{"id":60357,"date":"2024-02-28T06:45:27","date_gmt":"2024-02-28T06:45:27","guid":{"rendered":"https:\/\/medsname.com\/rcifax\/"},"modified":"2026-04-30T10:23:48","modified_gmt":"2026-04-30T10:23:48","slug":"rcifax","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/rcifax\/","title":{"rendered":"Rcifax"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Rcifax?<\/h3>\n<p style=\"margin:0;\"><strong>Rcifax<\/strong> este <strong>rifaximin 400 mg sau 550 mg<\/strong> \u2014 un antibiotic rifamicinic neabsorbabil care ac\u021bioneaz\u0103 aproape \u00een \u00eentregime \u00een lumenul intestinal. Trei indica\u021bii validate: <strong>diareea c\u0103l\u0103torului (E. coli neinvaziv), prevenirea encefalopatiei hepatice manifeste \u00een ciroz\u0103 \u0219i IBS-D (sindromul intestinului iritabil cu predominan\u021b\u0103 diareic\u0103)<\/strong>. Sub 0,4% din doza oral\u0103 este absorbit\u0103 sistemic, astfel \u00eenc\u00e2t efectele secundare extraintestinale, interac\u021biunile medicamentoase \u0219i presiunea de rezisten\u021b\u0103 asupra bacteriilor comensale sunt minime. Produc\u0103tor certificat WHO-GMP.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>De ce s\u0103 comanzi de la MedsBase:<\/strong> \u2714 <strong>produc\u0103tor certificat WHO-GMP<\/strong> \u2714 Ambalaj discret \u2714 Livrare worldwide \u2714 <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">Recenzii verificate ale clien\u021bilor (peste 1.400 de clien\u021bi)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>\ud83d\udca1 De ce \u201cselectiv intestinal\u201d?<\/strong> Rifaximinul este un analog structural al rifamicinului SV cu un inel suplimentar de piridoimidazol care previne absorb\u021bia intestinal\u0103. Prin urmare, compusul atinge concentra\u021bii foarte ridicate \u00een lumenul intestinal, dar nu p\u0103trunde \u00een circula\u021bia sistemic\u0103 \u00een cantit\u0103\u021bi semnificative. Acest lucru explic\u0103 profilul s\u0103u de siguran\u021b\u0103 \u0219i efectul preferen\u021bial asupra bacteriilor enterice.<\/div>\n<h3 class=\"wp-block-heading\">De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Rcifax este furnizat de la <strong>produc\u0103tor certificat WHO-GMP<\/strong>. Fiecare comand\u0103 este expediat\u0103 discret \u00een \u00eentreaga lume \u0219i este acoperit\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> \u2014 dac\u0103 nu ajunge \u00een 20 de zile lucr\u0103toare, retrimitem f\u0103r\u0103 costuri suplimentare. Rifaximinul este recomandat de AASLD 2021 pentru prevenirea encefalopatiei hepatice \u0219i de ACG 2021 pentru diareea c\u0103l\u0103torului \u0219i IBS-D \u2014 unul dintre pu\u021binele antibiotice cu dovezi solide \u00een tulbur\u0103ri gastrointestinale func\u021bionale.<\/p>\n<h2 class=\"wp-block-heading\">Mecanism de ac\u021biune<\/h2>\n<p>Rifaximinul se leag\u0103 de subunitatea \u03b2 a ARN-polimerazei dependente de ADN bacterian (rpoB), inhib\u00e2nd sinteza ARN-ului bacterian. Spectrul acoper\u0103 aerobe \u0219i anaerobe Gram-pozitive \u0219i Gram-negative, inclusiv E. coli, Shigella, Salmonella, Campylobacter \u0219i multe anaerobe enterice. Deoarece absorb\u021bia este &lt; 0,4% din doza oral\u0103, medicamentul ac\u021bioneaz\u0103 eficient doar asupra organismelor intraluminale.<\/p>\n<h2 class=\"wp-block-heading\">Indica\u021bii &amp; doze<\/h2>\n<table border=\"1\" cellpadding=\"6\" style=\"border-collapse:collapse;width:100%;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th>Indica\u021bie<\/th>\n<th>Doza<\/th>\n<th>Durat\u0103<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Diareea c\u0103l\u0103torului (neinvaziv\u0103)<\/td>\n<td>200\u2013400 mg de trei ori pe zi<\/td>\n<td>3 zile<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Encefalopatie hepatic\u0103 \u2014 prevenire<\/td>\n<td>550 mg de dou\u0103 ori pe zi<\/td>\n<td>Pe termen lung, cu lactuloz\u0103<\/td>\n<\/tr>\n<tr>\n<td>IBS-D<\/td>\n<td>550 mg de trei ori pe zi<\/td>\n<td>14 zile; poate fi repetat de p\u00e2n\u0103 la 2 ori dac\u0103 simptomele recidiveaz\u0103<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Supracrescerea bacterian\u0103 a intestinului sub\u021bire (SIBO)<\/td>\n<td>550 mg de trei ori pe zi<\/td>\n<td>14 zile (off-label)<\/td>\n<\/tr>\n<tr>\n<td>Diverticulit\u0103 (u\u0219oar\u0103)<\/td>\n<td>400 mg de dou\u0103 ori pe zi<\/td>\n<td>7 zile (off-label, cu diet\u0103)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">C\u00e2nd NU este medicamentul potrivit<\/h2>\n<ul>\n<li>Infec\u021bie enteric\u0103 invaziv\u0103 (febr\u0103, scaun s\u00e2ngeros, afec\u021biune sistemic\u0103 sever\u0103) \u2014 necesit\u0103 ciprofloxacina sau azitromicina sistemic.