{"id":60749,"date":"2024-02-28T07:06:28","date_gmt":"2024-02-28T07:06:28","guid":{"rendered":"https:\/\/medsname.com\/temozol-20\/"},"modified":"2026-04-30T10:23:43","modified_gmt":"2026-04-30T10:23:43","slug":"temozol-20","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/temozol-20\/","title":{"rendered":"Temozol 20"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Temozol?<\/h3>\n<p style=\"margin:0;\"><strong>Temozol<\/strong> is an oral capsule from Cipla containing <strong>temozolomide<\/strong> la <strong>20 mg<\/strong> &mdash; an oral alkylating cytotoxic agent and the standard chemotherapy for <strong>glioblastoma multiforme (GBM)<\/strong> \u0219i <strong>anaplastic astrocytoma<\/strong>. Standard regimen: <strong>concurrent<\/strong> with radiotherapy (75 mg\/m&sup2; daily for 6 weeks), then <strong>maintenance<\/strong> 150&ndash;200 mg\/m&sup2; daily for days 1&ndash;5 of each 28-day cycle for 6 cycles (Stupp protocol). <strong>Lua\u021bi pe stomacul gol<\/strong> at the same time each day, with antiemetic (ondansetron) 1 hour before. Mandatory: <strong>Profilaxia PCP<\/strong> with co-trimoxazole during radiotherapy phase. FBC weekly during concurrent phase, then before each maintenance cycle.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Supraveghere specializat\u0103 necesar\u0103.<\/strong> Medicamentele pentru cancer trebuie prescrise de un oncolog tratant, cu un diagnostic confirmat, stadializare ini\u021bial\u0103 \u0219i un plan de tratament definit. Nu \u00eencepe\u021bi, nu opri\u021bi, nu modifica\u021bi doza \u0219i nu utiliza\u021bi medicamente pentru cancer \u00een afara unui plan de \u00eengrijire condus de oncologie. Majoritatea medicamentelor pentru cancer necesit\u0103 monitorizare regulat\u0103 prin analize de s\u00e2nge (hemoleucogram\u0103, teste hepatice, func\u021bie renal\u0103), sunt absolut contraindicate \u00een sarcin\u0103 \u0219i au interac\u021biuni medicamentoase semnificative.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 Checkout criptat<\/strong> \u00b7 <strong>\ud83d\udcb3 Procesor verificat<\/strong> \u00b7 <strong>\ud83d\ude9a Livrare worldwide<\/strong> \u00b7 <strong>\u2b50 4,9\/5 de la peste 1.400 de clien\u021bi<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Temozol?<\/h2>\n<p>Temozol is an oral capsule from Cipla containing <strong>temozolomide<\/strong> (20 mg). Temozolomide is an oral alkylating cytotoxic agent of the imidazotetrazine class. It crosses the blood-brain barrier (CSF concentration ~30% of plasma) and is the only oral cytotoxic with proven survival benefit in glioblastoma multiforme. Standard combination with radiotherapy (the &ldquo;Stupp protocol&rdquo;, 2005) extended median GBM survival from 12 months to 15 months and 2-year survival from 11% to 27%.<\/p>\n<h2 class=\"wp-block-heading\">Utiliz\u0103ri \u0219i indica\u021bii<\/h2>\n<ul>\n<li><strong>Newly-diagnosed glioblastoma multiforme (GBM)<\/strong> &mdash; concurrent with radiotherapy then maintenance (Stupp protocol)<\/li>\n<li><strong>Anaplastic astrocytoma<\/strong> after recurrence<\/li>\n<li><strong>Recurrent high-grade glioma<\/strong><\/li>\n<li><strong>Off-label:<\/strong> melanoma brain metastases, neuroendocrine tumours<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dosage (Stupp protocol)<\/h2>\n<ul>\n<li><strong>Concurrent phase:<\/strong> 75 mg\/m&sup2;\/day continuously during 6 weeks of radiotherapy (total ~42 days)<\/li>\n<li><strong>4-week break<\/strong> after radiotherapy completion<\/li>\n<li><strong>Faza de \u00eentre\u021binere:<\/strong> 150 mg\/m&sup2;\/day for days 1&ndash;5 of a 28-day cycle (cycle 1); escalate to 200 mg\/m&sup2;\/day if tolerated for cycles 2&ndash;6 (total 6 cycles, with newer evidence supporting up to 12 cycles in younger MGMT-methylated patients)<\/li>\n<\/ul>\n<ol>\n<li><strong>Take on an empty stomach at the same time each day<\/strong> &mdash; food slows absorption and reduces peak concentration. Most patients take it at bedtime, &ge; 2 hours after the last meal.<\/li>\n<li><strong>Antiemetic:<\/strong> ondansetron 8 mg orally 1 hour before each temozolomide dose, especially during the maintenance phase 5-day pulse.<\/li>\n<li>Swallow capsules whole with water. Do NOT open or chew &mdash; powder is cytotoxic.<\/li>\n<li><strong>Profilaxia PCP<\/strong> with co-trimoxazole 480 mg three times weekly during the concurrent phase &mdash; lymphopenia risk. Continue until CD4 &gt; 200 cells\/&micro;L.<\/li>\n<li><strong>Monitorizare obligatorie:<\/strong> FBC weekly during concurrent phase; before each maintenance cycle (day 22 of previous cycle and day 1 of each new cycle); LFTs monthly. Hold cycle for ANC &lt; 1,500\/&micro;L or platelets &lt; 100,000\/&micro;L.<\/li>\n<li>If a dose is vomited within 1 hour, do NOT re-dose. Resume next day per schedule.