{"id":60802,"date":"2024-02-28T07:09:25","date_gmt":"2024-02-28T07:09:25","guid":{"rendered":"https:\/\/medsname.com\/unicontin-e\/"},"modified":"2026-04-30T10:23:42","modified_gmt":"2026-04-30T10:23:42","slug":"unicontin-e","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/unicontin-e\/","title":{"rendered":"Unicontin-E"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 10px 0;font-size:18px;color:#1a1a1a;\">\u26a1 Quick Answer \u2014 What is Unicontin-E?<\/h3>\n<p><strong>Unicontin-E<\/strong> con\u021bine <strong>theophylline<\/strong>, un <strong>bronhodilatator metilxantinic<\/strong> cu efecte antiinflamatoare, utilizat ca terapie adjunct\u0103 \u00een astmul cronic \u0219i BPOC. Teofilina ac\u021bioneaz\u0103 pe mai multe \u021binte \u2014 inhibarea fosfodiesterazei (cre\u0219terea cAMP), antagonismul receptorilor de adenozin\u0103 \u0219i activarea HDAC2 (antiinflamator). Are un <strong>indice terapeutic \u00eengust<\/strong> (target serum 10\u201320 mg\/L; toxicity at 20+) and many drug interactions, requiring careful dosing and (in some patients) blood-level monitoring. Each controlled-release tablet contains <strong>400 mg<\/strong>, fabricat\u0103 de <strong>Modi-Mundipharma<\/strong> \u00een fabrici certificate WHO-GMP.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Ce beneficii ofer\u0103 MedsBase:<\/strong> Produc\u0103tor certificat WHO-GMP \u00b7 Ambalaj discret \u00b7 Livrare la nivel mondial \u00b7 Peste 1.400 de recenzii verificate <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Medicamentele noastre generice sunt procurate de la produc\u0103tori certifica\u021bi WHO-GMP \u0219i expediate la nivel mondial \u00een ambalaje discrete \u0219i simple \u2014 f\u0103r\u0103 denumirea medicamentului pe exteriorul coletului. Pl\u0103\u021bile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 \u201cMedsBase\u201d sau numele vreunui medicament). Accept\u0103m \u0219i criptomonede \u0219i transferuri bancare SEPA. Fiecare comand\u0103 este sus\u021binut\u0103 de Politica noastr\u0103 de Asigurare pentru Relivrare.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #e0e0e0;padding:12px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;text-align:center;\">\n<strong>\ud83d\udd12 Checkout criptat<\/strong> \u00b7 <strong>\ud83d\udcb3 Procesator Verificat<\/strong> \u00b7 <strong>\ud83d\ude9a Livrare Worldwide<\/strong> \u00b7 <strong>\u2b50 4,9\/5 de la peste 1.400 de clien\u021bi<\/strong>\n<\/div>\n<h2>What Is Unicontin-E?<\/h2>\n<p>Unicontin-E is an oral methylxanthine bronchodilator. Methylxanthines are derived from natural alkaloids (theophylline is the dimethylxanthine present in tea). Their use has declined since the 1990s as inhaled \u03b22-agonists and corticosteroids became first-line \u2014 but they retain a role as third-line add-on therapy in difficult asthma and COPD.<\/p>\n<h2>How Does Unicontin-E Work?<\/h2>\n<ul>\n<li><strong>Inhibarea fosfodiesterazei (PDE3, PDE4)<\/strong> \u2014 cre\u0219te nivelul de AMP ciclic \u00een mu\u0219chii netezi ai c\u0103ilor respiratorii \u0219i \u00een celulele inflamatorii; rezultatul net este bronhodilata\u021bia \u0219i reducerea eliber\u0103rii de mediatorii.<\/li>\n<li><strong>Antagonismul receptorilor de adenozin\u0103<\/strong> \u2014 blocheaz\u0103 bronhoconstric\u021bia mediat\u0103 de adenozin\u0103 \u0219i eliberarea de mediatorii din celulele mast.<\/li>\n<li><strong>Activarea HDAC2<\/strong> (teofilina la niveluri serice sc\u0103zute 5\u201310 mg\/L) \u2014 restabile\u0219te r\u0103spunsul la corticosteroizi \u00een BPOC \u0219i astmul sever, unde rezisten\u021ba la steroizi este par\u021bial mediat\u0103 de sc\u0103derea HDAC2.<\/li>\n<li><strong>Contractilitatea diafragmatic\u0103<\/strong> \u2014 metilxantinele reduc oboseala diafragmatic\u0103, utile \u00een BPOC cu limitare sever\u0103 a fluxului de aer.