{"id":60451,"date":"2024-02-28T06:49:25","date_gmt":"2024-02-28T06:49:25","guid":{"rendered":"https:\/\/medsname.com\/xarelto-20\/"},"modified":"2026-05-01T10:49:16","modified_gmt":"2026-05-01T10:49:16","slug":"xarelto-20","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/xarelto-20\/","title":{"rendered":"Xarelto 20"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Xarelto 20?<\/h3>\n<p style=\"margin:0;\"><strong>Xarelto 20<\/strong> sunt comprimate de rivaroxaban 20 mg de la Bayer \u2014 anticoagulant oral direct (DOAC) \u2014 inhibitor direct al factorului Xa. Rivaroxaban a fost introdus de Bayer \u00een 2008 ca <strong>Xarelto<\/strong> \u2014 primul inhibitor oral direct al factorului Xa. ROCKET-AF (2011) \u0219i EINSTEIN-DVT\/PE (2010) au stabilit non-inferioritatea fa\u021b\u0103 de warfarin \u00een FA \u0219i TEV. inhibeaz\u0103 direct factorul Xa, punctul central de convergen\u021b\u0103 al cascadelor de coagulare intrinseci \u0219i extrinseci, reduc\u00e2nd generarea de trombina. Timp de \u00eenjum\u0103t\u0103\u021bire: 5-13 ore; eliminare renal\u0103 \u0219i hepatic\u0103. Dozare: <strong>Fibrila\u021bie atrial\u0103 non-valvular\u0103:<\/strong> 20 mg o dat\u0103 pe zi cu m\u00e2ncare (15 mg dac\u0103 CrCl 15-50 mL\/min). <strong>Tratament TEV\/EP:<\/strong> 15 mg de dou\u0103 ori pe zi timp de 3 s\u0103pt\u0103m\u00e2ni, apoi 20 mg o dat\u0103 pe zi. <strong>COMPASS profilaxia vascular\u0103:<\/strong> 2,5 mg de dou\u0103 ori pe zi cu aspirin\u0103 75-100 mg zilnic. S\u00e2nger\u0103ri majore ~3-5%\/an \u00een FA; s\u00e2nger\u0103ri gastrointestinale u\u0219or mai frecvente dec\u00e2t cu warfarin\u0103. Nu necesit\u0103 monitorizare rutin\u0103 spre deosebire de warfarin\u0103 \u2014 un avantaj practic major. Reversare cu andexanet alfa (antidot specific) acolo unde este disponibil, sau concentrat de protrombin\u0103 complex cu 4 factori. Selectia anticoagulantului \u0219i antiagregantului se face individual \u00een func\u021bie de diagnostic, risc de s\u00e2ngerare, func\u021bia renal\u0103 \u0219i interac\u021biunile medicamentoase. Supravegherea de c\u0103tre specialist sau medic de familie este standard.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<h2 class=\"wp-block-heading\">Ce este Xarelto 20?<\/h2>\n<p>Xarelto 20 sunt comprimate de 20 mg rivaroxaban de la Bayer, furnizate \u00een cutii de 14-112 comprimate. Rivaroxabanul a fost introdus de Bayer \u00een 2008 ca <strong>Xarelto<\/strong> \u2014 primul inhibitor oral direct al factorului Xa. Studiile ROCKET-AF (2011) \u0219i EINSTEIN-DVT\/PE (2010) au demonstrat non-inferioritatea fa\u021b\u0103 de warfarin \u00een FA \u0219i TEV.<\/p>\n<h2 class=\"wp-block-heading\">Cum ac\u021bioneaz\u0103 rivaroxabanul<\/h2>\n<p>Rivaroxabanul inhib\u0103 direct factorul Xa, punctul central de convergen\u021b\u0103 al cascadelor de coagulare intrinsec\u0103 \u0219i extrinsec\u0103, reduc\u00e2nd generarea de trombina. Timp de \u00eenjum\u0103t\u0103\u021bire de 5-13 ore; eliminat renal \u0219i hepatic.<\/p>\n<h2 class=\"wp-block-heading\">Utiliz\u0103ri aprobate<\/h2>\n<ul>\n<li><strong>Fibrila\u021bie atrial\u0103 non-valvular\u0103<\/strong> \u2014 prevenirea accidentului vascular cerebral (ROCKET-AF)<\/li>\n<li><strong>Tromboza venoas\u0103 profund\u0103 \u0219i embolie pulmonar\u0103<\/strong> \u2014 tratament (studiile EINSTEIN) \u0219i profilaxie prelungit\u0103<\/li>\n<li><strong>Profilaxia VTE<\/strong> dup\u0103 interven\u021bii chirurgicale ortopedice majore<\/li>\n<li><strong>Boal\u0103 coronarian\u0103 stabil\u0103 sau boal\u0103 arterial\u0103 periferic\u0103<\/strong> \u2014 2,5 mg de dou\u0103 ori pe zi + aspirin\u0103 (COMPASS 2017) pentru preven\u021bia aterotrombotic\u0103 la pacien\u021bii cu risc ridicat<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dozaj<\/h2>\n<p><strong>Fibrila\u021bie atrial\u0103 non-valvular\u0103:<\/strong> 20 mg o dat\u0103 pe zi cu m\u00e2ncare (15 mg dac\u0103 CrCl 15-50 mL\/min). <strong>Tratament TEV\/EP:<\/strong> 15 mg de dou\u0103 ori pe zi timp de 3 s\u0103pt\u0103m\u00e2ni, apoi 20 mg o dat\u0103 pe zi. <strong>COMPASS profilaxia vascular\u0103:<\/strong> 2,5 mg de dou\u0103 ori pe zi cu aspirin\u0103 75-100 mg pe zi.