{"id":60669,"date":"2024-02-28T07:01:42","date_gmt":"2024-02-28T07:01:42","guid":{"rendered":"https:\/\/medsname.com\/saaz\/"},"modified":"2026-04-30T10:23:43","modified_gmt":"2026-04-30T10:23:43","slug":"saaz","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/saaz\/","title":{"rendered":"Saaz"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 R\u0103spuns rapid \u2014 Ce este Saaz?<\/h3>\n<p style=\"margin:0;\"><strong>Saaz<\/strong> este <strong>sulfasalazina 500 mg comprimate gastrorezistente<\/strong> \u2014 un prodrog cu leg\u0103tur\u0103 sulfa de mesalazina (acid 5-aminosalicilic) utilizat pentru <strong>colita ulcerativ\u0103 u\u0219oar\u0103 p\u00e2n\u0103 la moderat\u0103<\/strong> (induc\u021bie \u0219i men\u021binere), <strong>colita Crohn<\/strong>, \u0219i ca <strong>DMARD sintetic conven\u021bional pentru artrita reumatoid\u0103 \u0219i artrita idiopatic\u0103 juvenil\u0103<\/strong>. Bacteriile colonice desfac leg\u0103tura azo, eliber\u00e2nd 5-ASA (moietatea GI activ\u0103) \u0219i sulfapiridina (vectorul responsabil pentru majoritatea efectelor adverse). Doza standard pentru adul\u021bi: <strong>CU 2\u20134 g\/zi \u00een doze divizate; AR 2\u20133 g\/zi dup\u0103 titrare lent\u0103 pe 4 s\u0103pt\u0103m\u00e2ni<\/strong>. Produc\u0103tor certificat WHO-GMP.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>De ce s\u0103 comanzi de la MedsBase:<\/strong> \u2714 <strong>produc\u0103tor certificat WHO-GMP<\/strong> \u2714 Ambalaj discret \u2714 Livrare worldwide \u2714 <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">Recenzii verificate ale clien\u021bilor (peste 1.400 de clien\u021bi)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>\u26a0\ufe0f Alergia la sulfa este o contraindica\u021bie absolut\u0103.<\/strong> Sulfasalazina elibereaz\u0103 sulfapiridin\u0103 \u00een colon. Pacien\u021bii cu alergie documentat\u0103 la sulfa (Stevens-Johnson, TEN sau anafilaxie sistemic\u0103 la antibiotice sulfa) nu trebuie s\u0103 o ia \u2014 trece\u021bi la mesalamin\u0103 (Asacol, Mesacol, Pentasa). Deficien\u021ba de G6PD necesit\u0103 precau\u021bie din cauza riscului de hemoliz\u0103. Alte contraindica\u021bii: porfirie, obstruc\u021bie intestinal\u0103\/urinar\u0103, insuficien\u021b\u0103 hepatic\u0103 sau renal\u0103 sever\u0103.<\/div>\n<h3 class=\"wp-block-heading\">De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Saaz este furnizat cu <strong>produc\u0103tor certificat WHO-GMP<\/strong>. Fiecare comand\u0103 este expediat\u0103 discret \u00een \u00eentreaga lume \u0219i este acoperit\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a> \u2014 dac\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, retrimitem f\u0103r\u0103 costuri suplimentare. Sulfasalazina este pe Lista Medicamentelor Esen\u021biale a OMS at\u00e2t pentru boala inflamatorie intestinal\u0103, c\u00e2t \u0219i pentru artrita reumatoid\u0103 \u2014 este cel mai studiat DMARD conven\u021bional cu urm\u0103rire pe parcursul mai multor decenii.