{"id":61039,"date":"2024-02-28T07:21:56","date_gmt":"2024-02-28T07:21:56","guid":{"rendered":"https:\/\/medsname.com\/ursodec\/"},"modified":"2026-04-30T10:23:39","modified_gmt":"2026-04-30T10:23:39","slug":"ursodec","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/ursodec\/","title":{"rendered":"Ursodec"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:0 0 18px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 8px 0;font-size:1.05em;\">R\u0103spuns rapid<\/h3>\n<p><strong>Ursodec<\/strong> con\u021bine <strong>acid ursodeoxicolic (UDCA) 150 mg<\/strong> pe comprimat \u2014 terapia oral\u0103 de prim\u0103 linie pentru colangita biliar\u0103 primar\u0103 (PBC) \u0219i principala op\u021biune oral\u0103 pentru dizolvarea pietrelor biliare de colesterol. Doza tipic\u0103 pentru adul\u021bi este de 13\u201315 mg\/kg\/zi \u00een doze divizate cu mese pentru PBC, 8\u201310 mg\/kg\/zi pentru dizolvarea pietrelor biliare. Comprimatele cu doze mai mari (Udiliv 300mg) reduc num\u0103rul de pastile necesare.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f6f8;border:1px solid #e1e4e8;border-radius:4px;padding:14px 18px;margin:18px 0;display:flex;flex-wrap:wrap;gap:14px;font-size:0.95em;\"><span>\u2705 <strong>Certificat WHO-GMP<\/strong> produc\u0103tor<\/span><span>\ud83d\udce6 <strong>Ambalaj discret<\/strong><\/span><span>\ud83c\udf0d <strong>Livrare \u00een toat\u0103 lumea<\/strong><\/span><span>\ud83d\udcac <a href=\"\/ro\/reviews\/\">Peste 1.400 de recenzii ale clien\u021bilor<\/a><\/span><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Fiecare comand\u0103 este acoperit\u0103 de politica noastr\u0103 de <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\"><strong>Politica noastr\u0103 de Reexpediere Garantat\u0103<\/strong><\/a> \u2014 dac\u0103 coletul dumneavoastr\u0103 nu sose\u0219te \u00een 20 de zile lucr\u0103toare, \u00eel relivr\u0103m.<\/p>\n<h2>Ce este acidul ursodeoxicolic<\/h2>\n<p>Acidul ursodeoxicolic (UDCA, numit \u0219i ursodiol) este un acid biliar secundar natural. Terapeutic, face trei lucruri simultan: <strong>\u00eenlocuie\u0219te acizii biliari hidrofobi citotoxici<\/strong> (chenodeoxicolic, deoxicolic, litocolic) din pool-ul de acizi biliari, acesta <strong>reduce secre\u021bia de colesterol biliar<\/strong> (care dizolv\u0103 calculii biliari de colesterol \u00een c\u00e2teva luni) \u0219i <strong>protejeaz\u0103 colangiocitele<\/strong> de leziunile mediate de acizii biliari prin efecte citoprotectoare \u0219i imunomodulatoare. Este singura terapie oral\u0103 cu beneficii \u00een mortalitate \u0219i supravie\u021buire f\u0103r\u0103 transplant \u00een colangita biliar\u0103 primar\u0103 (Poupon 1991, 1994; meta-analize 2002, 2014).<\/p>\n<h2>Indica\u021bii<\/h2>\n<ul>\n<li><strong>Colangita biliar\u0103 primar\u0103 (PBC)<\/strong> \u2014 terapie de prim\u0103 linie; 13\u201315 mg\/kg\/zi \u00een doze divizate la mese. R\u0103spuns biochimic \u00een ~60\u201370% (normalizarea fosfatazei alcaline sau sc\u0103dere semnificativ\u0103) \u00een 12 luni. Pacien\u021bii f\u0103r\u0103 r\u0103spuns sunt trecu\u021bi sau augmenta\u021bi cu acid obeticholic sau fibrate.<\/li>\n<li><strong>Dizolvarea calculilor biliari de colesterol<\/strong> \u2014 pentru calculi radiotransparen\u021bi &lt; 15 mm \u00eentr-o vezic\u0103 biliar\u0103 func\u021bional\u0103, la pacien\u021bii care nu pot sau nu doresc s\u0103 fac\u0103 colecistectomie. 8\u201310 mg\/kg\/zi timp de 6\u201324 luni. Recuren\u021ba calculilor dup\u0103 \u00eentrerupere este semnificativ\u0103 (\u2248 50% la 5 ani).