<\/li>\n<li>Colit\u0103 pseudomembranoas\u0103 (C. difficile) \u2014 vancomicina oral\u0103 sau fidaxomicina sunt de prim\u0103 inten\u021b\u0103; rifaximina are dovezi limitate ca adjuvant pentru prevenirea recidivelor.<\/li>\n<li>Suspect de tifos \u2014 necesit\u0103 antibiotic sistemic.<\/li>\n<li>Suspect de apendicit\u0103\/colangit\u0103\/pielonefrit\u0103 \u2014 necesit\u0103 tratament sistemic.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Efecte secundare<\/h2>\n<ul>\n<li>Gastrointestinale: grea\u021b\u0103, dureri abdominale, flatulen\u021b\u0103 (\u00een general u\u0219oare)<\/li>\n<li>Dureri de cap, ame\u021beli<\/li>\n<li>Edem periferic (la tratamente lungi pentru prevenirea encefalopatiei hepatice)<\/li>\n<li>Diaree asociat\u0103 cu C. difficile (rar; profilul selectiv intestinal reduce, dar nu elimin\u0103 complet acest risc)<\/li>\n<li>Reac\u021bii de hipersensibilitate (rare): erup\u021bie cutanat\u0103, urticarie, anafilaxie<\/li>\n<li>Reactivitate \u00eencruci\u0219at\u0103 cu rifampicin\u0103\/rifabutin\u0103 la pacien\u021bii cu alergie la rifamicin\u0103<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<p>Absorb\u021bia sistemic\u0103 foarte sc\u0103zut\u0103 a rifaximinei face ca interac\u021biunile clinice semnificative s\u0103 fie neobi\u0219nuite. Totu\u0219i:<\/p>\n<ul>\n<li><strong>Inhibitori P-gp<\/strong> (ciclosporina) cresc frac\u021biunea mic\u0103 absorbit\u0103.<\/li>\n<li><strong>Warfarin:<\/strong> raport\u0103ri izolate de modificare a INR \u2014 verifica\u021bi INR dac\u0103 este utilizat concomitent.<\/li>\n<li><strong>Pilul\u0103 contraceptiv\u0103 combinat\u0103:<\/strong> eficacitatea contraceptivelor orale este teoretic redus\u0103 dac\u0103 rifaximina provoac\u0103 diaree sever\u0103 (efect de timp de tranzit).<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">C\u00e2t de repede ac\u021bioneaz\u0103 \u00een diareea c\u0103l\u0103torului?<\/h3>\n<p>\u00cembun\u0103t\u0103\u021birea simptomelor apare de obicei \u00een 24\u201348 de ore. Cursul de 3 zile este suficient pentru E. coli neinvaziv, cauza cea mai frecvent\u0103. Dac\u0103 simptomele sunt severe (febr\u0103, scaun s\u00e2ngeros) sau nu se \u00eembun\u0103t\u0103\u021besc \u00een 48 de ore, trece\u021bi la un antibiotic sistemic.<\/p>\n<h3 class=\"wp-block-heading\">Vindec\u0103 IBS-ul?<\/h3>\n<p>Nu. Rifaximina reduce simptomele IBS-D la aproximativ 40% dintre pacien\u021bi; beneficiul dureaz\u0103 10\u201312 s\u0103pt\u0103m\u00e2ni. Poate fi repetat\u0103 dac\u0103 simptomele reap\u0103r. Nu este o vindecare, ci o interven\u021bie simptomatic\u0103 util\u0103.<\/p>\n<h3 class=\"wp-block-heading\">De ce am nevoie de lactuloz\u0103 cu ea pentru encefalopatia hepatic\u0103?<\/h3>\n<p>Lactuloza acidific\u0103 colonul \u0219i capteaz\u0103 ionii de amoniac. Rifaximina reduce bacteriile produc\u0103toare de amoniac. Cele dou\u0103 ac\u021bioneaz\u0103 sinergic; terapia combinat\u0103 reduce recuren\u021ba HE cu ~60% fa\u021b\u0103 de lactuloz\u0103 singur\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Pot consuma alcool \u00een timpul tratamentului?<\/h3>\n<p>Nu exist\u0103 o interac\u021biune de tip disulfiram. Cu toate acestea, recuperarea de la diareea c\u0103l\u0103torului \u0219i prevenirea HE beneficiaz\u0103 ambele de o ingestie minim\u0103 de alcool.<\/p>\n<h3 class=\"wp-block-heading\">Este sigur \u00een sarcin\u0103?<\/h3>\n<p>Categoria C. Utilizat \u00een sarcin\u0103 atunci c\u00e2nd indica\u021bia o justific\u0103 (HE la gravide cu ciroz\u0103) sub \u00eendrumare specializat\u0103. Discuta\u021bi cu medicul obstetrician prescriptor.