{"id":60809,"date":"2024-02-28T07:09:30","date_gmt":"2024-02-28T07:09:30","guid":{"rendered":"https:\/\/medsname.com\/metabolis\/"},"modified":"2026-04-30T10:23:42","modified_gmt":"2026-04-30T10:23:42","slug":"metabolis","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/metabolis\/","title":{"rendered":"Metabolis"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">R\u0103spuns rapid<\/h3>\n<p><strong>Metabolis (methylation-support multivitamin tablet)<\/strong> is a methylation-support multivitamin combining methylated B vitamins (methylfolate, methylcobalamin, P-5-P pyridoxal) with key cofactor minerals for patients with elevated homocysteine or MTHFR polymorphisms.<\/p>\n<ul style=\"margin-bottom:0;\">\n<li>Methylated B-complex (methylfolate, methylcobalamin, P-5-P), choline, betaine, magnesium, zinc, selenium<\/li>\n<li>Indications: elevated homocysteine, MTHFR polymorphism, methylation-related conditions<\/li>\n<li>Daily oral tablet with food<\/li>\n<li>produc\u0103tor certificat WHO-GMP<\/li>\n<\/ul>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f6f8;border:1px solid #e0e4e7;padding:12px 16px;margin:18px 0;border-radius:4px;font-size:14px;color:#444;\">\n<strong>produc\u0103tor certificat WHO-GMP<\/strong> \u00b7 Ambalaj discret \u00b7 Livrare worldwide \u00b7 <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\" style=\"color:#2c7cb0;\">Peste 1.400 de recenzii verificate ale clien\u021bilor<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<p style=\"font-size:13px;color:#666;margin:4px 0 18px;\">Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\" style=\"color:#2c7cb0;\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a>.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Metabolis is sourced from a WHO-GMP certified manufacturer. Every order ships in discreet, unbranded packaging worldwide and is covered by our Reshipment Assurance Policy. Pay securely with credit card, SEPA bank transfer, or cryptocurrency. See our <a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">Peste 1.400 de recenzii verificate ale clien\u021bilor<\/a>.<\/p>\n<h2>What is Metabolis?<\/h2>\n<p>Metabolis is a methylation-support multivitamin built around bioactive forms of folate (5-methyltetrahydrofolate \/ 5-MTHF), vitamin B12 (methylcobalamin), and vitamin B6 (pyridoxal-5-phosphate, P-5-P), plus methyl-donor cofactors (choline, betaine, methionine) and key minerals (magnesium, zinc, selenium). It is designed for patients with elevated homocysteine, with MTHFR (C677T or A1298C) polymorphisms, or for whom standard B-complex preparations may not provide optimal methylation support.<\/p>\n<h2>Indica\u021bii<\/h2>\n<ul>\n<li><strong>Elevated homocysteine<\/strong> &mdash; cardiovascular and dementia risk factor; methylation cofactor support reduces levels<\/li>\n<li><strong>MTHFR polymorphism<\/strong> (C677T homozygous reduces enzyme activity ~70%; A1298C reduces ~40%) &mdash; methylated folate bypasses the MTHFR step<\/li>\n<li><strong>Adjunct in depression \/ mood disorders<\/strong> with low folate or B12 status &mdash; modest evidence for SSRI augmentation<\/li>\n<li><strong>Pregnancy planning in MTHFR carriers<\/strong> &mdash; methylated folate may be preferred over folic acid<\/li>\n<li><strong>Recurrent miscarriage with hyperhomocysteinaemia<\/strong><\/li>\n<li><strong>Adjunct in chronic fatigue with documented B-vitamin deficiency<\/strong><\/li>\n<li><strong>Long-term metformin or PPI users<\/strong> with documented B12 deficiency<\/li>\n<\/ul>\n<h3>Cum se administreaz\u0103<\/h3>\n<p>One tablet daily with food. Effects on homocysteine are visible at 4&ndash;8 weeks &mdash; recheck levels at 12 weeks to assess response.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Methylated forms versus folic acid &mdash; the practical reality<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Folic acid (synthetic) requires reduction by DHFR and methylation by MTHFR to become bioactive 5-MTHF. In patients with MTHFR polymorphisms (~30% of the population is heterozygous; ~10% homozygous), this conversion is inefficient. Methylated folate (5-MTHF in Metabolis) bypasses this step. For most healthy adults, regular folic acid works fine. For patients with confirmed MTHFR polymorphism plus elevated homocysteine, the methylated form is more rationally chosen. Routine MTHFR testing in healthy adults is not recommended &mdash; the clinical impact is small and not all guidelines support testing.