<\/li>\n<li><strong>Colangita sclerozant\u0103 primar\u0103 (PSC)<\/strong> \u2014 \u00eembun\u0103t\u0103\u021be\u0219te parametrii biochimici; beneficiul asupra mortalit\u0103\u021bii nu este dovedit. Dozele mari (28\u201330 mg\/kg\/zi) sunt asociate cu rezultate mai proaste \u0219i sunt contraindicate.<\/li>\n<li><strong>Colestaza intrahepatic\u0103 a sarcinii (ICP)<\/strong> \u2014 10\u201315 mg\/kg\/zi (sau 500 mg de dou\u0103 ori pe zi); reduce pruritul maternal \u0219i nivelurile de acizi biliari; poate reduce complica\u021biile fetale.<\/li>\n<li><strong>Boal\u0103 hepatic\u0103 gras\u0103 non-alcoolic\u0103 (NAFLD)<\/strong> \u2014 parametrii biochimici se \u00eembun\u0103t\u0103\u021besc, dar beneficiul histologic de calitate nu este dovedit; nu este o terapie de prim\u0103 linie pentru NAFLD \u00een ghidurile actuale.<\/li>\n<li><strong>Boala hepatic\u0103 asociat\u0103 fibrozei chistice<\/strong> \u2014 utilizat\u0103 \u00een colestaza la pacien\u021bii pediatrici \u0219i adul\u021bi cu fibroz\u0103 chistic\u0103.<\/li>\n<\/ul>\n<h2>Doza<\/h2>\n<table>\n<thead>\n<tr>\n<th>Indica\u021bie<\/th>\n<th>Doza (mg\/kg\/zi)<\/th>\n<th>Program<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>PBC<\/td>\n<td>13\u201315<\/td>\n<td>2\u20133 doze divizate la mese<\/td>\n<\/tr>\n<tr>\n<td>Dizolvarea calculilor biliari de colesterol<\/td>\n<td>8\u201310<\/td>\n<td>2 doze divizate (cea mai mare doz\u0103 la culcare)<\/td>\n<\/tr>\n<tr>\n<td>PSC<\/td>\n<td>13\u201315 (NU dep\u0103\u0219i\u021bi 28 mg\/kg)<\/td>\n<td>2\u20133 doze divizate<\/td>\n<\/tr>\n<tr>\n<td>ICP (sarcin\u0103)<\/td>\n<td>10\u201315<\/td>\n<td>2 doze divizate<\/td>\n<\/tr>\n<tr>\n<td>adjuvant \u00een NAFLD<\/td>\n<td>13\u201315<\/td>\n<td>2\u20133 doze divizate<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 8px 0;font-size:1.05em;\">Evita\u021bi \u00een<\/h3>\n<ul>\n<li>Colecistit\u0103 acut\u0103, colangit\u0103 sau obstruc\u021bie biliar\u0103<\/li>\n<li>Pietre biliare calcificate sau pigmentare (f\u0103r\u0103 efect de dizolvare<\/li>\n<li>Vezic\u0103 biliar\u0103 nefunc\u021bional\u0103 la colescistografia oral\u0103<\/li>\n<li>Decompensare hepatic\u0103 sever\u0103 (Child-Pugh C) \u2014 discuta\u021bi cu hepatologul<\/li>\n<\/ul>\n<\/div>\n<h2>Efecte secundare<\/h2>\n<p>\u00cen general, foarte bine tolerat. Cele mai frecvente: diaree u\u0219oar\u0103 (5\u201310%), disconfort abdominal, grea\u021b\u0103, erup\u021bie cutanat\u0103 u\u0219oar\u0103. Pruritul se poate agrava temporar \u00een PBC \u00een primele s\u0103pt\u0103m\u00e2ni \u00eenainte de \u00eembun\u0103t\u0103\u021bire. Rareori: calcificarea pietrelor biliare (deplasare radio-opac\u0103) la tratamente lungi.<\/p>\n<h2>Interac\u021biuni medicamentoase<\/h2>\n<ul>\n<li><strong>Sequestran\u021bi de acizi biliari (colestiramin\u0103, colesevelam, colestipol)<\/strong> \u2014 leag\u0103 UDCA \u00een intestin \u0219i reduce absorb\u021bia. Separa\u021bi cu \u2265 4\u20135 ore.<\/li>\n<li><strong>Antiaci\u021bi care con\u021bin aluminiu<\/strong> \u2014 leag\u0103 UDCA. Separa\u021bi cu \u2265 2 ore.<\/li>\n<li><strong>Estrogeni, contraceptive orale, clofibrat<\/strong> \u2014 cresc satura\u021bia de colesterol biliar \u0219i antagonizeaz\u0103 efectul de dizolvare a pietrelor.<\/li>\n<li><strong>Ciprofloxacin\u0103, dapson\u0103<\/strong> \u2014 absorb\u021bie moderat alterat\u0103; impact clinic minor.