<\/p>\n<h3 class=\"wp-block-heading\">Cum difer\u0103 de rifampicin\u0103?<\/h3>\n<p>Acela\u0219i \u021bint\u0103 de legare \u00een clasa de medicamente, dar rifampicina este foarte absorbit\u0103 (biodisponibilitate oral\u0103 ~90%) \u0219i utilizat\u0103 sistemic pentru tuberculoz\u0103, lepr\u0103 \u0219i profilaxie meningococic\u0103 \u2014 cu induc\u021bie semnificativ\u0103 a CYP3A4\/2C19 \u0219i interac\u021biuni mediate de CYP. Rifaximina este restric\u021bionat\u0103 la intestin, cu efect sistemic neglijabil.<\/p>\n<h3 class=\"wp-block-heading\">Va perturba flora intestinal\u0103 normal\u0103?<\/h3>\n<p>Da, dar temporar. Microbiomul intestinal se recupereaz\u0103 de obicei \u00een 2-4 s\u0103pt\u0103m\u00e2ni. Probioticele \u00een timpul \u0219i dup\u0103 tratament pot scurta perioada de recuperare (dovezi modeste).<\/p>\n<h3 class=\"wp-block-heading\">Rezisten\u021ba este o problem\u0103?<\/h3>\n<p>Rezisten\u021ba la rifaximin\u0103 poate ap\u0103rea la bacteriile enterice dup\u0103 cursuri repetate, dar impactul asupra utiliz\u0103rii sistemice a rifamicinelor (rifampicin\u0103 pentru TB, rifabutin\u0103 pentru HIV) este limitat deoarece rifaximina nu este utilizat\u0103 sistemic. Totu\u0219i, evita\u021bi repetarea nejustificat\u0103 a tratamentului.<\/p>\n<h3 class=\"wp-block-heading\">Depozitare<\/h3>\n<p>Sub 30\u00b0C, loc uscat. P\u0103stra\u021bi blisterul sigilat p\u00e2n\u0103 la utilizare.<\/p>\n<h3 class=\"wp-block-heading\">Ce fac dac\u0103 uit o doz\u0103?<\/h3>\n<p>Lua\u021bi-l c\u00e2t mai cur\u00e2nd v\u0103 aminti\u021bi, cu excep\u021bia cazului \u00een care este aproape de urm\u0103toarea doz\u0103. Nu dubla\u021bi doza. \u00cencerca\u021bi s\u0103 respecta\u021bi programul.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alte Medicamente pentru S\u0103n\u0103tatea Gastrointestinal\u0103<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/rifagut\/\">Rifagut \u2014 Rifaximin\u0103 (marc\u0103 alternativ\u0103)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/ciplox\/\">Ciplox \u2014 Ciprofloxacin\u0103 (op\u021biune sistemic\u0103 pentru infec\u021bii enterice invazive)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/synclar\/\">Synclar \u2014 Clarithromycin (H. pylori)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/cendox\/\">Cendox \u2014 Doxycycline<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/colospa\/\">Colospa \u2014 Mebeverin\u0103 (antispastic pentru sindromul colonului iritabil)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/gastro-health\/\"><strong>Vede\u021bi toate Medicamentele pentru S\u0103n\u0103tatea Gastrointestinal\u0103<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui profesionist calificat. Scaunul s\u00e2ngeros, febra mare, durerea abdominal\u0103 sever\u0103, deshidratarea sau lipsa \u00eembun\u0103t\u0103\u021birii \u00een 48 de ore necesit\u0103 evaluare urgent\u0103. Encefalopatia hepatic\u0103 este o urgen\u021b\u0103 medical\u0103.<\/div>","protected":false},"excerpt":{"rendered":"<p>Rcifax (Rifaximin 400 mg sau 550 mg) \u2014 rifamicin\u0103 neabsorbabil\u0103 pentru diareea c\u0103l\u0103torului, prevenirea encefalopatiei hepatice \u0219i IBS-D. Absorb\u021bie sistemic\u0103 sub 0,4%. Produc\u0103tor certificat WHO-GMP. Livrare worldwide de la MedsBase.<\/p>","protected":false},"featured_media":60358,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[4850,3585],"class_list":{"0":"post-60357","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","9":"product_tag-rcifax","10":"product_tag-rifaximin","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/60357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=60357"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/60358"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=60357"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=60357"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=60357"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=60357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}