<\/p>\n<\/div>\n<h2>Efecte secundare<\/h2>\n<ul>\n<li><strong>Disconfort gastrointestinal u\u0219or<\/strong> \u2014 grea\u021b\u0103, dispepsie; administrare cu alimente<\/li>\n<li><strong>Urin\u0103 galben\u0103 str\u0103lucitoare<\/strong> datorit\u0103 riboflavinei \u2014 inofensiv\u0103<\/li>\n<li><strong>Initial sensitivity<\/strong> to high-dose methylated B vitamins &mdash; some patients report transient anxiety, irritability, headache &mdash; ease in with half a tablet for the first week<\/li>\n<li><strong>Eritem cu niacin\u0103<\/strong> \u2014 tranzitorie<\/li>\n<li><strong>Neuropatie senzorial\u0103 cu piridoxin\u0103<\/strong> &mdash; only at sustained extreme doses; standard product doses are well below threshold<\/li>\n<\/ul>\n<h2>Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>Metotrexat<\/strong> &mdash; folate (any form) may reduce efficacy in oncology dosing; in low-dose RA \/ psoriasis dosing folate is co-prescribed to reduce side effects<\/li>\n<li><strong>Antiepileptics (phenytoin, carbamazepine, phenobarbital, valproate)<\/strong> &mdash; deplete folate; supplementation appropriate but discuss with neurologist<\/li>\n<li><strong>Trimetoprim, pirimetamin\u0103<\/strong> &mdash; antifolates; high-dose folate may theoretically reduce efficacy<\/li>\n<li><strong>Levodopa (f\u0103r\u0103 inhibitor de decarboxilaz\u0103)<\/strong> &mdash; B6 effect (rare)<\/li>\n<li><strong>Metformin\u0103 sau IBP pe termen lung<\/strong> &mdash; reduce B12 absorption; combination with Metabolis appropriate<\/li>\n<\/ul>\n<h2>Contraindica\u021bii<\/h2>\n<ul>\n<li>Hipersensibilitate la orice component\u0103<\/li>\n<li>Untreated B12 deficiency (folate alone &mdash; even methylated &mdash; can mask megaloblastic anaemia and let neurological B12 damage progress; Metabolis contains B12 so this risk is reduced but baseline B12 should still be checked)<\/li>\n<li>Active malignancy on antifolate chemotherapy without oncology approval<\/li>\n<\/ul>\n<h2>Depozitare<\/h2>\n<p>Se p\u0103streaz\u0103 la temperaturi sub 25\u00b0C \u00een ambalajul original, protejat de umiditate \u0219i lumin\u0103.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>What is methylation and why does it matter?<\/h3>\n<p>Methylation is the body&#8217;s reaction of adding a methyl group (-CH<sub>3<\/sub>) to molecules &mdash; central to DNA repair, neurotransmitter synthesis, hormone metabolism, and homocysteine clearance. The methyl donor is S-adenosyl-methionine (SAM), regenerated from homocysteine using B12, methylfolate, and B6 as cofactors. Inefficient methylation raises homocysteine and may contribute to cardiovascular and cognitive risk.<\/p>\n<h3>Ar trebui s\u0103 fac testul MTHFR?<\/h3>\n<p>For most healthy adults &mdash; no. The clinical impact of MTHFR polymorphism is modest, and not all guidelines recommend testing. Indications: unexplained recurrent miscarriage, premature thrombosis, hyperhomocysteinaemia, family history. Routine pre-conception MTHFR testing is not recommended.<\/p>\n<h3>Will it lower my homocysteine?<\/h3>\n<p>Yes &mdash; in patients with elevated homocysteine, B12 + methylfolate + B6 supplementation reliably reduces it (often by 25&ndash;30%). Whether this reduces cardiovascular events is less clear &mdash; large RCTs (HOPE-2, VISP, NORVIT, SEARCH) showed homocysteine lowering but no consistent reduction in MACE. Treatment is most justified when homocysteine is markedly elevated (&gt;15 &mu;mol\/l) or where there is also a clear deficiency.<\/p>\n<h3>Methylated folate or regular folic acid in pregnancy?<\/h3>\n<p>For most women, regular folic acid 400&ndash;800 mcg\/day from 3 months pre-conception works perfectly to prevent neural tube defects. In MTHFR homozygous carriers, methylated folate (5-MTHF) is more rationally chosen but evidence that it is superior to folic acid for NTD prevention is limited. Discuss with your obstetrician.<\/p>\n<h3>Will it help my mood?<\/h3>\n<p>Methylated folate at 7.5&ndash;15 mg\/day has modest evidence as SSRI augmentation in MDD (the L-methylfolate \/ Deplin protocol). At standard multivitamin doses (in Metabolis) the effect is smaller. Worth supplementing if folate or B12 is deficient; not a replacement for antidepressant therapy.<\/p>\n<h3>Can methylation supplements feel &#8220;too strong&#8221;?<\/h3>\n<p>Some patients (often labelled &#8220;slow methylators&#8221; in functional medicine circles) report transient anxiety, headache, or irritability at high methylated B doses. Start with half a tablet for the first week, then full dose; symptoms usually settle.