<\/li>\n<\/ul>\n<h2>Utiliz\u0103ri \u0219i indica\u021bii<\/h2>\n<ul>\n<li><strong>Astm cronic sever<\/strong> \u2014 ad\u0103ugare la terapie cu doze mari de ICS-LABA acolo unde este necesar\u0103 bronhodilata\u021bie suplimentar\u0103<\/li>\n<li><strong>Men\u021binerea BPOC<\/strong> \u2014 ad\u0103ugare la terapie cu LAMA-LABA sau terapie tripl\u0103<\/li>\n<li><strong>Astm nocturn<\/strong> \u2014 forma de eliberare prelungit\u0103 asigur\u0103 bronhodilata\u021bie pe timpul nop\u021bii<\/li>\n<li><strong>Apnee la prematuri<\/strong> (teofilin\u0103) \u2014 utilizare neonatal\u0103<\/li>\n<li><strong>Cor pulmonale \u0219i hipertensiune pulmonar\u0103<\/strong> \u2014 adjunct<\/li>\n<\/ul>\n<h2>Unicontin-E Dosage<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Pacient<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Doza<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Frecven\u021b\u0103<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Adul\u021bi \u2014 ini\u021bial<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>200 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Twice daily; titrate to serum level 10\u201320 mg\/L<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Adul\u021bi \u2014 \u00eentre\u021binere<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>400 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Twice daily (or 600 mg once daily ER)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Elderly \/ heart failure \/ liver disease<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u00cenjum\u0103t\u0103\u021bi\u021bi doza<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor serum level<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Side Effects of Unicontin-E<\/h2>\n<ul>\n<li>Grea\u021b\u0103, v\u0103rs\u0103turi, dispepsie<\/li>\n<li>Dureri de cap<\/li>\n<li>Tremur<\/li>\n<li>Insomnie, agita\u021bie<\/li>\n<li>Tahicardie, palpita\u021bii<\/li>\n<li>Hipokaliemie u\u0219oar\u0103 la doze mari<\/li>\n<\/ul>\n<p><strong>Niveluri toxice (&gt;20 mg\/L) \u2014 urgen\u021b\u0103:<\/strong><\/p>\n<ul>\n<li>Grea\u021b\u0103 sever\u0103, v\u0103rs\u0103turi persistente<\/li>\n<li>Aritmie cardiac\u0103 (fibrila\u021bie atrial\u0103, tahicardie supraventricular\u0103)<\/li>\n<li>Criz\u0103 epileptic\u0103 (adesea f\u0103r\u0103 avertisment)<\/li>\n<li>Hipotensiune, hiperglicemie, hipokaliemie, hipercalcemie<\/li>\n<\/ul>\n<h2>Avertismente \u0219i precau\u021bii<\/h2>\n<ul>\n<li><strong>Indice terapeutic \u00eengust.<\/strong> Nivelul \u021bint\u0103 \u00een ser: 10\u201320 mg\/L. Verifica\u021bi concentra\u021bia sanguin\u0103 la 5 zile dup\u0103 \u00eenceperea tratamentului, dup\u0103 modificarea dozei, la introducerea unui nou medicament interactiv, dup\u0103 renun\u021barea la fumat \u0219i \u00een timpul bolii\/febrei (clearance-ul scade).<\/li>\n<li><strong>Multe interac\u021biuni medicamentoase<\/strong> \u2014 consulta\u021bi tabelul de interac\u021biuni. Majoritatea sunt metabolizate de CYP1A2; numero\u0219i inhibitori \u0219i inductori modific\u0103 semnificativ nivelurile.<\/li>\n<li><strong>Fumatul<\/strong> induce CYP1A2 \u0219i reduce nivelurile de teofilin\u0103 cu ~50% \u2014 retitra\u021bi la \u00eencetarea fumatului.<\/li>\n<li><strong>Boal\u0103 cardiac\u0103:<\/strong> utiliza\u021bi cu precau\u021bie \u00een aritmii, insuficien\u021b\u0103 cardiac\u0103, hipertensiune sever\u0103.<\/li>\n<li><strong>Hipertiroidism:<\/strong> clearance crescut plus efecte adrenergice exagerate.<\/li>\n<li><strong>Sarcin\u0103 \u0219i al\u0103ptare:<\/strong> de obicei evitat; utiliza\u021bi doar dac\u0103 beneficiul este clar.