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Efecte Secundare<\/h2>\n<p><strong>Frecvente:<\/strong> nausea, vomiting (mostly preventable with ondansetron), fatigue, anorexia, constipation, headache, alopecia.<\/p>\n<p><strong>Important:<\/strong><\/p>\n<ul>\n<li><strong>Mielosupresie<\/strong> &mdash; especially thrombocytopenia (the dose-limiting toxicity); lymphopenia with PCP risk<\/li>\n<li><strong>Pneumonie Pneumocystis jirovecii<\/strong> &mdash; lymphopenia-driven; mandatory prophylaxis during concurrent phase<\/li>\n<li>Hepatotoxicity, including rare reactivation of hepatitis B<\/li>\n<li>Severe skin reactions including SJS\/TEN (rare)<\/li>\n<li>Secondary myelodysplastic syndrome \/ acute leukaemia (rare, long-term)<\/li>\n<li>Severe lymphopenia &gt; 6 months<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Avertismente<\/h2>\n<ul>\n<li><strong>Sarcina:<\/strong> teratogenic. Reliable contraception throughout treatment + 6 months after.<\/li>\n<li><strong>Al\u0103ptarea:<\/strong> evita\u021bi.<\/li>\n<li><strong>Insuficien\u021b\u0103 hepatic\u0103 sever\u0103:<\/strong> evita\u021bi.<\/li>\n<li><strong>Hepatitis B carrier status:<\/strong> screen and consider antiviral prophylaxis &mdash; reactivation risk.<\/li>\n<li><strong>Vaccinuri cu virus viu:<\/strong> contraindicated.<\/li>\n<li><strong>Severe lymphopenia \/ CD4 &lt; 200:<\/strong> continue PCP prophylaxis until lymphocyte recovery.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interac\u021biuni medicamentoase<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Combina\u021bi cu<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Efect<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Ce s\u0103 face\u021bi<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vaccinuri cu virus viu<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Infec\u021bie diseminat\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Contraindicated.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Alte medicamente mielosupresoare<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Suprimare medular\u0103 aditiv\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Supraveghere specializat\u0103.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Valproic acid<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Mildly reduces temozolomide clearance<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">No dose adjustment usually needed.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Co-trimoxazole (PCP prophylaxis)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Standard combination<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Continue throughout concurrent phase.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Depozitare<\/h2>\n<ul>\n<li>La temperatur\u0103 camerei, 15\u201330\u00b0C, \u00een blisterul original.<\/li>\n<li>Out of reach of children, women of childbearing potential, and pets &mdash; cytotoxic powder.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Alternative conexe pe MedsBase<\/h2>\n<p>Alte medicamente oncologice disponibile \u00eempreun\u0103 cu acest produs:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/endoxan\/\"><strong>Endoxan (ciclosfosfamid\u0103 50 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/celkeran\/\"><strong>Celkeran (clorambucil 2 \/ 5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/temotero\/\"><strong>Temotero (temozolomid\u0103 20\/100 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/lomoother\/\"><strong>Lomoother (lomustin\u0103 40 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/endace\/\"><strong>Endace (megestrol 40\/160 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/ro\/anti-cancer-medication\/\">R\u0103sfoi\u021bi toate medicamentele anti-cancer \u2192<\/a><\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3 class=\"wp-block-heading\">What is the Stupp protocol?<\/h3>\n<p>The Stupp protocol (2005) is the standard combined chemoradiotherapy regimen for newly-diagnosed glioblastoma multiforme: <strong>radiotherapy (60 Gy in 30 fractions) + concurrent temozolomide (75 mg\/m&sup2;\/day) for 6 weeks, then 4-week break, then maintenance temozolomide (150&ndash;200 mg\/m&sup2;\/day for days 1&ndash;5 of each 28-day cycle) for 6 cycles<\/strong>. The protocol extended median survival from 12 to 15 months and remains the global standard in 2026.<\/p>\n<h3 class=\"wp-block-heading\">Why must I take Temozol on an empty stomach?<\/h3>\n<p>Food slows temozolomide absorption and reduces peak plasma concentration. For consistent dosing, take temozolomide at the same time each day with no food for at least 2 hours before. Most patients take it at bedtime &ge; 2 hours after the last meal. Take ondansetron 8 mg orally 1 hour before each dose to prevent nausea.