<\/p>\n<h2 class=\"wp-block-heading\">Riscul de s\u00e2ngerare \u0219i monitorizare<\/h2>\n<p>Hemoragii majore ~3-5%\/an \u00een FA; hemoragiile gastrointestinale u\u0219or mai frecvente dec\u00e2t la warfarin. Nu necesit\u0103 monitorizare periodic\u0103, spre deosebire de warfarin \u2014 un avantaj practic major. Reversare cu andexanet alfa (antidot specific) unde este disponibil, sau concentrat de protrombin\u0103 complex cu 4 factori.<\/p>\n<p><strong>Nu este necesar\u0103 monitorizarea periodic\u0103 a s\u00e2ngelui<\/strong> \u2014 un avantaj practic major fa\u021b\u0103 de warfarin. Verifica\u021bi func\u021bia renal\u0103 la ini\u021biere, dup\u0103 3 luni, apoi anual (sau mai devreme \u00een caz de boal\u0103 acut\u0103 sau la v\u00e2rsta de 75+ ani). F\u0103r\u0103 restric\u021bii alimentare. Doze omise: lua\u021bi dac\u0103 a trecut mai pu\u021bin de 6 ore de la ora programat\u0103; altomi\u021bi \u2014 nu dubla\u021bi doza.<\/p>\n<h2 class=\"wp-block-heading\">Efecte Secundare<\/h2>\n<ul>\n<li>Hemoragii majore (~3-5%\/an \u00een FA)<\/li>\n<li>Hemoragii gastrointestinale (mai frecvente dec\u00e2t la apixaban, u\u0219or mai frecvente dec\u00e2t la warfarin)<\/li>\n<li>Anemie<\/li>\n<li>Hemoragii minore (epistaxis, echimoze)<\/li>\n<li>Hepatotoxicitate (rar\u0103)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindica\u021bii<\/h2>\n<ul>\n<li>Hemoragie patologic\u0103 activ\u0103<\/li>\n<li>Insuficien\u021b\u0103 renal\u0103 sever\u0103 (CrCl &lt;15 mL\/min)<\/li>\n<li>Insuficien\u021b\u0103 hepatic\u0103 sever\u0103 (Child-Pugh B sau C)<\/li>\n<li>Valv\u0103 cardiac\u0103 mecanic\u0103 (se utilizeaz\u0103 warfarin)<\/li>\n<li>Stenoza mitral\u0103 moderat-sever\u0103<\/li>\n<li>Sarcin\u0103 (trece placent\u0103; se utilizeaz\u0103 heparin\u0103\/warfarin)<\/li>\n<li>Inhibitori duali puternici concuren\u021bi ai CYP3A4 + P-gp (antifungice azolice, inhibitori de proteaz\u0103 HIV)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>Inhibitori duali puternici ai CYP3A4 + P-gp \u2014 CRITIC.<\/strong> Antifungice azolice (ketoconazol, itraconazol), inhibitori de proteaz\u0103 HIV, claritromicin\u0103 \u2014 cresc substan\u021bial nivelurile de rivaroxaban; contraindicate.<\/li>\n<li><strong>Inductori puternici CYP3A4 + P-gp<\/strong> (rifampicin\u0103, fenitoin\u0103, carbamazepin\u0103, iarba Sf\u00e2ntului Ioan) \u2014 scad nivelurile; evita\u021bi sau monitoriza\u021bi \u00eendeaproape.<\/li>\n<li><strong>Alte anticoagulante, heparine<\/strong> \u2014 nu combina\u021bi, cu excep\u021bia unor situa\u021bii specifice de punte sub supraveghere specializat\u0103.<\/li>\n<li><strong>AINS, antiagregante plachetare<\/strong> \u2014 risc crescut de s\u00e2ngerare.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Depozitare<\/h2>\n<p>P\u0103stra\u021bi Xarelto 20 sub 25\u00b0C. \u021aine\u021bi departe de copii.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">Am nevoie de analize de s\u00e2nge pentru Xarelto 20?<\/h3>\n<p>Nu sunt necesare analize de s\u00e2nge de rutin\u0103 pentru evaluarea eficacit\u0103\u021bii. Verifica\u021bi func\u021bia renal\u0103 anual.<\/p>\n<h3 class=\"wp-block-heading\">Ce ar trebui s\u0103 fac dac\u0103 m\u0103 tai \u00een timp ce iau Xarelto 20?<\/h3>\n<p>Aplica\u021bi presiune direct\u0103 ferm\u0103 timp de 15-20 de minute f\u0103r\u0103 a verifica. Majoritatea t\u0103ieturilor minore se opresc \u00een mod normal; s\u00e2nger\u0103rile care continu\u0103 &gt;20 de minute sau care str\u0103bat mai multe pansamente necesit\u0103 evaluare medical\u0103 urgent\u0103. Raporta\u021bi orice scaun negru sau s\u00e2ngeros, s\u00e2ngerare rectal\u0103 ro\u0219ie aprins\u0103, hematurie, v\u00e2n\u0103t\u0103i neexplicate, s\u00e2nger\u0103ri nazale &gt;15 minute sau s\u00e2nger\u0103ri menstruale mult mai abundente dec\u00e2t de obicei.<\/p>\n<h3 class=\"wp-block-heading\">Pot lua Xarelto 20 \u00een timpul sarcinii?<\/h3>\n<p>Nu \u2014 traverseaz\u0103 placenta; DOAC sunt contraindicate \u00een sarcin\u0103. Utiliza\u021bi LMWH.