<\/p>\n<h3>Ar trebui s\u0103 o iau pe termen lung?<\/h3>\n<p>Yes if the indication persists (chronic hyperhomocysteinaemia, MTHFR with documented benefit, ongoing depression with deficiency). Reassess every 6&ndash;12 months &mdash; recheck homocysteine and B12 levels.<\/p>\n<h3>Will it interfere with my antidepressant?<\/h3>\n<p>Generally compatible. Methylated folate is studied as SSRI augmentation. Discuss with your prescriber if you start or stop &mdash; baseline B12 and folate should be checked.<\/p>\n<h3>Is it different from Beplex Forte?<\/h3>\n<p>Beplex Forte uses standard cyanocobalamin and folic acid &mdash; cheap and effective for most. Metabolis uses methylated forms (methylcobalamin, 5-MTHF, P-5-P) and adds methyl-donor cofactors (choline, betaine). For patients with MTHFR polymorphism or elevated homocysteine, Metabolis is more rationally targeted. For everyone else, Beplex Forte does the job.<\/p>\n<h3>Should I avoid folic acid if I take methylated folate?<\/h3>\n<p>No need. The body handles both. Stacking is fine but pointless. Pick one. If you take a prenatal multivitamin with folic acid, that is sufficient unless you have a specific MTHFR-related indication for switching.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Alte Vitamine &amp; Minerale<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/multivite-gold\/\">Multivite Gold<\/a> \u2014 softgel cu multivitamine complexe<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/cheri\/\">Cheri<\/a> \u2014 capsul\u0103 cu fier + proteine + calciu + vitamine<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/becozinc\/\">Becozinc<\/a> \u2014 complex B cu zinc<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/c-vitan-z\/\">C Vitan Z<\/a> \u2014 vitamina C + zinc + minerale<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/metabolis\/\">Metabolis<\/a> \u2014 multivitamin\u0103 pentru sprijinirea metil\u0103rii<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/celin\/\">Celin<\/a> \u2014 vitamina C 500 mg<\/li>\n<\/ul>\n<h2>Declinare de responsabilitate medical\u0103<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:14px;color:#444;\">\nAceast\u0103 pagin\u0103 are scop strict informativ \u0219i nu \u00eenlocuie\u0219te sfatul medical profesionist. Suplimentarea cu vitamine \u0219i minerale ar trebui s\u0103 fie ghidat\u0103, ideal, de teste de laborator atunci c\u00e2nd se suspecteaz\u0103 deficien\u021be. Suplimentarea cu doze mari nu este benign\u0103 \u2014 vitamina A este teratogen\u0103, vitamina E cre\u0219te riscul de s\u00e2nger\u0103ri, beta-carotenul cre\u0219te riscul de cancer pulmonar la fum\u0103tori, iar calciul \u00een doze mari are un semnal cardiovascular. Pacientele gravide sau care al\u0103pteaz\u0103 trebuie s\u0103 urmeze recomand\u0103rile obstetrice pentru suplimentarea prenatal\u0103. Pacien\u021bii sub tratament cu warfarin trebuie s\u0103 men\u021bin\u0103 o aport constant de vitamina K. Pacien\u021bii care iau levotiroxin\u0103, fluoroquinolone sau tetracicline trebuie s\u0103 separe administrarea de fier \u0219i calciu cu 4 ore. Dezv\u0103lui\u021bi \u00eentotdeauna toate suplimentele medicului prescriptor \u0219i farmacistului.\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u2705 Boosts overall health<br \/>\n\u2705 Provides essential nutrients<br \/>\n\u2705 Sus\u021bine metabolismul<br \/>\n\u2705 \u00cembun\u0103t\u0103\u021be\u0219te nivelul de energie<br \/>\n\u2705 Strengthens immune system<\/p>\n<p>Metabolis contains multivitamins and multiminerals.<\/p>","protected":false},"featured_media":60810,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3863],"product_tag":[4927,4928,4021],"class_list":{"0":"post-60809","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-vitamins-and-minerals","9":"product_tag-metabolis","10":"product_tag-multimineral","11":"product_tag-multivitamin","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/60809","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=60809"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/60810"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=60809"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=60809"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=60809"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=60809"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}