<\/li>\n<\/ul>\n<h2>Sarcin\u0103 \u0219i al\u0103ptare<\/h2>\n<p>Folosit \u00een mod obi\u0219nuit off-label \u00een colestaza intrahepatic\u0103 a sarcinii cu date extinse de siguran\u021b\u0103. Compatibil cu al\u0103ptarea (eliminat \u00een cantit\u0103\u021bi infime \u00een lapte; nu s-au raportat efecte adverse la sugari).<\/p>\n<h2>Depozitare<\/h2>\n<p>Depozita\u021bi sub 25 \u00b0C \u00eentr-un loc uscat, \u00een ambalajul original. Comprimatele sunt stabile pe \u00eentreaga durat\u0103 de valabilitate indicat\u0103 pe etichet\u0103 atunci c\u00e2nd sunt p\u0103strate \u00een uscat.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Ursodec este furnizat printr-un produc\u0103tor certificat WHO-GMP cu documenta\u021bie COA complet\u0103. Livr\u0103m \u00een \u00eentreaga lume \u00een ambalaje simple \u0219i discrete, iar fiecare comand\u0103 este acoperit\u0103 de <a href=\"\/ro\/medsbase-re-shipment-assurance-policy\/\">Politica noastr\u0103 de Reexpediere Garantat\u0103<\/a>. Descrierea tranzac\u021biei la plata cu cardul afi\u0219eaz\u0103 procesatorul de pl\u0103\u021bi reglementat (un procesator de pl\u0103\u021bi cu card reglementat), niciodat\u0103 \"MedsBase\" sau numele vreunui medicament.<\/p>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>C\u00e2t dureaz\u0103 p\u00e2n\u0103 v\u0103d rezultate \u00een colangita biliar\u0103 primar\u0103?<\/h3>\n<p>Fosfataza alcalin\u0103 scade de obicei \u00een 4\u20138 s\u0103pt\u0103m\u00e2ni, iar evolu\u021bia la 12 luni prezice rezultatul pe termen lung. Criteriile Toronto, Paris-1 \u0219i Paris-2 definesc un \u201cr\u0103spuns biochimic\u201d la 1 an prin praguri de ALP, AST \u0219i bilirubin\u0103. Pacien\u021bii f\u0103r\u0103 r\u0103spuns ar trebui s\u0103 discute despre ad\u0103ugarea de acid obeticholic sau fibrate cu un hepatolog.<\/p>\n<h3>Poate UDCA dizolva orice tip de calcul biliar?<\/h3>\n<p>Doar calculii de colesterol, doar dac\u0103 sunt radiotransparen\u021bi la imagistic\u0103, doar \u00eentr-o vezic\u0103 biliar\u0103 func\u021bional\u0103 \u0219i doar dac\u0103 au &lt; 15 mm. Calculii calcifica\u021bi, pigmenta\u021bi sau par\u021bial calcifica\u021bi nu r\u0103spund.<\/p>\n<h3>De ce vrea medicul meu s\u0103 iau UDCA pe via\u021b\u0103 pentru PBC?<\/h3>\n<p>PBC este o colangit\u0103 cronic\u0103 autoimun\u0103. UDCA schimb\u0103 evolu\u021bia bolii, dar nu o vindec\u0103. \u00centreruperea UDCA este urmat\u0103 de recidiv\u0103 biochimic\u0103 \u00een c\u00e2teva s\u0103pt\u0103m\u00e2ni. Terapia pe via\u021b\u0103 la 13\u201315 mg\/kg\/zi este standard.<\/p>\n<h3>Pot s\u0103-l iau \u00een timpul sarcinii?<\/h3>\n<p>Da \u2014 UDCA este tratamentul standard pentru colestaza intrahepatic\u0103 a sarcinii. Decenii de utilizare nu arat\u0103 niciun risc fetal \u0219i reduce pruritul maternal \u0219i nivelurile de acizi biliari.<\/p>\n<h3>Va provoca UDCA pierdere sau cre\u0219tere \u00een greutate?<\/h3>\n<p>Niciuna, la majoritatea pacien\u021bilor. Diareea u\u0219oar\u0103 poate provoca o pierdere minor\u0103 de greutate timpurie la o mic\u0103 frac\u021biune.<\/p>\n<h3>Func\u021bioneaz\u0103 UDCA pentru ficatul gras non-alcoolic?<\/h3>\n<p>\u00cembun\u0103t\u0103\u021be\u0219te biochimia (ALT, AST). Dac\u0103 \u00eembun\u0103t\u0103\u021be\u0219te histologia hepatic\u0103 \u0219i rezultatele nu este stabilit \u00een studii mari. Ghidurile actuale NAFLD\/NASH nu recomand\u0103 UDCA ca terapie de rutin\u0103.<\/p>\n<h3>Pot consuma alcool \u00een timp ce iau UDCA?<\/h3>\n<p>Majoritatea pacien\u021bilor care iau UDCA au o afec\u021biune hepatic\u0103 subiacent\u0103. Alcoolul este de evitat \u00een totalitate \u00een PBC, PSC \u0219i \u00een afec\u021biunile hepatice semnificative.