oedema (with HE-prevention long courses)<\/li>\n<li>C. difficile-associated diarrhoea (rare; the gut-selective profile reduces but does not eliminate this risk)<\/li>\n<li>Hypersensitivity reactions (rare): rash, urticaria, anaphylaxis<\/li>\n<li>Cross-reactivity with rifampicin\/rifabutin in patients with rifamycin allergy<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<p>Rifaximin&#8217;s very low systemic absorption means clinically significant interactions are unusual. However:<\/p>\n<ul>\n<li><strong>P-gp inhibitors<\/strong> (cyclosporin) raise the small absorbed fraction.<\/li>\n<li><strong>Warfarin:<\/strong> isolated reports of INR change &mdash; check INR if used concurrently.<\/li>\n<li><strong>Pilul\u0103 contraceptiv\u0103 combinat\u0103:<\/strong> oral contraceptive efficacy is theoretically reduced if rifaximin causes severe diarrhoea (transit time effect).<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">How quickly does it work in traveller&#8217;s diarrhoea?<\/h3>\n<p>Symptom improvement is usually within 24&ndash;48 hours. The 3-day course is sufficient for non-invasive E. coli, the most common cause. If symptoms are severe (fever, bloody stool) or do not improve in 48 hours, change to systemic antibiotic.<\/p>\n<h3 class=\"wp-block-heading\">Does it cure IBS?<\/h3>\n<p>No. Rifaximin reduces IBS-D symptoms in about 40 percent of patients; benefit lasts 10&ndash;12 weeks. It can be repeated if symptoms recur. It is not a cure but a useful symptomatic intervention.<\/p>\n<h3 class=\"wp-block-heading\">Why do I need lactulose with it for hepatic encephalopathy?<\/h3>\n<p>Lactulose acidifies the colon and ion-traps ammonia. Rifaximin reduces ammonia-producing bacteria. The two work synergistically; combination therapy reduces HE recurrence by ~60 percent versus lactulose alone.<\/p>\n<h3 class=\"wp-block-heading\">Pot consuma alcool \u00een timpul tratamentului?<\/h3>\n<p>There is no disulfiram-like interaction. However, traveller&#8217;s diarrhoea recovery and HE prevention both benefit from minimal alcohol intake.<\/p>\n<h3 class=\"wp-block-heading\">Este sigur \u00een sarcin\u0103?<\/h3>\n<p>Category C. Used in pregnancy when the indication justifies it (HE in pregnant cirrhotic) under specialist advice. Discuss with obstetric prescriber.<\/p>\n<h3 class=\"wp-block-heading\">How is it different from rifampicin?<\/h3>\n<p>Same drug-class binding target but rifampicin is highly absorbed (oral bioavailability ~90 percent) and used systemically for tuberculosis, leprosy, and meningococcal prophylaxis &mdash; with significant CYP3A4\/2C19 induction and CYP-driven interactions. Rifaximin is gut-restricted with negligible systemic effect.<\/p>\n<h3 class=\"wp-block-heading\">Will it disrupt my normal gut bacteria?<\/h3>\n<p>Yes, but transiently. The gut microbiome typically recovers within 2&ndash;4 weeks. Probiotics during and after the course may shorten recovery (modest evidence).<\/p>\n<h3 class=\"wp-block-heading\">Is resistance a concern?<\/h3>\n<p>Rifaximin resistance can develop in enteric bacteria with repeated courses but the impact on systemic rifamycin use (rifampicin for TB, rifabutin for HIV) is limited because rifaximin is not used systemically. Still, avoid casual repeat courses.<\/p>\n<h3 class=\"wp-block-heading\">Depozitare<\/h3>\n<p>Below 30&deg;C, dry place. Keep blister sealed until use.<\/p>\n<h3 class=\"wp-block-heading\">Ce fac dac\u0103 uit o doz\u0103?<\/h3>\n<p>Take it as soon as you remember unless close to the next dose. Do not double up. Try to keep the schedule consistent.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alte Medicamente pentru S\u0103n\u0103tatea Gastrointestinal\u0103<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/rifagut\/\">Rifagut &mdash; Rifaximin (alternate brand)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/ciplox\/\">Ciplox &mdash; Ciprofloxacin (systemic option for invasive enteric infection)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/synclar\/\">Synclar \u2014 Clarithromycin (H. pylori)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/cendox\/\">Cendox \u2014 Doxycycline<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/colospa\/\">Colospa \u2014 Mebeverin\u0103 (antispastic pentru sindromul colonului iritabil)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/gastro-health\/\"><strong>Vede\u021bi toate Medicamentele pentru S\u0103n\u0103tatea Gastrointestinal\u0103<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> This page is for informational purposes only and does not replace medical advice from a qualified healthcare professional. Bloody stool, high fever, severe abdominal pain, dehydration, or no improvement in 48 hours needs urgent assessment. Hepatic encephalopathy is a medical emergency.<\/div>","protected":false},"excerpt":{"rendered":"<p>Rcifax (Rifaximin 400 mg or 550 mg) \u2014 non-absorbable rifamycin for traveller&#8217;s diarrhoea, hepatic encephalopathy prevention, and IBS-D. Less than 0.4 percent systemic absorption. WHO-GMP certified manufacturer. Worldwide shipping from MedsBase.<\/p>","protected":false},"featured_media":60358,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[4850,3585],"class_list":{"0":"post-60357","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","9":"product_tag-rcifax","10":"product_tag-rifaximin","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/60357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=60357"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/60358"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=60357"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=60357"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=60357"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=60357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}