<\/p>\n<h2 class=\"wp-block-heading\">Mecanism de ac\u021biune<\/h2>\n<p>Sulfasalazina este un prodrog: 5-ASA legat de sulfapiridin\u0103 printr-o leg\u0103tur\u0103 azo (-N=N-). Mai pu\u021bin de 30 la sut\u0103 este absorbit \u00een intestinul sub\u021bire; restul ajunge \u00een colon, unde azoreductazele bacteriene desfac leg\u0103tura. <strong>5-ASA<\/strong> ac\u021bioneaz\u0103 local pe mucosa colonic\u0103 prin agonism PPAR-\u03b3, inhibare COX\/LOX, suprimare NF-\u03baB \u0219i eliminare a speciilor reactive de oxigen \u2014 aceasta este ac\u021biunea relevant\u0103 pentru BCI. <strong>Sulfapiridin\u0103<\/strong> este absorbit sistemic \u0219i este responsabil pentru majoritatea efectelor adverse (erup\u021bie cutanat\u0103, fotosensibilitate, oligospermie, tulbur\u0103ri hematologice); \u00een artrita reumatoid\u0103, sulfapiridina sistemic\u0103 este considerat\u0103 principiul activ, modul\u00e2nd produc\u021bia de citokine \u0219i metabolismul folatelor.<\/p>\n<h2 class=\"wp-block-heading\">Indica\u021bii<\/h2>\n<ul>\n<li>Colit\u0103 ulceroas\u0103 u\u0219oar\u0103 p\u00e2n\u0103 la moderat\u0103 (induc\u021bie \u0219i men\u021binere)<\/li>\n<li>Colita Crohn (mai pu\u021bin eficient\u0103 \u00een boala Crohn a intestinului sub\u021bire)<\/li>\n<li>Artrit\u0103 reumatoid\u0103 (csDMARD)<\/li>\n<li>Artrita idiopatic\u0103 juvenil\u0103, \u00een special tipurile poliarticulare \u0219i cele legate de entezit\u0103<\/li>\n<li>Artrit\u0103 psoriazic\u0103 (afec\u021biune periferic\u0103)<\/li>\n<li>Spondilit\u0103 anchilozant\u0103 cu artrit\u0103 periferic\u0103<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Doza<\/h2>\n<p><strong>Induc\u021bie UC:<\/strong> 1\u20132 g de patru ori pe zi (max 4 g\/zi), reducere la 2 g\/zi pentru men\u021binere. <strong>RA \/ AIJ:<\/strong> \u00eencepe\u021bi cu 500 mg\/zi, cre\u0219te\u021bi cu 500 mg s\u0103pt\u0103m\u00e2nal p\u00e2n\u0103 la 1 g de dou\u0103 ori pe zi (maxim 3 g\/zi). Acid folic 5 mg s\u0103pt\u0103m\u00e2nal recomandat la doza pentru RA. Lua\u021bi cu m\u00e2ncare pentru a reduce disconfortul gastrointestinal. Insuficien\u021b\u0103 hepatic\u0103 sau renal\u0103: precau\u021bie, \u00eenjum\u0103t\u0103\u021bi\u021bi doza.<\/p>\n<h2 class=\"wp-block-heading\">Efecte secundare<\/h2>\n<ul>\n<li>Frecvente (10\u201330%): grea\u021b\u0103, anorexie, cefalee, dureri abdominale, oligospermie (infertilitate masculin\u0103 reversibil\u0103, se remite complet la 2\u20133 luni dup\u0103 \u00eentrerupere), fluide corporale portocalii-galbene (urin\u0103, transpira\u021bie, lacrimi, lentile de contact)<\/li>\n<li>Piele: erup\u021bii cutanate, fotosensibilitate, urticarie; rar sindromul Stevens-Johnson \u0219i TEN<\/li>\n<li>Hematologice: leucopenie, trombocitopenie, anemie megaloblastic\u0103 (antagonism folat), hemoliz\u0103 \u00een deficien\u021b\u0103 G6PD \u2014 hemogram\u0103 de baz\u0103 \u0219i trimestrial\u0103 \u00een primul an<\/li>\n<li>Hepatic: cre\u0219tere a transaminazelor (hepatit\u0103 rar\u0103); teste hepatice ini\u021biale \u0219i trimestriale<\/li>\n<li>Pulmonar: pneumonit\u0103 intersti\u021bial\u0103 rar\u0103<\/li>\n<li>Sindrom lupus-like (rar, cu anticorpi anti-histone)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li>Azatioprin\u0103, mercaptopurin\u0103: 5-ASA inhib\u0103 TPMT, cresc\u00e2nd nivelurile de 6-MP \u2014 monitoriza\u021bi hemograma.