<\/p>\n<h3>Care este diferen\u021ba dintre UDCA \u0219i s\u0103rurile biliare \u00een suplimente?<\/h3>\n<p>UDCA este un acid biliar specific (ursodezoxicolic). Suplimentele generice \u201cs\u0103ruri biliare\u201d sunt amestecuri de acizi biliari naturali f\u0103r\u0103 standardizare terapeutic\u0103 a dozei. Doar comprimatele de UDCA purificat sunt utilizate \u00een clinic\u0103 pentru PBC \u0219i dizolvarea pietrelor biliare.<\/p>\n<h3>Cum se monitorizeaz\u0103 UDCA?<\/h3>\n<p>Pentru PBC: ALP, ALT, AST, GGT, bilirubin total la fiecare 3 luni \u00een primul an, apoi la 6 luni. Pentru dizolvarea pietrelor biliare: ecografie la 6, 12 \u0219i 24 de luni pentru a urm\u0103ri dimensiunea pietrelor.<\/p>\n<h3>Poate fi nociv\u0103 doza mare de UDCA?<\/h3>\n<p>\u00cen colangita sclerozant\u0103 primar\u0103, dozele \u2265 28 mg\/kg\/zi au fost asociate cu rezultate clinice MAI SLABE (Lindor 2009 NEJM). Respecta\u021bi doza de 13\u201315 mg\/kg\/zi \u00een PSC \u0219i nu cre\u0219te\u021bi doza f\u0103r\u0103 consult specialistic.<\/p>\n<h2>Alte produse pentru ficat \u0219i hepatologie<\/h2>\n<ul>\n<li><a href=\"\/ro\/udiliv\/\">Udiliv (UDCA 300 mg) \u2014 UDCA cu concentra\u021bie mai mare, mai pu\u021bine comprimate<\/a><\/li>\n<li><a href=\"\/ro\/hepatitis-medication\/\">Toate medicamentele pentru hepatit\u0103 \u0219i ficat<\/a><\/li>\n<li><a href=\"\/ro\/hepcinat\/\">Hepcinat (sofosbuvir) \u2014 antiviral cu ac\u021biune direct\u0103 pentru HCV cronic<\/a><\/li>\n<li><a href=\"\/ro\/myhep-all\/\">MyHep All (sofosbuvir + velpatasvir) \u2014 pan-genotipic pentru HCV<\/a><\/li>\n<li><a href=\"\/ro\/celin\/\">Celin (vitamina C) \u2014 adjuvant antioxidant<\/a><\/li>\n<li><a href=\"\/ro\/l-glutathione-250mg\/\">L-Glutathion 250 mg \u2014 antioxidant pentru sprijin hepatic redox<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0 0 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 8px 0;font-size:1.05em;\">Declinare de responsabilitate medical\u0103<\/h3>\n<p style=\"margin:0;\">Aceast\u0103 informa\u021bie este furnizat\u0103 \u00een scop educa\u021bional \u0219i nu \u00eenlocuie\u0219te sfatul medical. Consulta\u021bi \u00eentotdeauna un profesionist calificat \u00een s\u0103n\u0103tate \u00eenainte de a \u00eencepe, modifica sau \u00eentrerupe orice tratament medicamentos.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u2705 Dissolves gallstones<br \/>\n\u2705 Protejeaz\u0103 celulele hepatice<br \/>\n\u2705 Reduces bile toxicity<br \/>\n\u2705 \u00cembun\u0103t\u0103\u021be\u0219te func\u021bia hepatic\u0103<br \/>\n\u2705 Alleviates liver inflammation<\/p>\n<p>Ursodec contains Ursodeoxycholic Acid.<\/p>","protected":false},"featured_media":61040,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3334],"product_tag":[4967,4728],"class_list":{"0":"post-61039","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-hepatitis-medication","9":"product_tag-ursodec","10":"product_tag-ursodeoxycholic-acid","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/61039","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=61039"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/61040"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=61039"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=61039"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=61039"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=61039"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}