<\/p>\n<h3 class=\"wp-block-heading\">Ce fac dac\u0103 am nevoie de opera\u021bie?<\/h3>\n<p>Informa\u021bi echipa chirurgical\u0103 cu mult \u00eenainte. Rivaroxabanul este \u00eentrerupt cu 24-48 de ore \u00eenainte de interven\u021bie chirurgical\u0103, \u00een func\u021bie de riscul de s\u00e2ngerare \u0219i func\u021bia renal\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Unde pot cump\u0103ra Xarelto 20 online?<\/h3>\n<p>Pute\u021bi achizi\u021biona Xarelto 20 (rivaroxaban 20 mg, 14-112 comprimate) de la MedsBase cu ambalaj discret \u0219i livrare la nivel mondial.<\/p>\n<h2 class=\"wp-block-heading\">Medicamente cardio-vasculare conexe<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/aldactone\/\">Aldactone \u2014 Spironolacton\u0103<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/cordarone\/\">Cordarone \u2014 Amiodaron\u0103 100\/200 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/ivabrad\/\">Ivabrad \u2014 Ivabradin\u0103 7,5 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/lonitab\/\">Lonitab \u2014 Minoxidil 5 mg (vasodilatator oral)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/rioci-1\/\">Rioci 1 \u2014 Riociguat 1 mg (stimulator sGC pentru HAP)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/vymada\/\">Vymada \u2014 Sacubitril\/Valsartan ARNI<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/high-blood-pressure-medication\/\"><strong>R\u0103sfoi\u021bi toate medicamentele pentru hipertensiune arterial\u0103<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui medic calificat. Hipertensiunea, insuficien\u021ba cardiac\u0103 \u0219i aritmiile necesit\u0103 diagnostic, monitorizare \u0219i individualizarea dozei de c\u0103tre un medic \u2014 utiliza\u021bi \u00eentotdeauna beta-blocante sub \u00eendrumare medical\u0103.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alternative conexe<\/h3>\n<p>Alte produse din <strong>Afec\u021biuni cronice<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/ivrea-shampoo\/\">Ivrea Shampoo<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/rosu-hdl\/\">Rosu-HDL<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tiova-rotacaps\/\">Tiova Rotacaps<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/glynase-xl\/\">Glynase Xl<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/trajenta-duo\/\">Trajenta Duo<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Xarelto 20 reprezint\u0103 comprimatele de rivaroxaban 20 mg de la Bayer \u2014 primul inhibitor oral direct al factorului Xa. ROCKET-AF (2011) a demonstrat non-inferioritate fa\u021b\u0103 de warfarin \u00een FA non-valvular\u0103; EINSTEIN-DVT\/PE (2010) a stabilit tratamentul unic pentru TEV. COMPASS (2017) a ar\u0103tat c\u0103 2,5 mg de dou\u0103 ori pe zi + aspirin\u0103 reduc evenimentele CV \u00een CAD\/PAD stabil\u0103. Nu este necesar\u0103 monitorizarea sanguin\u0103 rutin\u0103 (fa\u021b\u0103 de INR la warfarin). Contraindicat la valve cardiace mecanice, sarcin\u0103, IRC sever\u0103. Andexanet alfa inverseaz\u0103 efectul \u00een urgen\u021be.<\/p>","protected":false},"featured_media":60452,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3635,3141,3223,3342,3260,3356],"product_tag":[4863,4864],"class_list":{"0":"post-60451","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-coagulants","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_cat-general-health","10":"product_cat-heart-blood-pressure","11":"product_cat-high-blood-pressure-medication","12":"product_tag-rivaroxaban","13":"product_tag-xarelto","15":"first","16":"instock","17":"shipping-taxable","18":"purchasable","19":"product-type-variable","20":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/60451","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=60451"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/60452"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=60451"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=60451"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=60451"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=60451"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}