<\/li>\n<li>Metotrexat: antagonism aditiv de folat \u2014 suplimenta\u021bi cu acid folic.<\/li>\n<li>Digoxin: sulfasalazina reduce absorb\u021bia digoxinului.<\/li>\n<li>Diet\u0103 deficitar\u0103 \u00een folat sau cu con\u021binut sc\u0103zut de folat: deficien\u021ba se poate agrava.<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">Chiar mi se va \u00eencolori urina \u00een portocaliu?<\/h3>\n<p>Da \u2014 sulfasalazina \u0219i metabolitul s\u0103u sulfapiridina sunt colorate. Urina, transpira\u021bia, lacrimile \u0219i lentilele de contact pot c\u0103p\u0103ta o nuan\u021b\u0103 portocalie-g\u0103lbuie. Este inofensiv \u0219i se remit\u0103 la \u00eentreruperea medicamentului.<\/p>\n<h3 class=\"wp-block-heading\">C\u00e2t dureaz\u0103 p\u00e2n\u0103 m\u0103 simt mai bine?<\/h3>\n<p>Pentru UC: s\u00e2ngele din scaun \u0219i tenesmul se \u00eembun\u0103t\u0103\u021besc adesea \u00een 2\u20134 s\u0103pt\u0103m\u00e2ni; efect complet \u00een 8\u201312 s\u0103pt\u0103m\u00e2ni. Pentru RA: dureaz\u0103 8\u201312 s\u0103pt\u0103m\u00e2ni pentru a sim\u021bi beneficiul; nu \u00eentrerupe\u021bi prea devreme.<\/p>\n<h3 class=\"wp-block-heading\">De ce am nevoie de acid folic cu acesta?<\/h3>\n<p>Sulfasalazina inhib\u0103 absorb\u021bia \u0219i metabolismul folatului. Deficien\u021ba de folat provoac\u0103 anemie megaloblastic\u0103 \u0219i agraveaz\u0103 citopenia. 5 mg s\u0103pt\u0103m\u00e2nal este standard cu doza pentru AR.<\/p>\n<h3 class=\"wp-block-heading\">Este sigur \u00een sarcin\u0103?<\/h3>\n<p>Da \u2014 printre cele mai sigure DMARD-uri \u00een sarcin\u0103. Continua\u021bi \u00een timpul sarcinii dac\u0103 este necesar pentru IBD sau AR. Suplimentarea cu acid folic 5 mg\/zi este esen\u021bial\u0103. Sulfasalazina provoac\u0103 oligospermie reversibil\u0103 la b\u0103rba\u021bi \u0219i ar trebui \u00eentrerupt\u0103 cu 3 luni \u00eenainte de \u00eencerc\u0103rile de concepere la partenerii de sex masculin.<\/p>\n<h3 class=\"wp-block-heading\">Ce analize de s\u00e2nge am nevoie?<\/h3>\n<p>Analize de baz\u0103: hemoleucogram\u0103, teste hepatice, electroli\u021bi \u0219i G6PD dac\u0103 provine\u021bi din Africa, Asia sau Mediterana. Apoi hemoleucograma \u0219i testele hepatice la 2 s\u0103pt\u0103m\u00e2ni, 4 s\u0103pt\u0103m\u00e2ni, apoi la 3 luni \u00een primul an, apoi la 6 luni.<\/p>\n<h3 class=\"wp-block-heading\">Pot consuma alcool \u00een timpul tratamentului?<\/h3>\n<p>Consumul u\u0219or p\u00e2n\u0103 la moderat de alcool este acceptabil; consumul excesiv de alcool cre\u0219te hepatotoxicitatea. Discuta\u021bi cu medicul prescriptor.<\/p>\n<h3 class=\"wp-block-heading\">Cum difer\u0103 de mesalazina (Asacol\/Mesacol)?<\/h3>\n<p>Mesalazina este doar por\u021biunea de 5-ASA f\u0103r\u0103 purt\u0103torul sulfa. Mesalazina are mai pu\u021bine efecte adverse (niciun risc de alergie la sulfa, nicio oligospermie), dar este mai scump\u0103. Sulfasalazina este preferat\u0103 atunci c\u00e2nd este necesar efect DMARD pentru afec\u021biuni articulare \u00een plus fa\u021b\u0103 de afec\u021biunile intestinale.