<\/p>\n<h3 class=\"wp-block-heading\">Why do I need PCP prophylaxis?<\/h3>\n<p>The continuous 6-week concurrent phase causes prolonged lymphopenia &mdash; particularly low CD4 counts &mdash; that creates a real risk of <strong>Pneumocystis jirovecii pneumonia (PCP)<\/strong>, a potentially fatal opportunistic infection. Standard prophylaxis: <strong>co-trimoxazole 480 mg three times weekly<\/strong> throughout concurrent phase, continued until CD4 recovery (often takes 6+ months).<\/p>\n<h3 class=\"wp-block-heading\">What does &ldquo;MGMT methylation&rdquo; mean for my treatment?<\/h3>\n<p>MGMT (O6-methylguanine-DNA methyltransferase) is a DNA repair enzyme that undoes temozolomide&#39;s alkylation damage. <strong>MGMT-methylated<\/strong> tumours have low MGMT expression &mdash; they cannot repair the damage, so respond much better to temozolomide. <strong>MGMT-unmethylated<\/strong> tumours have high MGMT expression and are relatively temozolomide-resistant. MGMT status is determined on the surgical biopsy and influences treatment intensity (longer maintenance, more aggressive regimens) and prognosis.<\/p>\n<h3 class=\"wp-block-heading\">Ce analize de s\u00e2nge am nevoie?<\/h3>\n<p>FBC weekly during the concurrent radiotherapy phase. Before each maintenance cycle: FBC on day 22 of the previous cycle and day 1 of the new cycle. LFTs monthly. Hold cycle for ANC &lt; 1,500\/&micro;L or platelets &lt; 100,000\/&micro;L &mdash; thrombocytopenia is the dose-limiting toxicity.<\/p>\n<h3 class=\"wp-block-heading\">What if I vomit a dose?<\/h3>\n<p>If you vomit within 1 hour of taking Temozol, do NOT re-dose &mdash; the safety risk of double-dosing is greater than the modest loss of efficacy from one missed dose. Resume the next dose at the scheduled time. Speak to your oncology team about pre-medication adjustment if vomiting recurs.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Temozol?<\/h3>\n<p>Avoid during active treatment. Both alcohol and temozolomide are hepatotoxic, and alcohol increases nausea. Even after treatment finishes, limit alcohol given the hepatic and bone marrow recovery period.<\/p>\n<h3 class=\"wp-block-heading\">Will Temozol cure my brain tumour?<\/h3>\n<p>Glioblastoma multiforme remains one of the most aggressive cancers. The Stupp protocol is the established standard and improves median survival, but cure is uncommon at present. Specific situations carry better prognosis: younger age, MGMT methylation, complete surgical resection, IDH mutation. Discuss prognosis honestly with your neuro-oncologist &mdash; treatment goals depend on individual disease characteristics.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Fiecare lot este procurat de la un <strong>produc\u0103tor certificat WHO-GMP<\/strong>. Comenzile sunt expediate \u00een ambalaje simple, f\u0103r\u0103 marc\u0103, de la partenerii no\u0219tri de onorare \u0219i acoperite de <a href=\"\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a>: dac\u0103 un colet nu ajunge \u00een 20 de zile lucr\u0103toare, trimitem gratuit o nou\u0103 comand\u0103, f\u0103r\u0103 \u00eentreb\u0103ri.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Medicamente Anticanceroase Asem\u0103n\u0103toare<\/h3>\n<p>Alte medicamente oncologice disponibile \u00eempreun\u0103 cu acest produs:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/temotero\/\">Temotero (temozolomid\u0103 100\/250 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/lomoother\/\">Lomoother (lomustin\u0103 40 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/endoxan\/\">Endoxan (ciclosfosfamid\u0103 50 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/hydrosar\/\">Hydrosar (hidroxiuree 500 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/folitrax\/\">Folitrax (metotrexat 2,5\/7,5\/10 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Shrinks brain tumors<br \/>\n\u2705 Delays tumor growth<br \/>\n\u2705 Cre\u0219te ratele de supravie\u021buire<br \/>\n\u2705 \u00cembun\u0103t\u0103\u021be\u0219te calitatea vie\u021bii<br \/>\n\u2705 Reduces cancer symptoms<\/p>\n<p>Temozol contains Temozolomide.<\/p>","protected":false},"featured_media":60750,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[4914,4915],"class_list":{"0":"post-60749","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-temozol","10":"product_tag-temozolomide","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/60749","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=60749"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/60750"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=60749"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=60749"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=60749"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=60749"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}