<\/li>\n<li><strong>Boal\u0103 hepatic\u0103:<\/strong> reduce\u021bi doza \u2014 metilxantinele sunt metabolizate hepatic.<\/li>\n<\/ul>\n<h2>Contraindica\u021bii<\/h2>\n<ul>\n<li>Hipersensibilitate la teofilin\u0103 sau alte xantine (cafein\u0103, teobromin\u0103)<\/li>\n<li>Boal\u0103 ulceroas\u0103 peptic\u0103 activ\u0103<\/li>\n<li>Tahiartmii necontrolate<\/li>\n<li>Insuficien\u021b\u0103 cardiac\u0103 sever\u0103 (NYHA IV)<\/li>\n<\/ul>\n<h2>Interac\u021biuni medicamentoase<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Medicament interactiv<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Efect<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Ce s\u0103 face\u021bi<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Ciprofloxacin\u0103, eritromicin\u0103, claritromicin\u0103, fluvoxamin\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Inhib\u0103 CYP1A2 \u2192 cre\u0219te nivelul teofilinei \u2192 toxicitate (grea\u021b\u0103, aritmii, convulsii)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Evita\u021bi sau reduce\u021bi doza de teofilin\u0103 cu 50%; verifica\u021bi nivelul seric<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Cimetidin\u0103, alopurinol<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Cre\u0219te nivelul teofilinei<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce\u021bi doza; monitoriza\u021bi nivelurile<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Fenitoin\u0103, carbamazepin\u0103, rifampicin\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Induc CYP \u2014 niveluri mai sc\u0103zute<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Poate fi necesar\u0103 o doz\u0103 mai mare<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Fumatul<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Induce CYP1A2 \u2014 niveluri mai sc\u0103zute<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Re-titra\u021bi doza la renun\u021barea la fumat<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03b2-agoni\u0219ti, diuretice<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Hipokaliemie aditiv\u0103<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitorizare potasiu<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Depozitare<\/h2>\n<ul>\n<li>Depozita\u021bi la temperaturi sub <strong>25\u00b0C<\/strong> \u00eentr-un loc r\u0103coros \u0219i uscat, departe de lumina direct\u0103 a soarelui.<\/li>\n<li>P\u0103stra\u021bi \u00een ambalajul original p\u00e2n\u0103 la utilizare pentru a proteja de umiditate \u0219i lumin\u0103.<\/li>\n<li>Nu utiliza\u021bi dup\u0103 data de expirare tip\u0103rit\u0103 pe blister.<\/li>\n<li>P\u0103stra\u021bi la distan\u021b\u0103 de copii.<\/li>\n<\/ul>\n<h2>Alternative conexe pe MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/asthalin-inhaler\/\"><strong>Asthalin Inhaler \u2014 salbutamol pentru ameliorarea simptomelor<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/budecort-inhaler\/\"><strong>Budecort Inhaler \u2014 budesonide ICS pentru preven\u021bie<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/foracort-inhaler\/\"><strong>Foracort Inhaler \u2014 budesonide + formoterol ICS-LABA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tiova-inhaler\/\"><strong>Tiova Inhaler \u2014 tiotropium LAMA pentru BPOC<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/montair\/\"><strong>Montair \u2014 comprimat montelukast LTRA<\/strong><\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>Is theophylline still used in modern asthma management?<\/h3>\n<p>Yes, but as third-line add-on. Inhaled \u03b22 agonists, ICS, ICS-LABA, LTRA, and LAMA are first-line; theophylline is added for refractory disease, particularly nocturnal asthma. The narrow therapeutic index and many drug interactions limit its use.<\/p>\n<h3>How is the dose decided?