<\/p>\n<h3 class=\"wp-block-heading\">Am alergie la sulfa. Pot s\u0103 o iau?<\/h3>\n<p>Nu. Trece\u021bi la mesalazin\u0103 (Asacol, Mesacol sau Pentasa) pentru IBD; trece\u021bi la un alt DMARD (metotrexat, leflunomid\u0103) pentru artrit\u0103.<\/p>\n<h3 class=\"wp-block-heading\">Depozitare<\/h3>\n<p>Sub 30\u00b0C \u00eentr-un loc uscat. P\u0103stra\u021bi comprimatele \u00een blisterul original.<\/p>\n<h3 class=\"wp-block-heading\">Ce fac dac\u0103 uit o doz\u0103?<\/h3>\n<p>Lua\u021bi-o c\u00e2nd v\u0103 aminti\u021bi, cu excep\u021bia cazului \u00een care este aproape de urm\u0103toarea doz\u0103. Nu dubla\u021bi doza.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alte Medicamente pentru S\u0103n\u0103tatea Gastrointestinal\u0103<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/asacol\/\">Asacol \u2014 Mesalazin\u0103 400 mg DR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/mesacol\/\">Mesacol \u2014 Mesalazin\u0103 400 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/sazo\/\">Sazo \u2014 Sulfasalazin\u0103 500 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/salazar\/\">Salazar \u2014 Sulfasalazin\u0103 500 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/pentasa-suppositories\/\">Supozitoare Pentasa \u2014 Mesalazina 1 g<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/gastro-health\/\"><strong>Vede\u021bi toate Medicamentele pentru S\u0103n\u0103tatea Gastrointestinal\u0103<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Dezaprobare medical\u0103.<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical al unui profesionist calificat din domeniul s\u0103n\u0103t\u0103\u021bii. Alergia la sulfa, deficien\u021ba de G6PD, afec\u021biuni hepatice sau renale severe \u0219i porfiria sunt contraindica\u021bii absolute. Spune\u021bi medicului prescriptor dac\u0103 apar dureri articulare, febr\u0103, dificult\u0103\u021bi de respira\u021bie sau v\u00e2n\u0103t\u0103i neexplicate.<\/div>","protected":false},"excerpt":{"rendered":"<p>Saaz (Sulfasalazin\u0103 500 mg comprimate gastro-rezistente) \u2014 prodrog de 5-ASA pentru colita ulcerativ\u0103 u\u0219oar\u0103 p\u00e2n\u0103 la moderat\u0103, colita Crohn \u0219i DMARD sintetic conven\u021bional pentru artrita reumatoid\u0103 \u0219i artrita idiopatic\u0103 juvenil\u0103. Medicament esen\u021bial WHO. Livrare worldwide de la MedsBase.<\/p>","protected":false},"featured_media":60670,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[4902,4682],"class_list":{"0":"post-60669","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","9":"product_tag-saaz","10":"product_tag-sulfasalazine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/60669","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=60669"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/60670"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=60669"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=60669"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=60669"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=60669"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}