<\/p>\n
Saaz<\/strong> este sulfasalazine 500 mg gastro-resistant tablet<\/strong> — a sulfa-linked prodrug of mesalazine (5-aminosalicylic acid) used for mild-to-moderate ulcerative colitis<\/strong> (induction and maintenance), Crohn’s colitis<\/strong>, \u0219i ca conventional synthetic DMARD for rheumatoid and juvenile idiopathic arthritis<\/strong>. Colonic bacteria cleave the azo bond, releasing 5-ASA (the active GI moiety) and sulfapyridine (the carrier responsible for most side effects). Standard adult dose: UC 2–4 g\/day in divided doses; RA 2–3 g\/day after slow titration over 4 weeks<\/strong>. Produc\u0103tor certificat WHO-GMP.<\/p>\n<\/div>\n \ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n Saaz is supplied from a produc\u0103tor certificat WHO-GMP<\/strong>. Fiecare comand\u0103 este expediat\u0103 discret \u00een \u00eentreaga lume \u0219i este acoperit\u0103 de Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> — if it does not arrive within 20 business days, we reship at no cost. Sulfasalazine is on the WHO Essential Medicines List for both inflammatory bowel disease and rheumatoid arthritis — it is the most extensively studied conventional DMARD with multi-decade follow-up.<\/p>\n Sulfasalazine is a prodrug: 5-ASA linked to sulfapyridine through an azo (-N=N-) bond. Less than 30 percent is absorbed in the small intestine; the remainder reaches the colon where bacterial azoreductases cleave the bond. 5-ASA<\/strong> acts locally on colonic mucosa via PPAR-γ agonism, COX\/LOX inhibition, NF-κB suppression, and reactive-oxygen scavenging — this is the IBD-relevant action. Sulfapiridin\u0103<\/strong> is absorbed systemically and accounts for most side effects (rash, photosensitivity, oligospermia, haematological); in rheumatoid arthritis the systemic sulfapyridine is thought to be the active moiety, modulating cytokine production and folate metabolism.<\/p>\n UC induction:<\/strong> 1–2 g four times daily (max 4 g\/day), reduce to 2 g\/day for maintenance. RA \/ JIA:<\/strong> start 500 mg\/day, increase by 500 mg weekly to 1 g twice daily (max 3 g\/day). Folic acid 5 mg weekly recommended on RA dose. Take with food to reduce GI upset. Hepatic or renal impairment: caution, halve the dose.<\/p>\n Yes — sulfasalazine and its metabolite sulfapyridine are coloured. Urine, sweat, tears, and contact lenses can take an orange-yellow tint. It is harmless and reverses on stopping the drug.<\/p>\n For UC: stool blood and tenesmus often improve within 2–4 weeks; full effect by 8–12 weeks. For RA: it takes 8–12 weeks to feel benefit; do not stop early.<\/p>\n Sulfasalazine inhibits folate absorption and metabolism. Folate deficiency causes megaloblastic anaemia and worsens cytopenia. 5 mg weekly is standard with the RA dose.<\/p>\n Yes — among the safest DMARDs in pregnancy. Continue through pregnancy if needed for IBD or RA. Folic acid supplementation 5 mg\/day is essential. Sulfasalazine causes reversible oligospermia in men and should be stopped 3 months before conception attempts in male partners.<\/p>\n Baseline FBC, LFTs, U&E, and G6PD if of African, Asian, or Mediterranean ancestry. Then FBC and LFTs at 2 weeks, 4 weeks, then 3-monthly for the first year, then 6-monthly thereafter.<\/p>\n Light to moderate alcohol is acceptable; heavy alcohol increases hepatotoxicity. Discuss with the prescriber.<\/p>\n Mesalamine is just the 5-ASA portion without the sulfa carrier. Mesalamine has fewer side effects (no sulfa allergy risk, no oligospermia) but is more expensive. Sulfasalazine is preferred when DMARD effect is needed for joint disease in addition to gut disease.<\/p>\n No. Switch to mesalamine (Asacol, Mesacol, or Pentasa) for IBD; switch to a different DMARD (methotrexate, leflunomide) for arthritis.<\/p>\n Below 30°C in a dry place. Keep tablets in the original blister.<\/p>\n Take it as soon as you remember unless it is close to the next dose. Do not double up.<\/p>\n <\/p>\n Saaz (Sulfasalazine 500 mg gastro-resistant tablet) \u2014 5-ASA prodrug for mild-to-moderate ulcerative colitis, Crohn’s colitis, and conventional synthetic DMARD for rheumatoid and juvenile idiopathic arthritis. WHO Essential Medicine. Worldwide shipping from MedsBase.<\/p>","protected":false},"featured_media":60670,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[4902,4682],"class_list":{"0":"post-60669","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","9":"product_tag-saaz","10":"product_tag-sulfasalazine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/60669","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=60669"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/60670"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=60669"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=60669"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=60669"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=60669"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}De ce s\u0103 comanzi de la MedsBase<\/h3>\n
De ce s\u0103 comanzi de la MedsBase<\/h3>\n
Mecanism de ac\u021biune<\/h2>\n
Indica\u021bii<\/h2>\n
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Doza<\/h2>\n
Efecte secundare<\/h2>\n
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Interac\u021biuni medicamentoase<\/h2>\n
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\u00centreb\u0103ri frecvente<\/h2>\n
Will my urine really turn orange?<\/h3>\n
C\u00e2t dureaz\u0103 p\u00e2n\u0103 m\u0103 simt mai bine?<\/h3>\n
Why do I need folic acid with it?<\/h3>\n
Este sigur \u00een sarcin\u0103?<\/h3>\n
Ce analize de s\u00e2nge am nevoie?<\/h3>\n
Pot consuma alcool \u00een timpul tratamentului?<\/h3>\n
How is it different from mesalamine (Asacol\/Mesacol)?<\/h3>\n
I have a sulfa allergy. Can I take it?<\/h3>\n
Depozitare<\/h3>\n
Ce fac dac\u0103 uit o doz\u0103?<\/h3>\n
Alte Medicamente pentru S\u0103n\u0103tatea Gastrointestinal\u0103<\/h3>\n
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