<\/h3>\n<p>Adjusted to serum theophylline level 10\u201320 mg\/L. Check 5 days after starting, after dose change, with new interacting drug, with smoking cessation, and during illness\/fever.<\/p>\n<h3>Why so many interactions?<\/h3>\n<p>Theophylline is metabolised by CYP1A2 \u2014 many drugs raise levels (ciprofloxacin, erythromycin, fluvoxamine, cimetidine) or lower levels (rifampicin, phenytoin, smoking).<\/p>\n<h3>How long does Unicontin-E last?<\/h3>\n<p>The controlled-release tablet provides 12-hour cover. Twice-daily dosing maintains stable serum levels.<\/p>\n<h3>What are the toxic symptoms?<\/h3>\n<p>Severe nausea, persistent vomiting, tachycardia, palpitations, tremor, hyperactivity, seizures (often without warning), arrhythmias, hypotension. Toxicity above 20 mg\/L is an emergency \u2014 withhold dose, check level, supportive care.<\/p>\n<h3>Can I take it with caffeine?<\/h3>\n<p>Caffeine and theophylline are both methylxanthines with overlapping effects. Heavy caffeine can amplify tremor, tachycardia, and insomnia. Reduce caffeine if symptomatic.<\/p>\n<h3>Why does smoking affect dose?<\/h3>\n<p>Smoking induces CYP1A2 (the enzyme that metabolises theophylline). Smokers need higher doses; on stopping, levels rise \u2014 re-titrate.<\/p>\n<h3>Is Unicontin-E safe in pregnancy?<\/h3>\n<p>Generally avoided unless benefit clear. Inhaled therapy is preferred.<\/p>\n<h3>Can I crush or split Unicontin-E tablets?<\/h3>\n<p>No \u2014 controlled-release tablets must be swallowed whole. Crushing destroys the release matrix and risks acute toxicity.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Avertizare medical\u0103:<\/strong> Aceast\u0103 pagin\u0103 are scop informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical profesionist. Consult\u0103 \u00eentotdeauna un profesionist calificat \u00een s\u0103n\u0103tate \u00eenainte de a \u00eencepe, \u00eentrerupe sau schimba orice inhalator sau medicament respirator, mai ales dac\u0103 ai alte afec\u021biuni medicale, iei alte re\u021bete, e\u0219ti gravid\u0103 sau al\u0103ptezi, sau ai peste 65 de ani.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Alternative conexe<\/h3>\n<p>Alte produse din <strong>Afec\u021biuni cronice<\/strong> pe care clien\u021bii le vizualizeaz\u0103 de asemenea:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/topme-xl\/\">Topme XL<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/amifru\/\">Amifru<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/unibrom-eye-drops\/\">Unibrom Pic\u0103turi Oculare<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/nise-gel\/\">Nise Gel<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/dynapar\/\">Dynapar<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Amelioreaz\u0103 bronhospasmul<br \/>\n\u2705 Enhances lung function<br \/>\n\u2705 Reduces shortness of breath<br \/>\n\u2705 Improves airway flow<br \/>\n\u2705 Manages asthma symptoms<\/p>\n<p>Unicontin-E contains Theophylline.<\/p>","protected":false},"featured_media":60803,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3681,3141,3223],"product_tag":[3731,4926],"class_list":{"0":"post-60802","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-asthma-copd-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-theophylline","10":"product_tag-unicontin-e","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/60802","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=60802"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/60803"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=60802"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=60802"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=60802"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=60802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}